Excessive daytime sleepiness is associated with changes in salivary inflammatory genes transcripts

Mediators of Inflammation

Volumn 2015, Issue , 2015, Pages

  Thimgan, Matthew S ^a,b   Toedebusch, Cristina ^a   McLeland, Jennifer ^a   Duntley, Stephen P ^a,c   Shaw, Paul J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^c Critical Care Pulmonary and Sleep Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; BETA 2 MICROGLOBULIN; BETA ACTIN; BIOLOGICAL MARKER; CD18 ANTIGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROPHOSPHOINOSITOL INOSITOLPHOSPHODIESTERASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2 RECEPTOR GAMMA; LIPOCORTIN 1; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE 2; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; MESSENGER RNA; PTGS2 PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DAYTIME SOMNOLENCE; FEMALE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; MALE; PRIORITY JOURNAL; SALIVA LEVEL; SLEEP DISORDERED BREATHING; AGED; BODY MASS; GENETICS; METABOLISM; MIDDLE AGED; SALIVA; SOMNOLENCE;

ADULT; AGED; BIOMARKERS; BODY MASS INDEX; CASPASE 1; CYCLOOXYGENASE 2; DISORDERS OF EXCESSIVE SOMNOLENCE; FEMALE; HUMANS; MALE; MIDDLE AGED; RNA, MESSENGER; SALIVA; SLEEP APNEA SYNDROMES;

EID: 84927154632     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/539627     Document Type: Article

References (61)

1. H. P. A. van Dongen, G. Maislin, J. M. Mullington, and D. F. Dinges, "The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation, " Sleep, vol. 26, no. 2, pp. 117-126, 2003.
2. J. Lamphere, T. Roehrs, R. Wittig, F. Zorick, W. A. Conway, and T. Roth, "Recovery of alertness after CPAP in apnea, " Chest, vol. 96, no. 6, pp. 1364-1367, 1989.
3. M. W. Johns, "A new method for measuring daytime sleepiness: The Epworth sleepiness scale, " Sleep, vol. 14, no. 6, pp. 540-545, 1991.
4. L. Ferini-Strambi, C. Baietto, M. R. di Gioia et al., "Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP), " Brain Research Bulletin, vol. 61, no. 1, pp. 87-92, 2003.
5. G. K. Zammit, V. N. Joish, M. C. Kong, R. Balkrishnan, D. Lerner, and M. Rosekind, "Impact of nighttime awakenings on worker productivity and performance, " Journal of Occupational & Environmental Medicine, vol. 52, no. 5, pp. 513-518, 2010.
6. J. Teran-Santos, A. Jimenez-Gomez, J. Cordero-Guevara, and Cooperative Group Burgos-Santander, "The association between sleep apnea and the risk of traffic accidents, " The New England Journal of Medicine, vol. 340, no. 11, pp. 847-851, 1999.
7. T. Young, L. Finn, P. E. Peppard et al., "Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort, " Sleep, vol. 31, no. 8, pp. 1071-1078, 2008.
8. A. M. Ingiosi, M. R. Opp, and J. M. Krueger, "Sleep and immune function: glial contributions and consequences of aging, " Current Opinion in Neurobiology, vol. 23, no. 5, pp. 806- 811, 2013.
9. R. Nadeem, J. Molnar, E. M. Madbouly et al., "Serum inflammatory markers in obstructive sleep apnea: A meta-analysis, " Journal of Clinical Sleep Medicine, vol. 9, pp. 1003-1012, 2013.
10. J. K. Cremeans-Smith, K. Millington, E. Sledjeski, K. Greene, and D. L. Delahanty, "Sleep disruptions mediate the relationship between early postoperative pain and later functioning following total knee replacement surgery, " Journal of Behavioral Medicine, vol. 29, no. 2, pp. 215-222, 2006.
11. E. Vanninen, A. Tuunainen, M. Kansanen, M. Uusitupa, and E. Länsimies, "Cardiac sympathovagal balance during sleep apnea episodes, " Clinical Physiology, vol. 16, no. 3, pp. 209-216, 1996.
12. E. Tasali, R. Leproult, D. A. Ehrmann, and E. van Cauter, "Slow-wave sleep and the risk of type 2 diabetes in humans, " Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 3, pp. 1044-1049, 2008.
13. M. W. Johns, A. Tucker, R. Chapman, K. Crowley, and N. Michael, "Monitoring eye and eyelid movements by infrared reflectance oculography to measure drowsiness in drivers, " Somnologie, vol. 11, no. 4, pp. 234-242, 2007.
14. A. Tietäväinen, F. K. Gates, A. Meriläinen, J. E. Mandel, and E. Haggström, "Nintendo Wii Fit based sleepiness tester detects impairment of postural steadiness due to 24 h of wakefulness, " Medical Engineering and Physics, vol. 35, no. 12, pp. 1850-1853, 2013.
15. N. Naidoo, "Potential of proteomics as a bioanalytic technique for quantifying sleepiness, " Journal of Clinical Sleep Medicine, vol. 7, no. 5, pp. S28-S30, 2011.
16. M. Sánchez-de-la-Torre, A. Barceló, J. Piérola et al., "Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea, " Respiratory Medicine, vol. 105, no. 12, pp. 1954-1960, 2011.
17. S. Nishino, B. Ripley, S. Overeem, G. J. Lammers, and E. Mignot, "Hypocretin (orexin) deficiency in human narcolepsy, " The Lancet, vol. 355, no. 9197, pp. 39-40, 2000.
18. E. Mignot, G. J. Lammers, B. Ripley et al., "The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias, " Archives of Neurology, vol. 59, no. 10, pp. 1553-1562, 2002.
19. O. Andlauer, H. Moore IV, S.-C. Hong et al., "Predictors of hypocretin (orexin) deficiency in narcolepsywithout cataplexy, " Sleep, vol. 35, no. 9, pp. 1247-1255, 2012.
20. G. E. Carpagnano, S. A. Kharitonov, O. Resta, M. P. Foschino- Barbaro, E. Gramiccioni, and P. J. Barnes, "Increased 8- isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients, " Chest, vol. 122, no. 4, pp. 1162-1167, 2002.
21. L. Seugnet, J. Boero, L. Gottschalk, S. P. Duntley, and P. J. Shaw, "Identification of a biomarker for sleep drive in flies and humans, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 52, pp. 19913-19918, 2006.
22. L. Seugnet, Y. Suzuki, M. Thimgan et al., "Identifying sleep regulatory genes using a Drosophila model of insomnia, " The Journal of Neuroscience, vol. 29, no. 22, pp. 7148-7157, 2009.
23. M. S. Thimgan, S. P. Duntley, and P. J. Shaw, "Changes in gene expression with sleep, " Journal of Clinical Sleep Medicine, vol. 7, no. 5, pp. S26-S27, 2011.
24. M. S. Thimgan, L. Gottschalk, C. Toedebusch et al., "Crosstranslational studies in human and Drosophila identifymarkers of sleep loss, " PLoS ONE, vol. 8, no. 4, Article ID e61016, 2013.
25. V. Bachmann, F. Klaus, S. Bodenmann et al., "Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans, " Cerebral Cortex, vol. 22, no. 4, pp. 962- 970, 2012.
26. A. N. Vgontzas, D. A. Papanicolaou, E. O. Bixler, A. Kales, K. Tyson, and G. P. Chrousos, "Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity, " The Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 5, pp. 1313-1316, 1997.
27. E. Ohga, T. Tomita, H. Wada, H. Yamamoto, T. Nagase, and Y. Ouchi, "Effects of obstructive sleep apnea on circulating ICAM- 1, IL-8, andMCP-1, " Journal of Applied Physiology, vol. 94, no. 1, pp. 179-184, 2003.
28. M. A. Alzoghaibi and A. S. O. Bahammam, "Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: A pilot study, " Sleep and Breathing, vol. 9, no. 3, pp. 119-126, 2005.
29. T. U. Ciftci, O. Kokturk, N. Bukan, and A. Bilgihan, "The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome, " Cytokine, vol. 28, no. 2, pp. 87-91, 2004.
30. L. M. O'Brien, R. Tauman, and D. Gozal, "Sleep pressure correlates of cognitive and behavioral morbidity in snoring children, " Sleep, vol. 27, no. 2, pp. 279-282, 2004.
31. A. Ursavas, M. Karadaʇ, E. Rodoplu, A. Yilmaztepe, H. B. Oral, and R. O. Gözü, "Circulating ICAM-1 and VCAM-1 levels in patients with obstructive sleep apnea syndrome, " Respiration, vol. 74, no. 5, pp. 525-532, 2007.
32. K. Chin, T. Nakamura, K. Shimizu, M. Mishima, M. Miyasaka, and M. Ohi, "Effects of nasal continuous positive airway pressure on soluble cell adhesion molecules in patients with obstructive sleep apnea syndrome, " American Journal of Medicine, vol. 109, no. 7, pp. 562-567, 2000.
33. S. P. Duntley, A. H. Kim, D. L. Silbergeld, and J. W. Miller, "Characterization of the mu rhythm during rapid eye movement sleep, " Clinical Neurophysiology, vol. 112, no. 3, pp. 528-531, 2001.
34. K. J. Livak and T. D. Schmittgen, "Analysis of relative gene expression data using real-time quantitative PCR and the 2 -method, " Methods, vol. 25, no. 4, pp. 402-408, 2001.
35. Y. Benjamini and Y. Hochberg, "Controlling the false discovery rate: A practical and powerful approach to multiple testing, " Journal of the Royal Statistical Society Series B: Methodological, vol. 57, no. 1, pp. 289-300, 1995.
36. E. F. Alf and J. M. Grossberg, "The geometric mean: confidence limits and significance tests, " Perception and Psychophysics, vol. 26, no. 5, pp. 419-421, 1979.
37. T. Young, M. Palta, J. Dempsey, J. Skatrud, S.Weber, and S. Badr, "The occurrence of sleep-disordered breathing among middleaged adults, "The New England Journal of Medicine, vol. 328, no. 17, pp. 1230-1235, 1993.
38. D. M. Hiestand, P. Britz, M. Goldman, and B. Phillips, "Prevalence of symptoms and risk of sleep apnea in the US population: results from the national sleep foundation sleep in America 2005 poll, " Chest, vol. 130, no. 3, pp. 780-786, 2006.
39. K. J. Finkel, A. C. Searleman, H. Tymkew et al., "Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center, " Sleep Medicine, vol. 10, no. 7, pp. 753-758, 2009.
40. F. Rahaghi and R. C. Basner, "Delayed diagnosis of obstructive sleep apnea: don't ask, don't tell, " Sleep and Breathing, vol. 3, no. 4, pp. 119-124, 1999.
41. P. E. Peppard, T. Young, M. Palta, J. Dempsey, and J. Skatrud, "Longitudinal study of moderate weight change and sleepdisordered breathing, " The Journal of the American Medical Association, vol. 284, no. 23, pp. 3015-3021, 2000.
42. P. E. Peppard, T. Young, J.H. Barnet, M. Palta, E.W. Hagen, and K. M. Hla, "Increased prevalence of sleep-disordered breathing in adults, " The American Journal of Epidemiology, vol. 177, no. 9, pp. 1006-1014, 2013.
43. P. E. Peppard, T. Young, M. Palta, and J. Skatrud, "Prospective study of the association between sleep-disordered breathing and hypertension, " The New England Journal of Medicine, vol. 342, no. 19, pp. 1378-1384, 2000.
44. T. Young, P. Peppard, M. Palta et al., "Population-based study of sleep-disordered breathing as a risk factor for hypertension, " Archives of Internal Medicine, vol. 157, no. 15, pp. 1746-1752, 1997.
45. K. Cheshire, H. Engleman, I. Deary, C. Shapiro, and N. J. Douglas, "Factors impairing daytime performance in patients with sleep apnea/hypopnea syndrome, " Archives of Internal Medicine, vol. 152, no. 3, pp. 538-541, 1992.
46. M.- Á. Martínez-García, F. Capote, F. Campos-Rodríguez et al., "Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: The HIPARCO randomized clinical trial, " The Journal of the American Medical Association, vol. 310, no. 22, pp. 2407-2415, 2013.
47. H. M. Engleman, K. E. Cheshire, I. J. Deary, and N. J. Douglas, "Daytime sleepiness, cognitive performance and mood after continuous positive airway pressure for the sleep apnoea/hypopnoea syndrome, " Thorax, vol. 48, no. 9, pp. 911- 914, 1993.
48. G. E. Carpagnano, A. Spanevello, R. Sabato et al., "Systemic and airway inflammation in sleep apnea and obesity: The role of ICAM-1 and IL-8, " Translational Research, vol. 155, no. 1, pp. 35-43, 2010.
49. A. S. M. Shamsuzzaman, M. Winnicki, P. Lanfranchi et al., "Elevated C-reactive protein in patients with obstructive sleep apnea, " Circulation, vol. 105, no. 21, pp. 2462-2464, 2002.
50. T. Yokoe, K.Minoguchi, H. Matsuo et al., "Elevated levels of Creactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure, " Circulation, vol. 107, no. 8, pp. 1129- 1134, 2003.
51. E. Ohga, T. Nagase, T. Tomita et al., "Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome, " Journal of Applied Physiology, vol. 87, no. 1, pp. 10-14, 1999.
52. G. E. Carpagnano, A. Spanevello, R. Sabato, A. Depalo, V. Turchiarelli, and M. P. Foschino Barbaro, "Exhaled pH, exhaled nitric oxide, and induced sputum cellularity in obese patients with obstructive sleep apnea syndrome, " Translational Research, vol. 151, no. 1, pp. 45-50, 2008.
53. D. Gozal, S. Jortani, A. B. Snow et al., "Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea, " American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 12, pp. 1253-1261, 2009.
54. L. Redwine, R. L. Hauger, J. C. Gillin, and M. Irwin, "Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans, " Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 10, pp. 3597-3603, 2000.
55. D. J. Frey, M. Fleshner, and K. P. Wright Jr., "The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults, " Brain, Behavior, and Immunity, vol. 21, no. 8, pp. 1050-1057, 2007.
56. S. Maret, S. Dorsaz, L. Gurcel et al., "Homer1a is a core brain molecular correlate of sleep loss, " Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 50, pp. 20090-20095, 2007.
57. E. Ricciotti and G. A. Fitzgerald, "Prostaglandins and inflammation, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 5, pp. 986-1000, 2011.
58. Y. Dauvilliers, C. R. Baumann, B. Carlander et al., "CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions, " Journal of Neurology, Neurosurgery and Psychiatry, vol. 74, no. 12, pp. 1667- 1673, 2003.
59. M. Wennström, E. Londos, L. Minthon, and H. M. Nielsen, "Altered CSF orexin and alpha-synuclein levels in dementia patients, " Journal of Alzheimer's Disease, vol. 29, no. 1, pp. 125- 132, 2012.
60. R. Fronczek, S. Van Geest, M. Frölich et al., "Hypocretin (orexin) loss in Alzheimer's disease, " Neurobiology of Aging, vol. 33, no. 8, pp. 1642-1650, 2012.
61. R. Lopez, L. Barateau, S. Chenini, and Y. Dauvilliers, "Preliminary results on CSF biomarkers for hypothalamic dysfunction in Kleine-Levin syndrome, " Sleep Medicine, vol. 16, no. 1, pp. 194-196, 2015.