Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: The HIPARCO randomized clinical trial

JAMA

Volumn 310, Issue 22, 2013, Pages 2407-2415

  Martínez García, Miguel Ángel ^a   Capote, Francisco ^b   Campos Rodríguez, Francisco ^c   Lloberes, Patricia ^d   Díaz De Atauri, María Josefa ^e   Somoza, María ^f   Masa, Juan F ^g   González, Mónica ^h   Sacristán, Lirios ⁱ   Barbé, Ferrán ^j   Durán Cantolla, Joaquín ^k,l   Aizpuru, Felipe ^k,l   Mañas, Eva ^m   Barreiro, Bienvenido ⁿ   Mosteiro, Mar ^o   Cebrián, Juan J ^p   De La Peña, Mónica ^q   García Río, Francisco ^r   Maimó, Andrés ^s   Zapater, Jordi ^t   Hernández, Concepción ^u   Grau SanMarti, Nuria ^v   Montserrat, Josep María ^w   more..

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^c HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^f Respiratory Medicine Department   (Spain)

^g Hospital Universitario San Pedro Alcántara   (Spain)

^h HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

ⁱ Hospital de Villajoyosa   (Spain)

^j UNIVERSITY OF LLEIDA   (Spain)

^k Academy of Nursing Sciences of Bizkaia   (Spain)

^l HOSPITAL TXAGORRITXU   (Spain)

^m HOSPITAL RAMÓN Y CAJAL   (Spain)

ⁿ HOSPITAL MÚTUA DE TERRASSA   (Spain)

^o Xeral Hospital   (Spain)

^p HOSPITAL COSTA DEL SOL   (Spain)

^q HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^r HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^s HOSPITAL SON LLÀTZER   (Spain)

^t Hospital de Igualada   (Spain)

^u UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^v HOSPITAL DEL MAR   (Spain)

^w INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; APNEA HYPOPNEA INDEX; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE AGED; MULTICENTER STUDY; OUTCOME ASSESSMENT; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANT HYPERTENSION; SLEEP DISORDERED BREATHING; SPAIN; SYSTOLIC BLOOD PRESSURE; THERAPY EFFECT; AGED; BLOOD PRESSURE; CIRCADIAN RHYTHM; CLINICAL TRIAL; COMPLICATION; DRUG RESISTANCE; HYPERTENSION; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME;

ANTIHYPERTENSIVE AGENT;

AGED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CIRCADIAN RHYTHM; CONTINUOUS POSITIVE AIRWAY PRESSURE; DRUG RESISTANCE; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME;

EID: 84889784451     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2013.281250     Document Type: Article

References (40)

1. Mancia G, De Backer G, Dominiczak A, et al. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens. 2007;25(9):1751-1762.
2. Persell SD. Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension. 2011;57(6):1076-1080.
3. de la Sierra A, Segura J, Banegas JR, et al. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension. 2011;57(5):898-902.
4. Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;51(6):1403-1419.
5. Daugherty SL, Powers JD, Magid DJ, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125(13):1635-1642.
6. Durán J, Esnaola S, Rubio R, Iztueta A. Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 years. Am J Respir Crit Care Med. 2001;163(3 pt 1):685-689.
7. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230-1235.
8. Pavlova MK, Duffy JF, Shea SA. Polysomnographic respiratory abnormalities in asymptomatic individuals. Sleep. 2008;31(2):241-248.
9. Eckert DJ, Malhotra A. Pathophysiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008;5(2):144-153.
10. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378-1384.
11. Logan AG, Perlikowski SM, Mente A, et al. High prevalence of unrecognized sleep apnea in drug-resistant hypertension. J Hypertens. 2001;19(12):2271-2277. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&list-uids=11204288&dopt=Abstract
12. Sanders MH, Montserrat JM, Farré R, Givelber RJ. Positive pressure therapy: a perspective on evidence-based outcomes and methods of application. Proc Am Thorac Soc. 2008;5(2):161-172.
13. Bazzano LA, Khan Z, Reynolds K, He J. Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea. Hypertension. 2007;50(2):417-423.
14. Martínez-García MA, Gómez-Aldaraví R, Soler-Cataluña JJ, Martínez TG, Bernácer-Alpera B, Román-Sánchez P. Positive effect of CPAP treatment on the control of difficult-to-treat hypertension. Eur Respir J. 2007;29(5):951-957.
15. Logan AG, Tkacova R, Perlikowski SM, et al. Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. Eur Respir J. 2003;21(2):241-247.
16. Lozano L, Tovar JL, Sampol G, et al. Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial. J Hypertens. 2010;28(10):2161-2168.
17. Haynes RB, Sackett DL, Gibson ES, et al. Improvement of medication compliance in uncontrolled hypertension. Lancet. 1976;1(7972):1265-1268.
18. Masa JF, Corral J, Pereira R, et al. Effectiveness of home respiratory polygraphy for the diagnosis of sleep apnoea and hypopnoea syndrome. Thorax. 2011;66(7):567-573.
19. Pickering TG, Hall JE, Appel LJ, et al Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Recommendations for blood pressure measurement in humans and experimental animals. Hypertension. 2005;45(1):142-161.
20. Head GA, McGrath BP, Mihailidou AS, et al. Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement. J Hypertens. 2012;30(2):253-266.
21. Franklin SS, Gustin W IV, Wong ND, et al. Hemodynamic patterns of age-related changes in blood pressure: The Framingham Heart Study. Circulation. 1997;96(1):308-315.
22. Masa JF, Jimenez A, Durán J, et al. Alternative methods of titrating continuous positive airway pressure: a large multicenter study. Am J Respir Crit Care Med. 2004;170(11):1218-1224.
23. Hein H. Is sham CPAP a true placebo? Am J Respir Crit Care Med. 2002;165(2):305.
24. Grote L, Hedner J, Peter JH. Sleep-related breathing disorder is an independent risk factor for uncontrolled hypertension. J Hypertens. 2000;18(6):679-685.
25. Campos-Rodriguez F, Grilo-Reina A, Perez-Ronchel J, et al. Effect of continuous positive airway pressure on ambulatory blood pressure in patients with sleep apnea and hypertension: a placebo-controlled trial. Chest. 2006;129(6):1459-1467.
26. Alajmi M, Mulgrew AT, Fox J, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: ameta-analysis of randomized controlled trials. Lung. 2007;185(2):67-72.
27. Haentjens P, Van Meerhaeghe A, Moscariello A, et al. The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials. Arch Intern Med. 2007;167(8):757-764.
28. Montesi SB, Edwards BA, Malhotra A, Bakker JP. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2012;8(5):587-596.
29. Durán-Cantolla J, Aizpuru F, Montserrat JM, et al Spanish Sleep and Breathing Group. Continuous positive airway pressure as treatment for systemic hypertension in people with obstructive sleep apnoea: randomised controlled trial. BMJ. 2010;341:c5991.
30. Martínez-García MA, Gómez-Aldaraví R, Gil-Martínez T, Soler-Cataluña JJ, Bernácer-Alpera B, Román-Sánchez P. Sleep-disordered breathing in patients with difficult-to-control hypertension. Arch Bronconeumol. 2006;42(1):14-20.
31. Lloberes P, Lozano L, Sampol G, et al. Obstructive sleep apnoea and 24-hour blood pressure in patients with resistant hypertension. J Sleep Res. 2010;19(4):597-602.
32. Chobanian AV, Bakris GL, Black HR, et al National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560-2572.
33. Ben-Dov IZ, Kark JD, Ben-Ishay D, Mekler J, Ben-Arie L, Bursztyn M. Predictors of all-cause mortality in clinical ambulatory monitoring: unique aspects of blood pressure during sleep. Hypertension. 2007;49(6):1235-1241.
34. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension. 1994;24(6):793-801.
35. Weaver TE, Grunstein RR. Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc. 2008;5(2):173-178.
36. Schwartz SW, Cimino CR, Anderson WM. CPAP or placebo-effect? Sleep. 2012;35(12):1585-1586.
37. Hui DS, To KW, Ko FW, et al. Nasal CPAP reduces systemic blood pressure in patients with obstructive sleep apnoea and mild sleepiness. Thorax. 2006;61(12):1083-1090.
38. Robinson GV, Smith DM, Langford BA, Davies RJ, Stradling JR. Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients. Eur Respir J. 2006;27(6):1229-1235.
39. Gugger M. Comparison of ResMed AutoSet (version 3.03) with polysomnography in the diagnosis of the sleep apnoea/hypopnoea syndrome. Eur Respir J. 1997;10(3):587-591.
40. Marrone O, Salvaggio A, Bue AL, et al. Blood pressure changes after automatic and fixed CPAP in obstructive sleep apnea: relationship with nocturnal sympathetic activity. Clin Exp Hypertens. 2011;33(6):373-380.