VgrG2 of type VI secretion system 2 of Vibrio parahaemolyticus induces autophagy in macrophages

Frontiers in Microbiology

Volumn 6, Issue MAR, 2015, Pages

  Yu, Ying ^a,b   Fang, Lihua ^b   Zhang, Yan ^b   Sheng, Hongxia ^b   Fang, Weihuan ^b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Autophagy; Effector proteins; Secretion system; Type VI secretion system; Vibrio parahaemolyticus

Indexed keywords

BACTERIAL PROTEIN; CHLOROQUINE; CYCLIC AMP; PROTEIN LC3; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BACTERIAL GENE; BACTERIAL VIRULENCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; EGFP GENE; GENETIC TRANSFECTION; HOMOLOGOUS RECOMBINATION; IMMUNOBLOTTING; LC3B GENE; MACROPHAGE; MOLECULAR CLONING; NONHUMAN; SIGNAL TRANSDUCTION; TYPE VI SECRETION SYSTEM; VIBRIO PARAHAEMOLYTICUS;

BACTERIA (MICROORGANISMS); PROTEOBACTERIA; VIBRIO PARAHAEMOLYTICUS;

EID: 84927133928     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00168     Document Type: Article

References (33)

1. Bernard, C. S., Brunet, Y. R., Gueguen, E., and Cascales, E. (2010). Nooks and crannies in type VI secretion regulation. J. Bacteriol. 192, 3850-3860. doi: 10.1128/JB.00370-10.
2. Bingle, L. E., Bailey, C. M., and Pallen, M. J. (2008). Type VI secretion: a beginner's guide. Curr. Opin. Microbiol. 11, 3-8. doi: 10.1016/j.mib.2008.01.006.
3. Boyer, F., Fichant, G., Berthod, J., Vandenbrouck, Y., and Attree, I. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? BMC Genomics 10:104. doi: 10.1186/1471-2164-10-104.
4. Burdette, D. L., Seemann, J., and Orth, K. (2009a). Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis. Mol. Microbiol. 73, 639-649. doi: 10.1111/j.1365-2958.2009.06798.x.
5. Burdette, D. L., Yarbrough, M. L., and Orth, K. (2009b). Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death. Autophagy 5, 100-102. doi: 10.4161/auto.5.1.7264.
6. Burdette, D. L., Yarbrough, M. L., Orvedahl, A., Gilpin, C. J., and Orth, K. (2008). Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. Proc. Natl. Acad. Sci. U.S.A. 105, 12497-12502. doi: 10.1073/pnas.0802773105.
7. Cascales, E. (2008). The type VI secretion toolkit. EMBO Rep. 9, 735-741. doi: 10.1038/embor.2008.131.
8. Cascales, E., and Cambillau, C. (2012). Structural biology of type VI secretion systems. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 1102-1111. doi: 10.1098/rstb.2011.0209.
9. Chen, M. L., Yi, L., Jin, X., Liang, X. Y., Zhou, Y., Zhang, T., et al. (2013). Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy 9, 2033-2045. doi: 10.4161/auto.26336.
10. Deretic, V., and Levine, B. (2009). Autophagy, immunity, and microbial adaptations. Cell Host Microbe 5, 527-549. doi: 10.1016/j.chom.2009.05.016.
11. Gutierrez, M. G., Saka, H. A., Chinen, I., Zoppino, F. C., Yoshimori, T., Bocco, J. L., et al. (2007). Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc. Natl. Acad. Sci. U.S.A. 104, 1829-1834. doi: 10.1073/pnas.0601437104.
12. Jani, A. J., and Cotter, P. A. (2010). Type VI secretion: not just for pathogenesis anymore. Cell Host Microbe 8, 2-6. doi: 10.1016/j.chom.2010.06.012.
13. Kaper, J. B., Campen, R. K., Seidler, R. J., Baldini, M. M., and Falkow, S. (1984). Cloning of the thermostable direct or Kanagawa phenomenon-associated hemolysin of Vibrio parahaemolyticus. Infect. Immun. 45, 290-292.
14. Levine, B., and Deretic, V. (2007). Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 7, 767-777. doi: 10.1038/nri2161.
15. Liu, X., Chen, Y., Wang, X., and Ji, R. (2004). Foodborne disease outbreaks in China from 1992 to 2001 national foodborne disease surveillance system. Wei Sheng Yan Jiu 33, 725-727.
16. Menzies, F. M., Moreau, K., Puri, C., Renna, M., and Rubinsztein, D. C. (2012). Measurement of autophagic activity in mammalian cells. Curr. Protoc. Cell Biol. Chap. 15, Unit 1516. doi: 10.1002/0471143030.cb1516s54.
17. Mestre, M. B., and Colombo, M. I. (2012). cAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the alpha-hemolysin autophagic response. PLoS Pathog. 8:e1002664. doi: 10.1371/journal.ppat.1002664.
18. Mizushima, N., Yoshimori, T., and Levine, B. (2010). Methods in mammalian autophagy research. Cell 140, 313-326. doi: 10.1016/j.cell.2010.01.028.
19. Mougous, J. D., Cuff, M. E., Raunser, S., Shen, A., Zhou, M., Gifford, C. A., et al. (2006). A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312, 1526-1530. doi: 10.1126/science.1128393.
20. Okada, N., Iida, T., Park, K. S., Goto, N., Yasunaga, T., Hiyoshi, H., et al. (2009). Identification and characterization of a novel type III secretion system in trh-positive Vibrio parahaemolyticus strain TH3996 reveal genetic lineage and diversity of pathogenic machinery beyond the species level. Infect. Immun. 77, 904-913. doi: 10.1128/IAI.01184-08.
21. Park, K. S., Ono, T., Rokuda, M., Jang, M. H., Okada, K., Iida, T., et al. (2004). Functional characterization of two type III secretion systems of Vibrio parahaemolyticus. Infect. Immun. 72, 6659-6665. doi: 10.1128/IAI.72.11.6659-6665.2004.
22. Pukatzki, S., Ma, A. T., Revel, A. T., Sturtevant, D., and Mekalanos, J. J. (2007). Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc. Natl. Acad. Sci. U.S.A. 104, 15508-15513. doi: 10.1073/pnas.0706532104.
23. Pukatzki, S., Ma, A. T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W. C., et al. (2006). Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc. Natl. Acad. Sci. U.S.A. 103, 1528-1533. doi: 10.1073/pnas.0510322103.
24. Pukatzki, S., Mcauley, S. B., and Miyata, S. T. (2009). The type VI secretion system: translocation of effectors and effector-domains. Curr. Opin. Microbiol. 12, 11-17. doi: 10.1016/j.mib.2008.11.010.
25. Schwarz, S., Hood, R. D., and Mougous, J. D. (2010). What is type VI secretion doing in all those bugs? Trends Microbiol. 18, 531-537. doi: 10.1016/j.tim.2010.09.001.
26. Shaw, R. J. (2009). LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol. (Oxf.) 196, 65-80. doi: 10.1111/j.1748-1716.2009.01972.x.
27. Suarez, G., Sierra, J. C., Sha, J., Wang, S., Erova, T. E., Fadl, A. A., et al. (2008). Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila. Microb. Pathog. 44, 344-361. doi: 10.1016/j.micpath.2007.10.005.
28. Weber, B., Hasic, M., Chen, C., Wai, S. N., and Milton, D. L. (2009). Type VI secretion modulates quorum sensing and stress response in Vibrio anguillarum. Environ. Microbiol. 11, 3018-3028. doi: 10.1111/j.1462-2920.2009.02005.x.
29. Yeung, P. S., and Boor, K. J. (2004). Epidemiology, pathogenesis, and prevention of foodborne Vibrio parahaemolyticus infections. Foodborne Pathog. Dis. 1, 74-88. doi: 10.1089/153531404323143594.
30. Yu, Y., Yang, H., Li, J., Zhang, P., Wu, B., Zhu, B., et al. (2012). Putative type VI secretion systems of Vibrio parahaemolyticus contribute to adhesion to cultured cell monolayers. Arch. Microbiol. 194, 827-835. doi: 10.1007/s00203-012-0816-z.
31. Zheng, J., and Leung, K. Y. (2007). Dissection of a type VI secretion system in Edwardsiella tarda. Mol. Microbiol. 66, 1192-1206. doi: 10.1111/j.1365-2958.2007.05993.x.
32. Zhou, X., Konkel, M. E., and Call, D. R. (2010). Vp1659 is a Vibrio parahaemolyticus type III secretion system 1 protein that contributes to translocation of effector proteins needed to induce cytolysis, autophagy, and disruption of actin structure in HeLa cells. J. Bacteriol. 192, 3491-3502. doi: 10.1128/JB.01493-09.
33. Zhu, B., Xu, F., Li, J., Shuai, J., Li, X., and Fang, W. (2012). Porcine circovirus type 2 explores the autophagic machinery for replication in PK-15 cells. Virus Res. 163, 476-485. doi: 10.1016/j.virusres.2011.11.012.