High serum adiponectin concentration and low body mass index are significantly associated with increased all-cause and cardiovascular mortality in an elderly cohort, "adiponectin paradox": The Korean Longitudinal Study on Health and Aging (KLoSHA)

International Journal of Cardiology

Volumn 183, Issue , 2015, Pages 91-97

  Choi, Sung Hee ^a   Ku, Eu Jeong ^a   Hong, Eun Shil ^c   Lim, Soo ^a   Kim, Ki Woong ^a   Moon, Jae Hoon ^a   Kim, Kyoung Min ^a   Park, Young Joo ^b   Park, Kyong Soo ^b   Jang, Hak Chul ^a  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

Adiponectin; All cause mortality; Body mass index; Cardiovascular mortality; Cohort study; Elderly

Indexed keywords

ADIPONECTIN;

AGED; AGING; ALL CAUSE MORTALITY; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; COHORT ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; SOUTH KOREA; VERY ELDERLY; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CAUSE OF DEATH; LONGITUDINAL STUDY; PROSPECTIVE STUDY;

ADIPONECTIN; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; PROSPECTIVE STUDIES;

EID: 84926683190     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2015.01.057     Document Type: Article

References (52)

1. K. Moser, V. Shkolnikov, and D.A. Leon World mortality 1950-2000: divergence replaces convergence from the late 1980s Bull. World Health Organ. 83 2005 202 209
2. S. Tuljapurkar, N. Li, and C. Boe A universal pattern of mortality decline in the G7 countries Nature 405 2000 789 792
3. P. Lloyd-Sherlock, M. McKee, and S. Ebrahim et al. Population ageing and health Lancet 379 2012 1295 1296
4. Y. Takata, T. Ansai, and I. Soh et al. Association between body mass index and mortality in an 80-year-old population J. Am. Geriatr. Soc. 55 2007 913 917
5. C.J. Lavie Obesity and prognosis-just one of many cardiovascular paradoxes? Prog. Cardiovasc. Dis. 56 2014 367 368
6. J.H. Kim, S. Lim, and S.H. Choi et al. Sarcopenia: an independent predictor of mortality in community-dwelling older Korean men J. Gerontol. A: Biol. Med. Sci. 69 2014 1244 1252
7. M.J. Thun, B.D. Carter, and D. Feskanich et al. 50-year trends in smoking-related mortality in the United States N. Engl. J. Med. 368 2013 351 364
8. J.R. Kizer, D. Benkeser, and A.M. Arnold et al. Associations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: the Cardiovascular Health Study Circulation 126 2012 2951 2961
9. J. Zacho, A. Tybjaerg-Hansen, and B.G. Nordestgaard C-reactive protein and all-cause mortality - the Copenhagen City Heart Study Eur. Heart J. 31 2010 1624 1632
10. K. Tuomisto, P. Jousilahti, J. Sundvall, P. Pajunen, and V. Salomaa C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study Thromb. Haemost. 95 2006 511 518
11. C. Fibrinogen Studies, J. Danesh, and S. Lewington et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis JAMA 294 2005 1799 1809
12. C. Ruggiero, E.J. Metter, and A. Cherubini et al. White blood cell count and mortality in the Baltimore Longitudinal Study of Aging J. Am. Coll. Cardiol. 49 2007 1841 1850
13. N. Ouchi, J.L. Parker, J.J. Lugus, and K. Walsh Adipokines in inflammation and metabolic disease Nat. Rev. Immunol. 11 2011 85 97
14. N. Stefan, Q. Sun, and A. Fritsche et al. Impact of the adipokine adiponectin and the hepatokine fetuin-a on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies PLoS One 9 2014 e92238
15. M. Cnop, P.J. Havel, and K.M. Utzschneider et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex Diabetologia 46 2003 459 469
16. T. Yamauchi, Y. Nio, and T. Maki et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat. Med. 13 2007 332 339
17. S. Lim, J.W. Yoon, and S.H. Choi et al. Combined impact of adiponectin and retinol-binding protein 4 on metabolic syndrome in elderly people: the Korean Longitudinal Study on Health and Aging Obesity 18 2010 826 832
18. S.H. Choi, S.H. Kwak, and B.S. Youn et al. High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus J. Clin. Endocrinol. Metab. 93 2008 3142 3148
19. J. Poehls, C.L. Wassel, and T.B. Harris et al. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study Diabetologia 52 2009 591 595
20. Z.J. Wu, Y.J. Cheng, W.J. Gu, and L.H. Aung Adiponectin is associated with increased mortality in patients with already established cardiovascular disease: a systematic review and meta-analysis Metab. Clin. Exp. 63 2014 1157 1166
21. D.A. Lawlor, G. Davey Smith, S. Ebrahim, C. Thompson, and N. Sattar Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women J. Clin. Endocrinol. Metab. 90 2005 5677 5683
22. T. Pischon, C.J. Girman, G.S. Hotamisligil, N. Rifai, F.B. Hu, and E.B. Rimm Plasma adiponectin levels and risk of myocardial infarction in men JAMA 291 2004 1730 1737
23. C. Vache, P. Rousset, and P. Gachon et al. Bioelectrical impedance analysis measurements of total body water and extracellular water in healthy elderly subjects Int. J. Obes. Relat. Metab. Disord. 22 1998 537 543
24. S. Lim, H. Shin, and M.J. Kim et al. Vitamin D inadequacy is associated with significant coronary artery stenosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging J. Clin. Endocrinol. Metab. 97 2012 169 178
25. G. Fuiano, C. Zoccali, and E. Bertoni et al. Guidelines for ambulatory monitoring of kidney transplant patients. Adaptation of the Guidelines of the American Society of Transplantation (J Am Soc Nephrol 2000; 11 (S1): 86) G. Ital. Nefrol. 21 Suppl. 28 2004 S11 S50
26. Y. Chen, W.K. Copeland, and R. Vedanthan et al. Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium BMJ 347 2013 f5446
27. K.M. Flegal, B.I. Graubard, D.F. Williamson, and M.H. Gail Cause-specific excess deaths associated with underweight, overweight, and obesity JAMA 298 2007 2028 2037
28. K. Inoue, T. Shono, S. Toyokawa, and M. Kawakami Body mass index as a predictor of mortality in community-dwelling seniors Aging Clin. Exp. Res. 18 2006 205 210
29. F. Landi, A.J. Cruz-Jentoft, and R. Liperoti et al. Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study Age Ageing 42 2013 203 209
30. E. Jahangir, A. De Schutter, and C.J. Lavie Low weight and overweightness in older adults: risk and clinical management Prog. Cardiovasc. Dis. 57 2014 127 133
31. C.J. Lavie, A. De Schutter, D. Patel, S.M. Artham, and R.V. Milani Body composition and coronary heart disease mortality - an obesity or a lean paradox? Mayo Clin. Proc. 86 2011 857 864
32. A. De Schutter, C.J. Lavie, D.A. Patel, S.M. Artham, and R.V. Milani Relation of body fat categories by Gallagher classification and by continuous variables to mortality in patients with coronary heart disease Am. J. Cardiol. 111 2013 657 660
33. C.J. Lavie, A. De Schutter, D.A. Patel, A. Romero-Corral, S.M. Artham, and R.V. Milani Body composition and survival in stable coronary heart disease: impact of lean mass index and body fat in the "obesity paradox" J. Am. Coll. Cardiol. 60 2012 1374 1380
34. A. De Schutter, C.J. Lavie, and R.V. Milani The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease - the obesity paradox Prog. Cardiovasc. Dis. 56 2014 401 408
35. A. De Schutter, C.J. Lavie, S. Kachur, D.A. Patel, and R.V. Milani Body composition and mortality in a large cohort with preserved ejection fraction: untangling the obesity paradox Mayo Clin. Proc. 89 2014 1072 1079
36. J. Stevens, and E.M. Nowicki Body mass index and mortality in Asian populations: implications for obesity cut-points Nutr. Rev. 61 2003 104 107
37. C.J. Lavie, P.A. McAuley, T.S. Church, R.V. Milani, and S.N. Blair Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox J. Am. Coll. Cardiol. 63 2014 1345 1354
38. P.A. McAuley, E.G. Artero, and X. Sui et al. The obesity paradox, cardiorespiratory fitness, and coronary heart disease Mayo Clin. Proc. 87 2012 443 451
39. C.J. Lavie, L.P. Cahalin, and P. Chase et al. Impact of cardiorespiratory fitness on the obesity paradox in patients with heart failure Mayo Clin. Proc. 88 2013 251 258
40. G.A. Laughlin, E. Barrett-Connor, S. May, and C. Langenberg Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study Am. J. Epidemiol. 165 2007 164 174
41. S.S. Huang, P.H. Huang, Y.H. Chen, K.H. Chiang, J.W. Chen, and S.J. Lin Association of adiponectin with future cardiovascular events in patients after acute myocardial infarction J. Atheroscler. Thromb. 17 2010 295 303
42. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat. Med. 7 2001 947 953
43. T. Kadowaki, and T. Yamauchi Adiponectin and adiponectin receptors Endocr. Rev. 26 2005 439 451
44. J.L. Parker-Duffen, and K. Walsh Cardiometabolic effects of adiponectin Best Pract. Res. Clin. Endocrinol. Metab. 28 2014 81 91
45. T. Yamauchi, J. Kamon, and Y. Minokoshi et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat. Med. 8 2002 1288 1295
46. T. Yamauchi, J. Kamon, and H. Waki et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis J. Biol. Chem. 278 2003 2461 2468
47. H. Teoh, M.H. Strauss, P.E. Szmitko, and S. Verma Adiponectin and myocardial infarction: a paradox or a paradigm? Eur. Heart J. 27 2006 2266 2268
48. M. Iwabu, T. Yamauchi, and M. Okada-Iwabu et al. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2 +) and AMPK/SIRT1 Nature 464 2010 1313 1319
49. M. Okada-Iwabu, T. Yamauchi, and M. Iwabu et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity Nature 503 2013 493 499
50. A.M. Van Berendoncks, A. Garnier, and P. Beckers et al. Functional adiponectin resistance at the level of the skeletal muscle in mild to moderate chronic heart failure Circ. Heart Fail. 3 2010 185 194
51. S. Kaser, T. Tatarczyk, and A. Stadlmayr et al. Effect of obesity and insulin sensitivity on adiponectin isoform distribution Eur. J. Clin. Investig. 38 2008 827 834
52. U.B. Pajvani, M. Hawkins, and T.P. Combs et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity J. Biol. Chem. 279 2004 12152 12162