GC-MS analysis of cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female wistar rats

Chinese Journal of Natural Medicines

Volumn 12, Issue 9, 2014, Pages 677-684

  Soumya, V ^a   Muzib, Y Indira ^a   Venkatesh, P ^b   Hariprasath, K ^b  

^a INSTITUTE OF PHARMACEUTICAL TECHNOLOGY   (India)

^b Sir CR Reddy College of Pharmaceutical Sciences   (India)

Author keywords

Antioxidant; Cocus nucifera; Estrus cyclicity; Histopathology of ovary; Lipid profile; PCOD; Poly cystic ovarian disease

Indexed keywords

CHOLESTEROL; FLOWER EXTRACT; GLUTATHIONE REDUCTASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; ANTIOXIDANT; ESSENTIAL OIL; GLUCOSE BLOOD LEVEL; LETROZOLE; LIPID; NITRILE; PHYTOESTROGEN; PLANT EXTRACT; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COCONUT; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; MASS FRAGMENTOGRAPHY; NONHUMAN; OVARY POLYCYSTIC DISEASE; RAT; SOLVENT EXTRACTION; UTERUS WEIGHT; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ESTRUS; FLOWER; METABOLISM; OVARY; PATHOLOGY; PHYTOTHERAPY; POLYCYSTIC OVARY SYNDROME; UTERUS; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; COCOS; ESTRUS; FEMALE; FLOWERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYPOGLYCEMIC AGENTS; LIPIDS; NITRILES; OILS, VOLATILE; OVARY; PHYTOESTROGENS; PHYTOTHERAPY; PLANT EXTRACTS; POLYCYSTIC OVARY SYNDROME; RATS, WISTAR; TRIAZOLES; UTERUS;

EID: 84926677210     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60103-5     Document Type: Article

References (33)

1. Fauser BCMJ, Tarlatzis BC, Chang J, et al. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [J]. Hum Reprod 2004, 19(1):41-47.
2. Norman RJ, Dewailly D, Legro RS, et al. Polycystic ovary syndrome [J]. The Lancet 2007, 370(9588):685-697.
3. Ojaniemi M, Pugeat M An adolescent with polycystic ovary syndrome [J]. Eur J Endocrinol 2006, 155(1):149-152.
4. Witchel SF Puberty and polycystic ovary syndrome [J]. Mol Cell Endocrinol 2006, 25(254):146-153.
5. Carmina E, Lobo RA PCOD: arguably the most common endocrinopathy is associated with significant morbidity in women [J]. J Clin Endocrinol Metab 1999, 84(6):1897-1899.
6. Rodin DA, Bano G, Bland GM, et al. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women [J]. Clin Endocrinol 1998, 49(1):91-98.
7. Koivunen R Endocrine and metabolic changes in women with polycystic ovaries [J]. University of Oulu library 2001, 19-20.
8. Azziz R, Carmina D, Dewailly D, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: The complete task force report [J]. Fertil Steril 2009, 91(2):456-488.
9. Carmina E, Rosato F, Jannì A Extensive clinical experience: Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism [J]. J Clin Endocrinol Metab 2006, 91(1):2-6.
10. Rotterdam ESHRE/ASRM-Sponsored PCOD consensus workshop group Revised 2003 consensus on diagnostic criteria and long-term health risks related to Polycystic ovary syndrome (PCOD) [J]. Hum Reprod 2004, 19(1):41-47.
11. Balen AH, Joop SEL, Tan SL, et al. Ultrasound assessment of the polycystic ovary: international consensus definitions [J]. Hum Reprod Updat 2003, 9(6):505-514.
12. Chang RJ The reproductive phenotype in polycystic ovary syndrome [J]. Nat lin Pract Endocrinol Metab 2007, 3(10):688-695.
13. Franks S, Stark J, Hardy K Follicle dynamics and anovulation in poly-cystic ovary syndrome [J]. Hum Reprod Update 2008, 14(4):367-378.
14. Kavitha SPC, Beena J Evaluation of antimicrobial, antioxidant and antitumor activity of fresh and dry Cocos nucifera female flower extracts [J]. Int J Curr Pharm Res 2012, 4(3):169-174.
15. Kabra Mahaveer P, Rachhadiya Rakesh M, Desai Nilesh V, et al. Hypoglycemic effect of Cocos nucifera flower alcoholic extract and oil in normal and alloxanised hyperglycemic Rats [J]. Int J Phar Phytopharmacol Res 2012, 2(1):29-31.
16. Hasan K, Mehmet I, Ilyas O, et al. Letrozole-induced polycystic ovaries in the rat: A new model for cystic ovarian disease [J]. Arch Med Res 2004, 35(2):103-108.
17. Kulkarni SK. Hand book of experimental pharmacology [M]. New Delhi:1999.
18. Manneras L, Fazliana M, Wan nazaimoon WN, et al. Beneficial metabolic effectsof the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome [J]. J Ethnopharmcol 2010, 127(2):346-351.
19. Thomas PA, Devasagayam A Lipid peroxidation in rat uterus [J]. Biochim Biophys Acta 1986, 876:507-514.
20. Kakkar P, Das B, Viswanathan PN A modified spectrophotometric assay of SOD [J]. Indian J Biophys 1984, 21(2):130-132.
21. Ellmann GL Tissue sulfhydryl groups [J]. Arch Biochem Biophys 1959, 82(1):70-77.
22. Dukes' Phytochemical and Ethnobotanical Databases [M]. 1994, accessed at . http://www.ars.grin.gov/duke.
23. Tsilchorozidou T, Overton C, Conway GS The pathophysiology of polycystic ovary syndrome [J]. Clin Endocrinol 2004, 60(1):1-17.
24. Cody V, Middleton EJ, Harborne JB, et al. Plant flavonoids in biology and medicine II: biochemical, cellular and medicinal properties. Progress in Clinical and Biological Research [M] 1988, 45. John Wiley & Sons Inc.
25. Licy LY, Damian GR, Mohaddetheh M, et al. Cardiovascular-renal and metabolic characterization of a rat model of polycystic ovary syndrome [J]. Gender Med 2011, 8(2):103-115.
26. Sabuncu T, Vural H, Harma M, et al. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease [J]. Clin Biochem 2001, 34(5):407-413.
27. Wang HZ, Wu YF, Shen WX, et al. The hormonal control of human luteal cells. Growth Factor in Fertility Regulation [M] 1991, Cambridge University Press, New York. F.P. Hasseltine, J.K. Findley (Eds.).
28. Halliwell B, Gutteridge JMC Role of free radicals and catalytic metal ions in human disease: an overview [J]. Methods Enzymol 1990, 86:59-85.
29. Clara C, Rokia S, Francesco O Effects of Calotropis procera on oestrous cycle and on oestrogenic functionality in rats [J]. Il Farmaco 2001, 56:373-378.
30. Zafari ZF, Bagher M, ashraff A, et al. Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome [J]. J Reprod Infertil 2010, 11(3):169-174.
31. Maharjan R, Nagar PS Effect of Aloe barbadensis Mill. formulation on letrozole-induced polycystic ovarian syndrome rat model [J]. J Ayurveda Integr Med 2010, 1(4):273-279.
32. Anuradha JP, Pravin TA Prospective use of Tephrosia purpurea in remedial treatment of PCOs: study in Wistar rats [J]. J Biol Sci 2012, 1(3):1-6.
33. Shetty G, Krishnamurthy H, Krishnamurthy HN, et al. Effect of estrogen deprivation on the reproductive physiology of male and female primates [J]. J Steroid Biochem Mol Biol 1997, 61:157-166.