Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice

Cardiovascular Research

Volumn 106, Issue 1, 2015, Pages 32-42

  Skrbic, Biljana ^a,b,c,d   Engebretsen, Kristin V T ^a,b,c,d   Strand, Mari E ^c,d   Lunde, Ida G ^c,d,e   Herum, Kate M ^c,d   Marstein, Henriette S ^a,c,d   Sjaastad, Ivar ^b,c,d   Lunde, Per K ^c,d   Carlson, Cathrine R ^c,d   Christensen, Geir ^b,c,d   BjØrnstad, Johannes L ^a,c   TØnnessen, Theis ^a,b,c  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aortic banding; Collagen; Extracellular matrix; Heart failure; Remodelling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 8; GELATINASE A; MESSENGER RNA; PROTEIN; PROTEIN PXN; RECOMBINANT COLLAGEN VIII ALPHA1; RECOMBINANT PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSGELIN; UNCLASSIFIED DRUG; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SURGERY; AORTIC BANDING; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION; GENE INACTIVATION; HEART DILATATION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE FIBROSIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MORTALITY; MOUSE; MYOFIBROBLAST; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ARTERIAL PRESSURE; CARDIAC MUSCLE; DEFICIENCY; DISEASE MODEL; FIBROSIS; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SURVIVAL RATE;

ANIMALS; ARTERIAL PRESSURE; CELL DIFFERENTIATION; COLLAGEN TYPE VIII; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBROSIS; HEART FAILURE; HYPERTROPHY, LEFT VENTRICULAR; IN VITRO TECHNIQUES; MALE; MICE; MICE, KNOCKOUT; MYOCARDIUM; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84926673466     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv041     Document Type: Article

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