How does obesity affect fertility in men - And what are the treatment options?

Clinical Endocrinology

Volumn 82, Issue 5, 2015, Pages 633-638

  Stokes, Victoria J ^a   Anderson, Richard A ^b   George, Jyothis T ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE INHIBITOR; CLOMIFENE; METFORMIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TESTOSTERONE; ANDROGEN;

ARTICLE; BARIATRIC SURGERY; DIET THERAPY; HUMAN; HYPOGONADISM; MALE; MALE FERTILITY; MALE INFERTILITY; OBESITY; PENIS ERECTION; PRIORITY JOURNAL; SPERM QUALITY; SPERMATOGENESIS; SPERMATOZOON DENSITY; TESTOSTERONE BLOOD LEVEL; WEIGHT REDUCTION; BLOOD; BODY MASS; COMPLICATION; ERECTILE DYSFUNCTION; FEMALE; FERTILIZATION IN VITRO; INFERTILITY, MALE; ODDS RATIO; PREGNANCY; PREGNANCY OUTCOME; TREATMENT OUTCOME;

ADIPOSITY; ANDROGENS; AROMATASE INHIBITORS; BODY MASS INDEX; CLOMIPHENE; ERECTILE DYSFUNCTION; ESTROGEN RECEPTOR MODULATORS; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, MALE; MALE; METFORMIN; OBESITY; ODDS RATIO; OVERWEIGHT; PREGNANCY; PREGNANCY OUTCOME; SPERMATOGENESIS; TESTOSTERONE; TREATMENT OUTCOME;

EID: 84926664686     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12591     Document Type: Article

References (46)

1. Palmer, N.O., Bakos, H.W., Fullston, T., et al,. (2012) Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis, 2, 253-263.
2. Hedley, A.A., Ogden, C.L., Johnson, C.L., et al,. (2004) PRevalence of overweight and obesity among us children, adolescents, and adults, 1999-2002. JAMA, 291, 2847-2850.
3. Ramlau-Hansen, C.H., Thulstrup, A.M., Nohr, E.A., et al,. (2007) Subfecundity in overweight and obese couples. Human Reproduction, 22, 1634-1637.
4. Nguyen, R.H.N., Wilcox, A.J., Skjærven, R., et al,. (2007) Men's body mass index and infertility. Human Reproduction, 22, 2488-2493.
5. Jokela, M., Kivimäki, M., Elovainio, M., et al,. (2007) Body mass index in adolescence and number of children in adulthood. Epidemiology, 18, 599-606.
6. Sermondade, N., Faure, C., Fezeu, L., et al,. (2013) BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human Reproduction Update, 19, 221-231.
7. MacDonald, A.A., Stewart, A.W., &, Farquhar, C.M., (2013) Body mass index in relation to semen quality and reproductive hormones in New Zealand men: a cross-sectional study in fertility clinics. Human Reproduction, 28, 3178-3187.
8. Jensen, T.K., Andersson, A.-M., Jørgensen, N., et al,. (2004) Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertility and Sterility 82, 863-870.
9. Hammiche, F., Laven, J.S.E., Twigt, J.M., et al,. (2012) Body mass index and central adiposity are associated with sperm quality in men of subfertile couples. Human Reproduction, 27, 2365-2372.
10. Hammoud, A.O., Meikle, A.W., Reis, L.O., et al,. (2012) Obesity and male infertility: a practical approach. Seminars in Reproductive Medicine, 30, 486-495.
11. Bakos, H.W., Mitchell, M., Setchell, B.P., et al,. (2011) The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. International Journal of Andrology 34 (5pt1), 402-410.
12. Fernandez, C., Bellentani, F., Fernandes, G., et al,. (2011) Diet-induced obesity in rats leads to a decrease in sperm motility. Reproductive Biology and Endocrinology, 9, 32.
13. Bakos, H., Mitchell, M., Setchell, B., et al,. (2010) The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. International Journal of Andrology, 34, 402-410.
14. Martin, L., (2013) Implications of adiponectin in linking metabolism to testicular function. Endocrine, 46, 1-13.
15. Mitchell, M., Armstrong, D.T., Robker, R.L., et al,. (2005) Adipokines: implications for female fertility and obesity. Reproduction, 130, 583-597.
16. Sharpe, R.M., (2000) Lifestyle and environmental contribution to male infertility. British Medical Bulletin, 56, 630-642.
17. Colaci, D.S., Afeiche, M., Gaskins, A.J., et al,. (2012) Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertility and Sterility, 98, 1193-1199, e1.
18. Tajar, A., Huhtaniemi, I.T., O'Neill, T.W., et al,. (2012) Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS). Journal of Clinical Endocrinology & Metabolism, 97, 1508-1516.
19. Naftolin, F., Yen, S.S., &, Tsai, C.C., (1972) Rapid cycling of plasma gonadotrophins in normal men as demonstrated by frequent sampling. Nature Chemical Biology, 236, 92-93.
20. Vermeulen, A., Kaufman, J., Deslypere, J., et al,. (1993) Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. Journal of Clinical Endocrinology and Metabolism, 76, 1140-1146.
21. Isidori, A.M., Caprio, M., Strollo, F., et al,. (1999) Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. The Journal of Clinical Endocrinology & Metabolism, 84, 3673-3680.
22. Yen, S.S., &, Tsai, C.C., (1971) The biphasic pattern in the feedback action of ethinyl estradiol on the release of pituitary FSH and LH. Journal of Clinical Endocrinology & Metabolism, 33, 882-887.
23. Kley, H.K., Deselaers, T., Peerenboom, H., et al,. (1980) Enhanced conversion of androstenedione to estrogens in obese males. The Journal of Clinical Endocrinology & Metabolism, 51, 1128-1132.
24. Hammoud, A.O., Griffin, J., Meikle, A.W., et al,. (2010) Association of aromatase (TTTAn) repeat polymorphism length and the relationship between obesity and decreased sperm concentration. Human Reproduction, 25, 3146-3151.
25. George, J.T., Millar, R.P., &, Anderson, R.A., (2010) Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology, 91, 302-307.
26. Ojeda, E., Lopez, S., Rodriguez, P., et al,. (2014) Prevalence of sleep apnea syndrome in morbidly obese patients. CHEST Journal 145 (3-MeetingAbstracts), 601A.
27. Luboshitzky, R., Aviv, A., Hefetz, A., et al,. (2002) Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. The Journal of Clinical Endocrinology & Metabolism, 87, 3394-3398.
28. Blank, D.M., Clark, R.V., Heymsfield, S.B., et al,. (1994) Endogenous opioids and hypogonadism in human obesity. Brain Research Bulletin, 34, 571-574.
29. George, J.T., Veldhuis, J.D., Tena-Sempere, M., et al,. (2013) Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clinical Endocrinology, 79, 100-104.
30. O'Brien, J.H., Lazarou, S., Deane, L., et al,. (2005) Erectile dysfunction and andropause symptoms in infertile men. The Journal of Urology, 174, 1932-1934.
31. Feldman, H.A., Johannes, C.B., Derby, C.A., et al,. (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Preventive Medicine, 30, 328-338.
32. Kaukua, J., Pekkarinen, T., Sane, T., et al,. (2003) Sex hormones and sexual function in obese men losing weight. Obesity Research, 11, 689-694.
33. Esposito, K., Giugliano, F., Di Palo, C., et al,. (2004) Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA, 291, 2978-2984.
34. Lucchese, M., &, Maggi, M., (2013) Hypogonadism as a new comorbidity in male patient's selection for bariatric surgery: towards an extended concept of metabolic surgery? Obesity Surgery, 23, 2018-2019.
35. Hammoud, A., Gibson, M., Hunt, S.C., et al,. (2009) Effect of Roux-En-Y gastric bypass surgery on the sex steroids and quality of life in obese men. The Journal of Clinical Endocrinology & Metabolism, 94, 1329-1332.
36. Reis, L.O., Favaro, W.J., Barreiro, G.C., et al,. (2010) Erectile dysfunction and hormonal imbalance in morbidly obese male is reversed after gastric bypass surgery: a prospective randomized controlled trial. International Journal of Andrology, 33, 736-744.
37. di Frega, A.S., Dale, B., Di Matteo, L., et al,. (2005) Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: case report. Human Reproduction, 20, 997-998.
38. Ko, E.Y., Siddiqi, K., Brannigan, R.E., et al,. (2012) Empirical medical therapy for idiopathic male infertility: a survey of the american urological association. The Journal of Urology, 187, 973-978.
39. Anderson, R.A., &, Baird, D.T., (2002) Male contraception. Endocrine Reviews, 23, 735-762.
40. De Boer, H., Verschoor, L., Ruinemans-Koerts, J., et al,. (2005) Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. Diabetes, Obesity and Metabolism, 7, 211-215.
41. Ozata, M., Oktenli, C., Bingol, N., et al,. (2001) The effects of metformin and diet on plasma testosterone and leptin levels in obese men. Obesity Research, 9, 662-667.
42. Morgante, G., Tosti, C., Orvieto, R., et al,. (2011) Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome. Fertility and Sterility, 95, 2150-2152.
43. Isidori, A.M., Buvat, J., Corona, G., et al,. (2014) A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review. European Urology, 65, 99-112.
44. Guay, A.T., Bansal, S., &, Heatley, G.J., (1995) Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate. Journal of Clinical Endocrinology & Metabolism, 80, 3546-3552.
45. Moskovic, D.J., Katz, D.J., Akhavan, A., et al,. (2012) Clomiphene citrate is safe and effective for long-term management of hypogonadism. BJU International, 110, 1524-1528.
46. Kaminetsky, J., Werner, M., Fontenot, G., et al,. (2013) Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. The Journal of Sexual Medicine, 10, 1628-1635.