Impact of estrogens on atherosclerosis and bone in the apolipoprotein E-deficient mouse model

Menopause

Volumn 22, Issue 4, 2015, Pages 428-436

  Fernández Murga, Maria Leonor ^a   Vinué, Angela ^b   Ramón Caeiro, Jose ^c   Guede, David ^d   Tarín, Juan J ^e   Andrés, Vicente ^f   Cano, Antonio ^e,g  

^a Fundacion para el Fomento de la Investigacion Sanitaria y Biomedica de la Comunitat Valenciana   (Spain)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^d Trabeculae SL   (Spain)

^e UNIVERSITY OF VALENCIA   (Spain)

^f CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^g HOSPITAL UNIVERSITARIO DR PESET   (Spain)

Author keywords

Apolipoprotein E.; Cardiovascular disease; Estrogens; Osteoblast; Osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE; APOLIPOPROTEIN E; CARBOXY TERMINAL TELOPEPTIDE; ESTROGEN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BONE; BONE DENSITY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CORTICAL BONE; ESTROGEN BLOOD LEVEL; FEMALE; LIPID DIET; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY-INDUCED OSTEOPOROSIS; THORACIC AORTA; TRABECULAR BONE; ANIMAL; DEFICIENCY; DISEASE MODEL; HUMAN; METABOLISM; OVARIECTOMY; PHYSIOLOGY;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BONE DENSITY; BONE RESORPTION; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ESTROGENS; FEMALE; HUMANS; MICE; OSTEOPOROSIS; OVARIECTOMY;

EID: 84926639077     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/gme.0000000000000328     Document Type: Article

References (23)

1. den Uyl D, Nurmohamed MT, van Tuyl LH, Raterman HG, Lems WF,. (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis. Arthritis Res Ther 2011; 13: R5
2. Eriksen EF,. Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord 2010; 11: 219-227
3. Rolin J, Maghazachi AA,. Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. J Leukoc Biol 2014; 95: 575-585
4. Crandall CJ, Barrett-Connor E,. Endogenous sex steroid levels and cardiovascular disease in relation to the menopause: a systematic review. Endocrinol Metab Clin North Am 2013; 42: 227-253
5. Makovey J, Chen JS, Hayward C, Williams FM, Sambrook PN,. Association between serum cholesterol and bone mineral density. Bone 2009; 44: 208-213
6. Hodgin JB, Maeda N,. Minireview: estrogen and mouse models of atherosclerosis. Endocrinology 2002; 143: 4495-4501
7. Heeren J, Beisiegel U, Grewal T,. Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol 2006; 26: 442-448
8. Khosla S, Oursler MJ, Monroe DG,. Estrogen and the skeleton. Trends Endocrinol Metab 2012; 23: 576-581
9. Gonzalez-Navarro H, Vila-Caballer M, Pastor MF, Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Front Biosci 2007; 12: 2291-2298
10. Fuster JJ, González-Navarro H, Vinué A, Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism. Arterioscler Thromb Vasc Biol 2011; 31: 2455-2463
11. Cano A, Dapía S, Noguera I, Comparative effects of 17β-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice. Osteoporos Int 2008; 19: 793-800
12. Verhoeven MO, van der Mooren MJ, Teerlink T, Verheijen RH, Scheffer PG, Kenemans P,. The influence of physiological and surgical menopause on coronary heart disease risk markers. Menopause 2009; 16: 37-49
13. Tuna V, Alkiş I, Safiye AS, Imamoglu N, Bayram N, Ali Ismet T,. Variations in blood lipid profile, thrombotic system, arterial elasticity and psychosexual parameters in the cases of surgical and natural menopause. Aust N Z J Obstet Gynaecol 2010; 50: 194-199
14. Yoshida T, Takahashi K, Yamatani H, Takata K, Kurachi H,. Impact of surgical menopause on lipid and bone metabolism. Climacteric 2011; 14: 445-452
15. Elhage R, Arnal JF, Pieraggi MT, 17β-Estradiol prevents fatty streak formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 1997; 17: 2679-2684
16. Freudenberger T, Oppermann M, Heim HK, Proatherogenic effects of estradiol in a model of accelerated atherosclerosis in ovariectomized ApoE-deficient mice. Basic Res Cardiol 2010; 105: 479-486
17. Chiba T, Ikeda M, Umegaki K, Tomita T,. Estrogen-dependent activation of neutral cholesterol ester hydrolase underlying gender difference of atherogenesis in apoE mice. Atherosclerosis 2011; 219: 545-551
18. Parhami F, Jackson SM, Tintut Y, Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res 1999; 14: 2067-2078
19. Xiao Y, Cui J, Li YX, Shi YH, Le GW,. Expression of genes associated with bone resorption is increased and bone formation is decreased in mice fed a high-fat diet. Lipids 2010; 45: 345-355
20. Nelson ER, DuSell CD, Wang X, The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology 2011; 152: 4691-4705
21. Niemeier A, Niedzielska D, Secer R, Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function. Bone 2008; 43: 230-237
22. Bartelt A, Beil FT, Schinke T, Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity. Bone 2010; 47: 736-745
23. Hirasawa H, Tanaka S, Sakai A, ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res 2007; 22: 1020-1030