Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance

Annals of Hematology

Volumn 94, Issue 2, 2015, Pages 187-193

  Letouzey, Mathilde ^a   Penther, Dominique ^b   Roche Lestienne, Catherine ^c   Nelken, Brigitte ^c   Devoldère, Catherine ^d   Vannier, Jean Pierre ^a   Schneider, Pascale ^a  

^a ROUEN UNIVERSITY HOSPITAL   (France)

^b CENTRE HENRI BECQUEREL   (France)

^c UNIV LILLE   (France)

^d AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Acute lymphoblastic leukaemia; Dic(9; 20); Paediatric

Indexed keywords

ASPARAGINASE; CORTICOSTEROID; METHOTREXATE; PREDNISONE; ANTINEOPLASTIC AGENT;

ADOLESCENT; ARTICLE; B CELL LEUKEMIA; CANCER MORTALITY; CANCER PROGNOSIS; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM LEUKEMIA; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DICENTRIC CHROMOSOME; EVENT FREE SURVIVAL; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LABORATORY TEST; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MALE; MINIMAL RESIDUAL DISEASE; MONOSOMY; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT RESPONSE; CHROMOSOME 20; CHROMOSOME 9; CHROMOSOME ABERRATION; CHROMOSOME BANDING PATTERN; CLINICAL TRIAL; GENETICS; INFANT; KARYOTYPE; MULTICENTER STUDY; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOME BANDING; CHROMOSOMES, HUMAN, PAIR 20; CHROMOSOMES, HUMAN, PAIR 9; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; KARYOTYPE; MALE; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84926623236     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-014-2204-z     Document Type: Article

References (21)

1. Pichler H, Möricke A, Mann G et al (2010) Prognostic relevance of dic(9;20)(p11;q13) in childhood B-cell precursor acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing an intensive induction and post-induction consolidation therapy. Br J Haematol 149:93–100. doi:10.1111/j.1365-2141.2009.08059.x
2. Forestier E, Gauffin F, Andersen MK et al (2008) Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature. Gene Chromosome Cancer 47:149–158. doi:10.1002/gcc.20517
3. Clark R, Byatt SA, Bennett CF et al (2000) Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia. Leukemia 14:241–246
4. Rieder H, Schnittger S, Bodenstein H et al (1995) Dic(9;20): a new recurrent chromosome abnormality in adult acute lymphoblastic leukemia. Gene Chromosome Cancer 13:54–61
5. Heerema NA, Maben KD, Bernstein J et al (1996) Dicentric (9;20)(p11;q11) identified by fluorescence in situ hybridization in four pediatric acute lymphoblastic leukemia patients. Cancer Genet Cytogenet 92:111–115
6. Li T, Xue Y, Zhang J et al (2008) Isodicentric 20q- in two cases of B-cell acute lymphocytic leukemia with the respective t(9;20)(p11;q11.2) and t(9;22)(q34;q11.2). Cancer Genet Cytogenet 181:55–59. doi:10.1016/j.cancergencyto.2007.11.003
7. Slater R, Smit E, Kroes W et al (1995) A non-random chromosome abnormality found in precursor-B lineage acute lymphoblastic leukaemia: dic(9;20) (p13;q11). Leukemia 9:1613–1619
8. Song X, Gong S, Yang J, Wang J (2007) Clinical and molecular cytogenetic characteristics of dic(9;20) in adult acute lymphoblastic leukemia: a case report of three patients. Ann Hematol 86:347–351. doi:10.1007/s00277-007-0255-0
9. Zachariadis V, Gauffin F, Kuchinskaya E et al (2011) The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial. Leukemia 25:622–628. doi:10.1038/leu.2010.318
10. Béné MC, Boumsell L, Vannier JP et al (1989) Immunologic analysis of a thousand cases of acute leukemia. French Groupe d’Etude Immunologique des Leucémies (GEIL). Nouv Rev Française Hématologie 31:133–136
11. Garand R, Beldjord K, Cavé H et al (2013) Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL. Leukemia 27:370–376. doi:10.1038/leu.2012.234
12. Gandemer V, Chevret S, Petit A et al (2012) Excellent prognosis of late relapses of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia: lessons from the FRALLE 93 protocol. Haematologica 97:1743–1750. doi:10.3324/haematol.2011.059584
13. 2/day) were equally effective as induction therapy for childhood acute lymphoblastic leukemia in the EORTC CLG 58951 randomized trial. Haematologica 99:1220–1227. doi:10.3324/haematol.2014.103507
14. Smith M, Arthur D, Camitta B et al (1996) Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol Off J Am Soc Clin Oncol 14:18–24
15. Cavé H, Van der Werff ten Bosch J, Suciu S (1998) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer—Childhood Leukemia Cooperative Group. N Engl J Med 339:591–598. doi:10.1056/NEJM199808273390904
16. Mitelman F, Johansson B, Mertens F (2014) Mitelman database of chromosome aberration and gene fusions in cancer.
17. Lönnerholm G, Nordgren A, Frost B-M et al (2009) Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids. Leukemia 23:209–212. doi:10.1038/leu.2008.179
18. Kuchinskaya E, Heyman M, Nordgren A et al (2011) Interphase fluorescent in situ hybridization deletion analysis of the 9p21 region and prognosis in childhood acute lymphoblastic leukaemia (ALL): results from a prospective analysis of 519 Nordic patients treated according to the NOPHO-ALL 2000 protocol. Br J Haematol 152:615–622. doi:10.1111/j.1365-2141.2010.08532.x
19. Schoumans J, Johansson B, Corcoran M et al (2006) Characterisation of dic(9;20)(p11-13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2. Br J Haematol 135:492–499. doi:10.1111/j.1365-2141.2006.06328.x
20. An Q, Wright SL, Moorman AV et al (2009) Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21. Haematologica 94:1164–1169. doi:10.3324/haematol.2008.002808
21. Strefford JC, An Q, Harrison CJ (2009) Modeling the molecular consequences of unbalanced translocations in cancer: lessons from acute lymphoblastic leukemia. Cell Cycle Georget Tex 8:2175–2184