Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue , 2015, Pages 527-530

  Springo, Zsolt ^a,b   Toth, Peter ^a,b   Tarantini, Stefano ^a   Ashpole, Nicole M ^a   Tucsek, Zsuzsanna ^a   Sonntag, William E ^a,c   Csiszar, Anna ^a,b,c   Koller, Akos ^b,d   Ungvari, Zoltan I ^a,b,c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

autoregulation; cerebral blood flow; pulse wave; Windkessel

Indexed keywords

CALCIUM CHANNEL L TYPE;

ADAPTATION; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY CONSTRICTION; ARTERY MUSCLE; ARTERY TONE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN MICROCIRCULATION; CONTROLLED STUDY; GENE EXPRESSION; MALE; MICROANGIOPATHY; MIDDLE CEREBRAL ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULSE PRESSURE; ANIMAL; BLOOD PRESSURE; BRAIN; C57BL MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; PULSATILE FLOW; VASCULARIZATION; VASOCONSTRICTION;

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; BLOOD PRESSURE; BRAIN; MALE; MICE; MICE, INBRED C57BL; MIDDLE CEREBRAL ARTERY; PULSATILE FLOW; VASOCONSTRICTION;

EID: 84926524743     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.256     Document Type: Article

References (15)

1. Henskens LH, Kroon AA, van Oostenbrugge RJ, Gronenschild EH, Fuss-Lejeune MM, Hofman PA et al. Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients. Hypertension 2008; 52: 1120-1126.
2. O'Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005; 46: 200-204.
3. Tarumi T, Ayaz Khan M, Liu J, Tseng BM, Parker R, Riley J et al. Cerebral hemodynamics in normal aging: central artery stiffness, wave reflection, and pressure pulsatility. J Cereb Blood Flow Metab 2014; 34: 971-978.
4. Purkayastha S, Fadar O, Mehregan A, Salat DH, Moscufo N, Meier DS et al. Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. J Cereb Blood Flow Metab 2014; 34: 228-234.
5. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 2011; 42: 2672-2713.
6. Waldstein SR, Rice SC, Thayer JF, Najjar SS, Scuteri A, Zonderman AB. Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging. Hypertension 2008; 51: 99-104.
7. Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson O et al. Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility-Reykjavik study. Brain 2011; 134: 3398-3407.
8. Faraci FM, Heistad DD. Regulation of large cerebral arteries and cerebral microvascular pressure. Circ Res 1990; 66: 8-17.
9. Tan CO, Hamner JW, Taylor JA. The role of myogenic mechanisms in human cerebrovascular regulation. J Physiol 2013; 591: 5095-5105.
10. Vrselja Z, Brkic H, Mrdenovic S, Radic R, Curic G. Function of circle of Willis. J Cereb Blood Flow Metab 2014; 34: 578-584.
11. Castellani S, Bacci M, Ungar A, Prati P, Di Serio C, Geppetti P et al. Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension. Hypertension 2006; 48: 1143-1150.
12. Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A et al. Role of 20-HETE, TRP channels & BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. Am J Physiol Heart Circ Physiol 2013; 305: H1698-H1708.
13. Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S et al. Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. J Cereb Blood Flow Metab 2013; 33: 1732-1742.
14. Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB et al. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell 2015 (in press).
15. van de Vosse FN, Stergiopulos N. Pulsewave propagation in the arterial tree. Annu Rev Fluid Mech 2011; 43: 467-499.