Synthesis of 13C215N2-labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([13C215N2]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 57, Issue 10, 2014, Pages 606-610

  Zheng, Suqing ^a   Huang, Jeffrey T J ^b   Knatko, Elena V ^b   Sharp, Sheila ^b   Higgins, Maureen ^b   Ojima, Iwao ^a   Dinkova Kostova, Albena T ^b,c   Honda, Tadashi ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti inflammatory; Carbon 13; Cytoprotective; Isotopically labeled synthesis; Keap1 Nrf2 ARE activator; Nitrogen 15; Stable isotope dilution LC MS method

Indexed keywords

ATOMS; CARBON; ISOTOPES; LIQUID CHROMATOGRAPHY;

ANTI-INFLAMMATORIES; CARBON-13; CYTOPROTECTIVE; ISOTOPICALLY LABELED; ISOTOPICALLY LABELED SYNTHESIS; KEAP1/NRF2/ARE ACTIVATOR; LC-MS METHODS; NITROGEN-15; STABLE ISOTOPE DILUTION; STABLE ISOTOPE DILUTION LC-MS METHOD;

NITROGEN;

ANTIINFLAMMATORY AGENT; CARBON 13; CYCLOHEXANONE; CYTOPROTECTIVE AGENT; NITROGEN 15; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; STABLE ISOTOPE; TRICYCLIC BIS(CYANOENONE) 31; UNCLASSIFIED DRUG; CARBON; NITROGEN; PHENANTHRENE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TBE 31;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FORMYLATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SOLID PHASE EXTRACTION; STABLE ISOTOPE DILUTION LIQUID CHROMATOGRAPHY MASS SPECTROMETRY METHOD; ANIMAL; CHEMISTRY; ISOTOPE DILUTION ASSAY; MOUSE; STANDARD; STANDARDS; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARBON ISOTOPES; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; MICE; NITROGEN RADIOISOTOPES; PHENANTHRENES; RADIOISOTOPE DILUTION TECHNIQUE; RADIOPHARMACEUTICALS; REFERENCE STANDARDS;

EID: 84926469438     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.3230     Document Type: Article

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