Induced overexpression of Oct4A in human dental pulp cells enhances pluripotency and multilineage differentiation capability

Stem Cells and Development

Volumn 24, Issue 8, 2015, Pages 962-972

  Liu, Lu ^a   Wu, Lijing ^a   Wei, Xi ^a   Ling, Junqi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; HOMEODOMAIN PROTEIN; KRUPPEL LIKE FACTOR; MYC PROTEIN; NANOG PROTEIN, HUMAN; NUCLEAR PROTEIN; POU5F1 PROTEIN, HUMAN; SOX2 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR SOX; UTF1 PROTEIN, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS BY BODY ANATOMY; DENTAL PULP CELL; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; ONCOGENE C MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TOOTH PULP; WESTERN BLOTTING; ADOLESCENT; ADULT; CYTOLOGY; GENETICS; METABOLISM;

LENTIVIRUS;

ADOLESCENT; ADULT; CELL DIFFERENTIATION; CELL LINEAGE; DENTAL PULP; HOMEODOMAIN PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; PROTO-ONCOGENE PROTEINS C-MYC; SOXB1 TRANSCRIPTION FACTORS; TRANS-ACTIVATORS;

EID: 84926465930     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0388     Document Type: Article

References (21)

1. Wei X, J Ling, L Wu, L Liu and Y Xiao. (2007). Expression of mineralization markers in dental pulp cells. J Endod 33:703-708.
2. Liu L, J Ling, X Wei, L Wu and Y Xiao. (2009). Stem cell regulatory gene expression in human adult dental pulp and periodontal ligament cells undergoing odontogenic/ osteogenic differentiation. J Endod 35:1368-1376.
3. JB Kim, V Sebastiano, G Wu, MJ Araúzo-Bravo, P Sasse, L Gentile, K Ko, D Ruau, M Ehrich, et al. (2009). Oct4-induced pluripotency in adult neural stem cells. Cell 136:411-419.
4. Wang X and J Dai. (2010). Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells 28:885-893.
5. Ferro F, R Spelat, F D'Aurizio, E Puppato, M Pandolfi, AP Beltrami, D Cesselli, G Falini, CA Beltrami and F Curcio. (2012). Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. PLos One 7:e41774.
6. Wang X, Y Zhao, Z Xiao, B Chen, Z Wei, B Wang, J Zhang, J Han, Y Gao, et al. (2009). Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. Stem Cells 27:1265-1275.
7. Kong Q, L Liu, Y Huang, F Zhang, X Wei and J Ling. (2014). The effect of octamer-binding transcription factor 4B1 on microRNA signals in human dental pulp cells with inflammatory response. J Endod 40:101-108.
8. Liu L, X Wei, J Ling, L Wu and Y Xiao. (2011). Expression pattern of Oct-4, Sox2 and c-Myc in the primary culture of human dental pulp derived cells. J Endod 37: 466-472.
9. Takahashi K and S Yamanaka. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
10. Hammachi F, GM Morrison, AA Sharov, A Livigni, S Narayan, EP Papapetrou, J O'Malley, K Kaji, MS Ko, M Ptashne and JM Brickman. (2012). Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency. Cell Rep 1:99-109.
11. Lee J, HK Kim, JY Rho, YM Han and J Kim. (2006). The human OCT-4 isoforms differ in their ability to confer selfrenewal. J Biol Chem 281:33554-33565.
12. Jez M, S Ambady, O Kashpur, A Grella, C Malcuit, L Vilner, P Rozman and T Dominko. (2014). Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells. PLoS One 9:e89546.
13. Farashahi Yazd E, MR Rafiee, M Soleimani, M Tavallaei, MK Salmani and SJ Mowla. (2011). OCT4B1, a novel spliced variant of OCT4, generates a stable truncated protein with a potential role in stress response. Cancer Lett 309:170-175.
14. Asadi MH, SJ Mowla, F Fathi, A Aleyasin, J Asadzadeh and Y Atlasi. (2011). OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor. Int J Cancer 128:2645-2652.
15. Gao Y, J Wei, J Han, X Wang, G Su, Y Zhao, B Chen, Z Xiao, J Cao and J Dai. (2012). The novel function of OCT4B isoform-265 in genotoxic stress. Stem Cells 30:665-672.
16. Atlasi Y, SJ Mowla, SA Ziaee, PJ Gokhale and PW Andrews. (2008). OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. Stem Cells 26:3068-3074.
17. Tsai SC, DF Chang, CM Hong, P Xia, D Senadheera, L Trump, S Mishra and C Lutzko. (2014). Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency. Am J Physiol Cell Physiol 306:C1108-C1118.
18. Ono M, T Kajitani, H Uchida, T Arase, H Oda, S Nishikawa-Uchida, H Masuda, T Nagashima, Y Yoshimura and T Maruyama. (2010). OCT4 expression in human uterine myometrial stem/progenitor cells. Hum Reprod 25: 2059-2067.
19. Cai H, M Katoh-Kurasawa, T Muramoto, B Santhanam, Y Long, L Li, M Ueda, PA Iglesias, G Shaulsky and PN Devreotes. (2014). Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science 343:1249531.
20. Suszynska M, EK Zuba-Surma, M Maj, K Mierzejewska, J Ratajczak, M Kucia and MZ Ratajczak. (2014). The proper criteria for identification and sorting of very small embryoniclike stem cells, and some nomenclature issues. Stem Cells Dev 23:702-713.
21. Blanpain C and E Fuchs. (2014). Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science 344:1242281.