Clinical predictors of adverse outcome in severe sepsis patients with lactate 2-4 mM admitted to the hospital

QJM: An International Journal of Medicine

Volumn 108, Issue 4, 2015, Pages 279-287

  Tang, Y ^a   Choi, J ^a   Kim, D ^a   Tudtud Hans, L ^a   Li, J ^a   Michel, A ^a   Baek, H ^a   Hurlow, A ^a   Wang, C ^a   Nguyen, H B ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERTENSIVE FACTOR; LACTIC ACID; UREA; BIOLOGICAL MARKER;

ABNORMAL THINKING; ADULT; ADVERSE OUTCOME; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD TRANSFUSION; DIASTOLIC BLOOD PRESSURE; ETHNICITY; FEMALE; FLUID RESUSCITATION; HOSPITALIZATION; HUMAN; HYPOTENSION; INTENSIVE CARE UNIT; LACTATE BLOOD LEVEL; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MECHANICAL VENTILATOR; MENTAL HEALTH; MIDDLE AGED; MINI MENTAL STATE EXAMINATION; MORTALITY; OXYGEN CONSUMPTION; PNEUMONIA; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK FACTOR; SEPSIS; SYSTOLIC BLOOD PRESSURE; TACHYPNEA; UREA NITROGEN BLOOD LEVEL; URINARY TRACT INFECTION; AGED; BLOOD; COMORBIDITY; COMPLICATION; MICROBIOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; VITAL SIGN;

ADULT; AGED; BIOMARKERS; COMORBIDITY; FEMALE; HOSPITALIZATION; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; PNEUMONIA; PROGNOSIS; RETROSPECTIVE STUDIES; SEPSIS; URINARY TRACT INFECTIONS; VITAL SIGNS;

EID: 84926455912     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcu186     Document Type: Article

References (27)

1. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007; 35:1244-50.
2. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003; 29:530-8.
3. Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41:580-637.
4. Shapiro NI, Howell MD, Talmor D, et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med 2005; 45:524-8.
5. Mikkelsen ME, Miltiades AN, Gaieski DF, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009; 37:1670-7.
6. Broder G, Weil MH. Excess lactate: an index of reversibility of shock in human patients. Science 1964; 143:1457-9.
7. Peretz DI, Scott HM, Duff J, et al. The significance of lacticacidemia in the shock syndrome. Ann N Y Acad Sci 1965; 119:1133-41.
8. Rady MY, Rivers EP, Nowak RM. Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 1996; 14:218-25.
9. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-77.
10. Aduen J, Bernstein WK, Khastgir T, et al. The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations. JAMA 1994; 272:1678-85.
11. Gofton TE, Young GB. Sepsis-associated encephalopathy. Nat Rev Neurol 2012; 8:557-66.
12. Eidelman LA, Putterman D, Putterman C, et al. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA 1996; 275:470-3.
13. Sanz F, Restrepo MI, Fernandez E, et al. Hypoxemia adds to the CURB-65 pneumonia severity score in hospitalized patients with mild pneumonia. Respir Care 2011; 56:612-8.
14. Lim WS, van der Eerden MM, Laing R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 2003; 58:377-82.
15. Hernandez G, Bruhn A, Castro R, et al. Persistent sepsis-induced hypotension without hyperlactatemia: a distinct clinical and physiological profile within the spectrum of septic shock. Crit Care Res Pract 2012; 2012:536852.
16. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-74.
17. Muckart DJ, Bhagwanjee S. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med 1997; 25:1789-95.
18. Lukaszewicz AC, Payen D. The future is predetermined in severe sepsis, so what are the implications? Crit Care Med 2010; 38(10 Suppl):S512-7.
19. Zimmerman JE, Kramer AA, McNair DS, et al. Acute physiology and chronic health evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients. Crit Care Med 2006; 34:1297-310.
20. Ferreira FL, Bota DP, Bross A, et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286:1754-8.
21. Marshall JC, Cook DJ, Christou NV, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995; 23:1638-52.
22. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-55.
23. Zhao H, Heard SO, Mullen MT, et al. An evaluation of the diagnostic accuracy of the 1991 American College of Chest Physicians/Society of Critical Care Medicine and the 2001 Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society sepsis definition. Crit Care Med 2012; 40:1700-6.
24. Nguyen HB, Corbett SW, Steele R, et al. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007; 35:1105-12.
25. Levy MM, Dellinger RP, Townsend SR, et al. The surviving sepsis campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010; 38:367-74.
26. Kumar G, Kumar N, Taneja A, et al. Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 2011; 140:1223-31.
27. Stevenson EK, Rubenstein AR, Radin GT, et al. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med 2014; 42:625-31.