Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: An electromechanically detailed biophysical modeling study

Frontiers in Physiology

Volumn 6, Issue MAR, 2015, Pages

  Adeniran, Ismail ^a   MacIver, David H ^a,b   Hancox, Jules C ^a,c   Zhang, Henggui ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b TAUNTON AND SOMERSET HOSPITAL   (United Kingdom)

^c Dept Anat Sch Med Sci U   (United Kingdom)

^d HARBIN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

3D model; Calcium; Heart failure; Ventricle

Indexed keywords

CALCIUM; ION CHANNEL; SODIUM CALCIUM EXCHANGE PROTEIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CHANNEL GATING; DIASTOLIC DYSFUNCTION; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE RELAXATION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE POTENTIAL; HEART RATE; ION CURRENT; MATHEMATICAL MODEL; SARCOMERE LENGTH; SARCOPLASMIC RETICULUM; SIMULATION;

EID: 84926453479     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2015.00078     Document Type: Article

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