Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 10, 2014, Pages 2676-2680

  Ewers, Christa ^a   Stamm, Ivonne ^b   Pfeifer, Yvonne ^c   Wieler, Lothar H ^d   Kopp, Peter A ^b   Schonning K ^e,f   Prenger Berninghoff, Ellen ^a   Scheufen, Sandra ^a   Stolle, Inka ^a   Günther, Sebastian ^d   Bethe, Astrid ^d  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Vet Med Labor GmbH   (Germany)

^c ROBERT KOCH INSTITUTE   (Germany)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

^e HVIDOVRE HOSPITAL   (Denmark)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antimicrobial resistance; ESBLs; Urinary tract infections; Wound infections

Indexed keywords

CEFOXITIN; COTRIMOXAZOLE; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; STREPTOMYCIN; SULFONAMIDE; TETRACYCLINE; TOBRAMYCIN; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE CTX-M-15;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CAT; CLONAL VARIATION; CORYNEBACTERIUM STRIATUM; DOG; GENOTYPE; HORSE; HOSPITAL INFECTION; KLEBSIELLA PNEUMONIAE; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PHENOTYPE; PHYLOGENY; PLASMID; PULSED FIELD GEL ELECTROPHORESIS; SOFT TISSUE INFECTION; URINARY TRACT INFECTION; ZOONOSIS; ANIMAL; ANIMAL DISEASE; BACTERIUM CONJUGATION; CLASSIFICATION; DRUG EFFECTS; GENETICS; HORSE DISEASE; KLEBSIELLA INFECTION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; VETERINARY;

ANIMAL DISEASES; ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CONJUGATION, GENETIC; GENOTYPE; HORSE DISEASES; HORSES; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MULTILOCUS SEQUENCE TYPING; PHENOTYPE; PHYLOGENY;

EID: 84926438535     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku217     Document Type: Article

References (28)

1. Woodford N, Turton JF, Livermore DM. Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev 2011; 35: 736-55.
2. Ewers C, Bethe A, Semmler T et al. Extended-spectrum b-lactamaseproducing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective. Clin Microbiol Infect 2012; 18: 646-55.
3. Groebner S, Linke D, Schutz W et al. Emergence of carbapenem-nonsusceptible extended-spectrum b-lactamase-producing Klebsiella pneumoniae isolates at the university hospital of Tubingen, Germany. J Med Microbiol 2009; 58: 912-22.
4. Brisse S, Duijkeren E. Identification and antimicrobial susceptibility of 100 Klebsiella animal clinical isolates. Vet Microbiol 2005; 105: 307-12.
5. Munoz MA, Welcome FL, Schukken YH et al. Molecular epidemiology of two Klebsiella pneumoniae mastitis outbreaks on a dairy farm in New York State. J Clin Microbiol 2007; 45: 3964-71.
6. Paulin-Curlee GG, Singer RS, Sreevatsan S et al. Genetic diversity of mastitis-associated Klebsiella pneumoniae in dairy cows. J Dairy Sci 2007; 90: 3681-9.
7. Locatelli C, Scaccabarozzi L, Pisoni G et al. CTX-M1 ESBL-producing Klebsiella pneumoniae subsp. pneumoniae isolated from cases of bovine mastitis. J Clin Microbiol 2010; 48: 3822-3.
8. Vo AT, van Duijkeren E, Fluit AC et al. Characteristics of extendedspectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates from horses. Vet Microbiol 2007; 124: 248-55.
9. Haenni M, Ponsin C, Metayer V et al. Veterinary hospital-acquired infections in pets with a ciprofloxacin-resistant CTX-M-15-producing Klebsiella pneumoniae ST15 clone. J Antimicrob Chemother 2012; 67: 770-1.
10. Poirel L, Nordmann P, Ducroz S et al. Extended-spectrum b-lactamase CTX-M-15-producing Klebsiella pneumoniae of sequence type ST274 in companion animals. Antimicrob Agents Chemother 2013; 57: 2372-5.
11. Donati V, Feltrin F, Hendriksen RS et al. Extended-spectrumb-lactamases, AmpC b-lactamases and plasmid mediated quinolone resistance in Klebsiella spp. from companion animals in Italy. PLoS One 2014; 9: e90564.
12. Damjanova I, Toth A, Paszti J et al. Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type b-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005: the new 'MRSAs'? J Antimicrob Chemother 2008; 62: 978-85.
13. Nielsen JB, Skov MN, Jorgensen RL et al. Identification of CTX-M15-, SHV-28-producing Klebsiella pneumoniae ST15 as an epidemic clone in the Copenhagen area using a semi-automated Rep-PCR typing assay. Eur J Clin Microbiol Infect Dis 2011; 30: 773-8.
14. Breurec S, Guessennd N, Timinouni M et al. Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258. Clin Microbiol Infect 2013; 19: 349-55.
15. Stolle I, Prenger-Berninghoff E, Stamm I et al. Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs. J Antimicrob Chemother 2013; 68: 2802-8.
16. Dahmen S, Metayer V, Gay E et al. Characterization of extendedspectrum b-lactamase (ESBL)-carrying plasmids and clones of Enterobacteriaceae causing cattle mastitis in France. Vet Microbiol 2013; 162: 793-9.
17. Brisse S, Fevre C, Passet V et al. Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS One 2009; 4: e4982.
18. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals-Third Edition: Approved Standard M31-A3. CLSI, Wayne, PA, USA, 2008.
19. Perez-Perez FJ, Hanson ND. Detection of plasmid-mediated AmpC b-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002; 40: 2153-62.
20. Ewers C, Bethe A, Stamm I et al. CTX-M-15-D-ST648 Escherichia coli from companion animals and horses: another pandemic clone combining multiresistance and extraintestinal virulence? J Antimicrob Chemother 2014; 69: 1224-30.
21. Ewers C, Grobbel M, Stamm I et al. Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum b-lactamase-producing Escherichia coli among companion animals. J Antimicrob Chemother 2010; 65: 651-60.
22. Diancourt L, Passet V, Verhoef J et al. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 2005; 43: 4178-82.
23. European Centre for Disease Prevention and Control (ECDC). Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). 2011. http://www.ecdc.europa.eu/en/publications/Publications/1111_SUR_AMR_data.pdf (2 April 2014, date last accessed).
24. Elhani D, Bakir L, Aouni M et al. Molecular epidemiology of extendedspectrum b-lactamase-producing Klebsiella pneumoniae strains in a university hospital in Tunis, Tunisia, 1999-2005. Clin Microbiol Infect 2010; 16: 157-64.
25. Lee MY, Ko KS, Kang CI et al. High prevalence of CTX-M-15-producing Klebsiella pneumoniae isolates in Asian countries: diverse clones and clonal dissemination. Int J Antimicrob Agents 2011; 38: 160-3.
26. Marcade G, Brisse S, Bialek S et al. The emergence of multidrugresistant Klebsiella pneumoniae of international clones ST13, ST16, ST35, ST48 and ST101 in a teaching hospital in the Paris region. Epidemiol Infect 2012; 141: 1-8.
27. Carattoli A. Plasmids and the spread of resistance. Int J Med Microbiol 2013; 303: 298-304.
28. Pitart C, Sole M, Roca I et al. First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 b-lactamase in Klebsiella pneumoniae in Spain. Antimicrob Agents Chemother 2011; 55: 4398-401.