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Volumn 88, Issue 4, 2014, Pages 257-260

RANK ligand blockade with denosumab in combination with sorafenib in chemorefractory osteosarcoma: A possible step forward?

Author keywords

Denosumab; Osteosarcoma; RANK; RANK ligand; Sorafenib

Indexed keywords

CARBOPLATIN; CISPLATIN; DENOSUMAB; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; METHOTREXATE; OSTEOCLAST DIFFERENTIATION FACTOR; SORAFENIB; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; MONOCLONAL ANTIBODY; NICOTINAMIDE;

EID: 84926419149     PISSN: 00302414     EISSN: 14230232     Source Type: Journal    
DOI: 10.1159/000369975     Document Type: Article
Times cited : (36)

References (19)
  • 1
    • 80054914908 scopus 로고    scopus 로고
    • Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand?
    • Anninga JK, Gelderblom H, Fiocco M, et al: Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer 2011; 47: 2431-2445.
    • (2011) Eur J Cancer , vol.47 , pp. 2431-2445
    • Anninga, J.K.1    Gelderblom, H.2    Fiocco, M.3
  • 2
    • 77955443177 scopus 로고    scopus 로고
    • Osteosarcoma of the spine: Experience in 26 patients treated at the Massachusetts General Hospital
    • Schoenfeld AJ, Hornicek FJ, Pedlow FX, et al: Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J 2010; 10: 708-714.
    • (2010) Spine J , vol.10 , pp. 708-714
    • Schoenfeld, A.J.1    Hornicek, F.J.2    Pedlow, F.X.3
  • 3
    • 84882932037 scopus 로고    scopus 로고
    • Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: Findings from a meta-analysis
    • Collins M, Wilhelm M, Conyers R, et al: Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis. J Clin Oncol 2013; 31: 2303-2312.
    • (2013) J Clin Oncol , vol.31 , pp. 2303-2312
    • Collins, M.1    Wilhelm, M.2    Conyers, R.3
  • 4
    • 59149095843 scopus 로고    scopus 로고
    • Second and subsequent recurrences of osteosarcoma: Presentation, treatment, and outcomes of 249 consecutive cooperative osteosarcoma study group patients
    • Bielack SS, Kempf-Bielack B, Branscheid D, et al: Second and subsequent recurrences of osteosarcoma: presentation, treatment, and outcomes of 249 consecutive cooperative osteosarcoma study group patients. J Clin Oncol 2009; 27: 557-565.
    • (2009) J Clin Oncol , vol.27 , pp. 557-565
    • Bielack, S.S.1    Kempf-Bielack, B.2    Branscheid, D.3
  • 5
    • 84856343533 scopus 로고    scopus 로고
    • A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: An Italian Sarcoma Group study
    • Grignani G, Palmerini E, Dileo P, et al: A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study. Ann Oncol 2012; 23: 508-516.
    • (2012) Ann Oncol , vol.23 , pp. 508-516
    • Grignani, G.1    Palmerini, E.2    Dileo, P.3
  • 6
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • Dougall WC, Glaccum M, Charrier K, et al: RANK is essential for osteoclast and lymph node development. Genes Dev 1999; 13: 2412-2424.
    • (1999) Genes Dev , vol.13 , pp. 2412-2424
    • Dougall, W.C.1    Glaccum, M.2    Charrier, K.3
  • 7
    • 84861213409 scopus 로고    scopus 로고
    • Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells
    • Beristain AG, Narala SR, Di Grappa MA, Khokha R: Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. J Cell Sci 2012; 125: 943-955.
    • (2012) J Cell Sci , vol.125 , pp. 943-955
    • Beristain, A.G.1    Narala, S.R.2    Di Grappa, M.A.3    Khokha, R.4
  • 8
    • 34547629223 scopus 로고    scopus 로고
    • Therapeutic relevance of osteoprotegrin gene therapy in osteosarcoma: Blockade of the vicious cycle between tumor cell proliferation and bone resorption
    • Lamoureux F, Richard P, Wittrand Y, et al: Therapeutic relevance of osteoprotegrin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. Cancer Res 2007; 67: 7308-7318.
    • (2007) Cancer Res , vol.67 , pp. 7308-7318
    • Lamoureux, F.1    Richard, P.2    Wittrand, Y.3
  • 9
    • 77953259922 scopus 로고    scopus 로고
    • RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells
    • Akiyama T, Choong PF, Dass CR: RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells. Clin Exp Metastasis 2010; 27: 207-215.
    • (2010) Clin Exp Metastasis , vol.27 , pp. 207-215
    • Akiyama, T.1    Choong, P.F.2    Dass, C.R.3
  • 10
    • 55749083203 scopus 로고    scopus 로고
    • Therapeutic efficacy of soluble receptor activator of nuclear factor-?B-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma
    • Lamoureux F, Picarda G, Rousseau J, et al: Therapeutic efficacy of soluble receptor activator of nuclear factor-?B-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma. Mol Cancer Ther 2008; 7: 3389-3398.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3389-3398
    • Lamoureux, F.1    Picarda, G.2    Rousseau, J.3
  • 11
    • 77952798405 scopus 로고    scopus 로고
    • Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma in a murine model via activity against osteoclasts
    • Akiyama T, Dass CR, Shinoda Y, et al: Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma in a murine model via activity against osteoclasts. J Pharm Pharmacol 2010; 62: 470-476.
    • (2010) J Pharm Pharmacol , vol.62 , pp. 470-476
    • Akiyama, T.1    Dass, C.R.2    Shinoda, Y.3
  • 13
    • 84906812780 scopus 로고    scopus 로고
    • Impact of RANK signaling on survival and chemotherapy response in osteosarcoma
    • Bago-Horvath Y, Schmid K, Rosseler F, et al: Impact of RANK signaling on survival and chemotherapy response in osteosarcoma. Pathology 2014; 46: 411-415.
    • (2014) Pathology , vol.46 , pp. 411-415
    • Bago-Horvath, Y.1    Schmid, K.2    Rosseler, F.3
  • 14
    • 79952131163 scopus 로고    scopus 로고
    • RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma
    • Lee JA, Jung JS, Kim DH, et al: RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. Pediatr Blood Cancer 2011; 56: 738-743.
    • (2011) Pediatr Blood Cancer , vol.56 , pp. 738-743
    • Lee, J.A.1    Jung, J.S.2    Kim, D.H.3
  • 15
    • 84860364397 scopus 로고    scopus 로고
    • Bench to bedside: Elucidation of the OPG-RANKRANKL pathway and the development of denosumab
    • Lacey DL, Boyle WJ, Simonet WS, et al: Bench to bedside: elucidation of the OPG-RANKRANKL pathway and the development of denosumab. Nat Rev Drug Discov 2012; 11: 401-419.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 401-419
    • Lacey, D.L.1    Boyle, W.J.2    Simonet, W.S.3
  • 16
    • 84869094189 scopus 로고    scopus 로고
    • Denosumab in patients with cancer and skeletal metastases: A systematic review and metaanalysis
    • Peddi P, Lopez-Olivo MA, Pratt GF, et al: Denosumab in patients with cancer and skeletal metastases: a systematic review and metaanalysis. Cancer Treat Rev 2013; 39: 97-104.
    • (2013) Cancer Treat Rev , vol.39 , pp. 97-104
    • Peddi, P.1    Lopez-Olivo, M.A.2    Pratt, G.F.3
  • 17
    • 84880770534 scopus 로고    scopus 로고
    • Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: Interim analysis of an open-label, parallel-group, phase 2 study
    • Chawla S, Henshaw R, Seeger L: Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol 2013; 14: 901-908.
    • (2013) Lancet Oncol , vol.14 , pp. 901-908
    • Chawla, S.1    Henshaw, R.2    Seeger, L.3
  • 18
    • 74549210540 scopus 로고    scopus 로고
    • Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
    • Pignochino Y, Grignani G, Cavalloni G, et al: Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. Mol Cancer 2009; 8: 118.
    • (2009) Mol Cancer , vol.8 , pp. 118
    • Pignochino, Y.1    Grignani, G.2    Cavalloni, G.3
  • 19
    • 84899426256 scopus 로고    scopus 로고
    • VEGFR, RET and RAF/MEK/ERK pathway take part in the inhibition of osteosarcoma MG63 cells with sorafenib treatment
    • Mei J, Zhu X, Wang Y, Wang Z: VEGFR, RET and RAF/MEK/ERK pathway take part in the inhibition of osteosarcoma MG63 cells with sorafenib treatment. Cell Biochem Biophys 2014; 69: 151-156.
    • (2014) Cell Biochem Biophys , vol.69 , pp. 151-156
    • Mei, J.1    Zhu, X.2    Wang, Y.3    Wang, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.