Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: Prescribing patterns according to pain prevalence and adherence to clinical guidelines

Pain

Volumn 155, Issue 9, 2014, Pages 1814-1820

  Gnjidic, Danijela ^a,b,c   Blyth, Fiona M ^b,c   Le Couteur, David G ^b,c,d   Cumming, Robert G ^c,e   McLachlan, Andrew J ^a,c   Handelsman, David J ^b,d   Seibel, Markus ^b,d   Waite, Louise ^b,c   Naganathan, Vasi ^b,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Centre for Education and Research on Ageing and Concord RG Hospital   (Australia)

^d ANZAC Research Institute   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Clinical guidelines; NSAIDs; Older people; Pain prevalence

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IBUPROFEN; INDOMETACIN; KETOPROFEN; LUMIRACOXIB; MELOXICAM; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PIROXICAM; PROTON PUMP INHIBITOR; SULINDAC; TIAPROFENIC ACID;

ADULT; AGED; ARTICLE; CHRONIC PAIN; CROSS-SECTIONAL STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN; PATIENT COMPLIANCE; PRACTICE GUIDELINE; PRESCRIPTION; PREVALENCE; PRIORITY JOURNAL; TREATMENT DURATION; CLINICAL PRACTICE; FEMALE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CROSS-SECTIONAL STUDIES; FEMALE; GUIDELINE ADHERENCE; HUMANS; MALE; PAIN; PHYSICIAN'S PRACTICE PATTERNS;

EID: 84926418028     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.06.009     Document Type: Article

References (42)

1. Abdulla A, Adams N, Bone M, Elliott AM, Gaffin J, Jones D, Knaggs R, Martin D, Sampson L, Schofield P. Guidance on the management of pain in older people. Age Ageing 2013;42:i1-i57.
2. Adams RJ, Appleton SL, Gill TK, Taylor AW, Wilson DH, Hill CL. Cause for concern in the use of nonsteroidal anti-inflammatory medications in the community-a population-based study. BMC Fam Pract 2011;12:70.
3. Bair MJ, Robinson RL, Katon W, Kroenke K. Depression and pain comorbidity: a literature review. Arch Intern Med 2003;163:2433-45.
4. Barkin RL, Beckerman M, Blum SL, Clark FM, Koh EK, Wu DS. Should nonsteroidal anti-inflammatory drugs (NSAIDs) be prescribed to the older adult? Drugs Aging 2010;27:775-89.
5. Bartlett C, Doyal L, Ebrahim S, Davey P, Bachmann M, Egger M, Dieppe P. The causes and effects of sociodemographic exclusions from clinical trials. Health Technol Assess 2005;9:38.
6. Blyth FM, March LM, Brnabic AJ, Jorm LR, Williamson M, Cousins MJ. Chronic pain in Australia: a prevalence study. PAIN 2001;89:127-34.
7. Blyth FM, Rochat S, Cumming RG, Creasey H, Handelsman DJ, Le Couteur DG, Naganathan V, Sambrook PN, Seibel MJ, Waite LM. Pain, frailty and comorbidity on older men: the CHAMP study. PAIN 2008;140:224-30.
8. Bryant LL, Grigsby J, Swenson C, Scarbro S, Baxter J. Chronic pain increases the risk of decreasing physical performance in older adults: the San Luis Valley Health and Aging Study. J Gerontol A Biol Sci Med Sci 2007;62: 989-96.
9. Caughey GE, Roughead EE, Pratt N, Killer G, Gilbert AL. Stroke risk and NSAIDs: an Australian population-based study. Med J Aust 2011;195:525-9.
10. Cumming RG, Handelsman D, Seibel MJ, Creasey H, Sambrook P, Waite L, Naganathan V, Le Couteur D, Litchfield M. Cohort profile: the Concord Health and Ageing in Men Project (CHAMP). Int J Epidemiol 2009;38:374-8.
11. Day RO, Graham GG. Nonsteroidal anti-inflammatory drugs (NSAIDs). BMJ 2013;346:f3195.
12. Dominick CH, Blyth FM, Nicholas MK. Unpacking the burden: understanding the relationships between chronic pain and comorbidity in the general population. PAIN 2012;153:293-304.
13. Fillenbaum GG, Smyer MA. The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 1981;36:428-34.
14. Fosbol EL, Gislason GH, Jacobsen S, Abildstrom SZ, Hansen ML, Schramm TK, Folke F, Sorensen R, Rasmussen JN, Kober L, Madsen M, Torp-Pedersen C. The pattern of use of nonsteroidal anti-inflammatory drugs (NSAIDs) from 1997 to 2005: a nationwide study on 4.6 million people. Pharmacoepidemiol Drug Saf 2008;17:822-33.
15. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146-56.
16. Garcia Rodriguez LA, Hernandez-Diaz S. Nonsteroidal antiinflammatory drugs as a trigger of clinical heart failure. Epidemiology 2003;14:240-6.
17. Gnjidic D, Hilmer SN, Blyth F, Naganathan V, Cumming RG, Handelsman D, McLachlan AJ, Abernethy DR, Banks E, Le Couteur DG. High risk prescribing and incidence of frailty among older community-dwelling men. Clin Pharmacol Ther 2012;91:521-8.
18. Gnjidic D, Hilmer SN, Blyth F, Naganathan V, Waite L, Seibel MJ, McLachlan AJ, Cumming RG, Handelsman D, Le Couteur DG. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiology 2012;65:989-95.
19. Gnjidic D, Le Couteur DG, Naganathan V, Cumming RG, Creasey H, Waite L, Sharma A, Blyth F, Hilmer SN. Effects of Drug Burden Index on cognitive function in older men. J Clin Psychopharmacol 2012;32:218-24.
20. Jyrkka J, Enlund H, Lavikainen P, Sulkava R, Hartikainen S. Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three-year period in an elderly population. Pharmacoepidemiol Drug Saf 2011;20:514-22.
21. Kamaleri Y, Natvig B, Ihlebaek CM, Benth JS, Bruusgaard D. Change in the number of musculoskeletal pain sites: a 14-year prospective study. PAIN 2009;141:25-30.
22. Katz S, Downs TD, Cash HR, Grotz RC. Progress in development of the index of ADL. Gerontologist 1970;10:20-30.
23. Lanas A, Ferrandez A. Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly. Drugs Aging 2007;24:121-31.
24. Landi F, Marzetti E, Liperoti R, Pahor M, Russo A, Martone AM, Colloca G, Capoluongo E, Bernabei R. Nonsteroidal anti-inflammatory drug (NSAID) use and sarcopenia in older people: results from the ilSIRENTE study. J AmMed Dir Assoc 2013;14. 626.e9-13.
25. Loboz KK, Shenfield GM. Drug combinations and impaired renal function-the 'triple whammy'. Br J Clin Pharmacol 2005;59:239-43.
26. Macintyre PE, Schug SA, Scott DA, Visser EJ, Walker SM, APM:SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine. Acute pain management: scientific evidence. 3rd ed. Melbourne, Australia: ANZCA & FPM; 2010.
27. Mantyselka PT, Turunen JH, Ahonen RS, Kumpusalo EA. Chronic pain and poor self-rated health. JAMA 2003;290:2435-42.
28. McLachlan AJ, Bath S, Naganathan V, Hilmer SN, Le Couteur DG, Gibson SJ, Blyth FM. Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol 2011;71:351-64.
29. Measuring alcohol risk in the 2010 National Drug Strategy Household Survey: implementation of the 2009 alcohol guidelines. Drug statistics series no. 26. Cat. no. PHE 152. Canberra: AIHW. Available at: [accessed 4.6.2013].
30. Medicines and Healthcare products Regulatory Agency. Safety of selective and non-selective NSAIDs. Available at: [accessed 9.12.2013].
31. Morgan TK, Williamson M, Pirotta M, Stewart K, Myers SP, Barnes J. A national census of medicines use: a 24-hour snapshot of Australians aged 50 years and older. Med J Aust 2012;196:50-3.
32. National Institute for Health and Clinical Excellence. Clinical guideline for care and management of osteoarthritis in adults. Clinical Guideline 59. Available at: [accessed 9.12.2013.
33. National Institute for Health and Clinical Excellence. Clinical guideline for the early management of persistent low back pain. Clinical guideline 88. Available at: [accessed 9.12.2013].
34. Page J, Henry D. Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem. Arch Intern Med 2000;160:777-84.
35. Reid MC, Bennett DA, Chen WG, Eldadah BA, Farrar JT, Ferrell B, Gallagher RM, Hanlon JT, Herr K, Horn SD, Inturrisi CE, Lemtouni S, Lin YW, Michaud K, Morrison RS, Neogi T, Porter LL, Solomon DH, Von Korff M, Weiss K, Witter J, Zacharoff KL. Improving the pharmacologic management of pain in older adults: identifying the research gaps and methods to address them. Pain Med 2011;12:1336-57.
36. Rochat S, Cumming RG, Blyth F, Creasey H, Handelsman D, Le Couteur DG, Naganathan V, Sambrook PN, Seibel MJ, Waite L. Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age Ageing 2010;39:228-33.
37. Roughead EE, Ramsay E, Pratt N, Gilbert AL. NSAID use in individuals at risk of renal adverse events: an observational study to investigate trends in Australian veterans. Drug Saf 2008;31:997-1003.
38. Sawyer P, Bodner EV, Ritchie CS, Allman RM. Pain and pain medication use in community-dwelling older adults. Am J Geriatr Pharmacother 2006;4:316-24.
39. Thomas MC. Diuretics, ACE inhibitors and NSAIDs-the triple whammy. Med J Aust 2000;172:184-5.
40. Washburn RA, Smith KW, Jette AM, Janney CA. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol 1993;46:153-62.
41. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1982;17:37-49.
42. Zhou Y, Boudreau DM, Freedman AN. Trends in the use of aspirin and nonsteroidal anti-inflammatory drugs in the general U.S. population. Pharmacoepidemiol Drug Saf 2014;23:43-50.