Molecular characterization of extended spectrum beta-lactamases produced by Klebsiella pneumoniae clinical strains from a Tunisian hospital

Medecine et Maladies Infectieuses

Volumn 45, Issue 4, 2015, Pages 139-143

  Alibi, S ^a   Ferjani, A ^a   Boukadida, J ^a  

^a FARHAT HACHED HOSPITAL   (Tunisia)

Author keywords

CTX M; ESBL; Klebsiella; SHV; TEM

Indexed keywords

AMIKACIN; BETA LACTAMASE CTX M; BETA LACTAMASE SHV; BETA LACTAMASE TEM 1; EXTENDED SPECTRUM BETA LACTAMASE; FOSFOMYCIN; BACTERIAL DNA; BACTERIAL PROTEIN; BETA LACTAMASE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLACTX M 15 GENE; BLACTX M GENE; BLASHV 1 GENE; BLASHV 11 GENE; BLASHV 28 GENE; BLASHV GENE; BLATEM 158 GENE; BLATEM 53 GENE; BLATEM1 GENE; CONTROLLED STUDY; DRUG EFFICACY; EXTENDED SPECTRUM BETA LACTAMASE GENE; GENE SEQUENCE; GENETIC ANALYSIS; GENOTYPE; KLEBSIELLA PNEUMONIAE; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PREVALENCE; TUNISIA; URINARY TRACT; ADOLESCENT; ADULT; AGED; ANTIBIOTIC RESISTANCE; CHILD; CLASSIFICATION; CROSS INFECTION; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; HOSPITAL DEPARTMENT; HUMAN; INFANT; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; MALE; MICROBIOLOGY; MIDDLE AGED; NEWBORN; PRESCHOOL CHILD; SPECIES DIFFERENCE; UNIVERSITY HOSPITAL; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; DNA, BACTERIAL; FEMALE; GENES, BACTERIAL; GENOTYPE; HOSPITAL DEPARTMENTS; HOSPITALS, UNIVERSITY; HUMANS; INFANT; INFANT, NEWBORN; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; MULTIPLEX POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; TUNISIA; YOUNG ADULT;

EID: 84926410004     PISSN: 0399077X     EISSN: 17696690     Source Type: Journal    
DOI: 10.1016/j.medmal.2015.01.010     Document Type: Article

References (34)

1. El Hani D., Bakir L., Aouni M., Passet V., Ariet G., Brisse S., et al. Molecular epidemiology of extended-spectrum-β-lactamase producing Klebsiella pneumoniae strains in a university hospital in Tunis, Tunisia 1999-2005. Clin Microbiol Infect 2010, 16(2):157-164.
2. Ruiz de Alegría C., Rodríguez-Bano J., Cano M.E., Hernandez-Bello J.R., Calvo J., Roman E., et al. Klebsiella pneumoniae strains producing extended-spectrum-β-lactamases in Spain: microbiological and clinical features. J Clin Microbiol 2011, 49(3):1134-1136.
3. Al-Agamy M.H., Shibl A.M., Tawfik A.F. Prevalence and molecular characterization of extended-spectrum β-lactamase in Klebsiella pneumonia in Ryadh, Saoudi Arabia. Ann Saoudi Med 2009, 29(4):253-257.
4. Wollheim C., Guerra I.M., Conte V.D., Hoffman S.P., Schreiner F.J., Delamare A.P., et al. Nosocomial and community infections due to class A extended-spectrum b-lactamase (ESBLA)-producingEscherichia coli and Klebsiella spp. in southern Brazil. Braz J Infect Dis 2011, 15(2):138-143.
5. Mahesh E., Ramesh D., Indumathi V.A., Khan M.W., Kumar P.S., Punith K. Risk factors community acquired urinary tract infection caused by ESBL producing bacteria. JIACM 2010, 11(4):271-276.
6. Boukadida J., Monastiri K., Lamouri N., Bouallegue O., Snoussi N., Essoussi A.S., et al. Aspects épidémiologiques de la résistance des entérobactéries aux céphalosporines de troisième génération en Tunisie Centrale (étude rétrospective sur 3ans). Med Mal Infect 1996, 26(12):1155-1158.
7. Ben Haj A., Khedher M. Épidémiologie des souches de Klebsiella spp. uropathogènes productrices de -lactamases à spectre élargi dans un hÔpital universitaire tunisien, 2009. Pathol Biol (Paris) 2010, 10.1016/j.patbio.2010.11.003.
8. Boutiba-Ben Boubaker I., Ghozzi R., Ben Abdallah H., Mamlouk K., Kamoun A., Ben Redjeb S. Evolution of acquired resistance to third-generation cephalosporins in Enterobacteriaceae in a Tunisian hospital 1993-2001. Clin Microbiol Infect 2004, 10:665-667. 10.1111/j.1469-0691.2004.00959.x.
9. Pirouth L., Aubé H., Doise J.M., Martin M.V. Spread of extended spectrum beta-lactamase producing Klebsiella pneumoniae: are-β-lactamase inhibitors of therapeutic value?. Clin Infect Dis 1998, 27(1):76-80.
10. Ben-Hamouda T., Foulon T., Ben-Cheikh-Masmoudi A., Fendri C., Belhadj O., et al. Molecular epidemiology of an outbreak of multiresistant Klebsiella pneumoniae in a Tunisian neonatal ward. J Med Microbiol 2003, 52:427-433. 10.1099/jmm.0.04981-0.
11. Bouallègue-Godet O., Grimont F., Ben Salem Y., Saïdani M., Mzoughi R., Sboui H., et al. Investigation of the clonal dissemination of Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases in a neonatal ward, Sousse, Tunisia. Pathol Biol 2005, 53(2):75-80.
12. Kang C.I., Kim S.H., Kim D.M., Park W.B., Lee K.D., Kim H.B., et al. Risk factors for and clinical outcomes of bloodstream infectious caused by extended spectrum beta-lactamase producing Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2004, 25(10):860-867.
13. Seid J., Asrat D. Occurrence of extended spectrum β-lactamase enzymes in clinical isolates of Klebsiella species from Harar region, eastern Ethiopia. Acta Tropica 2005, 95:143-148.
14. Chaikittisuk N., Munsrichoom A. Extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae in children at Queen Sirikit National Institute of Child Health. J Infect Dis Antimicrob Agents 2007, 24(3):107-115.
15. Cantón R., Coque T.M. The CTX-M β-lactamase pandemic. Curr Opin Microbiol 2006, 9(5):466-475.
16. Cantón R., Novais A., Valverde A., Machado E., Peixe L., Baquero F., et al. Prevalence and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect 2008, 14(suppl. 1):144-153.
17. Ehlers M.M., Veldsman C., Makgotlho E.P., Dove M.G., Hoosen A.A., Kock M.M. Detection of blaSHV, blaTEM and blaCTX-M antibiotic resistance genes in randomly selected bacterial pathogens from the Steve Biko Academic Hospital. FEMS Immunol Med Microbiol 2009, 56(3):191-196.
18. Winokur P.L., Canton R., Casselas J.M., Legakis N. Variation in the prevalence of strain expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the Americas and the Western Pacific region. Clin Infect Dis 2001, 32(suppl. 2):94-103.
19. Hirakata Y., Matsuda J., Miyazaki Y., Kamihira S., Kawakami-Miyazawa Y. Regional variation in the prevalence of extended-spectrum-beta-lactamase producing clinical isolates in the Asia-Pacific region (SENTRY 1998-2002). Diagn Microbiol Infect Dis 2005, 52(4):323-329.
20. Tharavichichitkul P., Khantawa B., Bousoung V., Boonchoo M. Activity of fosfomycin against extended-spectrum-beta-lactamase producing Klebsiella pneumoniae and Escherichia coli in Maharaj Nakorn Mai Hospital. J Infect Dis Antimicrobiol Agents 2005, 22:121-126.
21. Dubois V., Corinne A., Noury P., Andre C., Coulange L., Quentine C. Prolonged outbreak of infection due to TEM-21-producing strains of Pseudomonas aeruginosa and enterobacteria in a nursing home. J Clin Microbiol 2005, 43(8):4129-4138.
22. Shiju M.P., Yashavanth R., Narendra N. Detection of extended spectrum beta-lactamase production and multidrug resistance in clinical isolates E.coli and K.pneumoniae in Mangalore. Research 2010, 4(3):2442-2445.
23. Xionq Z., Zhu D., Wang F., Zhang Y., Okamoto R., Inoue M. Investigation of extended-spectrum beta-lactamase in Klebsiella pneumoniae and Escherichia coli from China. Diagn Microbiol Infect Dis 2002, 44(2):195-200.
24. Monstein H.J., Ostholm-Balkhed A., Nilsson M.V., Nilsson M., Dornbusch K., Nilsson L.E. Multiplex PCR amplification assay for the detection of blaSHV, blaTEM and blaCTX-M genes in Enterobacteriaceae. APMIS 2007, 115(12):1400-1408. 10.1111/j.1600-0463.2007.00722.x.
25. Gniadkowski M. Evolution of extended-spectrum β-lactamases by mutation. Clin Microbiol Infect 2008, 14(suppl. 1):11-32.
26. Paterson D.L., Hujer K.M., Hujer A.M., Yeiser B., Bonomo M.D., Rice L.B., et al. Extended-spectrum-beta-lactamase in Klebsiella pneumoniae bloodstream isolates from 7 countries: dominance and widespread prevalence of SHV and CTX-M type β-lactamases. Antimicrob Agents Chemther 2003, 47(11):3554-3560.
27. Abbassi M.S., Torres C., Achour W., Vinué L., Saenz Y., Costa D., et al. Genetic characterization of CTX-M-15 producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia. Int J Antimicrob Agents 2008, 32(4):308-314.
28. Ben Achour N., Mercuri P.S., Bel Hadj C., Ben Moussa M., Galleni M., Bel Hadj O. Cefotaxime and ceftriaxon resistant Klebsiella pneumoniae with SHV-11. Ann Microbiol 2008, 58(4):717-730.
29. Babini G.S., Livermore D.M., Are S.H.V. β-lactamases universal in Klebsiella pneumoniae?. Antimicrob Agents Chemother 2000, 44(8):2230.
30. Gangoué-Piéboji L., Bedenic B., Koulla-Shiros, Randegger C., Adiogo D., Ngassam P., et al. Extended-spectrum-β-lactamase producing Enterobacteriaceae in Yaounde Cameroun. J Clin Microbiol 2005, 43(7):3273-3277.
31. Messai Y., Iabadene H., Benhassine T., Alouache S., Tazir M., Gautier V., et al. Prevalence and characterization of extended-spectrumb-lactamases in Klebsiella pneumoniae in Algiers hospitals (Algeria). Pathol Biol 2008, 56:319-325.
32. Smaoui H., Jouhaîhia W., Greco A., Ben Hassen A. Klebsiella.spp productrices de bêta-lactamases à spectre étendu isolée au centre national de greffe de moelle osseuse de Tunis. Tunisie Med 2002, 78(5):291-292.
33. Vranic-Ladavac M., Bosnjak Z., Beader N., Barisic N., Kalenic S., Bedenic B. Clonal spread of CTX-M-15 producing Klebsiella pneumoniae in Croatian hospital. J Med Microbiol 2010, 59(Pt 9):1069-1078.
34. Onnberg A., Mölling P., Zimmerman J., Söderquist B. Molecular and phenotypic characterization of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum-beta-lactamase with focus on CTX-M in a low endemic area. APMIS 2010, 119(4-5):285-295.