Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy

Journal of Hepatology

Volumn 62, Issue 4, 2015, Pages 897-904

  Kremer, Andreas E ^a,b   Bolier, Ruth ^a   Dixon, Peter H ^c   Geenes, Victoria ^c   Chambers, Jenny ^c   Tolenaars, Dagmar ^a   Ris Stalpers, Carrie ^a   Kaess, Bernhard M ^d   Rust, Christian ^e,f   Van Der Post, Joris A ^a   Williamson, Catherine ^c   Beuers, Ulrich ^a   Elferink, Ronald P J Oude ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^f Hospital Barmherzige Brüder Munich   (Germany)

Author keywords

Autotaxin; Bile salts; Cholestasis; Pregnancy; Pruritus

Indexed keywords

AUTOTAXIN; MESSENGER RNA; ORAL CONTRACEPTIVE AGENT; ALKYLGLYCEROPHOSPHOETHANOLAMINE PHOSPHODIESTERASE; AMINOTRANSFERASE; BIOLOGICAL MARKER; PHOSPHODIESTERASE;

ADULT; ARTICLE; BLOOD SAMPLING; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HELLP SYNDROME; HUMAN; HUMAN TISSUE; HYPERTRANSAMINASEMIA; INTRAHEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS OF PREGNANCY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; ORAL CONTRACEPTION; PLACENTA; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PREGNANCY DISORDER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PRURITUS; QUANTITATIVE STUDY; SENSITIVITY AND SPECIFICITY; WESTERN BLOTTING; BLOOD; COMPLICATION; DIFFERENTIAL DIAGNOSIS; GENETICS; PREGNANCY; PREGNANCY COMPLICATION;

ADULT; BIOMARKERS; CHOLESTASIS, INTRAHEPATIC; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; PHOSPHORIC DIESTER HYDROLASES; PREGNANCY; PREGNANCY COMPLICATIONS; PRURITUS; SENSITIVITY AND SPECIFICITY; TRANSAMINASES;

EID: 84926407923     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.10.041     Document Type: Article

References (33)

1. T. Pusl, and U. Beuers Intrahepatic cholestasis of pregnancy Orphanet J Rare Dis 2 2007 26
2. V. Geenes, and C. Williamson Intrahepatic cholestasis of pregnancy World J Gastroenterol 15 2009 2049 2066
3. V. Geenes, L.C. Chappell, P.T. Seed, P.J. Steer, M. Knight, and C. Williamson Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study Hepatology 59 2014 1482 1491
4. M. Rook, J. Vargas, A. Caughey, P. Bacchetti, P. Rosenthal, and L. Bull Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort PLoS One 7 2012 e28343
5. J.D. Bos Reappraisal of dermatoses of pregnancy Lancet 354 1999 1140
6. F. Lammert, H.U. Marschall, A. Glantz, and S. Matern Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management J Hepatol 33 2000 1012 1021
7. A. Glantz, H.U. Marschall, and L.A. Mattsson Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates Hepatology 40 2004 467 474
8. EASL clinical practice guidelines: management of cholestatic liver diseases J Hepatol 51 2009 237 267
9. Y. Bacq, L. Sentilhes, H.B. Reyes, A. Glantz, J. Kondrackiene, and T. Binder Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis Gastroenterology 143 2012 1492 1501
10. P.H. Dixon, S.W. van Mil, J. Chambers, S. Strautnieks, R.J. Thompson, and F. Lammert Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy Gut 58 2009 537 544
11. C.M. Ambros-Rudolph, M. Glatz, M. Trauner, H. Kerl, and R.R. Mullegger The importance of serum bile acid level analysis and treatment with ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a case series from central Europe Arch Dermatol 143 2007 757 762
12. M.J. Pascual, M.A. Serrano, M.Y. El-Mir, R.I. Macias, F. Jimenez, and J.J. Marin Relationship between asymptomatic hypercholanaemia of pregnancy and progesterone metabolism Clin Sci (Lond) 102 2002 587 593
13. G. Castano, S. Lucangioli, S. Sookoian, M. Mesquida, A. Lemberg, and M. Di Scala Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy Clin Sci (Lond) 110 2006 459 465
14. K. Nakanaga, K. Hama, and J. Aoki Autotaxin-an LPA producing enzyme with diverse functions J Biochem 148 2010 13 24
15. L.A. van Meeteren, P. Ruurs, C. Stortelers, P. Bouwman, M.A. van Rooijen, and J.P. Pradere Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development Mol Cell Biol 26 2006 5015 5022
16. G.B. Mills, and W.H. Moolenaar The emerging role of lysophosphatidic acid in cancer Nat Rev Cancer 3 2003 582 591
17. A. Tokumura, Y. Kanaya, M. Miyake, S. Yamano, M. Irahara, and K. Fukuzawa Increased production of bioactive lysophosphatidic acid by serum lysophospholipase D in human pregnancy Biol Reprod 67 2002 1386 1392
18. A.E. Kremer, J.J. Martens, W. Kulik, F. Rueff, E.M. Kuiper, and H.R. van Buuren Lysophosphatidic acid is a potential mediator of cholestatic pruritus Gastroenterology 139 2010 1008 1018
19. C.M. Ambros-Rudolph, R.R. Mullegger, S.A. Vaughan-Jones, H. Kerl, and M.M. Black The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients J Am Acad Dermatol 54 2006 395 404
20. J.M. Roberts, G. Pearson, J. Cutler, and M. Lindheimer Summary of the NHLBI working group on research on hypertension during pregnancy Hypertension 41 2003 437 445
21. K. Nakamura, R. Ohkawa, S. Okubo, M. Tozuka, M. Okada, and S. Aoki Measurement of lysophospholipase D/autotaxin activity in human serum samples Clin Biochem 40 2007 274 277
22. M. Tanaka, S. Okudaira, Y. Kishi, R. Ohkawa, S. Iseki, and M. Ota Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid J Biol Chem 281 2006 25822 25830
23. H.Y. Lee, J. Murata, T. Clair, M.H. Polymeropoulos, R. Torres, and R.E. Manrow Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells Biochem Biophys Res Commun 218 1996 714 719
24. W.H. Moolenaar, and A. Perrakis Insights into autotaxin: how to produce and present a lipid mediator Nat Rev Mol Cell Biol 12 2011 674 679
25. Y. Iwasawa, T. Fujii, T. Nagamatsu, K. Kawana, S. Okudaira, and S. Miura Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta Am J Reprod Immunol 62 2009 90 95
26. A.E. Kremer, R. van Dijk, P. Leckie, F.G. Schaap, E.M. Kuiper, and T. Mettang Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions Hepatology 56 2012 1391 1400
27. E. Weisshaar, and F. Dalgard Epidemiology of itch: adding to the burden of skin morbidity Acta Derm Venereol 89 2009 339 350
28. C.M. Ambros-Rudolph Dermatoses of pregnancy - clues to diagnosis, fetal risk and therapy Ann Dermatol 23 2011 265 275
29. V.L. Geenes, Y.H. Lim, N. Bowman, H. Tailor, P.H. Dixon, and J. Chambers A placental phenotype for intrahepatic cholestasis of pregnancy Placenta 32 2011 1026 1032
30. J. Kondrackiene, U. Beuers, and L. Kupcinskas Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy Gastroenterology 129 2005 894 901
31. A. Glantz, S.J. Reilly, L. Benthin, F. Lammert, L.A. Mattsson, and H.U. Marschall Intrahepatic cholestasis of pregnancy: amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine Hepatology 47 2008 544 551
32. L.C. Chappell, V. Gurung, P.T. Seed, J. Chambers, C. Williamson, and J.G. Thornton Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial BMJ 344 2012 e3799
33. B. Berg, G. Helm, L. Petersohn, and N. Tryding Cholestasis of pregnancy. Clinical and laboratory studies Acta Obstet Gynecol Scand 65 1986 107 113