Prospective observational study of hemostatic alterations during adult extracorporeal membrane oxygenation (ECMO) using point-of-care thromboelastometry and platelet aggregometry

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 29, Issue 2, 2015, Pages 288-296

  Nair, Priya ^a,b   Hoechter, Dominik Johannes ^c   Buscher, Hergen ^a,b   Venkatesh, Karthik ^b   Whittam, Susan ^a   Joseph, Joanne ^a,b   Jansz, Paul ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

coagulation abnormalities; coagulation monitoring; ECMO; platelet aggregometry; ROTEM

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN; FRESH FROZEN PLASMA; RISTOCETIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BLEEDING; BLOOD CLOTTING PARAMETERS; BLOOD CLOTTING TIME; BLOOD EXAMINATION; BLOOD TRANSFUSION; CARDIOGENIC SHOCK; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CRYOPRECIPITATE; DEVICE COMPARISON; ERYTHROCYTE TRANSFUSION; EXTRACORPOREAL OXYGENATION; FEMALE; HEMATOLOGICAL PROCEDURE; HEMOSTASIS; HOSPITAL DISCHARGE; HUMAN; LENGTH OF STAY; MALE; MAXIMUM CLOT FIRMNESS; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PLATELET AGGREGOMETRY; POINT OF CARE TESTING; POSTCARDIOTOMY SYNDROME; PRIMARY GRAFT DYSFUNCTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; SURVIVAL RATE; THROMBOCYTE COUNT; THROMBOCYTE DYSFUNCTION; THROMBOCYTE FUNCTION ANALYZER; THROMBOCYTE TRANSFUSION; THROMBOELASTOGRAPH; THROMBOELASTOGRAPHY; ADVERSE EFFECTS; BLOOD; BLOOD CLOTTING TEST; BLOOD COAGULATION DISORDERS; MIDDLE AGED; POINT OF CARE SYSTEM; PROCEDURES; STATISTICS AND NUMERICAL DATA; THROMBOCYTE;

ADULT; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; BLOOD PLATELETS; COHORT STUDIES; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; POINT-OF-CARE SYSTEMS; PROSPECTIVE STUDIES; THROMBELASTOGRAPHY;

EID: 84926407607     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2014.06.006     Document Type: Article

References (49)

1. C. Aubron, A.C. Cheng, and D. Pilcher Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study Crit Care Med 17 2013 R73
2. H. Welp, B. Ellger, and M. Scherer Heparin-induced thrombocytopenia during extracorporeal membrane oxygenation J Cardiothorac Vasc Anesth. 28 2013 342 344
3. S. Allen, D. Holena, and M. McCunn A review of the fundamental principles and evidence base in the use of extracorporeal membrane oxygenation (ECMO) in critically ill adult patients J Intensive Care Med 26 2011 13 26
4. S.K. Balasubramanian, R. Tiruvoipati, and M. Amin Factors influencing the outcome of paediatric cardiac surgical patients during extracorporeal circulatory support J Cardiothorac Surg 2 2007 4
5. A. Davies Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome JAMA 302 2009 1888 1895
6. A. Agren, A.T. Wikman, and M. Holmstrom Thromboelastography (TEG(R)) compared to conventional coagulation tests in surgical patients - a laboratory evaluation Scand J Clin Lab Invest 73 2013 214 220
7. A. Combes, P. Leprince, and C.E. Luyt Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock Crit Care Med 36 2008 1404 1411
8. A.M. Gaffney, S.M. Wildhirt, and M.J. Griffin Extracorporeal life support BMJ 341 2010 c5317
9. S.F. Marasco, G. Lukas, and M. McDonald Review of ECMO (extra-corporeal membrane oxygenation) support in critically ill adult patients Heart Lung Circ 17 Suppl 4 2008 S41 S47
10. M.M. Bembea, G. Annich, and P. Rycus Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: an international survey Pediatr Crit Care Med 14 2013 e77 e84
11. S.A. Conrad, P.T. Rycus, and H. Dalton Extracorporeal Life Support Registry Report 2004 ASAIO J 51 2005 4 10
12. W.C. Oliver Anticoagulation and coagulation management for ECMO Semin Cardiothorac Vasc Anesth 13 2009 154 175
13. C. Heilmann, U. Geisen, and F. Beyersdorf Acquired von Willebrand syndrome in patients with extracorporeal life support (ECLS) Intensive Care Med 38 2012 62 68
14. K.A. Tanaka, D. Bolliger, and R. Vadlamudi Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma J Cardiothorac Vasc Anesth 26 2012 1083 1093
15. M.T. Ganter, and C.K. Hofer Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices Anesth Analg 106 2008 1366 1375
16. A. Sankarankutty, B. Nascimento, and L. Teodoro da Luz TEG(R) and ROTEM(R) in trauma: similar test but different results? World J Emerg Surg 7 Suppl 1 2012 S3
17. R.J. Luddington Thrombelastography/thromboelastometry Clin Lab Haematol 27 2005 81 90
18. G.N. Jackson, K.J. Ashpole, and S.M. Yentis The TEG vs the ROTEM thromboelastography/thromboelastometry systems Anaesthesia 64 2009 212 215
19. D. Bolliger, M.D. Seeberger, and K.A. Tanaka Principles and practice of thromboelastography in clinical coagulation management and transfusion practice Transfus Med Rev 26 2012 1 13
20. O. Toth, A. Calatzis, and S. Penz Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood Thromb Haemost 96 2006 781 788
21. L. Rugeri, A. Levrat, and J.S. David Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography J Thromb Haemost 5 2007 289 295
22. K. Gorlinger, L. Bergmann, and D. Dirkmann Coagulation management in patients undergoing mechanical circulatory support Best Pract Res Clin Anaesthesiol 26 2012 179 198
23. C.F. Weber, M. Klages, and K. Zacharowski Perioperative coagulation management during cardiac surgery Curr Opin Anaesthesiol 26 2013 60 64
24. S. Kozek-Langenecker Management of massive operative blood loss Minerva Anestesiol 73 2007 401 415
25. L. Zuckerman, E. Cohen, and J.P. Vagher Comparison of thrombelastography with common coagulation tests Thromb Haemost 46 1981 752 756
26. W.L. Chandler The thromboelastography and the thromboelastograph technique Semin Thromb Hemost 21 Suppl 4 1995 1 6
27. Y.G. Kang, D.J. Martin, and J. Marquez Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation Anesth Analg 64 1985 888 896
28. U. Geisen, C. Heilmann, and F. Beyersdorf Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease Eur J Cardiothorac Surg 33 2008 679 684
29. J. Klovaite, F. Gustafsson, and S.A. Mortensen Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II) J Am Coll Cardiol 53 2009 2162 2167
30. B. Steinlechner, M. Dworschak, and B. Birkenberg Platelet dysfunction in outpatients with left ventricular assist devices Ann Thorac Surg 87 2009 131 137
31. P.M. Mannucci Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders Blood 72 1988 1449 1455
32. M. Cattaneo, R. Lombardi, and D. Bettega Shear-induced platelet aggregation is potentiated by desmopressin and inhibited by ticlopidine Arterioscler Thromb 13 1993 393 397
33. K.S. Sakariassen, M. Cattaneo, and A. vd Berg DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium Blood 64 1984 229 236
34. C.F. Weber, W. Dietrich, and M. Spannagl A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery Anesth Analg 110 2010 702 707
35. P. Harrison, B. Wilbourn, and N. Debili Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets J Clin Invest 84 1989 1320 1324
36. K.A. Tanaka, K. Egan, and F. Szlam Transfusion and hematologic variables after fibrinogen or platelet transfusion in valve replacement surgery: preliminary data of purified lyophilized human fibrinogen concentrate versus conventional transfusion Transfusion 54 2014 109 118
37. K. Gorlinger, D. Dirkmann, and C. Solomon Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability Br J Anaesth 110 2013 222 230
38. L. Shore-Lesserson, H.E. Manspeizer, and M. DePerio Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery Anesth Analg 88 1999 312 319
39. S. Manikappa, Y. Mehta, and R. Juneja Changes in transfusion therapy guided by thromboelastograph in cardiac surgery Ann Card Anaesth 4 2001 21 27
40. D. Royston, and S. von Kier Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass Br J Anaesth 86 2001 575 578
41. K. Ak, C.S. Isbir, and S. Tetik Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study J Card Surg 24 2009 404 410
42. A.J. Westbrook, J. Olsen, and M. Bailey Protocol based on thromboelastograph (TEG) out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: a pilot study Heart Lung Circ 18 2009 277 288
43. E. Girdauskas, J. Kempfert, and T. Kuntze Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial J Thorac Cardiovasc Surg 140 2010 1117 1124 e1112
44. H. Schochl, W. Voelckel, and A. Grassetto Practical application of point-of-care coagulation testing to guide treatment decisions in trauma J Trauma Acute Care Surg 74 2013 1587 1598
45. K. Gorlinger Coagulation management during liver transplantation Hamostaseologie 26 2006 S64 S76
46. C. Solomon, C. Hagl, and N. Rahe-Meyer Time course of haemostatic effects of fibrinogen concentrate administration in aortic surgery Br J Anaesth 110 2013 947 956
47. N. Rahe-Meyer, C. Solomon, and M. Winterhalter Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery J Thorac Cardiovasc Surg 138 2009 694 702
48. N.F. Collins, M. Bloor, and N.J. McDonnell Hyperfibrinolysis diagnosed by rotational thromboelastometry in a case of suspected amniotic fluid embolism Int J Obstet Anesth 22 2013 71 76
49. M. Toukh, D.R. Siemens, and A. Black Thromboelastography identifies hypercoagulablilty and predicts thromboembolic complications in patients with prostate cancer Thromb Res 133 2013 88 95