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Volumn 103, Issue 2, 2015, Pages 225-235

AMPFLUID: Aggregation Magnified Post-Assay Fluorescence for Ultrasensitive Immunodetection on Digital Microfluidics

Author keywords

Aggregation; bead based immunoassay; concentration; digital microfluidic (DMF); electrowetting; electrowetting on dielectric (EWOD); immunoassay; immunochip; lab on achip; magnetic beads; micro total analysis system ( TAS); microfluidics

Indexed keywords

AGGLOMERATION; CHARGE COUPLED DEVICES; CONCENTRATION (PROCESS); FLOW MEASURING INSTRUMENTS; FLUORESCENCE; IMMUNOLOGY; MICROFLUIDICS; WETTING;

EID: 84926385959     PISSN: 00189219     EISSN: 15582256     Source Type: Journal    
DOI: 10.1109/JPROC.2014.2376967     Document Type: Article
Times cited : (18)

References (50)
  • 1
    • 79961171532 scopus 로고    scopus 로고
    • Microfluidics-based diagnostics of infectious diseases in the developing world
    • Jul.
    • C. D. Chin et al., "Microfluidics-based diagnostics of infectious diseases in the developing world," Nature Med., vol. 17, pp. 1015-1019, Jul. 2011.
    • (2011) Nature Med. , vol.17 , pp. 1015-1019
    • Chin, C.D.1
  • 2
    • 33747086959 scopus 로고    scopus 로고
    • Microfluidic diagnostic technologies for global public health
    • Jul.
    • P. Yager et al., "Microfluidic diagnostic technologies for global public health,"Nature, vol. 442, pp. 412-418, Jul. 2006.
    • (2006) Nature , vol.442 , pp. 412-418
    • Yager, P.1
  • 3
    • 75749113741 scopus 로고    scopus 로고
    • Diagnostics for the developing world: Microfluidic paper-based analytical devices
    • Jan.
    • A. W. Martinez, S. T. Phillips, G. M. Whitesides, and E. Carrilho, "Diagnostics for the developing world: Microfluidic paper-based analytical devices," Anal. Chem., vol. 82, pp. 3-10, Jan. 2010.
    • (2010) Anal. Chem. , vol.82 , pp. 3-10
    • Martinez, A.W.1    Phillips, S.T.2    Whitesides, G.M.3    Carrilho, E.4
  • 4
    • 38849155318 scopus 로고    scopus 로고
    • Droplet microfluidics
    • Jan.
    • S.-Y. Teh, R. Lin, L.-H. Hung, and A. P. Lee, "Droplet microfluidics," Lab Chip, vol. 8, pp. 198-220, Jan. 2008.
    • (2008) Lab Chip , vol.8 , pp. 198-220
    • Teh, S.-Y.1    Lin, R.2    Hung, L.-H.3    Lee, A.P.4
  • 5
    • 84862212456 scopus 로고    scopus 로고
    • Droplet microfluidics for high-throughput biological assay
    • Feb.
    • M. T. Guo, A. Rotem, J. A. Heyman, and D. A. Weitz, "Droplet microfluidics for high-throughput biological assay," Lab Chip, vol. 12, pp. 2146-2155, Feb. 2012.
    • (2012) Lab Chip , vol.12 , pp. 2146-2155
    • Guo, M.T.1    Rotem, A.2    Heyman, J.A.3    Weitz, D.A.4
  • 6
    • 79551487057 scopus 로고    scopus 로고
    • Droplet microfluidics: Recent developments and future applications
    • Oct.
    • X. Casadevall I Solvas and A. deMello, "Droplet microfluidics: Recent developments and future applications," Chem. Commun., vol. 47, pp. 1936-1942, Oct. 2011.
    • (2011) Chem. Commun. , vol.47 , pp. 1936-1942
    • Casadevall, X.1    Solvas, I.2    DeMello, A.3
  • 8
    • 84862841785 scopus 로고    scopus 로고
    • Digital microfluidics: A versatile tool for applications in chemistry, biology and medicine
    • May
    • M. J. Jebrail, M. S. Bartsch, and K. D. Patel, "Digital microfluidics: A versatile tool for applications in chemistry, biology and medicine," Lab Chip, vol. 12, pp. 2452-2463, May 2012.
    • (2012) Lab Chip , vol.12 , pp. 2452-2463
    • Jebrail, M.J.1    Bartsch, M.S.2    Patel, K.D.3
  • 9
    • 75749107796 scopus 로고    scopus 로고
    • Integration and detection of biochemical assays in digital microfluidic LOC devices
    • Dec.
    • L. Malic, D. Brassard, T. Veres, and M. Tabrizian, "Integration and detection of biochemical assays in digital microfluidic LOC devices," Lab Chip, vol. 10, pp. 418-431, Dec. 2010.
    • (2010) Lab Chip , vol.10 , pp. 418-431
    • Malic, L.1    Brassard, D.2    Veres, T.3    Tabrizian, M.4
  • 10
    • 56549119892 scopus 로고    scopus 로고
    • Development of a digital microfluidic platform for point of care testing
    • Nov.
    • R. Sista et al., "Development of a digital microfluidic platform for point of care testing," Lab Chip, vol. 8, pp. 2091-2104, Nov. 2008.
    • (2008) Lab Chip , vol.8 , pp. 2091-2104
    • Sista, R.1
  • 11
    • 42549096051 scopus 로고    scopus 로고
    • DNA ligation of ultramicro volume using an EWOD microfluidic system with coplanar electrodes
    • Mar.
    • Y.-J. Liu, D.-J. Yao, H.-C. Lin, W.-Y. Chang, and H.-Y. Chang, "DNA ligation of ultramicro volume using an EWOD microfluidic system with coplanar electrodes," J. Micromech. Microeng., vol. 18, Mar. 2008, Art. ID. 045017.
    • (2008) J. Micromech. Microeng. , vol.18
    • Liu, Y.-J.1    Yao, D.-J.2    Lin, H.-C.3    Chang, W.-Y.4    Chang, H.-Y.5
  • 12
    • 33747062694 scopus 로고    scopus 로고
    • Integrated polymerase chain reaction chips utilizing digital microfluidics
    • May
    • Y.-H. Chang, G.-B. Lee, F.-C. Huang, Y.-Y. Chen, and J.-L. Lin, "Integrated polymerase chain reaction chips utilizing digital microfluidics," Biomed. Microdevices, vol. 8, pp. 215-225, May 2006.
    • (2006) Biomed. Microdevices , vol.8 , pp. 215-225
    • Chang, Y.-H.1    Lee, G.-B.2    Huang, F.-C.3    Chen, Y.-Y.4    Lin, J.-L.5
  • 13
    • 4043091975 scopus 로고    scopus 로고
    • Electrowetting-based microfluidics for analysis of peptides and proteins by matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS)
    • Jul.
    • A. R. Wheeler, H. Moon, C.-J. Kim, J. A. Loo, and R. L. Garrell, "Electrowetting-based microfluidics for analysis of peptides and proteins by matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS),"Anal. Chem., vol. 76, pp. 4833-4838, Jul. 2004.
    • (2004) Anal. Chem. , vol.76 , pp. 4833-4838
    • Wheeler, A.R.1    Moon, H.2    Kim, C.-J.3    Loo, J.A.4    Garrell, R.L.5
  • 14
    • 84886891601 scopus 로고    scopus 로고
    • Automated digital microfluidic platform for magnetic-particle-based immunoassays with optimization by design of experiments
    • Aug.
    • K. Choi et al., "Automated digital microfluidic platform for magnetic-particle-based immunoassays with optimization by design of experiments," Anal. Chem., vol. 85, pp. 9638-9646, Aug. 2013.
    • (2013) Anal. Chem. , vol.85 , pp. 9638-9646
    • Choi, K.1
  • 15
    • 47949131535 scopus 로고    scopus 로고
    • Cross-scale electric manipulations of cells and droplets by frequency-modulated dielectrophoresis and electrowetting
    • Apr.
    • S.-K. Fan, T.-T. Wang, P.-W. Huang, and Y.-H. Peng, "Cross-scale electric manipulations of cells and droplets by frequency-modulated dielectrophoresis and electrowetting," Lab Chip, vol. 8, pp. 1325-1331, Apr. 2008.
    • (2008) Lab Chip , vol.8 , pp. 1325-1331
    • Fan, S.-K.1    Wang, T.-T.2    Huang, P.-W.3    Peng, Y.-H.4
  • 16
    • 41149144716 scopus 로고    scopus 로고
    • Digital microfluidics for cell-based assays
    • Feb.
    • I. Barbulovic-Nad, H. Yang, P. S. Park, and A. R. Wheeler, "Digital microfluidics for cell-based assays," Lab Chip, vol. 8, pp. 519-526, Feb. 2008.
    • (2008) Lab Chip , vol.8 , pp. 519-526
    • Barbulovic-Nad, I.1    Yang, H.2    Park, P.S.3    Wheeler, A.R.4
  • 17
    • 0001047405 scopus 로고    scopus 로고
    • Electrowetting-based actuation of liquid droplets for microfluidic applications
    • Sep.
    • M. G. Pollack, R. B. Fair, and A. D. Shenderov, "Electrowetting-based actuation of liquid droplets for microfluidic applications," Appl. Phys. Lett., vol. 77, no. 11, pp. 1725-1726, Sep. 2000.
    • (2000) Appl. Phys. Lett. , vol.77 , Issue.11 , pp. 1725-1726
    • Pollack, M.G.1    Fair, R.B.2    Shenderov, A.D.3
  • 18
    • 0037301514 scopus 로고    scopus 로고
    • Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
    • Feb.
    • S. K. Cho, H. Moon, and C.-J. Kim, "Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits,"J. Microelectromech. Syst., vol. 12, no. 1, pp. 70-80, Feb. 2002.
    • (2002) J. Microelectromech. Syst. , vol.12 , Issue.1 , pp. 70-80
    • Cho, S.K.1    Moon, H.2    Kim, C.-J.3
  • 19
    • 4344632455 scopus 로고    scopus 로고
    • An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids
    • May
    • V. Srinivasan, V. K. Pamula, and R. B. Fair, "An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids," Lab Chip, vol. 4, pp. 310-315, May 2004.
    • (2004) Lab Chip , vol.4 , pp. 310-315
    • Srinivasan, V.1    Pamula, V.K.2    Fair, R.B.3
  • 20
    • 33645506648 scopus 로고    scopus 로고
    • Droplet-based microfluidics with nonaqueous solvents and solutions
    • Jan.
    • D. Chatterjee, B. Hetatothin, A. R. Wheeler, D. J. King, and R. L. Garrell, "Droplet-based microfluidics with nonaqueous solvents and solutions," Lab Chip, vol. 6, pp. 199-206, Jan. 2006.
    • (2006) Lab Chip , vol.6 , pp. 199-206
    • Chatterjee, D.1    Hetatothin, B.2    Wheeler, A.R.3    King, D.J.4    Garrell, R.L.5
  • 21
    • 77952650291 scopus 로고    scopus 로고
    • Microfluidic immunoassays
    • Jun.
    • C.-C. Lin, J.-H. Wang, H.-W. Wu, and G.-B. Lee, "Microfluidic immunoassays,"JALA, vol. 15, pp. 253-274, Jun. 2010.
    • (2010) JALA , vol.15 , pp. 253-274
    • Lin, C.-C.1    Wang, J.-H.2    Wu, H.-W.3    Lee, G.-B.4
  • 22
    • 0034250670 scopus 로고    scopus 로고
    • Micromachined flow-through filter-chamber for chemical reactions on beads
    • Aug.
    • H. Andersson, W. van der Wijngaart, P. Enoksson, and G. Stemme, "Micromachined flow-through filter-chamber for chemical reactions on beads," Sens. Actuator B, Chem., vol. 67, pp. 203-208, Aug. 2000.
    • (2000) Sens. Actuator B, Chem. , vol.67 , pp. 203-208
    • Andersson, H.1    Van Der Wijngaart, W.2    Enoksson, P.3    Stemme, G.4
  • 23
    • 34547111796 scopus 로고    scopus 로고
    • Bead-based immunoassays using a micro-chip flow cytometer
    • Jun.
    • D. Holmes, J. K. She, P. L. Roach, and H. Morgan, "Bead-based immunoassays using a micro-chip flow cytometer,"Lab Chip, vol. 7, pp. 1048-1056, Jun. 2007.
    • (2007) Lab Chip , vol.7 , pp. 1048-1056
    • Holmes, D.1    She, J.K.2    Roach, P.L.3    Morgan, H.4
  • 25
    • 84877737085 scopus 로고    scopus 로고
    • Microfluidic immunomagnetic bead-based system for the rapid detection of influenza infections: From purified virus particles to clinical specimens
    • Feb.
    • L. Y. Hung et al., "Microfluidic immunomagnetic bead-based system for the rapid detection of influenza infections: From purified virus particles to clinical specimens," Biomed. Microdevices, vol. 15, pp. 539-551, Feb. 2013.
    • (2013) Biomed. Microdevices , vol.15 , pp. 539-551
    • Hung, L.Y.1
  • 26
    • 56549101649 scopus 로고    scopus 로고
    • Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform
    • Oct.
    • R. S. Sista et al., "Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform," Lab Chip, vol. 8, pp. 2188-2196, Oct. 2008.
    • (2008) Lab Chip , vol.8 , pp. 2188-2196
    • Sista, R.S.1
  • 27
    • 84869412540 scopus 로고    scopus 로고
    • Digital Microfluidic Magnetic Separation for Particle-Based Immunoassays
    • Sep.
    • A. H. C. Ng, K. Choi, R. P. Luoma, J. M. Robinson, and A. R. Wheeler, "Digital Microfluidic Magnetic Separation for Particle-Based Immunoassays," Anal. Chem., vol. 84, pp. 8805-8812, Sep. 2012.
    • (2012) Anal. Chem. , vol.84 , pp. 8805-8812
    • Ng, A.H.C.1    Choi, K.2    Luoma, R.P.3    Robinson, J.M.4    Wheeler, A.R.5
  • 28
    • 79451474193 scopus 로고    scopus 로고
    • A digital microfluidic approach to heterogeneous immunoassays
    • Nov.
    • E. M. Miller, A. H. C. Ng, U. Uddayasankar, and A. R. Wheeler, "A digital microfluidic approach to heterogeneous immunoassays,"Anal. Bioanal. Chem., vol. 399, pp. 337-345, Nov. 2011.
    • (2011) Anal. Bioanal. Chem. , vol.399 , pp. 337-345
    • Miller, E.M.1    Ng, A.H.C.2    Uddayasankar, U.3    Wheeler, A.R.4
  • 29
    • 33748058506 scopus 로고    scopus 로고
    • Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications
    • Oct.
    • U. Lehmann et al., "Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications," Sens. Actuator B, Chem., vol. 117, pp. 457-463, Oct. 2006.
    • (2006) Sens. Actuator B, Chem. , vol.117 , pp. 457-463
    • Lehmann, U.1
  • 30
    • 0037648348 scopus 로고    scopus 로고
    • The case for early detection
    • Apr.
    • R. Etzioni et al., "The case for early detection," Nature Rev. Cancer, vol. 3, pp. 243-252, Apr. 2003.
    • (2003) Nature Rev. Cancer , vol.3 , pp. 243-252
    • Etzioni, R.1
  • 31
    • 84887530408 scopus 로고    scopus 로고
    • Ultrasensitive protein detection: A case for microfluidic magnetic bead-based assays
    • Sep.
    • H. C. Tekin and M. A. M. Gijs, "Ultrasensitive protein detection: A case for microfluidic magnetic bead-based assays," Lab Chip, vol. 13, pp. 4711-4739, Sep. 2013.
    • (2013) Lab Chip , vol.13 , pp. 4711-4739
    • Tekin, H.C.1    Gijs, M.A.M.2
  • 32
    • 33846543385 scopus 로고    scopus 로고
    • Bead-based microfluidic immunoassays: The next generation
    • Feb.
    • C. T. Lim and Y. Zhang, "Bead-based microfluidic immunoassays: The next generation," Biosens. Bioelectron., vol. 22, pp. 1197-1204, Feb. 2007.
    • (2007) Biosens. Bioelectron. , vol.22 , pp. 1197-1204
    • Lim, C.T.1    Zhang, Y.2
  • 34
    • 78049283378 scopus 로고    scopus 로고
    • μFBI: A microfluidic bead-based immunoassay for multiplexed detection of proteins from a μL sample volume
    • Oct.
    • X. Yu et al., " μFBI: A microfluidic bead-based immunoassay for multiplexed detection of proteins from a μL sample volume," PLoS One, vol. 5, Oct. 2010, Art. ID. e13125.
    • (2010) PLoS One , vol.5
    • Yu, X.1
  • 35
    • 0141892535 scopus 로고    scopus 로고
    • An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities
    • Dec.
    • J.-W. Choi et al., "An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities," Lab Chip, vol. 2, pp. 27-30, Dec. 2002.
    • (2002) Lab Chip , vol.2 , pp. 27-30
    • Choi, J.-W.1
  • 36
    • 0033040483 scopus 로고    scopus 로고
    • Amplification methods to increase the sensitivity of in situ hybridization: Play CARD(S)
    • Mar.
    • E. J. M. Speel, A. H. N. Hopman, and P. Komminoth, "Amplification methods to increase the sensitivity of in situ hybridization: Play CARD(S)," J. Histochem. Cytochem., vol. 47, pp. 281-288, Mar. 1999.
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 281-288
    • Speel, E.J.M.1    Hopman, A.H.N.2    Komminoth, P.3
  • 37
    • 0033635093 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization of scarce leptin receptor mRNA using the enzyme-labeled fluorescent substrate method and tyramide signal amplification
    • Dec.
    • J. F. Breininger and D. G. Baskin, "Fluorescence in situ hybridization of scarce leptin receptor mRNA using the enzyme-labeled fluorescent substrate method and tyramide signal amplification,"J. Histochem. Cytochem., vol. 48, pp. 1593-1599, Dec. 2000.
    • (2000) J. Histochem. Cytochem. , vol.48 , pp. 1593-1599
    • Breininger, J.F.1    Baskin, D.G.2
  • 38
    • 84886077738 scopus 로고    scopus 로고
    • Oligonucleotide-linked gold nanoparticle aggregates for enhanced sensitivity in lateral flow assays
    • Aug.
    • J. Hu et al., "Oligonucleotide-linked gold nanoparticle aggregates for enhanced sensitivity in lateral flow assays," Lab Chip, vol. 13, pp. 4352-4357, Aug. 2013.
    • (2013) Lab Chip , vol.13 , pp. 4352-4357
    • Hu, J.1
  • 39
    • 84890087085 scopus 로고    scopus 로고
    • Advances in paper-based point-of-care diagnostics
    • Apr.
    • J. Hu et al., "Advances in paper-based point-of-care diagnostics," Biosens. Bioelectron., vol. 54, pp. 585-597, Apr. 2014.
    • (2014) Biosens. Bioelectron. , vol.54 , pp. 585-597
    • Hu, J.1
  • 40
    • 84904290183 scopus 로고    scopus 로고
    • Hybrid magnetic nanoparticle/nanogold clusters and their distance-dependent metal-enhanced fluorescence effect via DNA hybridization
    • Apr.
    • X. Gu et al., "Hybrid magnetic nanoparticle/nanogold clusters and their distance-dependent metal-enhanced fluorescence effect via DNA hybridization,"Nanoscale, vol. 6, pp. 8681-8693, Apr. 2014.
    • (2014) Nanoscale , vol.6 , pp. 8681-8693
    • Gu, X.1
  • 42
    • 40549141071 scopus 로고    scopus 로고
    • Miniaturized parallelized sandwich immunoassays
    • H.-Y. Hsu, S. Wittemann, and T. O. Joos, "Miniaturized parallelized sandwich immunoassays," Methods Mol. Biol., vol. 428, pp. 247-261, 2008.
    • (2008) Methods Mol. Biol. , vol.428 , pp. 247-261
    • Hsu, H.-Y.1    Wittemann, S.2    Joos, T.O.3
  • 43
    • 65349130617 scopus 로고    scopus 로고
    • General digital microfluidic platform manipulating dielectric and conductive droplets by dielectrophoresis and electrowetting
    • Feb.
    • S.-K. Fan, T.-H. Hsieh, and D.-Y. Lin, "General digital microfluidic platform manipulating dielectric and conductive droplets by dielectrophoresis and electrowetting," Lab Chip, vol. 9, pp. 1236-1242, Feb. 2009.
    • (2009) Lab Chip , vol.9 , pp. 1236-1242
    • Fan, S.-K.1    Hsieh, T.-H.2    Lin, D.-Y.3
  • 44
    • 78650392759 scopus 로고    scopus 로고
    • Droplet-on-a-wristband: Chip-to-chip digital microfluidic interfaces between replaceable and flexible electrowetting modules
    • Oct.
    • S.-K. Fan, H. Yang, and W. Hsu, "Droplet-on-a-wristband: Chip-to-chip digital microfluidic interfaces between replaceable and flexible electrowetting modules," Lab Chip, vol. 11, pp. 343-347, Oct. 2011.
    • (2011) Lab Chip , vol.11 , pp. 343-347
    • Fan, S.-K.1    Yang, H.2    Hsu, W.3
  • 45
    • 66149125923 scopus 로고    scopus 로고
    • Reconfigurable liquid pumping in electric-field-defined virtual microchannels by dielectrophoresis
    • Mar.
    • S.-K. Fan, W.-J. Chen, T.-H. Lin, T.-T. Wang, and Y.-C. Lin, "Reconfigurable liquid pumping in electric-field-defined virtual microchannels by dielectrophoresis,"Lab Chip, vol. 9, pp. 1590-1595, Mar. 2009.
    • (2009) Lab Chip , vol.9 , pp. 1590-1595
    • Fan, S.-K.1    Chen, W.-J.2    Lin, T.-H.3    Wang, T.-T.4    Lin, Y.-C.5
  • 46
    • 41149180115 scopus 로고    scopus 로고
    • Pluronic additives: A solution to sticky problems in digital microfluidics
    • May
    • V. N. Luk, G. C. Mom, and A. R. Wheeler, "Pluronic additives: A solution to sticky problems in digital microfluidics,"Langmuir, vol. 24, pp. 6382-6389, May 2008.
    • (2008) Langmuir , vol.24 , pp. 6382-6389
    • Luk, V.N.1    Mom, G.C.2    Wheeler, A.R.3
  • 47
    • 79959780526 scopus 로고    scopus 로고
    • A new angle on pluronic additives: Advancing droplets and understanding in digital microfluidics
    • Jun.
    • S. H. Au, P. Kumar, and A. R. Wheeler, "A new angle on pluronic additives: advancing droplets and understanding in digital microfluidics," Langmuir, vol. 27, pp. 8586-8594, Jun. 2011.
    • (2011) Langmuir , vol.27 , pp. 8586-8594
    • Au, S.H.1    Kumar, P.2    Wheeler, A.R.3
  • 48
    • 53049097300 scopus 로고    scopus 로고
    • Suspension microarrays to identify the response patterns in hyper inflammatory diseases
    • Oct.
    • H.-Y. Hsu, E. M. Schneider, M. Weiss, and T. O. Joos, "Suspension microarrays to identify the response patterns in hyper inflammatory diseases," Med. Eng. Phys., vol. 30, pp. 976-983, Oct. 2008.
    • (2008) Med. Eng. Phys. , vol.30 , pp. 976-983
    • Hsu, H.-Y.1    Schneider, E.M.2    Weiss, M.3    Joos, T.O.4
  • 49
    • 0029958774 scopus 로고    scopus 로고
    • Early prediction of outcome in score-identified, postcardiac surgical patients at high risk for sepsis, using soluble tumor necrosis factor receptor-p55 concentrations
    • Apr.
    • G. Pilz et al., "Early prediction of outcome in score-identified, postcardiac surgical patients at high risk for sepsis, using soluble tumor necrosis factor receptor-p55 concentrations," Critical Care Med., vol. 24, pp. 596-600, Apr. 1996.
    • (1996) Critical Care Med. , vol.24 , pp. 596-600
    • Pilz, G.1
  • 50
    • 67649201746 scopus 로고    scopus 로고
    • Crucial role of TNF receptors1 and 2 in the control of polymicrobial sepsis
    • Jun.
    • T. Secher et al., "Crucial role of TNF receptors1 and 2 in the control of polymicrobial sepsis,"J. Immunol., vol. 182, pp. 7855-7864, Jun. 2009.
    • (2009) J. Immunol. , vol.182 , pp. 7855-7864
    • Secher, T.1


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