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Volumn 20, Issue 2, 2015, Pages 93-97

Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): Enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors)

(1)  Stahl, Stephen M a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND GATED ION CHANNEL; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN TRANSPORTER; VORTIOXETINE; PIPERAZINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; SULFIDE;

EID: 84926383738     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1092852915000139     Document Type: Article
Times cited : (53)

References (28)
  • 1
    • 84881250142 scopus 로고    scopus 로고
    • Classifying psychotropic drugs by mode of action and not by target disorder
    • Stahl SM. Classifying psychotropic drugs by mode of action and not by target disorder. CNS Spectr. 2013; 18(3): 113-117.
    • (2013) CNS Spectr , vol.18 , Issue.3 , pp. 113-117
    • Stahl, S.M.1
  • 2
    • 0003558989 scopus 로고    scopus 로고
    • Cambridge, UK: Cambridge University Press
    • th ed. Cambridge, UK: Cambridge University Press; 2013.
    • (2013) th Ed.
    • Stahl, S.M.1
  • 4
    • 84863403855 scopus 로고    scopus 로고
    • Pharmacological effects of Lu AA21004: A novel multimodal compound for the treatment of major depressive disorder
    • Mork A, Pehrson A, Brennum LT, et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012; 340(3): 666-675.
    • (2012) J Pharmacol Exp Ther , vol.340 , Issue.3 , pp. 666-675
    • Mork, A.1    Pehrson, A.2    Brennum, L.T.3
  • 5
    • 79955856369 scopus 로고    scopus 로고
    • Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A novel multimodal compound for the treatment ofmajor depressive disorder
    • Bang-Andersen B, Ruhland T, Jorgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment ofmajor depressive disorder. J Med Chem. 2011; 54(9): 3206-3221.
    • (2011) J Med Chem , vol.54 , Issue.9 , pp. 3206-3221
    • Bang-Andersen, B.1    Ruhland, T.2    Jorgensen, M.3
  • 6
    • 84858618643 scopus 로고    scopus 로고
    • Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects
    • Areberg J, Luntang-Jensen M, Søgaard B, Nilausen DØ. Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects. Basic Clin Pharmacol Toxicol. 2012; 110(4): 401-404.
    • (2012) Basic Clin Pharmacol Toxicol , vol.110 , Issue.4 , pp. 401-404
    • Areberg, J.1    Luntang-Jensen, M.2    Søgaard, B.3    Nilausen, D.Ø.4
  • 7
    • 84926393137 scopus 로고    scopus 로고
    • Modes and nodes explain the mechanism of action of vortioxetine, a multi-modal agent (MMA): Modifying serotonin's downstream effects on glutamate and GABA (gamma-aminobutyric acid) release by blocking 5HT3 and 5HT7 receptors
    • In press
    • Stahl SM. Modes and nodes explain the mechanism of action of vortioxetine, a multi-modal agent (MMA): modifying serotonin's downstream effects on glutamate and GABA (gamma-aminobutyric acid) release by blocking 5HT3 and 5HT7 receptors. CNS Spectr. In press.
    • CNS Spectr
    • Stahl, S.M.1
  • 8
    • 84926334855 scopus 로고    scopus 로고
    • Modes and nodes explain the mechanism of action of vortioxetine, a multi-modal agent (MMA): Enhancing downstream release of neurotransmitters by blocking 5HT3 receptors
    • In press
    • Stahl SM. Modes and nodes explain the mechanism of action of vortioxetine, a multi-modal agent (MMA): enhancing downstream release of neurotransmitters by blocking 5HT3 receptors. CNS Spectr. In press.
    • CNS Spectr
    • Stahl, S.M.1
  • 9
    • 84926384340 scopus 로고    scopus 로고
    • Modes and nodes explain the mechanism of action of vortioxetine, a multi-modal agent (MMA): Enhancing downstream release of four pro-cognitive neurotransmitters by blocking 5HT1D receptors
    • In press
    • Stahl SM. Modes and nodes explain the mechanism of action of vortioxetine, a multi-modal agent (MMA): enhancing downstream release of four pro-cognitive neurotransmitters by blocking 5HT1D receptors. CNS Spectr. In press.
    • CNS Spectr
    • Stahl, S.M.1
  • 10
    • 77954230363 scopus 로고    scopus 로고
    • Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders
    • Insel T, Cuthbert B, Garvey M, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010; 167(7): 748-751.
    • (2010) Am J Psychiatry , vol.167 , Issue.7 , pp. 748-751
    • Insel, T.1    Cuthbert, B.2    Garvey, M.3
  • 11
    • 84901720404 scopus 로고    scopus 로고
    • Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction
    • Pehrson AL, Sanchez C. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS Spectr. 2014; 19(2): 121-133.
    • (2014) CNS Spectr , vol.19 , Issue.2 , pp. 121-133
    • Pehrson, A.L.1    Sanchez, C.2
  • 12
    • 84873523331 scopus 로고    scopus 로고
    • Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters - A rat microdialysis and electrophysiology study
    • Pehrson AL, Cremers T, Betry C, et al. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters - a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol. 2013; 23(2): 133-145.
    • (2013) Eur Neuropsychopharmacol , vol.23 , Issue.2 , pp. 133-145
    • Pehrson, A.L.1    Cremers, T.2    Betry, C.3
  • 13
    • 37549064027 scopus 로고    scopus 로고
    • 5HT receptor regulation of neurotransmitter release
    • Fink KB, Gothert M. 5HT receptor regulation of neurotransmitter release. Pharmacol Rev. 2007; 59(4): 360-417.
    • (2007) Pharmacol Rev , vol.59 , Issue.4 , pp. 360-417
    • Fink, K.B.1    Gothert, M.2
  • 14
    • 33748493597 scopus 로고    scopus 로고
    • Rapid desensitization of somatodendritic 5HT1A receptors by chronic administration of the high-efficacy 5HT1A agonist, F13714: A microdialysis study in the rat
    • Assié MB, Lomentach H, Ravailhe V, Faucillon V, Newman-Tancredi A. Rapid desensitization of somatodendritic 5HT1A receptors by chronic administration of the high-ef ficacy 5HT1A agonist, F13714: a microdialysis study in the rat. Br J Pharmacol. 2006; 149(2): 170-178.
    • (2006) Br J Pharmacol , vol.149 , Issue.2 , pp. 170-178
    • Assié, M.B.1    Lomentach, H.2    Ravailhe, V.3    Faucillon, V.4    Newman-Tancredi, A.5
  • 15
    • 0029670276 scopus 로고    scopus 로고
    • Role of 5HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: Recent findings from in vivo microdialysis studies
    • Gardier AM, Malgie I, Trillat AC, Jacquot C, Artigas F. Role of 5HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies. Fundam Clin Pharmacol. 1996; 10(1): 16-27.
    • (1996) Fundam Clin Pharmacol , vol.10 , Issue.1 , pp. 16-27
    • Gardier, A.M.1    Malgie, I.2    Trillat, A.C.3    Jacquot, C.4    Artigas, F.5
  • 16
    • 0030271632 scopus 로고    scopus 로고
    • Effect of pindolol on the function of pre- and postsynaptic 5HT1A receptors: In vivo microdialysis and electrophysiological studies in the rat brain
    • Romero L, Ben N, Artigas F, De Montigny C, Blier P. Effect of pindolol on the function of pre- and postsynaptic 5HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology. 1996; 15(4): 349-360.
    • (1996) Neuropsychopharmacology , vol.15 , Issue.4 , pp. 349-360
    • Romero, L.1    Ben, N.2    Artigas, F.3    De Montigny, C.4    Blier, P.5
  • 17
    • 0023165062 scopus 로고
    • Electrophysiological responses of serotoninergic dorsal raphe neurons to 5HT1A and 5HT1B agonists
    • Sprouse JS, Aghajanian GK. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5HT1A and 5HT1B agonists. Synapse. 1987; 1(1): 3-9.
    • (1987) Synapse , vol.1 , Issue.1 , pp. 3-9
    • Sprouse, J.S.1    Aghajanian, G.K.2
  • 18
    • 0034740791 scopus 로고    scopus 로고
    • The role of 5HT1B receptors in the regulation of serotonin cell firing and release in the rat brain
    • Adell A, Celada P, Artigas F. The role of 5HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. J Neurochem. 2001; 79(1): 172-182.
    • (2001) J Neurochem , vol.79 , Issue.1 , pp. 172-182
    • Adell, A.1    Celada, P.2    Artigas, F.3
  • 20
    • 70450203483 scopus 로고    scopus 로고
    • The 5HT1B receptor: A novel target for the pathophysiology of depression
    • Ruf BM, Bhagwagar Z. The 5HT1B receptor: a novel target for the pathophysiology of depression. Curr Drug Targets. 2009; 10(11): 1118-1138.
    • (2009) Curr Drug Targets , vol.10 , Issue.11 , pp. 1118-1138
    • Ruf, B.M.1    Bhagwagar, Z.2
  • 21
    • 7444254932 scopus 로고    scopus 로고
    • Serotonin 1B receptors: From protein to physiological function and behavior
    • Sari Y. Serotonin 1B receptors: from protein to physiological function and behavior. Neurosci Biobehav Rev. 2004; 28(6): 565-582.
    • (2004) Neurosci Biobehav Rev , vol.28 , Issue.6 , pp. 565-582
    • Sari, Y.1
  • 22
    • 77549084645 scopus 로고    scopus 로고
    • The 5HT7 receptor as a mediator and modulator of antidepressant-like behavior
    • Sarkisyan G, Roberts AJ, Hedlund PB. The 5HT7 receptor as a mediator and modulator of antidepressant-like behavior. Behav Brain Res. 2010; 209(1): 99-108.
    • (2010) Behav Brain Res , vol.209 , Issue.1 , pp. 99-108
    • Sarkisyan, G.1    Roberts, A.J.2    Hedlund, P.B.3
  • 23
    • 34247270861 scopus 로고    scopus 로고
    • Selective blockade of 5-hydroxytryptamine (5HT)7 receptors enhances 5HT neurotransmission, antidepressant-like behavior and rapid eye movement sleep suppression induced by citalopram in rodents
    • Bonaventure P, Kelly L, Aluisio L, et al. Selective blockade of 5-hydroxytryptamine (5HT)7 receptors enhances 5HT neurotransmission, antidepressant-like behavior and rapid eye movement sleep suppression induced by citalopram in rodents. J Pharmacol Exp Ther. 2007; 321(2): 690-698.
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.2 , pp. 690-698
    • Bonaventure, P.1    Kelly, L.2    Aluisio, L.3
  • 24
    • 84884281105 scopus 로고    scopus 로고
    • 5HTT and 5HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects
    • Stenkrona P, Halldin C, Lundberg J. 5HTT and 5HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects. Eur Neuropsychopharmacol. 2013; 23(10): 1190-1198.
    • (2013) Eur Neuropsychopharmacol , vol.23 , Issue.10 , pp. 1190-1198
    • Stenkrona, P.1    Halldin, C.2    Lundberg, J.3
  • 25
    • 34247137134 scopus 로고    scopus 로고
    • Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
    • Meyer JH. Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neuosci. 2007; 32(2): 86-102.
    • (2007) J Psychiatry Neuosci , vol.32 , Issue.2 , pp. 86-102
    • Meyer, J.H.1
  • 26
    • 84864563043 scopus 로고    scopus 로고
    • Serotonin transporter occupancy with TCAs and SSRIs: A PET study in patients with major depressive disorder
    • Lundberg J, Tiger M, Landén M, Halldin C, Farde L. Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder. Int J Neuropsychopharmacol. 2012; 15(8): 1167-1172.
    • (2012) Int J Neuropsychopharmacol , vol.15 , Issue.8 , pp. 1167-1172
    • Lundberg, J.1    Tiger, M.2    Landén, M.3    Halldin, C.4    Farde, L.5
  • 27
    • 2442457724 scopus 로고    scopus 로고
    • Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An 11C-DASB positron emission tomography study
    • Meyer JH, Wilson AA, Sagrati S, et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an 11C-DASB positron emission tomography study. Am J Psychiatry. 2004; 161(5): 826-835.
    • (2004) Am J Psychiatry , vol.161 , Issue.5 , pp. 826-835
    • Meyer, J.H.1    Wilson, A.A.2    Sagrati, S.3
  • 28
    • 84890570648 scopus 로고    scopus 로고
    • Vortioxetine for major depressive disorder: A systematic review of the efficacy and safety profile for this newly approved antidepressant - What is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
    • Citrome L. Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract. 2014; 68(1): 60-82.
    • (2014) Int J Clin Pract , vol.68 , Issue.1 , pp. 60-82
    • Citrome, L.1


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