Acute and repeated dose toxicity studies of different β-cyclodextrin-based nanosponge formulations

Journal of Pharmaceutical Sciences

Volumn 104, Issue 5, 2015, Pages 1856-1863

  Shende, Pravin ^a   Kulkarni, Yogesh A ^b   Gaud, R S ^b   Deshmukh, Kiran ^a,c   Cavalli, Roberta ^a   Trotta, Francesco ^a   Caldera, Fabrizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b SVKM s Narsee Monjee Institute of Management Studies   (India)

^c Jodhpur National University   (India)

Author keywords

Acute toxicity; Bulk condensation method; Complexation; Cyclodextrin nanosponge; Interfacial condensation method; Nanotechnology; OECD guidelines; Pharmacokinetics; Protein delivery; Repeated dose toxicity; Surface active

Indexed keywords

BETA CYCLODEXTRIN; CARBONYLDIIMIDAZOLE; CROSS LINKING REAGENT; HEXAMETHYLENE DIISOCYNATE; NANOPARTICLE; NANOSPONGE; ORGANIC COMPOUND; PYROMELLITIC DIANHYDRIDE; UNCLASSIFIED DRUG; BETA CYCLODEXTRIN DERIVATIVE; NANOSPHERE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; DRUG FORMULATION; FEMALE; HEMATOLOGICAL PARAMETERS; MALE; MAXIMUM TOLERATED DOSE; MORTALITY; NONHUMAN; PARTICLE SIZE; RAT; TOXICITY TESTING; WEIGHT CHANGE; ANIMAL; CHEMISTRY; DOSE RESPONSE; MEDICINAL CHEMISTRY; PROCEDURES; WISTAR RAT;

ANIMALS; BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; NANOSPHERES; RATS; RATS, WISTAR; TOXICITY TESTS, ACUTE;

EID: 84926350446     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24416     Document Type: Article

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