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Volumn 10, Issue 3, 2015, Pages

Drug combinations against Borrelia burgdorferi persisters in vitro: Eradication achieved by using daptomycin, cefoperazone and doxycycline

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CARBENICILLIN; CARBOMYCIN; CEFOPERAZONE; CEFTRIAXONE; CLARITHROMYCIN; CLOFAZIMINE; DAPTOMYCIN; DOXYCYCLINE; HYDROXYCHLOROQUINE; MICONAZOLE; OFLOXACIN; POLYMYXIN B; PROPIDIUM IODIDE; RIFAMPICIN; SULFAMETHOXAZOLE; SYBR GREEN I PROPIDIUM IODIDE; TIGECYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT;

EID: 84926341095     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117207     Document Type: Article
Times cited : (86)

References (40)
  • 1
    • 84926371571 scopus 로고    scopus 로고
    • Available Accessed 2014 Sep 13
    • CDC (2014) Lyme Disease website. Available: http://www.cdc.gov/lyme/. Accessed 2014 Sep 13.
    • (2014) Lyme Disease website
  • 2
    • 33750132121 scopus 로고    scopus 로고
    • The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: Clinical practice guidelines by the Infectious Diseases Society of America
    • PMID: 17029130
    • Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, et al. (2006) The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 43: 1089-1134. doi: 10.1086/508667 PMID: 17029130
    • (2006) Clin Infect Dis , vol.43 , pp. 1089-1134
    • Wormser, G.P.1    Dattwyler, R.J.2    Shapiro, E.D.3    Halperin, J.J.4    Steere, A.C.5
  • 3
    • 84880642836 scopus 로고    scopus 로고
    • Treatment trials for post-Lyme disease symptoms revisited
    • PMID: 23764268
    • Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, et al. (2013) Treatment trials for post-Lyme disease symptoms revisited. Am J Med 126: 665-669. doi: 10.1016/j.amjmed.2013.02.014 PMID: 23764268
    • (2013) Am J Med , vol.126 , pp. 665-669
    • Klempner, M.S.1    Baker, P.J.2    Shapiro, E.D.3    Marques, A.4    Dattwyler, R.J.5
  • 4
    • 84890216511 scopus 로고    scopus 로고
    • Review of evidence for immune evasion and persistent infection in Lyme disease
    • PMID: 23637552
    • Berndtson K (2013) Review of evidence for immune evasion and persistent infection in Lyme disease. Int J Gen Med 6: 291-306. doi: 10.2147/IJGM.S44114 PMID: 23637552
    • (2013) Int J Gen Med , vol.6 , pp. 291-306
    • Berndtson, K.1
  • 5
    • 1142310887 scopus 로고    scopus 로고
    • Elucidation of Lyme arthritis
    • PMID: 15040587
    • Steere AC, Glickstein L (2004) Elucidation of Lyme arthritis. Nat Rev Immunol 4: 143-152. doi: 10.1038/nri1267 PMID: 15040587
    • (2004) Nat Rev Immunol , vol.4 , pp. 143-152
    • Steere, A.C.1    Glickstein, L.2
  • 6
    • 84863541924 scopus 로고    scopus 로고
    • Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy
    • PMID: 22728937
    • Bockenstedt LK, Gonzalez DG, Haberman AM, Belperron AA (2012) Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. J Clin Invest 122: 2652-2660. doi: 10.1172/JCI58813 PMID: 22728937
    • (2012) J Clin Invest , vol.122 , pp. 2652-2660
    • Bockenstedt, L.K.1    Gonzalez, D.G.2    Haberman, A.M.3    Belperron, A.A.4
  • 7
    • 42949137383 scopus 로고    scopus 로고
    • Persistence of Borrelia burgdorferi following antibiotic treatment in mice
    • PMID: 18316520
    • Hodzic E, Feng S, Holden K, Freet KJ, Barthold SW (2008) Persistence of Borrelia burgdorferi following antibiotic treatment in mice. Antimicrobial Agents and Chemotherapy 52: 1728-1736. doi: 10.1128/AAC.01050-07 PMID: 18316520
    • (2008) Antimicrobial Agents and Chemotherapy , vol.52 , pp. 1728-1736
    • Hodzic, E.1    Feng, S.2    Holden, K.3    Freet, K.J.4    Barthold, S.W.5
  • 8
    • 0037634212 scopus 로고    scopus 로고
    • Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression
    • PMID: 12819085
    • Diterich I, Rauter C, Kirschning CJ, Hartung T (2003) Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression. Infect Immun 71: 3979-3987. doi: 10.1128/IAI.71.7.3979-3987.2003 PMID: 12819085
    • (2003) Infect Immun , vol.71 , pp. 3979-3987
    • Diterich, I.1    Rauter, C.2    Kirschning, C.J.3    Hartung, T.4
  • 9
    • 75749107000 scopus 로고    scopus 로고
    • Ineffectiveness of tigecycline against persistent Borrelia burgdorferi
    • PMID: 19995919
    • Barthold SW, Hodzic E, Imai DM, Feng S, Yang X, et al. (2010) Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrobial Agents and Chemotherapy 54: 643-651. doi: 10.1128/AAC.00788-09 PMID: 19995919
    • (2010) Antimicrobial Agents and Chemotherapy , vol.54 , pp. 643-651
    • Barthold, S.W.1    Hodzic, E.2    Imai, D.M.3    Feng, S.4    Yang, X.5
  • 10
    • 84855694512 scopus 로고    scopus 로고
    • Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection
    • PMID: 22253822
    • Embers ME, Barthold SW, Borda JT, Bowers L, Doyle L, et al. (2012) Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection. PLoS One 7: e29914. doi: 10.1371/journal.pone.0029914 PMID: 22253822
    • (2012) PLoS One , vol.7 , pp. e29914
    • Embers, M.E.1    Barthold, S.W.2    Borda, J.T.3    Bowers, L.4    Doyle, L.5
  • 11
    • 84899865015 scopus 로고    scopus 로고
    • Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice
    • PMID: 24466286
    • Hodzic E, Imai D, Feng S, Barthold SW (2014) Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice. PLoS One 9: e86907. doi: 10.1371/journal.pone.0086907 PMID: 24466286
    • (2014) PLoS One , vol.9 , pp. e86907
    • Hodzic, E.1    Imai, D.2    Feng, S.3    Barthold, S.W.4
  • 12
    • 0031060071 scopus 로고    scopus 로고
    • Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment
    • PMID: 8968890
    • Straubinger RK, Summers BA, Chang YF, Appel MJ (1997) Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment. Journal of clinical microbiology 35: 111-116. PMID: 8968890
    • (1997) Journal of Clinical Microbiology , vol.35 , pp. 111-116
    • Straubinger, R.K.1    Summers, B.A.2    Chang, Y.F.3    Appel, M.J.4
  • 13
    • 41349111096 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy
    • PMID: 17928580
    • Fallon BA, Keilp JG, Corbera KM, Petkova E, Britton CB, et al. (2008) A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology 70: 992-1003. doi: 10.1212/01.WNL.0000284604.61160.2d PMID: 17928580
    • (2008) Neurology , vol.70 , pp. 992-1003
    • Fallon, B.A.1    Keilp, J.G.2    Corbera, K.M.3    Petkova, E.4    Britton, C.B.5
  • 14
    • 84985955398 scopus 로고    scopus 로고
    • Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study
    • PMID: 24523212
    • Marques A, Telford SR III, Turk SP, Chung E, Williams C, et al. (2014) Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study. Clin Infect Dis 58: 937-945. doi: 10.1093/cid/cit939 PMID: 24523212
    • (2014) Clin Infect Dis , vol.58 , pp. 937-945
    • Marques, A.1    Telford, S.R.2    Turk, S.P.3    Chung, E.4    Williams, C.5
  • 15
    • 0038714584 scopus 로고    scopus 로고
    • Study and treatment of post Lyme disease (STOP-LD): A randomized double masked clinical trial
    • PMID: 12821734
    • Krupp LB, Hyman LG, Grimson R, Coyle PK, Melville P, et al. (2003) Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology 60: 1923-1930. doi: 10.1212/01.WNL.0000071227.23769.9E PMID: 12821734
    • (2003) Neurology , vol.60 , pp. 1923-1930
    • Krupp, L.B.1    Hyman, L.G.2    Grimson, R.3    Coyle, P.K.4    Melville, P.5
  • 16
    • 84903757348 scopus 로고    scopus 로고
    • Identification of Novel Activity against Borrelia burgdorferi Persisters Using an FDA Approved Drug Library
    • Feng J, Wang T, Shi W, Zhang S, Sullivan D, et al. (2014) Identification of Novel Activity against Borrelia burgdorferi Persisters Using an FDA Approved Drug Library. Emerg Microb Infect July 2, 2014: 3, e49.
    • (2014) Emerg Microb Infect July 2, 2014 , vol.3 , pp. e49
    • Feng, J.1    Wang, T.2    Shi, W.3    Zhang, S.4    Sullivan, D.5
  • 17
    • 73249127383 scopus 로고    scopus 로고
    • Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic tigecycline
    • PMID: 19843691
    • Brorson O, Brorson SH, Scythes J, MacAllister J, Wier A, et al. (2009) Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic tigecycline. Proc Natl Acad Sci U S A 106: 18656-18661. doi: 10.1073/pnas.0908236106 PMID: 19843691
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18656-18661
    • Brorson, O.1    Brorson, S.H.2    Scythes, J.3    MacAllister, J.4    Wier, A.5
  • 18
    • 84868108265 scopus 로고    scopus 로고
    • Characterization of biofilm formation by Borrelia burgdorferi in vitro
    • PMID: 23110225
    • Sapi E, Bastian SL, Mpoy CM, Scott S, Rattelle A, et al. (2012) Characterization of biofilm formation by Borrelia burgdorferi in vitro. PLoS One 7: e48277. doi: 10.1371/journal.pone.0048277 PMID: 23110225
    • (2012) PLoS One , vol.7 , pp. e48277
    • Sapi, E.1    Bastian, S.L.2    Mpoy, C.M.3    Scott, S.4    Rattelle, A.5
  • 19
    • 53949118915 scopus 로고    scopus 로고
    • Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis
    • PMID: 18817547
    • Miklossy J, Kasas S, Zurn AD, McCall S, Yu S, et al. (2008) Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J Neuroinflammation 5: 40. doi: 10.1186/1742-2094-5-40 PMID: 18817547
    • (2008) J Neuroinflammation , vol.5 , pp. 40
    • Miklossy, J.1    Kasas, S.2    Zurn, A.D.3    McCall, S.4    Yu, S.5
  • 20
    • 0033969719 scopus 로고    scopus 로고
    • Serum-starvation-induced changes in protein synthesis and morphology of Borrelia burgdorferi
    • PMID: 10658658
    • Alban PS, Johnson PW, Nelson DR (2000) Serum-starvation-induced changes in protein synthesis and morphology of Borrelia burgdorferi. Microbiology 146 (Pt 1): 119-127. PMID: 10658658
    • (2000) Microbiology , vol.146 , Issue.1 , pp. 119-127
    • Alban, P.S.1    Johnson, P.W.2    Nelson, D.R.3
  • 21
    • 0029031377 scopus 로고
    • Effects of penicillin, ceftriaxone, and doxycycline on morphology of Borrelia burgdorferi
    • PMID: 7625800
    • Kersten A, Poitschek C, Rauch S, Aberer E (1995) Effects of penicillin, ceftriaxone, and doxycycline on morphology of Borrelia burgdorferi. Antimicrob Agents Chemother 39: 1127-1133. doi: 10.1128/AAC.39.5.1127 PMID: 7625800
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1127-1133
    • Kersten, A.1    Poitschek, C.2    Rauch, S.3    Aberer, E.4
  • 22
    • 0031813035 scopus 로고    scopus 로고
    • In vitro conversion of Borrelia burgdorferi to cystic forms in spinal fluid, and transformation to mobile spirochetes by incubation in BSK-H medium
    • PMID: 9646104
    • Brorson O, Brorson SH (1998) In vitro conversion of Borrelia burgdorferi to cystic forms in spinal fluid, and transformation to mobile spirochetes by incubation in BSK-H medium. Infection 26: 144-150. doi: 10.1007/BF02771839 PMID: 9646104
    • (1998) Infection , vol.26 , pp. 144-150
    • Brorson, O.1    Brorson, S.H.2
  • 23
    • 84894280898 scopus 로고    scopus 로고
    • A systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme disease
    • PMID: 24336823
    • Lantos PM, Auwaerter PG, Wormser GP (2014) A systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme disease. Clin Infect Dis 58: 663-671. doi: 10.1093/cid/cit810 PMID: 24336823
    • (2014) Clin Infect Dis , vol.58 , pp. 663-671
    • Lantos, P.M.1    Auwaerter, P.G.2    Wormser, G.P.3
  • 24
    • 84859698233 scopus 로고    scopus 로고
    • Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi
    • Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, et al. (2011) Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi. Infect Drug Resistance 4: 97-113.
    • (2011) Infect Drug Resistance , vol.4 , pp. 97-113
    • Sapi, E.1    Kaur, N.2    Anyanwu, S.3    Luecke, D.F.4    Datar, A.5
  • 25
    • 33845683283 scopus 로고    scopus 로고
    • Antimicrobial susceptibility of Borrelia burgdorferi sensu lato: What we know, what we don't know, and what we need to know
    • PMID: 17160604
    • Hunfeld KP, Brade V (2006) Antimicrobial susceptibility of Borrelia burgdorferi sensu lato: what we know, what we don't know, and what we need to know. Wien Klin Wochenschr 118: 659-668. doi: 10.1007/s00508-006-0693-z PMID: 17160604
    • (2006) Wien Klin Wochenschr , vol.118 , pp. 659-668
    • Hunfeld, K.P.1    Brade, V.2
  • 26
    • 84863559201 scopus 로고    scopus 로고
    • In vitro and in vivo activity of clofazimine against Mycobacterium tuberculosis persisters
    • PMID: 22691726
    • Xu J, Lu Y, Fu L, Zhu H, Wang B, et al. (2012) In vitro and in vivo activity of clofazimine against Mycobacterium tuberculosis persisters. Int J Tuberc Lung Dis 16: 1119-1125. doi: 10.5588/ijtld.11.0752 PMID: 22691726
    • (2012) Int J Tuberc Lung Dis , vol.16 , pp. 1119-1125
    • Xu, J.1    Lu, Y.2    Fu, L.3    Zhu, H.4    Wang, B.5
  • 27
    • 0024942128 scopus 로고
    • Biochemical approaches to selective antifungal activity. Focus on azole antifungals
    • PMID: 2561184
    • Vanden Bossche H, Marichal P, Gorrens J, Coene MC, Willemsens G, et al. (1989) Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses 32 1: 35-52. doi: 10.1111/j.1439-0507.1989.tb02293.x PMID: 2561184
    • (1989) Mycoses , vol.32 , Issue.1 , pp. 35-52
    • Vanden Bossche, H.1    Marichal, P.2    Gorrens, J.3    Coene, M.C.4    Willemsens, G.5
  • 28
    • 0033757708 scopus 로고    scopus 로고
    • Borrelia genomes in the year 2000
    • PMID: 11075912
    • Casjens S (2000) Borrelia genomes in the year 2000. J Mol Microbiol Biotechnol 2: 401-410. PMID: 11075912
    • (2000) J Mol Microbiol Biotechnol , vol.2 , pp. 401-410
    • Casjens, S.1
  • 29
    • 84865425113 scopus 로고    scopus 로고
    • Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins
    • PMID: 22661688
    • Pogliano J, Pogliano N, Silverman JA (2012) Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins. J Bacteriol 194: 4494-4504. doi: 10.1128/JB.00011-12 PMID: 22661688
    • (2012) J Bacteriol , vol.194 , pp. 4494-4504
    • Pogliano, J.1    Pogliano, N.2    Silverman, J.A.3
  • 30
    • 84892188759 scopus 로고    scopus 로고
    • Persisters, Persistent Infections and the Yin-Yang Model
    • Nature Publishing Group
    • Zhang Y (2014) Persisters, Persistent Infections and the Yin-Yang Model. Emerg Microb Infect (Nature Publishing Group) 3, e3. doi: 10.1038/emi.2014.3
    • (2014) Emerg Microb Infect , vol.3 , pp. e3
    • Zhang, Y.1
  • 31
    • 79959722946 scopus 로고    scopus 로고
    • Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: Role of enhanced daptomycin binding
    • PMID: 21690622
    • Dhand A, Bayer AS, Pogliano J, Yang SJ, Bolaris M, et al. (2011) Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding. Clin Infect Dis 53: 158-163. doi: 10.1093/cid/cir340 PMID: 21690622
    • (2011) Clin Infect Dis , vol.53 , pp. 158-163
    • Dhand, A.1    Bayer, A.S.2    Pogliano, J.3    Yang, S.J.4    Bolaris, M.5
  • 32
    • 84904569642 scopus 로고    scopus 로고
    • Evaluation of the novel combination of daptomycin plus ceftriaxone against vancomycin-resistant enterococci in an in vitro pharmacokinetic/pharmacodynamic simulated endocardial vegetation model
    • PMID: 24777900
    • Hall Snyder A, Werth BJ, Barber KE, Sakoulas G, Rybak MJ (2014) Evaluation of the novel combination of daptomycin plus ceftriaxone against vancomycin-resistant enterococci in an in vitro pharmacokinetic/pharmacodynamic simulated endocardial vegetation model. The Journal of antimicrobial chemotherapy 69: 2148-2154. doi: 10.1093/jac/dku113 PMID: 24777900
    • (2014) The Journal of Antimicrobial Chemotherapy , vol.69 , pp. 2148-2154
    • Hall Snyder, A.1    Werth, B.J.2    Barber, K.E.3    Sakoulas, G.4    Rybak, M.J.5
  • 33
    • 0027289406 scopus 로고
    • In vitro activity of vancomycin against the spirochete Borrelia burgdorferi
    • PMID: 8517700
    • Dever LL, Jorgensen JH, Barbour AG (1993) In vitro activity of vancomycin against the spirochete Borrelia burgdorferi. Antimicrob Agents Chemother 37: 1115-1121. doi: 10.1128/AAC.37.5.1115 PMID: 8517700
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 1115-1121
    • Dever, L.L.1    Jorgensen, J.H.2    Barbour, A.G.3
  • 34
    • 0028876538 scopus 로고
    • Effect of polymyxin B nonapeptide on daptomycin permeability and cell surface properties in Pseudomonas aeruginosa, Escherichia coli, and Pasteurella multocida
    • Morris CM, George A, Wilson WW, Champlin FR (1995) Effect of polymyxin B nonapeptide on daptomycin permeability and cell surface properties in Pseudomonas aeruginosa, Escherichia coli, and Pasteurella multocida. J Antibiot (Tokyo) 48: 67-72. doi: 10.7164/antibiotics.48.67
    • (1995) J Antibiot (Tokyo) , vol.48 , pp. 67-72
    • Morris, C.M.1    George, A.2    Wilson, W.W.3    Champlin, F.R.4
  • 35
    • 1542359138 scopus 로고    scopus 로고
    • Induction of cystic forms by different stress conditions in Borrelia burgdorferi
    • PMID: 14961976
    • Murgia R, Cinco M (2004) Induction of cystic forms by different stress conditions in Borrelia burgdorferi. APMIS: acta pathologica, microbiologica, et immunologica Scandinavica 112: 57-62. doi: 10.1111/j.1600-0463.2004.apm1120110.x PMID: 14961976
    • (2004) APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica , vol.112 , pp. 57-62
    • Murgia, R.1    Cinco, M.2
  • 36
    • 0346492817 scopus 로고    scopus 로고
    • Persister cells and tolerance to antimicrobials
    • PMID: 14734160
    • Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K (2004) Persister cells and tolerance to antimicrobials. FEMS Microbiol Lett 230: 13-18. doi: 10.1016/S0378-1097(03)00856-5 PMID: 14734160
    • (2004) FEMS Microbiol Lett , vol.230 , pp. 13-18
    • Keren, I.1    Kaldalu, N.2    Spoering, A.3    Wang, Y.4    Lewis, K.5
  • 37
    • 34250218203 scopus 로고    scopus 로고
    • PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli
    • PMID: 17420206
    • Li Y, Zhang Y (2007) PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. Antimicrob Agents Chemother 51: 2092-2099. doi: 10.1128/AAC.00052-07 PMID: 17420206
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2092-2099
    • Li, Y.1    Zhang, Y.2
  • 38
    • 65349084964 scopus 로고    scopus 로고
    • Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement
    • Clinical and Laboratory Standards Institute (2007) Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement. CLSI document M100-S17 27: 154-161.
    • (2007) CLSI Document M100-S17 , vol.27 , pp. 154-161
    • Clinical and Laboratory Standards Institute1
  • 39
    • 84909606249 scopus 로고    scopus 로고
    • An Optimized SYBR Green I/PI Assay for Rapid Viability Assessment and Antibiotic Susceptibility Testing for Borrelia burgdorferi
    • PMID: 25365247
    • Feng J, Wang T, Zhang S, Shi W, Zhang Y (2014) An Optimized SYBR Green I/PI Assay for Rapid Viability Assessment and Antibiotic Susceptibility Testing for Borrelia burgdorferi. PLoS ONE 9(11): e111809. doi: 10.1371/journal.pone.0111809 PMID: 25365247
    • (2014) PLoS ONE , vol.9 , Issue.11 , pp. e111809
    • Feng, J.1    Wang, T.2    Zhang, S.3    Shi, W.4    Zhang, Y.5
  • 40
    • 0034622803 scopus 로고    scopus 로고
    • Improvements in image analysis and fluorescence microscopy to discriminate and enumerate bacteria and viruses in aquatic samples
    • Shopov A, Williams SC, Verity PG (2000) Improvements in image analysis and fluorescence microscopy to discriminate and enumerate bacteria and viruses in aquatic samples. Aquatic Microbial Ecology 22: 103-110. doi: 10.3354/ame022103
    • (2000) Aquatic Microbial Ecology , vol.22 , pp. 103-110
    • Shopov, A.1    Williams, S.C.2    Verity, P.G.3


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