FC RECEPTOR;
G PROTEIN COUPLED RECEPTOR;
I KAPPA B KINASE ALPHA;
I KAPPA B KINASE BETA;
INTERLEUKIN 12P70;
INTERLEUKIN 6;
LIPOPOLYSACCHARIDE;
MITOGEN ACTIVATED PROTEIN KINASE P38;
PROTEIN KINASE SYK;
PROTEIN SH3;
RAC PROTEIN;
RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;
STRESS ACTIVATED PROTEIN KINASE 1;
TOLL LIKE RECEPTOR;
VAV PROTEIN;
ACTIN;
CYTOKINE;
LIPOPOLYSACCHARIDE, E COLI O55-B5;
SH3BP2 PROTEIN, HUMAN;
SH3BP2 PROTEIN, MOUSE;
SIGNAL TRANSDUCING ADAPTOR PROTEIN;
TLR4 PROTEIN, MOUSE;
TOLL LIKE RECEPTOR 4;
ACTIN FILAMENT;
ACTIN POLYMERIZATION;
ANIMAL MODEL;
ARTICLE;
BONE MARROW DERIVED MACROPHAGE;
CELL DIFFERENTIATION;
CELL PROLIFERATION;
CONTROLLED STUDY;
CYTOKINE PRODUCTION;
CYTOKINE RESPONSE;
ESCHERICHIA COLI;
FIBROUS DYSPLASIA;
GENE;
GENE AMPLIFICATION;
GENETIC ASSOCIATION;
HETEROZYGOSITY;
IN VITRO STUDY;
IN VIVO STUDY;
INFECTION;
INNATE IMMUNITY;
MACROPHAGE;
MACROPHAGE ACTIVATION;
MACROPHAGE FUNCTION;
MONOCYTE;
MOUSE;
NONHUMAN;
PHAGOCYTOSIS;
PRIORITY JOURNAL;
PROTEIN BLOOD LEVEL;
PROTEIN EXPRESSION;
PROTEIN PHOSPHORYLATION;
PROTEIN PROTEIN INTERACTION;
SH3BP2 GENE;
SIGNAL TRANSDUCTION;
ADOPTIVE TRANSFER;
AMINO ACID SUBSTITUTION;
ANIMAL;
C57BL MOUSE;
CHEMISTRY;
DEFICIENCY;
DISEASE MODEL;
DRUG EFFECTS;
GENETICS;
HETEROZYGOTE;
HUMAN;
INFLAMMATION;
KNOCKOUT MOUSE;
METABOLISM;
MICROBIOLOGY;
MISSENSE MUTATION;
OSTEOCLAST;
PATHOLOGY;
PATHOPHYSIOLOGY;
PERITONEUM MACROPHAGE;
PHYSIOLOGY;
POINT MUTATION;
SECRETION (PROCESS);
SITE DIRECTED MUTAGENESIS;
TRANSPLANTATION;
The role of SH3BP2 in the pathophysiology of cherubism
Reichenberger EJ, Levine MA, Olsen BR, Papadaki ME, Lietman SA. The role of SH3BP2 in the pathophysiology of cherubism. Orphanet J Rare Dis. 2012;7(suppl 1):S5.
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation
Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity. 1998;9(5):595-605.
The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor
Foucault I, Le Bras S, Charvet C, Moon C, Altman A, Deckert M. The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor. Blood. 2005;105(3):1106-1113.
The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response
Chen G, et al. The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol. 2007;27(8):3109-3122.
3BP2 Adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells
GuezGuez A, et al. 3BP2 Adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. J Biol Chem. 2010;285(27):20952-20963.
(2010)J Biol Chem., vol.285, Issue.27, pp. 20952-20963
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice
Ueki Y, et al. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell. 2007;128(1):71-83.
Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties
Wang CJ, et al. Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties. Bone. 2010;46(5):1306-1315.
Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism
Yoshitaka T, et al. Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep. 2014;8(6):1752-1766.
