Estrogen receptor alpha polymorphisms, estradiol level, and occurrence of atherosclerosis risk factors in healthy postmenopausal women

Medical Science Monitor

Volumn 21, Issue , 2015, Pages 970-979

  Bojar, Iwona ^a   Gujski, Mariusz ^b   Raczkiewicz, Dorota ^c   Łyszcz, Robert ^d   Owoc, Jakub ^e   Walecka, Irena ^f  

^a INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c WARSAW SCHOOL OF ECONOMICS   (Poland)

^d St John Regional Hospital   (Poland)

^e College of Public Health   (Poland)

^f CENTRAL CLINICAL HOSPITAL   (Poland)

Author keywords

Atherosclerosis; Estradiol; Estrogen receptor alpha; Menopause

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RESTRICTION ENDONUCLEASE; TRIACYLGLYCEROL; ESTROGEN RECEPTOR ALPHA, HUMAN; LIPID;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; ESTRADIOL BLOOD LEVEL; ESTROGEN RECEPTOR ALPHA GENE; FEMALE; HIP CIRCUMFERENCE; HUMAN EXPERIMENT; HYPERTENSION; MIDDLE AGED; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POSTMENOPAUSE; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; WAIST HIP RATIO; BLOOD; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; RISK FACTOR;

AGED; ATHEROSCLEROSIS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LIPIDS; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POSTMENOPAUSE; RISK FACTORS; WAIST-HIP RATIO;

EID: 84926325950     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.892831     Document Type: Article

References (32)

1. Islami F, Mańczuk M, Vedanthan R et al: A cross-sectional study of cardiovascular disease and associated factors. Ann Agric Environ Med, 2011; 18(2): 255–59
2. Matyjaszczyk P, Hoffmann K, Bryl W: Epidemiology of selected risk factors of cardiovascular diseases. Cardio-Diabetological Review, 2011; 6(4): 255–62
3. Berenson GS: Cardiovascular health promotion for elementary school children. Risk Factors, 1998; Supl.5: 11–13
4. Gerhard M, Ganz P: How do we explain the clinical benefits of estrogen? From bedside to bench. Circulation, 1995; 92: 5–8
5. Hu FB, Grodstein F, Hennekens CH et al: Age at natural menopause and risk of cardiovascular disease. Arch Intern Med, 1999; 159: 1061–66
6. Mendelsohn ME, Karas RH: The protective effects of estrogen on the cardiovascular system. N Engl J Med, 1999; 340: 1801–11
7. Lundeen SG, Carver JM, McKean ML, Winneker RC: Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels. Endocrinology, 1997; 138: 1552–58
8. Campos H, Walsh BW, Judge H, Sacks FM: Effect of estrogen on very low density lipoprotein and low density lipoprotein subclass metabolism in postmenopausal women. J Clin Endocrinol Metab, 1997; 82: 3955–63
9. Mendelsohn ME, Karas RH: Estrogen and the blood vessel wall. Curr Opin Cardiol, 1994; 9: 619–26
10. Couse JF, Curtis SW, Washburn TF et al: Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol, 1995; 9: 1441–54
11. Pedersen SB, Borglum JD, Moller-Pedersen T, Richelsen B: Effects of in vivo estrogen treatment on adipose tissue metabolism and nuclear estrogen receptor binding in isolated rat adipocytes. Mol Cell Endocrinol, 1992; 85: 13–19
12. Herrington DM, Howard TD, Hawkins GA et al: Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med, 2002; 346: 967–74
13. Schuit SC, Oei HH, Witteman JC et al: Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. JAMA, 2004; 291: 2969–77
14. Deng HW, Li J, Li JL et al: Association of estrogen receptor-alpha genotypes with Body mass index in normal healthy postmenopausal Caucasian women. J Clin Endocrinol Metab, 2000; 85: 2748–51
15. Fox CS, Yang Q, Cupples LA et al: Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. J Clin Endocrinol Metab, 2005; 90: 6257–62
16. Speer G, Cseh K, Winkler G et al: Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. Eur J Endocrinol, 2001; 144: 385–89
17. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S: Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: evidence for association with risk and histopathological tumor characteristics in Iranian men. Mol Carcinog, 2012; 51(Suppl.1): E104–17
18. Kozakiewicz K, Wycisk A: [Hormonal Replacement Therapy and Selective Estrogen Receptor Modulators in Prevention of Cardiovascular Disease.] Medical News, 2006; 59(5–6): 377–82 [in Polish]
19. Ilow R, Regulska-Ilow B, Rożańska D et al: Prevalence of metabolic syndrome among 40- and 50-year-old inhabitants of Wroclaw, Poland. Ann Agric Environ Med, 2012; 19(3): 551–56
20. Rossouw JE: Hormones, genetic factors, and gender differences in cardiovascular disease. Cardiovasc Res, 2002; 53: 550–57
21. Matsubara Y, Murata M, Kawano K et al: Genotype distribution of estrogen receptor polymorphisms in men and postmenopausal women from healthy and coronary populations and its relation to serum lipid levels. Arterioscler Thromb Vasc Biol, 1997; 17(11): 3006–12
22. Kikuchi T, Kawasaki T, Uchiyama M: Association of serum low-density lipoprotein metabolism with oestrogen receptor gene polymorphisms in healthy children. Acta Paediatr, 2000; 89: 42–45
23. Shen C, Chen J, Fan S et al: Association between the polymorphism of estrogen receptor a and coronary artery disease in a Chinese population. Eur J Intern Med, 2012; 23(2): 175–78
24. Schuit SCE, de Jong FH, Stolk L et al: Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women. Eur J Endocrinol, 2005; 153: 327–34
25. Schuit SC, Oei HH, Witteman JC et al: Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. JAMA, 2004; 291: 2969–77
26. Ferrero V, Ribichini F, Matullo G et al: Estrogen receptor-alpha polymorphisms and angiographic outcome after coronary artery stenting. Arterioscler Thromb Vasc Biol, 2003; 23: 2223–28
27. Nordstrom P, Glader CA, Dahlen G et al: Oestrogen receptor a gene polymorphism is related to aortic valve sclerosis in postmenopausal women. J Int Med, 2003; 254: 140–46
28. Thomas KL, Honeycutt E, Shaw LK et al: Racial differences in long-term survival among patients with coronary artery disease. Am Heart J, 2010; 160(4): 744–51
29. Batchelor WB, Ellis SG, Ormiston JA et al: Racial differences in long-term outcomes after percutaneous coronary intervention with paclitaxel-eluting coronary stents. J Interv Cardiol, 2013; 26(1): 49–57
30. Ioana M, Ferwerda B, Plantinga TS et al: Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins. Infect Immun, 2012; 80(5): 1917–22
31. Labonte B, Suderman M, Maussion G et al: Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry, 2012; 69(7): 722–31
32. Yu Q, Liu EQ, Zhao SH et al: Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population. J Zhejiang Univ Sci B, 2012; 13(5): 342–47