The ability of 17 β-estradiol to attenuate intrahepatic vasoconstriction to endothelin-1 in female rats is lost in cirrhosis

Annals of Hepatology

Volumn 14, Issue 3, 2015, Pages 404-413

  Ho, Hsin Ling ^a   Lee, Fa Yauh ^a   Hsu, Shao Jung ^a,b   Wang, Sun Sang ^a   Hsin, I Fang ^a,b   Huang, Hui Chun ^a   Lee, Jing Yi ^a,b   Lin, Han Chieh ^a   Lee, Shou Dong ^c  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHENG HSIN GENERAL HOSPITAL   (Taiwan)

Author keywords

Endothelin 1; Liver cirrhosis; Portal hypertension; Sex hormone

Indexed keywords

ANDROGEN RECEPTOR; ENDOTHELIN 1; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; TESTOSTERONE; ESTROGEN; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ESTROGEN RECEPTOR ALPHA GENE; FEMALE; GENE EXPRESSION; HORMONE ACTION; LIVER CIRRHOSIS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PORTAL VEIN BLOOD FLOW; PORTAL VEIN BLOOD PRESSURE; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; VASOCONSTRICTION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPATIC ARTERY; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; ENDOTHELIN-1; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION; HEPATIC ARTERY; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA; VASOCONSTRICTION;

EID: 84926209412     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31281-5     Document Type: Article

References (42)

1. Bosch J, Pizcueta P, Feu F, Fernández M, Garciá-Pagán JC. Pathophysiology of portal hypertension. Gastroenterol Clin Nor Am 1992; 21: 1-14.
2. D’Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: A meta-analytic review. Hepatology 1995; 22: 332-54.
3. Rockey DC. Vasoactive agents in intrahepatic portal hypertension and fibrogenesis: Implications for therapy. Gastroenterology 2000; 118: 1261-5.
4. Moller S, Gulberg V, Henriksen JH, Gerbes AL. Endothelin-1 and endothelin-3 in cirrhosis: Relations to systemic and splanchnic haemodynamics. J Hepatol 1995; 23: 135-44.
5. Sogni P, Moreau R, Gomola A, Gadano A, Cailmail S, Calmus Y, Clozel M, et al. Beneficial hemodynamic effects of bosentan, a mixed ET(A) and ET(B) receptor antagonist, in portal hypertensive rats. Hepatology 1998; 28: 655-9.
6. Chan CC, Wang SS, Lee FY, Chang FY, Lin HC, Chu CJ, Chen CT, et al. Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats. Hepatology 2001; 33: 816-20.
7. Baker HW, Burger HG, de Kretser DM, Dulmanis A, Hudson B, O’Connor S, Paulsen CA, et al. A study of the endocrine manifestations of hepatic cirrhosis. Q J Med 1976; 45: 145-78.
8. Bannister P, Losowsky MS. Sex hormones and chronic liver disease. J Hepatol 1988; 6: 258-62.
9. Farrell GC, Koltai A, Zaluzny L, Murray M. Effects of portal vein ligation on sex hormone metabolism in male rats: Relationship to lowered hepatic cytochrome P450 levels. Gastroenterology 1986; 90: 299-305.
10. Van Thiel DH, Gavaler JS, Schade RR. Liver disease and the hypothalamic pituitary gonadal axis. Semin Liver Dis 1985; 5: 35-45.
11. Gordon GG, Olivo J, Rafil F, Southren AL. Conversion of androgens to estrogens in cirrhosis of the liver. J Clin Endocrinol Metab 1975; 40: 1018-26.
12. Farrell G, Koltai A. Hepatic testosterone metabolism in male rats with portal bypass. Gastroenterology 1988; 95: 425-33.
13. Levy D. Kannel WB. Cardiovascular risks: New insights from Framingham. Am Heart J 1988; 116: 266-72.
14. Kastrup A, Dichgans J, Niemeier M, Schabet M. Changes of cerebrovascular CO2 reactivity during normal aging. Stroke 1998; 29: 1311-4.
15. Reis SE, Gloth ST, Blumenthal RS, Resar JR, Zacur HA, Gerstenblith G, Brinker JA, et al. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 1994; 89: 52-60.
16. Kauser K, Rubanyi GM. Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae. A J Physiol 1994; 267: H2311-H2317.
17. Brandes RP, Mugge A. Gender differences in the generation of superoxide anions in the rat aorta. Life Sci 1997; 60: 391-6.
18. Franco F, Gigou M, Szekely AM, Bismuth H. Portal hypertension after bile duct obstruction: Effect of bile diversion on portal pressure in the rat. Arch Surg 1979; 114: 1064-7.
19. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct ligation obstruction: A new experimental model for cirrhosis in the rat. Br J Exp Pathol 1984; 65: 305-11.
20. Lee FY, Colombato LA, Albillos A, Groszmann RJ. Administration of ω-nitro-L-arginine ameliorates portal-systemic shunting in portal hypertensive rats. Gastroenterology 1993; 105: 1464-70.
21. Mittal MK, Gupta TK, Lee FY, Sieber CC, Groszmann RJ. Nitric oxide modulates hepatic vascular tone in normal rat liver. Am J Physiol 1994; 267: G416-G422.
22. Hamilton RL, Berry MN, Williams MC, Severinghaus EM. A simple and inexpensive membrane “lung” for small organ perfusion. J Lipid Res 1974; 15: 182-6.
23. Chen J, Rider DA, Ruan R. Identification of valid housekeeping genes and antioxidant enzyme gene expression change in the aging rat liver. J Gerontol 2006; 61: 20-7.
24. Okada A, Ohta Y, Inoue S, Hiroi H, Muramatsu M, Iguchi T. Expression of estrogen, progesterone and androgen receptors in the oviduct of developing, cycling and pre-implantation rats. J Mol Endocrinol 2003; 30: 301-15.
25. Khoury S, Yarows SA, O’Brien TK, Sowers JR. Ambulatory blood pressure monitoring in a nonacademic setting: Effects of age and sex. Am J Hypertens 1992; 5: 616-23.
26. Ganten U, Schroder G, Witt M, Zimmerman F, Ganten D, Stock G. Sexual dimorphism of blood pressure in spontaneously hypertensive rats: Effects of anti-androgen treatment. J Hypertens 1989; 7: 721-6.
27. Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: From the patient to the molecule. Hepatology 2006; 43: S121-S131.
28. Jiang C, Sarrel PM, Poole-Wilson PA, Collins P. Acute effect of 17 beta-estradiol on rabbit coronary artery contractile responses to endothelin-1. Am J Physiol 1992; 263: H271-H275.
29. Sudhir K, Ko E, Zellner C, Wong HE, Hutchison SJ, Chou TM, Chatterjee K. Physiological concentrations of estradiol attenuate endothelin 1-induced coronary vasoconstriction in vivo. Circulation 1997; 96: 3626-32.
30. Yokoyama Y, Toth B, Kitchens WC, Schwacha MG, Rue LW 3rd, Bland KI, . Estradiol’s effect on portal response to endothelin- 1 after trauma-hemorrhage. Journal Surg Res 2004; 121: 25-30.
31. Sakamoto M, Uen T, Nakamura T, Hashimoto O, Sakata R, Kin M, Ogata R , et al. Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells. J Hepatol 2001; 34: 858-64.
32. Tatchum-Talom R, Martel C, Labrie C, Labrie F, Marette A. Gender differences in hemodynamic responses to endothelin-1. J Cardiovasc Pharmacol 2000; 36: S102-S104.
33. Laughlin MH, Schrage WG, McAllister RM, Garverick HA, Jones AW. Interaction of gender and exercise training: Vasomotor reactivity of porcine skeletal muscle arteries. J Appl Physiol 2001; 90: 216-27.
34. Miller VM, Barber DA, Fenton AM, Wang X, Sieck GC. Gender differences in response to endothelin-1 in coronary arteries: Transcription, receptors and calcium regulation. Clin Exp Pharmacol Physiol 1996; 23: 256-9.
35. Barber DA, Sieck GC, Fitzpatrick LA, Miller VM. Endothelin receptors are modulated in association with endogenous fluctuations in estrogen. Am J Physiol Heart Circ Physiol 1996; 271: H1999-H2006.
36. Fernandez N, Sanz E, Monge L, Martinez MA, Dieguez G, Garcia-Villalon AL. Potentiation by endothelin-1 and vasopressin of sympathetic vasoconstriction in male and female rats. Clin Sci 2002; 103: 158s-61s.
37. Saceda M, Lippman ME, Chambon P, Lindsey RL, Ponglikitmongkol M, Puente M, Martin MB, et al. Regulation of the estrogen receptor in MCF-7 cells by estradiol. Molecular Endocrinol 1988; 2: 1157-62.
38. Miller VM, Vanhoutte PM. Progesterone and modulation of endothelium-dependent responses in canine coronary arteries. Am J Physiol 1991; 261: R1022-R1027.
39. Lamping KG, Nuno DW. Effects of 17 beta-estradiol on coronary microvascular responses to endothelin-1. Am J Physiol 1996; 271: H1117-H1124.
40. Yue P, Chatterjee K, Beale C, Poole-Wilson PA, Collins P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995; 91: 1154-60.
41. Costarella CE, Stallone JN, Rutecki GW, Whittier FC. Testosterone causes direct relaxation of rat thoracic aorta. J Pharmacol Exp Ther 1996; 277: 34-9.
42. Chou TM, Sudhir K, Hutchison SJ, Ko E, Amidon TM, Collins P, Chatterjee K. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 1996; 94: 2614-9.