Associations of obsessive-compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness

Psychiatry Research

Volumn 226, Issue 1, 2015, Pages 368-375

  Kim, Sung Wan ^a   Jeong, Bo Ok ^a   Kim, Jae Min ^a   Shin, Il Seon ^a   Hwang, Michael Y ^b   Paul Amminger, G ^c   Nelson, Barnaby ^c   Berk, Michael ^c,d   McGorry, Patrick ^c   Yoon, Jin Sang ^a  

^a Chonnam National University Medical School   (South Korea)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d DEAKIN UNIVERSITY   (Australia)

Author keywords

Cognition; Comorbidity; Depression; Obsessive compulsive symptoms; Quality of life; Schizophrenia

Indexed keywords

RISPERIDONE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; CALGARY DEPRESSION SCALE; CLINICAL FEATURE; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; LEARNING; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NEUROPSYCHOLOGICAL TEST; OBSESSIVE COMPULSIVE DISORDER; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; QUALITY OF LIFE; SCHIZOPHRENIA; SCORING SYSTEM; YALE BROWN OBSESSIVE COMPULSIVE SCALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PERSONALITY TEST; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOTIC DISORDERS; SEVERITY OF ILLNESS INDEX;

ADULT; ANTIPSYCHOTIC AGENTS; COMORBIDITY; DEPRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PERSONALITY INVENTORY; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; QUALITY OF LIFE; RISPERIDONE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEVERITY OF ILLNESS INDEX;

EID: 84926191697     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2015.01.021     Document Type: Article

References (83)

1. Achim A.M., Maziade M., Raymond E., Olivier D., Merette C., Roy M.A. How prevalent anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association. Schizophrenia Bulletin 2011, 37:811-821.
2. Addington D., Addington J., Schissel B. A depression rating scale for schizophrenics. Schizophrenia Research 1990, 3:247-251.
3. Allen L., Tejera C. Treatment of clozapine-induced obsessive-compulsive symptoms with sertraline. American Journal of Psychiatry 1994, 151:1096-1097.
4. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Press Inc., Washington, DC. 4th ed.
5. Barch D.M., Bustillo J., Gaebel W., Gur R., Heckers S., Malaspina D., Owen M.J., Schultz S., Tandon R., Tsuang M., Van Os J., Carpenter W. Logic and justification for dimensional assessment of symptoms and related clinical phenomena in psychosis: relevance to DSM-5. Schizophrenia Research 2013, 150:15-20.
6. Beck A.T., Ward C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Archives General Psychiatry 1961, 4:561-571.
7. Berman I., Merson A., Viegner B., Losonczy M.F., Pappas D., Green A.I. Obsessions and compulsions as a distinct cluster of symptoms in schizophrenia: a neuropsychological study. Journal of Nervous and Mental Disease 1998, 186:150-156.
8. Birchwood M., Todd P., Jackson C. Early intervention in psychosis. The critical period hypothesis. British Journal of Psychiatry 1998, 172:s53-59.
9. Bleuler M. The Schizophrenic Disorders: Long-Term Patient and Family Studies 1978, Yale University Press, Oxford.
10. Borkowska A., Pilaczynska E., Rybakowski J.K. The frontal lobe neuropsychological tests in patients with schizophrenia and/or obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neuroscience 2003, 15:359-362.
11. Bottas A., Cooke R.G., Richter M.A. Comorbidity and pathopysiology of obsessive-compulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia?. Journal of Psychiatry and Neuroscience 2005, 30:187-193.
12. Boyette L., Swets M., Meijer C., Wouters L., GROUP Authors Factor structure of the Yale-Brown Obsessive-Compulsive Scale (Y-B obsessive-compulsive symptoms) in a large sample of patients with schizophrenia or related disorders and comorbid obsessive-compulsive symptoms. Psychiatry Research 2011, 186:409-413.
13. Cleare A.J. Reduced whole blood serotonin in major depression. Depression and Anxiety 1997, 5:108-111.
14. Craig T., Hwang M.Y., Bromet E.J. Obsessive-compulsive and panic symptoms in patients with first-admission psychosis. American Journal of Psychiatry 2002, 159:592-598.
15. Cunill R., Castells X., Simeon D. Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysis. Journal of Clinical Psychiatry 2009, 70:70-82.
16. de Haan L., Beuk N., Hoogenboom B., Dingemans P., Linszen D. Obsessive-compulsive symptoms during treatment with olanzapine and risperidone: a prospective study of 113 patients with recent-onset schizophrenia or related disorders. Journal of Clinical Psychiatry 2002, 63:104-107.
17. de Haan L., Hoogenboom B., Beuk N., van Amelsvoort T., Linszen D. Obsessive-compulsive symptoms and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. Canadian Journal of Psychiatry 2005, 50:519-524.
18. de Haan L., Hoogeboom B., Beuk N., Wouters L., Dingemans P.M., Linszen D.H. Reliability and validity of the Yale-Brown Obsessive-Compulsive Scale in schizophrenia patients. Psychopharmacology Bulletin 2006, 39:25-30.
19. de Haan L., Sterk B., Wouters L., Liszen D.H. The 5-year course of obsessive-compulsive symptoms and obsessive-compulsive disorder in first-episode schizophrenia and related disorders. Schizophrenia Bulletin 2013, 39:151-160.
20. de Haan L., Sterk B., van der Valk R. Presence of obsessive-compulsive symptoms in first-episode schizophrenia or related disorders is associated with subjective well-being and quality of life. Early Intervention in Psychiatry 2013, 7:285-290.
21. DeVylder J.E., Oh A.J., Ben-David S., Azimov N., Harkavy-Friedman J.M., Corcoran C.M. Obsessive-compulsive symptoms in individuals at clinical risk for psychosis: association with depressive symptoms and suicidal ideation. Schizophrenia Research 2012, 140:110-113.
22. Fontenelle L.F., Lin A., Pantelis C., Wood S.J., Nelson B., Yung A.R. A longitudinal study of obsessive--compulsive disorder in individuals at ultra-high risk for psychosis. Journal of Psychiatric Research 2011, 45:1140-1145.
23. Fenton W.S., McGlashan T.H. The prognostic significance of obsessive-compulsive symptoms in schizophrenia. American Journal of Psychiatry 1986, 143:437-441.
24. Goodman W.K., Price L.H., Rasmussen A., Mazure C., Fleichmann R.L., Hill C.L., Heninger G.R., Charney D.S. The Yale-Brown Obsessive-Compulsive Scale: I. Development, use, and reliability. Archives General Psychiatry 1989, 46:1006-1011.
25. Ha K.S., Kwon J.S., Lyoo I.K., Kong S.W., Lee D.W., Youn T. Development and standardization process, and factor analysis of the computerized cognitive function test system for Korea adults. Journal of Korean Neuropsychiatric Association 2002, 41:551-562.
26. Hagen K., Hansen B., Joa I., Larsen T.K. Prevalence and clinical characteristics of patients with obsessive-compulsive disorder in first-episode psychosis. BMC Psychiatry 2013, 13:156.
27. Hahn H.M., Yum T.H., Shin Y.W., Kim K.H., Yoon D.J., Chung K.J. Standardization study of Beck Depression Inventory in Korea. Journal of Korean Neuropsychiatric Assocciation 1986, 25:487-502.
28. Heaton R.K., Chelune G.J., Talley J.L., Kay G.G., Curtiss G. Wisconsin Card Sorting Test Manual: Revised and Expanded 1993, Psychological Assessment Resources, Odessa, FL.
29. Hwang M.Y., Opler L.A. Schizophrenia with obsessive-compulsive features: assessment and treatment. Psychiatric Annals 1994, 24:468-472.
30. Hwang M.Y., Morgan J.E., Losonczy M.F. Clinical and neuropsychological profiles of OC schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience 2000, 12:91-94.
31. Hwang M.Y., Kim S.W., Yum S.Y., Opler L.A. Management of schizophrenia with obsessive-compulsive features. Psychiatric Clinics of North America 2009, 32:835-851.
32. Jaherresis W. Obsessions during schizophrenia. Archives Psychiatry 1926, 77:740-788.
33. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scales (PANSS) for schizophrenia. Schizophrenia Bulletin 1987, 13:261-276.
34. Kim S.J., Choi N.K., Hong H.J., Hwang Y.S., Kim Y.K., Lee H.S., Kim C.H. Dimensional analyses ofthe Yale-Brown obsessive-compulsive scale and Yale-Brown obsessive-compulsivescale checklist. Korean Journal of Psychopharmacology 2004, 15:339-345.
35. Kim Y.K., Won S.D., Lee K.M., Choi H.S., Jang H.S., Lee B.H., Han C.S. A study on the reliability and validity of the Korean version of the Calgary Depression Scale for Schizophrenia (K-CDSS). Journal of Korean Neuropsychiatric Association 2005, 44:446-455.
36. Kim S.W., Kim S.J., Yoon B.H., Kim J.M., Shin I.S., Hwang M.Y., Yoon J.S. Diagnostic validity of assessment scales for depression in patients with schizophrenia. Psychiatry Research 2006, 144:57-63.
37. Kim S.W., Shin I.S., Kim J.M., Lee S.H., Lee J.H., Yoon B.H., Yang S.J., Hwnag M.Y., Yoon J.S. Amisulpride versus risperidone in the treatment of depression in patients with schizophrenia: a randomized, open-label, controlled trial. Progress in Neuropsychopharmacololgy and Biological Psychiatry 2007, 31:1504-1509.
38. Kim S.W., Shin I.S., Kim J.M., Yoo J.A., Ahn Y.M., Kwon J.S., Yang S.J., Yoon J.S. A validation study of the Korean version of Subjective Well-being under Neuroleptic Treatment Scale - short form. Korean Journal of Psychopharmacology 2007, 18:221-230.
39. Kim S.W., Shin I.S., Kim J.M., Yang S.J., Hwang M.Y., Yoon J.S. Amisulpride improves obsessive-compulsive symptoms in schizophrenia patients taking atypical antipsychotics: an open-label switch study. Journal of Clinical Psychopharmacology 2008, 28:349-352.
40. Kim S.W., Shin I.S., Kim J.M., Youn T., Yang S.J., Hwang M.Y., Yoon J.S. The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia. Clinical Neuropharmacology 2009, 32:224-226.
41. Kim S.W., Shin I.S., Kim J.M., Lee J.H., Lee Y.H., Yang S.J., Yoon J.S. Effectiveness of switching to aripiprazole from antipsychotics in patients with schizophrenia. Clinical Neuropharmacology 2009, 32:243-249.
42. Kim S.W., Shin I.S., Kim J.M., Lee S.H., Lee Y.H., Yang S.J., Yoon J.S. Effects of switching to long-acting injectable risperidone from oral atypical antipsychotics on cognitive function in patients with schizophrenia. Human Psychopharmacology 2009, 24:565-573.
43. Kim S.W., Chung Y.C., Lee Y.H., Lee J.H., Kim S.Y., Bae K.Y., Kim J.M., Shin I.S., Yoon J.S. Paliperidone ER versus risperidone for neurocognitive function in patients with schizophrenia: a randomized, open-label, controlled trial. International Clinical Psychopharmacology 2012, 27:267-274.
44. Kim S.W., Lindenmayer J.P., Hwang M.Y. Schizophrenia with obsessive-compulsive symptoms: clinical and conceptual issues. Psychiatric Annals 2013, 43:442-445.
45. Kuelz A.K., Hohagen F., Voderholzer U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biological Psychology 2004, 65:185-236.
46. Kwon J.S., Lyoo I.K., Hong K.S., Yeon B.K., Ha K.S. Development and standardization of the computerized memory assessment for Korean adults. Journal of Korean Neuropsychiatric Association 2002, 41:347-358.
47. Lezak M.D. Neuropsychological Assessment 1995, Oxford University Press, New York. 3rd ed.
48. Lee M.J., Shin Y.B., Sunwoo Y.K., Jung S.H., Kim W.H., Kang M.H., Lee J.S., Bae J.N., Kim C.E. Comparative analysis of cognitive function in schizophrenia with and without obsessive-compulsive disorder. Psychiatry Investigation 2009, 6:286-293.
49. Lim M., Park D.Y., Kwon J.S., Joo Y.H., Hong K.S. Prevalence and clinical characteristics of obsessive-compulsive symptoms associated with atypical antipsychotics. Journal of Clinical Psychopharmacology 2007, 27:712-713.
50. Lykouras l., Alevizos B., Michalopoulou P., Rabavilas A. Obsessive-compulsive symptoms induced by atypical antipsychotics. A review of reported cases. Progress in Neuropharmacology and Biological Psychiatry 2003, 27:333-346.
51. Lysaker P.H., Whitney K.A., Davis L.W. Associations of executive function with concurrent and prospective reports of obsessive--compulsive symptoms in schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience 2009, 21:38-42.
52. Ma N., Tan L.W., Wang Q., Li Z.X., Li L.J. Lower levels of whole blood serotonin in obsessive-compulsive disorder and in schizophrenia with obsessive-compulsive symptoms. Psychiatry Research 2007, 150:61-69.
53. Mann J.J., McBride P.A., Anderson G.M., Mieczkowski T.A. Platelet and whole blood serotonin content in depressed inpatients correlations with acute and life-time psychopathology. Biological Psychiatry 1992, 32:243-257.
54. McGorry P.D. The recognition and optimal management of early psychosis: an evidence-based reform. World Psychiatry 2002, 1:76-83.
55. Meijer J.H., Swets M., Keeman S., Nieman D.H., Meijer C.J., GROUP investigators Is a schizo-obsessive subtype associated with cognitive impairment? Results from a large cross-sectional study in patients with psychosis and their unaffected relatives. Journal of Nervous and Mental Disease 2013, 201:30-35.
56. Naber D., Mortiz S., Lambert M., Pajonk F.G., Holzbach R., Mass R., Andressen B. Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs. Schizophrenia Research 2001, 50:79-88.
57. Niendam T.A., Berzak J., Cannon T.D., Bearden C.E. Obsessive-compulsive symptoms in the psychosis prodrome: correlates of clinical and functional outcome. Schizophrenia Research 2009, 108:170-175.
58. Ongur D., Goff D.C. Obsessive-compulsive symptoms in schizophrenia: associated clinical features, cognitive function and medication status. Schizophrenia Research 2005, 75:349-362.
59. Owashi T., Ota A., Otsubo T., Susa Y., Kamijima K. Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia: a possible schizophrenic subtype. Psychiatry Research 2010, 179:241-246.
60. Patel D.D., Laws K.R., Padhi A., Farrow J.M., Mukhopadhaya K., Krishnaiah R., Fineberg N.A. The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis. Psychological Medicine 2010, 40:921-933.
61. Purcell R., Maruff P., Kyrios M., Pantelis C. Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biological Psychiatry 1998, 43:348-357.
62. Poyurovsky M., Fuchs C., Weizman A. Obsessive-compulsive disorder in patients with first-episode schizophrenia. American Journal of Psychiatry 1999, 156:1998-2000.
63. Poyurovsky M., Koran L.M. Obsessive-compulsive disorder (OCD) with schizotypy vs. schizophrenia with OCD: diagnostic dilemmas and therapeutic implications. Journal of Psychiatry Research 2005, 39:399-408.
64. Rajkumar R.P., Reddy Y.C., Kandavei T. Clinical profile of "schizo-obsessive" disorder: a comparative study. Comprehensive Psychiatry 2008, 49:262-268.
65. Rey A. L'examen Clinique en Psychologie 1964, Presses Universitaires de France, Paris.
66. Rosen I. The clinical significance of obsessions in schizophrenia. The Journal of Mental Science 1957, 103:773-785.
67. Scheltema Beduin A.A., Swets M., Machielsen M., Korver N., Genetic Risk and Outcome of Psychosis Investigators Obsessive-compulsive symptoms in patients with schizophrenia: a naturalistic cross-sectional study comparing treatment with clozapine, olanzapine, risperidone, and no antipsychotics in 543 patients. Journal of Clinical Psychiatry 2012, 73:1395-1402.
68. Schirmbeck F., Esslinger C., Rausch F., Englisch S., Meyer-Lindenberg A., Zink M. Antiserotonergic antipsychotics are associated with obsessive-compulsive symptoms in schizophrenia. Psychological Medicine 2011, 41:2361-2373.
69. Schirmbeck F., Zink M. Clozapine-induced obsessive-compulsive symptoms in schizophrenia: a critical review. Current Neuropharmacology 2012, 10:88-95.
70. Schirmbeck F., Rausch F., Englisch S., Eifler S., Esslinger C., Meyer-Lindenberg A., Zink M. Stable cognitive deficits in schizophrenia patients with comorbid obsessive-compulsive symptoms: a 12-month longitudinal study. Schizophrenia Bulletin 2013, 39:1261-1271.
71. Schirmbeck F., Rausch F., Englisch S., Eifler S., Esslinger C., Meyer-Lindenberg A., Zink M. Differential effects of antipsychotic agents on obsessive-compulsive symptoms in schizophrenia: a longitudinal study. Journal of Psychopharmacology 2013, 27:349-357.
72. Sevincok L., Akoglu A., Kokcu F. Suicidality in schizophrenic patients with and without obsessive-compulsive disorder. Schizophrenia Research 2007, 90:198-202.
73. Stangel E. A study of some clinical aspects of the relationship between obsessional neurosis and psychotic reaction types. The Journal of Mental Science 1945, 91:166-187.
74. Sterk B., Lankreijer K., Linszen D.H., de Haan L. Obsessive-compulsive symptoms in first episode psychosis and in subjects at ultra high risk for developing psychosis; onset ad relationship to psychotic symptoms. Australian and New Zealand Journal of Psychiatry 2011, 45:400-406.
75. Swets M., Dekker J., van Emmerik-van Oortmerssen K., Smid G.E., Smit F., de Haan L., Schoevers R.A. The obsessive-compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates. Schizophrenia Research 2014, 152:458-468.
76. Tibbo P., Kroestch M., Chue P., Warneke L. Obsessive-compulsive disorder in schizophrenia. Journal of Psychiatry Research 2000, 34:139-146.
77. Tiryaki A., Ozkorumak E. Do the obsessive-compulsive symptoms have an effect in schizophrenia?. Comprehensive Psychiatry 2010, 51:357-362.
78. Tumkaya S., Karadag F., Oguzhanoglu N.K., Tekkanat C., Varma G., Ozdel O., Atesci F. Schizophrenia with obsessive-compulsive disorder and obsessive-compulsive disorder with poor insight: a neuropsychological comparison. Psychiatry Research 2009, 165:38-46.
79. Üçok A., Tükel R., Ozgen G., Saylan M., Uzuner G. Frequency of obsessive-compulsive symptoms and disorder in patients with schizophrenia: importance for prognosis. L'Encéphale 2006, 32:41-44.
80. Üçok A., Ceylan M.E., Tihan A.K., Lapçin S., Ger C., Tükel R. Obsessive-compulsive disorder and symptoms may have different effects on schizophrenia. Progress in Neuropsychopharmacology and Biological Psychiatry 2011, 35:429-433.
81. Wetherell J.L., Palmer B.W., Thorp S.R., Patterson T.L., Golshan S., Jeste D.V. Anxiety symptoms and quality of life in middle-aged and older outpatients with schizophrenia and schizoaffective disorder. Journal of Clinical Psychiatry 2003, 64:1476-1482.
82. Whitney K.A., Fastenau P.S., Evans J.D., Lysaker P.H. Comparative neuropsychological function in obsessive-compulsive disorder and schizophrenia with and without obsessive-compulsive symptoms. Schizophrenia Research 2004, 69:75-83.
83. Yi J.S., Ahn Y.M., Shin H.K., An S.K., Joo Y.H., Kim S.H., Yoon D.J., Jho K.H., Koo Y.J., Lee J.Y., Cho I.H., Park Y.H., Kim K.S., Kim Y.S. Reliability and validity of the Korean version of the Positive and Negative Syndrome Scale. Journal of Korean Neuropsychiatric Association 2001, 40:1090-1105.