Treatment of multidrug-resistant Pseudomonas aeruginosa using extended-infusion antimicrobial regimens

Pharmacotherapy

Volumn 35, Issue 1, 2015, Pages 54-58

  Heil, Emily L ^a   Lowery, Ashleigh V ^a   Thom, Kerri A ^b   Nicolau, David P ^c  

^a UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c HARTFORD HOSPITAL   (United States)

Author keywords

Cefepime; Multidrug resistant; Pseudomonas

Indexed keywords

AMIKACIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; CEFEPIME; CIPROFLOXACIN; COLISTIMETHATE; COLISTIN; GENTAMICIN; IMIPENEM; MEROPENEM; PENICILLIN DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; ANTIINFECTIVE AGENT; CEPHALOSPORIN DERIVATIVE; COLISTINMETHANESULFONIC ACID;

ACUTE KIDNEY FAILURE; ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BLOOD CULTURE; CASE REPORT; CLINICAL DECISION MAKING; CONTINUOUS INFUSION; CRITICALLY ILL PATIENT; DEVICE INFECTION; DISEASE SEVERITY; DISK DIFFUSION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG INFUSION; DRUG INTERMITTENT THERAPY; DRUG METABOLISM; DRUG MONITORING; EXTENDED INFUSION; FEMALE; GRAM NEGATIVE SEPSIS; HEMODIALYSIS; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PSEUDOMONAS PNEUMONIA; RIGHT VENTRICULAR ASSIST DEVICE; VENTILATOR ASSOCIATED PNEUMONIA; ANALOGS AND DERIVATIVES; BLOOD; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; HEART ASSIST DEVICE; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PSEUDOMONAS INFECTIONS; RENAL REPLACEMENT THERAPY; TIME; TREATMENT OUTCOME;

ADULT; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; COLISTIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG THERAPY, COMBINATION; FEMALE; HEART-ASSIST DEVICES; HUMANS; INFUSIONS, INTRAVENOUS; METABOLIC CLEARANCE RATE; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RENAL DIALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84926190038     PISSN: 02770008     EISSN: 18759114     Source Type: Journal    
DOI: 10.1002/phar.1514     Document Type: Article

References (23)

1. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998;26:1-12.
2. Burgess DS, Hastings RW, Hardin TC. Pharmacokinetics and pharmacodynamics of cefepime administered by intermittent and continuous infusion. Clin Ther 2000;22:66-75.
3. Drusano GL. Antimicrobial pharmacodynamics: critical interactions of "bug and drug." Nat Rev Microbiol 2004;2:289-300.
4. Mouton JW, den Hollander JG. Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model. Antimicrob Agents Chemother 1994;38:931-6.
5. Crandon J, Bulik C, Kuti J, Nicolau DP. Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. Antimicrob Agents Chemother 2010;54:1111-6.
6. Sinnollareddy MG, Roberts MS, Lipman J, Roberts JA. Betalactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review. Clin Exp Pharmacol Physiol 2012;39:489-96.
7. Tam V, McKinnon P, Akins R, Rybak M, Drusano G. Pharmacodynamics of cefepime with gram-negative infections. J Antimicrob Chemother 2002;50:425-8.
8. Roberts J, Paul S, Akova M, et al. DALI: Defining Antibiotic Levels in Intensive care unit patients: are current beta-lactam antibiotic doses sufficient for critically ill? Clin Infect Dis 2014;58:1072-83.
9. Roberts J, Adbul-Aziz M, Lipman J, et al. Individualized antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis 2014;14:498-509.
10. Nicasio AM, Ariano RE, Zelenitsky SA, et al. Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. Antimicrob Agents Chemother 2009;53:1476-81.
11. Bauer K, West J, O'Brien J, Goff D. Extended-infusion cefepime reduces mortality in patients with Pseudomonas aeruginosa infections. Antimicrob Agents Chemother 2013;57:2907-12.
12. Hospira, Inc. Cefepime [package insert]. Lake Forest, IL; 2012.
13. Barbhaiya RH, Knupp CA, Forgue ST, Matzke GR, Guay DR, Pittman KA. Pharmacokinetics of cefepime in subjects with renal insufficiency. Clin Pharmacol Ther 1990;48:268-76.
14. Cronquist J, Nilsson-Ehle I, Oquist B, Norrby SR. Pharmacokinetics of cefepime dihydrochloride arginine in subjects with renal impairment. Antimicrob Agents Chemother 1992;36:2676-80.
15. Schmaldienst S, Tranunmuller F, Burgmann H, et al. Multiple dose pharmacokinetics of cefepime in long-term hemodialysis with high-flux membranes. Eur J Clin Pharmacol 2000;5:61-4.
16. Heintz BH, Matzke GR, Dager WE. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy 2009;29:562-77.
17. Boyd N, Nailor M. Combination antibiotic therapy for empiric and definitive treatment of gram-negative infections. Pharmacotherapy 2011;31:1073-84.
18. Pena C, Suarez C, Ocampo-Sosa A, et al. Effect of adequate single-drug vs combination antimicrobial therapy on mortality in Psuedomonas aeruginosa bloodstream infections: a post hoc analysis of a prospective cohort. Clin Infect Dis 2013;57:208-16.
19. Chin JN, Rybak MJ, Cha R, Rhomberg PR, Jones RN. Evaluation of colistin alone or in combination with antimicrobial agents against clinical isolates of carbapenem-resistant P. aeruginosa. Programs and abstracts of the 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 2006 Sept 27-30; San Francisco, CA.
20. Conway SP, Pond MN, Watson A, Etherington C, Robey HL, Goldman MH. Intravenous colistin sulphomethate in acute respiratory exacerbations in adult patients with cystic fibrosis. Thorax 1997;52:987-93.
21. Mouton JW. Combination therapy as a tool to prevent emergence of bacterial resistance. Infection 1999;27:S24-8.
22. Schentag J, Strenkoski-Nix LC, Nix DE, Forrest A. Pharmacodynamic interactions of antibiotics alone and in combination. Clin Infect Dis 1998;27:40-6.
23. Lamoth F, Buclin T, Pascual A, et al. High cefepime concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. Antimicrob Agents Chemother 2010;54:4360-7.