Hyperglycemia: An independent risk factor for poor outcome in children with traumatic brain injury

Pediatric Critical Care Medicine

Volumn 15, Issue 7, 2014, Pages 623-631

  Elkon, Benjamin ^a   Cambrin, Jay Riva ^a   Hirshberg, Eliotte ^a   Bratton, Susan L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Hyperglycemia; Outcome; Traumatic brain injury

Indexed keywords

ARTICLE; CHILD; DYING; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; TRAUMATIC BRAIN INJURY; BLOOD; BRAIN INJURIES; GLASGOW OUTCOME SCALE; INFANT; INTENSIVE CARE; LENGTH OF STAY; METABOLISM; MORTALITY; PRESCHOOL CHILD; PROGNOSIS; RETROSPECTIVE STUDY; TIME;

GLUCOSE BLOOD LEVEL;

BLOOD GLUCOSE; BRAIN INJURIES; CHILD; CHILD, PRESCHOOL; FEMALE; GLASGOW OUTCOME SCALE; HOSPITAL MORTALITY; HUMANS; HYPERGLYCEMIA; INFANT; INTENSIVE CARE; LENGTH OF STAY; MALE; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS;

EID: 84926076457     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000000170     Document Type: Article

References (37)

1. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002-2006. CDC MMWR Surveillance Summaries. Available at: http://www.cdc.gov/TraumaticBrainInjury/. Accessed May 6, 2014
2. Coronado VG, Xu L, Basavaraju S.V., et al; Centers for Disease Control and Prevention (CDC): Surveillance for traumatic brain injury-related deaths-United States, 1997-2007. MMWR Surveill Summ 2011; 60:1-32
3. Rutland-Brown W., Langlois JA, Thomas K.E., et al: Incidence of traumatic brain injury in the United States, 2003. J Head Trauma Rehabil 2006; 21:544-548
4. Seyed Saadat S.M., Bidabadi E, Seyed Saadat SN, et al: Association of persistent hyperglycemia with outcome of severe traumatic brain injury in pediatric population. Childs Nerv Syst 2012; 28:1773-1777
5. Legrand M, Dupuis C, Simon C., et al: Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: A retrospective observational study. Crit Care 2013; 17:R278
6. Mehari A, Alam S, Tian X., et al: Hemodynamic predictors of mortality in adults with sickle cell disease. Am J Respir Crit Care Med 2013; 187:840-847
7. Christensen DW, Jansen P, Perkin RM: Outcome and acute care hospital costs after warm water near drowning in children. Pediatrics 1997; 99:715-721
8. Graf WD, Cummings P, Quan L., et al: Predicting outcome in pediatric submersion victims. Ann Emerg Med 1995; 26:312-319
9. Cochran A, Scaife ER, Hansen K.W., et al: Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma 2003; 55:1035-1038
10. Wintergerst KA, Buckingham B, Gandrud L., et al: Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 2006; 118:173-179
11. Srinivasan V, Spinella PC, Drott H.R., et al: Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004; 5:329-336
12. Faustino EV, Apkon M: Persistent hyperglycemia in critically ill children. J Pediatr 2005; 146:30-34
13. Rovlias A, Kotsou S: The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 2000; 46:335-342
14. Vlasselaers D, Milants I, Desmet L., et al: Intensive insulin therapy for patients in paediatric intensive care: A prospective, randomised controlled study. Lancet 2009; 373:547-556
15. Agus MS, Steil GM, Wypij D, et al; SPECS Study Investigators: Tight glycemic control versus standard care after pediatric cardiac surgery. N Engl J Med 2012; 367:1208-1219
16. Macrae D, Grieve R, Allen E., et al; CHiP Investigators: A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med 2014; 370:107-118
17. Vespa P, Boonyaputthikul R, McArthur D.L., et al: Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 2006; 34:850-856
18. Oddo M, Schmidt JM, Carrera E, et al: Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: A micro-dialysis study. Crit Care Med 2008; 36:3233-3238
19. Vespa P, McArthur DL, Stein N, et al: Tight glycemic control increases metabolic distress in traumatic brain injury: A randomized controlled within-subjects trial. Crit Care Med 2012; 40:1923-1929
20. Holbein M, Béchir M, Ludwig S., et al: Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury. Crit Care 2009; 13:R13
21. Zebrack M, Dandoy C, Hansen K., et al: Early resuscitation of children with moderate-to-severe traumatic brain injury. Pediatrics 2009; 124:56-64
22. Liesemer K, Bratton SL, Zebrack C.M., et al: Early post-traumatic seizures in moderate to severe pediatric traumatic brain injury: Rates, risk factors, and clinical features. J Neurotrauma 2011; 28:755-762
23. Bailey BM, Liesemer K, Statler K.D., et al: Monitoring and prediction of intracranial hypertension in pediatric traumatic brain injury: Clinical factors and initial head computed tomography. J Trauma Acute Care Surg 2012; 72:263-270
24. Yuh EL, Cooper SR, Ferguson A.R., et al: Quantitative CT improves outcome prediction in acute traumatic brain injury. J Neurotrauma 2012; 29:735-746
25. Smith RL, Lin JC, Adelson P.D., et al: Relationship between hyperglycemia and outcome in children with severe traumatic brain injury. Pediatr Crit Care Med 2012; 13:85-91
26. Melo JR, Di Rocco F, Blanot S, et al: Acute hyperglycemia is a reliable outcome predictor in children with severe traumatic brain injury. Acta Neurochir (Wien) 2010; 152:1559-1565
27. Nadkarni VM, Nolan JP, Billi J.E., et al: Part 2: International collaboration in resuscitation science: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science Wth Treatment Recommendations. Circulation 2010; 122:S276-S282
28. Sharma D, Jelacic J, Chennuri R., et al: Incidence and risk factors for perioperative hyperglycemia in children with traumatic brain injury. Anesth Analg 2009; 108:81-89
29. Michaud LJ, Rivara FP, Longstreth WT Jr, et al: Elevated initial blood glucose levels and poor outcome following severe brain injuries in children. J Trauma 1991; 31:1356-1362
30. Adelson PD, Ragheb J, Kanev P., et al: Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery 2005; 56:740-754
31. Adelson PD, Wisniewski SR, Beca J, et al; Paediatric Traumatic Brain Injury Consortium: Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): A phase 3, randomised controlled trial. Lancet Neurol 2013; 12:546-553
32. Hutchison JS, Ward RE, Lacroix J, et al; Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group: Hypothermia therapy after traumatic brain injury in children. N Engl J Med 2008; 358:2447-2456
33. Shankaran S, Laptook AR, Ehrenkranz R.A., et al; National Institute of Child Health and Human Development Neonatal Research Network: Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353:1574-1584
34. The Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556
35. Jacobi J, Bircher N, Krinsley J., et al: Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med 2012; 40:3251-3276
36. Hirshberg E, Lacroix J, Sward K., et al: Blood glucose control in critically ill adults and children: A survey on stated practice. Chest 2008; 133:1328-1335
37. Di Gennaro J.L., Mack CD, Malakouti A, et al: Use and effect of vasopressors after pediatric traumatic brain injury. Dev Neurosci 2010; 32:420-430