Relationship between hyperglycemia and outcome in children with severe traumatic brain injury

Pediatric Critical Care Medicine

Volumn 13, Issue 1, 2012, Pages 85-91

  Smith, Rebecca L ^a,c   Lin, John C ^d   Adelson, P David ^e   Kochanek, Patrick M ^a,c   Fink, Ericka L ^a,c   Wisniewski, Stephen R ^b   Bayir, Hülya ^a,c   Tyler Kabara, Elizabeth C ^a   Clark, Robert S B ^a,c   Brown, S Danielle ^e   Bell, Michael J ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d NONE   (United States)

^e PHOENIX CHILDREN'S HOSPITAL   (United States)

Author keywords

hyperglycemia; outcome; traumatic brain injury

Indexed keywords

GLUCOSE; INSULIN;

AGE; ARTICLE; CHILD; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GLASGOW COMA SCALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

BLOOD GLUCOSE; BRAIN INJURIES; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; FEMALE; GLASGOW COMA SCALE; HOSPITALS, PEDIATRIC; HUMANS; HYPERGLYCEMIA; INJURY SEVERITY SCORE; INTENSIVE CARE UNITS, PEDIATRIC; LENGTH OF STAY; MONITORING, PHYSIOLOGIC; PROGNOSIS; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 80053547193     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3182192c30     Document Type: Article

References (35)

1. Yates AR, Dyke PC 2nd, Taeed R, et al: Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient. Pediatr Crit Care Med 2006; 7:351-355 (Pubitemid 44048279)
2. Hirshberg E, Larsen G, Van Duker H: Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatr Crit Care Med 2008; 9:361-366
3. Yung M, Wilkins B, Norton L, et al: Glucose control, organ failure, and mortality in pediatric intensive care. Pediatr Crit Care Med 2008; 9:147-152 (Pubitemid 351355025)
4. Ulate KP, Lima Falcao GC, Bielefeld MR, et al: Strict glycemic targets need not be so strict: A more permissive glycemic range for critically ill children. Pediatrics 2008; 122: e898-e904
5. Preissig CM, Rigby MR, Maher KO: Glycemic control for postoperative pediatric cardiac patients. Pediatr Cardiol 2009; 30: 1098-1104
6. Klein GW, Hojsak JM, Schmeidler J, et al: Hyperglycemia and outcome in the pediatric intensive care unit. J Pediatr 2008; 153: 379-384
7. Chiaretti A, Piastra M, Pulitanò S, et al: Prognostic factors and outcome of children with severe head injury: An 8-year experience. Childs Nerv Syst 2002; 18:129-136 (Pubitemid 36024319)
8. Michaud LJ, Rivara FP, Longstreth WT Jr, et al: Elevated initial blood glucose levels and poor outcome following severe brain injuries in children. J Trauma 1991; 31:1356-1362
9. Paret G, Tirosh R, Lotan D, et al: Early prediction of neurological outcome after falls in children: Metabolic and clinical markers. J Accid Emerg Med 1999; 16:186-188 (Pubitemid 29195609)
10. Cochran A, Scaife ER, Hansen KW, et al: Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma 2003; 55: 1035-1038 (Pubitemid 38044117)
11. Sharma D, Jelacic J, Chennuri R, et al: Incidence and risk factors for perioperative hyperglycemia in children with traumatic brain injury. Anesth Analg 2009; 108:81-89
12. Marton E, Mazzucco M, Nascimben E, et al: Severe head injury in early infancy: Analysis of causes and possible predictive factors for outcome. Childs Nerv Syst 2007; 23:873-880 (Pubitemid 47029081)
13. Ramos M, Khalpey Z, Lipsitz S, et al: Relationship of perioperative hyperglycemia and postoperative infections in patients who undergo general and vascular surgery. Ann Surg 2008; 248:585-591
14. Ambiru S, Kato A, Kimura F, et al: Poor postoperative blood glucose control increases surgical site infections after surgery for hepato-biliary-pancreatic cancer: A prospective study in a high-volume institute in Japan. J Hosp Infect 2008; 68:230-233
15. Vriesendorp TM, Morélis QJ, Devries JH, et al: Early post-operative glucose levels are an independent risk factor for infection after peripheral vascular surgery. A retrospective study. Eur J Vasc Endovasc Surg 2004; 28: 520-525
16. Hansen TK, Thiel S, Wouters PJ, et al: Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannosebinding lectin levels. J Clin Endocrinol Metab 2003; 88:1082-1088 (Pubitemid 36337759)
17. Langouche L, Vanhorebeek I, Vlasselaers D, et al: Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005; 115:2277-2286 (Pubitemid 41134169)
18. Vanhorebeek I, De Vos R, Mesotten D, et al: Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 2005; 365:53-59 (Pubitemid 40082146)
19. Lundgren J, Smith ML, Siesjö BK: Influence of moderate hypothermia on ischemic brain damage incurred under hyperglycemic conditions. Exp Brain Res 1991; 84:91-101
20. Davis LM, Pauly JR, Readnower RD, et al: Fasting is neuroprotective following traumatic brain injury. J Neurosci Res 2008; 86: 1812-1822 (Pubitemid 351859431)
21. Verweij BH, Muizelaar JP, Vinas FC, et al: Impaired cerebral mitochondrial function after traumatic brain injury in humans. J Neurosurg 2000; 93:815-820 (Pubitemid 32803405)
22. Bergsneider M, Hovda DA, Shalmon E, et al: Cerebral hyperglycolysis following severe traumatic brain injury in humans: A positron emission tomography study. J Neurosurg 1997; 86:241-251 (Pubitemid 27130684)
23. Hovda DA, Lee SM, Smith ML, et al: The neurochemical and metabolic cascade following brain injury: Moving from animal models to man. J Neurotrauma 1995; 12:903-906
24. Ashwal S, Holshouser BA, Shu SK, et al: Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury. Pediatr Neurol 2000; 23:114-125
25. Young B, Ott L, Dempsey R, et al: Relationship between admission hyperglycemia and neurologic outcome of severely brain-injured patients. Ann Surg 1989; 210:466-472; discussion 472-473
26. Yang SY, Zhang S, Wang ML: Clinical significance of admission hyperglycemia and factors related to it in patients with acute severe head injury. Surg Neurol 1995; 44:373-377 (Pubitemid 26036885)
27. Rovlias A, Kotsou S: The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 2000; 46:335-342; discussion 342-343
28. Jeremitsky E, Omert LA, Dunham CM, et al: The impact of hyperglycemia on patients with severe brain injury. J Trauma 2005; 58:47-50 (Pubitemid 40221732)
29. Van den Berghe G, Schoonheydt K, Becx P, et al: Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005; 64:1348-1353 (Pubitemid 40570499)
30. Vespa P, Boonyaputthikul R, McArthur DL, et al: Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 2006; 34:850-856
31. Parish RA, Webb KS: Hyperglycemia is not a poor prognostic sign in head-injured children. J Trauma 1988; 28:517-519
32. Adelson PD, Ragheb J, Kanev P, et al: Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery 2005; 56:740-754
33. Lam AM, Winn HR, Cullen BF, et al: Hyperglycemia and neurological outcome in patients with head injury. J Neurosurg 1991; 75:545-551
34. Walia S, Sutcliffe AJ: The relationship between blood glucose, mean arterial pressure and outcome after severe head injury: An observational study. Injury 2002; 33: 339-344 (Pubitemid 34667276)
35. Salim A, Hadjizacharia P, Dubose J, et al: Persistent hyperglycemia in severe traumatic brain injury: An independent predictor of outcome. Am Surg 2009; 75:25-29