Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice

NeuroToxicology

Volumn 48, Issue , 2015, Pages 100-108

  Shakarjian, Michael P ^a,b   Ali, Mahil S ^a   Velíšková, Jana ^a   Stanton, Patric K ^a   Heck, Diane E ^a   Velíšek, Libor ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

GABA; Isobologram; NMDA; Seizures; Tetramethylenedisulfotetramine

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RODENTICIDE; TETRAMETHYLENEDISULFOTETRAMINE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; BRIDGED COMPOUND; DIZOCILPINE MALEATE; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG DOSE SEQUENCE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ELECTROENCEPHALOGRAPHY; LETHALITY; MALE; MONOTHERAPY; MOUSE; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TONIC CLONIC SEIZURE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; CHEMICALLY INDUCED; COMBINATION DRUG THERAPY; DISEASE COURSE; DRUG EFFECTS; ELECTROENCEPHALOGRAM; EPILEPSY, TONIC-CLONIC; METABOLISM; PATHOPHYSIOLOGY; STATUS EPILEPTICUS; TIME FACTOR; VIDEORECORDING;

MUS;

ANIMALS; ANTICONVULSANTS; BRAIN WAVES; BRIDGED-RING COMPOUNDS; CENTRAL NERVOUS SYSTEM; DIAZEPAM; DISEASE PROGRESSION; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; EPILEPSY, TONIC-CLONIC; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; MICE, INBRED C57BL; RECEPTORS, N-METHYL-D-ASPARTATE; STATUS EPILEPTICUS; TIME FACTORS; VIDEO RECORDING;

EID: 84926015964     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2015.03.007     Document Type: Article

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