Advanced imaging tools rather than hemodynamics should be the primary approach for diagnosing, following, and managing pulmonary arterial hypertension

Canadian Journal of Cardiology

Volumn 31, Issue 4, 2015, Pages 521-528

  Gerges, Mario ^a   Gerges, Christian ^a   Lang, Irene M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARDIAC IMAGING; CLINICAL ASSESSMENT; FOLLOW UP; HEART CATHETERIZATION; HEART HEMODYNAMICS; HEART OUTPUT; HEART OUTPUT MEASUREMENT; HUMAN; NON INVASIVE PROCEDURE; PULMONARY HYPERTENSION; SENSITIVITY AND SPECIFICITY; CARDIOVASCULAR SYSTEM EXAMINATION; DIAGNOSTIC IMAGING; DISEASE MANAGEMENT; HEMODYNAMICS; HYPERTENSION, PULMONARY; PATHOPHYSIOLOGY; PHYSIOLOGIC MONITORING; PHYSIOLOGY; PROCEDURES;

DIAGNOSTIC IMAGING; DIAGNOSTIC TECHNIQUES, CARDIOVASCULAR; DISEASE MANAGEMENT; HEMODYNAMICS; HUMANS; HYPERTENSION, PULMONARY; MONITORING, PHYSIOLOGIC;

EID: 84925983028     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2015.01.019     Document Type: Article

References (82)

1. Galie N., Hoeper M.M., Humbert M., et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2009, 34:1219-1263.
2. McLaughlin V.V., Archer S.L., Badesch D.B., et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association. Circulation 2009, 119:2250-2294.
3. Hoeper M.M., Bogaard H.J., Condliffe R., et al. Definitions and diagnosis of pulmonary hypertension. JAm Coll Cardiol 2013, 62:D42-D50.
4. Hoeper M.M., Lee S.H., Voswinckel R., et al. Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. JAm Coll Cardiol 2006, 48:2546-2552.
5. Bonderman D., Pretsch I., Steringer-Mascherbauer R., et al. Acute hemodynamic effects of riociguat in patients with pulmonary hypertension associated with diastolic heart failure (DILATE-1): a randomized, double-blind, placebo-controlled, single-dose study. Chest 2014, 146:1274-1285.
6. McGoon M., Gutterman D., Steen V., et al. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004, 126:14S-34S.
7. Nichols W.W., O'Rourke M.F. McDonald's Blood Flow in Arteries, 6th Edition: Theoretical, Experimental and Clinical Principles 2011, 129-164. CRC Press, Philadelphia.
8. Kovacs G., Avian A., Olschewski A., Olschewski H. Zero reference level for right heart catheterisation. Eur Respir J 2013, 42:1586-1594.
9. Hillis L.D., Firth B.G., Winniford M.D. Analysis of factors affecting the variability of fick versus indicator dilution measurements of cardiac output. Am J Cardiol 1985, 56:764-768.
10. Ganz W., Donoso R., Marcus H.S., Forrester J.S., Swan H.J. Anew technique for measurement of cardiac output by thermodilution in man. Am J Cardiol 1971, 27:392-396.
11. Hoeper M.M., Maier R., Tongers J., et al. Determination of cardiac output by the Fick method, thermodilution, and acetylene rebreathing in pulmonary hypertension. Am J Respir Crit Care Med 1999, 160:535-541.
12. Halpern S.D., Taichman D.B. Misclassification of pulmonary hypertension due to reliance on pulmonary capillary wedge pressure rather than left ventricular end-diastolic pressure. Chest 2009, 136:37-43.
13. Robbins I.M., Hemnes A.R., Pugh M.E., et al. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail 2014, 7:116-122.
14. Bitar A., Selej M., Bolad I., Lahm T. Poor agreement between pulmonary capillary wedge pressure and left ventricular end-diastolic pressure in a veteran population. PLoS One 2014, 9:e87304.
15. Fujimoto N., Borlaug B.A., Lewis G.D., et al. Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure. Circulation 2013, 127:55-62.
16. LeVarge B.L., Pomerantsev E., Channick R.N. Reliance on end-expiratory wedge pressure leads to misclassification of pulmonary hypertension. Eur Respir J 2014, 44:425-434.
17. Ryan J.J., Rich J.D., Thiruvoipati T., et al. Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension. Am Heart J 2012, 163:589-594.
18. Bonderman D., Wexberg P., Heinzl H., Lang I.M. Non-invasive algorithms for the diagnosis of pulmonary hypertension. Thromb Haemost 2012, 108:1037-1041.
19. Raymond R.J., Hinderliter A.L., Willis P.W., et al. Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension. JAm Coll Cardiol 2002, 39:1214-1219.
20. Ghio S., Klersy C., Magrini G., et al. Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension. Int J Cardiol 2010, 140:272-278.
21. Rudski L.G., Lai W.W., Afilalo J., et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. JAm Soc Echocardiogr 2010, 23:685-713. quiz 686-8.
22. Ghio S., Pazzano A.S., Klersy C., et al. Clinical and prognostic relevance of echocardiographic evaluation of right ventricular geometry in patients with idiopathic pulmonary arterial hypertension. Am J Cardiol 2011, 107:628-632.
23. Vonk-Noordegraaf A., Haddad F., Chin K.M., et al. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. JAm Coll Cardiol 2013, 62:D22-D33.
24. Denton C.P., Cailes J.B., Phillips G.D., et al. Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis. Br J Rheumatol 1997, 36:239-243.
25. Parent F., Bachir D., Inamo J., et al. Ahemodynamic study of pulmonary hypertension in sickle cell disease. NEngl J Med 2011, 365:44-53.
26. Rajaram S., Swift A.J., Capener D., et al. Comparison of the diagnostic utility of cardiac magnetic resonance imaging, computed tomography, and echocardiography in assessment of suspected pulmonary arterial hypertension in patients with connective tissue disease. JRheumatol 2012, 39:1265-1274.
27. Wang B., Feng Y., Jia L.Q., et al. Accuracy of Doppler echocardiography in the assessment of pulmonary arterial hypertension in patients with congenital heart disease. Eur Rev Med Pharmacol Sci 2013, 17:923-928.
28. Kuriyama K., Gamsu G., Stern R.G., et al. CT-determined pulmonary artery diameters in predicting pulmonary hypertension. Invest Radiol 1984, 19:16-22.
29. Perez-Enguix D., Morales P., Tomas J.M., Vera F., Lloret R.M. Computed tomographic screening of pulmonary arterial hypertension in candidates for lung transplantation. Transplant Proc 2007, 39:2405-2408.
30. Stevens G.R., Garcia-Alvarez A., Sahni S., Garcia M.J., Fuster V., Sanz J. RV dysfunction in pulmonary hypertension is independently related to pulmonary artery stiffness. JACC Cardiovasc Imaging 2012, 5:378-387.
31. Meris A., Faletra F., Conca C., et al. Timing and magnitude of regional right ventricular function: a speckle tracking-derived strain study of normal subjects and patients with right ventricular dysfunction. JAm Soc Echocardiogr 2010, 23:823-831.
32. Bhave N.M., Patel A.R., Weinert L., et al. Three-dimensional modeling of the right ventricle from two-dimensional transthoracic echocardiographic images: utility of knowledge-based reconstruction in pulmonary arterial hypertension. JAm Soc Echocardiogr 2013, 26:860-867.
33. Gopal A.S., Chukwu E.O., Iwuchukwu C.J., et al. Normal values of right ventricular size and function by real-time 3-dimensional echocardiography: comparison with cardiac magnetic resonance imaging. JAm Soc Echocardiogr 2007, 20:445-455.
34. Grapsa J., Gibbs J.S., Cabrita I.Z., et al. The association of clinical outcome with right atrial and ventricular remodelling in patients with pulmonary arterial hypertension: study with real-time three-dimensional echocardiography. Eur Heart J Cardiovasc Imaging 2012, 13:666-672.
35. Moledina S., de Bruyn A., Schievano S., et al. Fractal branching quantifies vascular changes and predicts survival in pulmonary hypertension: a proof of principle study. Heart 2011, 97:1245-1249.
36. Jaff M.R., McMurtry M.S., Archer S.L., et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation 2011, 123:1788-1830.
37. Mehta S., Helmersen D., Provencher S., et al. Diagnostic evaluation and management of chronic thromboembolic pulmonary hypertension: a clinical practice guideline. Can Respir J 2010, 17:301-334.
38. Wilkens H., Lang I., Behr J., et al. Chronic thromboembolic pulmonary hypertension (CTEPH): updated Recommendations of the Cologne Consensus Conference 2011. Int J Cardiol 2011, 154(suppl 1):S54-S60.
39. Kim N.H., Delcroix M., Jenkins D.P., et al. Chronic thromboembolic pulmonary hypertension. JAm Coll Cardiol 2013, 62:D92-D99.
40. Lang I.M., Madani M. Update on chronic thromboembolic pulmonary hypertension. Circulation 2014, 130:508-518.
41. Lang I.M., Plank C., Sadushi-Kolici R., et al. Imaging in pulmonary hypertension. JACC Cardiovasc Imaging 2010, 3:1287-1295.
42. Sherrick A.D., Swensen S.J., Hartman T.E. Mosaic pattern of lung attenuation on CT scans: frequency among patients with pulmonary artery hypertension of different causes. AJR Am J Roentgenol 1997, 169:79-82.
43. Ley S., Ley-Zaporozhan J., Pitton M.B., et al. Diagnostic performance of state-of-the-art imaging techniques for morphological assessment of vascular abnormalities in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Eur Radiol 2012, 22:607-616.
44. Hoey E.T., Mirsadraee S., Pepke-Zaba J., et al. Dual-energy CT angiography for assessment of regional pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: initial experience. AJR Am J Roentgenol 2011, 196:524-532.
45. Pienn M., Kovacs G., Tscherner M., et al. Non-invasive determination of pulmonary hypertension with dynamic contrast-enhanced computed tomography: a pilot study. Eur Radiol 2014, 24:668-676.
46. Isobe M., Yazaki Y., Takaku F., et al. Prediction of pulmonary arterial pressure in adults by pulsed Doppler echocardiography. Am J Cardiol 1986, 57:316-321.
47. Tei C., Dujardin K.S., Hodge D.O., et al. Doppler echocardiographic index for assessment of global right ventricular function. JAm Soc Echocardiogr 1996, 9:838-847.
48. Saba T.S., Foster J., Cockburn M., Cowan M., Peacock A.J. Ventricular mass index using magnetic resonance imaging accurately estimates pulmonary artery pressure. Eur Respir J 2002, 20:1519-1524.
49. Hsu V.M., Moreyra A.E., Wilson A.C., et al. Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: comparison of noninvasive tests with results of right-heart catheterization. JRheumatol 2008, 35:458-465.
50. Dahiya A., Vollbon W., Jellis C., et al. Echocardiographic assessment of raised pulmonary vascular resistance: application to diagnosis and follow-up of pulmonary hypertension. Heart 2010, 96:2005-2009.
51. D'Alto M., Romeo E., Argiento P., et al. Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension. Int J Cardiol 2013, 168:4058-4062.
52. Gladue H., Steen V., Allanore Y., et al. Combination of echocardiographic and pulmonary function test measures improves sensitivity for diagnosis of systemic sclerosis-associated pulmonary arterial hypertension: analysis of 2 cohorts. JRheumatol 2013, 40:1706-1711.
53. Tan R.T., Kuzo R., Goodman L.R., et al. Utility of CT scan evaluation for predicting pulmonary hypertension in patients with parenchymal lung disease. Medical College of Wisconsin Lung Transplant Group. Chest 1998, 113:1250-1256.
54. Chan A.L., Juarez M.M., Shelton D.K., et al. Novel computed tomographic chest metrics to detect pulmonary hypertension. BMC Med Imaging 2011, 11:7.
55. Corson N., Armato S.G., Labby Z.E., et al. CT-based pulmonary artery measurements for the assessment of pulmonary hypertension. Acad Radiol 2014, 21:523-530.
56. Helmberger M., Pienn M., Urschler M., et al. Quantification of tortuosity and fractal dimension of the lung vessels in pulmonary hypertension patients. PLoS One 2014, 9:e87515.
57. Bouchard A., Higgins C.B., Byrd B.F., et al. Magnetic resonance imaging in pulmonary arterial hypertension. Am J Cardiol 1985, 56:938-942.
58. Sanz J., Kuschnir P., Rius T., et al. Pulmonary arterial hypertension: noninvasive detection with phase-contrast MR imaging. Radiology 2007, 243:70-79.
59. Nogami M., Ohno Y., Koyama H., et al. Utility of phase contrast MR imaging for assessment of pulmonary flow and pressure estimation in patients with pulmonary hypertension: comparison with right heart catheterization and echocardiography. JMagn Reson Imaging 2009, 30:973-980.
60. Shehata M.L., Harouni A.A., Skrok J., et al. Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study. Radiology 2013, 266:114-122.
61. Swift A.J., Rajaram S., Hurdman J., et al. Noninvasive estimation of PA pressure, flow, and resistance with CMR imaging: derivation and prospective validation study from the ASPIRE registry. JACC Cardiovasc Imaging 2013, 6:1036-1047.
62. Tunariu N., Gibbs S.J., Win Z., et al. Ventilation-perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease as a treatable cause of pulmonary hypertension. JNucl Med 2007, 48:680-684.
63. Skoro-Sajer N., Becherer A., Klepetko W., et al. Longitudinal analysis of perfusion lung scintigrams of patients with unoperated chronic thromboembolic pulmonary hypertension. Thromb Haemost 2004, 92:201-207.
64. Chow L.C., Dittrich H.C., Hoit B.D., Moser K.M., Nicod P.H. Doppler assessment of changes in right-sided cardiac hemodynamics after pulmonary thromboendarterectomy. Am J Cardiol 1988, 61:1092-1097.
65. Eysmann S.B., Palevsky H.I., Reichek N., Hackney K., Douglas P.S. Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension. Circulation 1989, 80:353-360.
66. Yeo T.C., Dujardin K.S., Tei C., et al. Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. Am J Cardiol 1998, 81:1157-1161.
67. Forfia P.R., Fisher M.R., Mathai S.C., et al. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med 2006, 174:1034-1041.
68. Fine N.M., Chen L., Bastiansen P.M., et al. Outcome prediction by quantitative right ventricular function assessment in 575 subjects evaluated for pulmonary hypertension. Circ Cardiovasc Imaging 2013, 6:711-721.
69. Grünig E., Tiede H., Enyimayew E.O., et al. Assessment and prognostic relevance of right ventricular contractile reserve in patients with severe pulmonary hypertension. Circulation 2013, 128:2005-2015.
70. Smith B.C., Dobson G., Dawson D., et al. Three-dimensional speckle tracking of the right ventricle: toward optimal quantification of right ventricular dysfunction in pulmonary hypertension. JAm Coll Cardiol 2014, 64:41-51.
71. Courand P.Y., Pina Jomir G., Khouatra C., et al. Prognostic value of right ventricular ejection fraction in pulmonary arterial hypertension. Eur Respir J 2015, 45:139-149.
72. Zylkowska J., Kurzyna M., Florczyk M., et al. Pulmonary artery dilatation correlates with the risk of unexpected death in chronic arterial or thromboembolic pulmonary hypertension. Chest 2012, 142:1406-1416.
73. van Wolferen S.A., Marcus J.T., Boonstra A., et al. Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. Eur Heart J 2007, 28:1250-1257.
74. van de Veerdonk M.C., Kind T., Marcus J.T., et al. Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. JAm Coll Cardiol 2011, 58:2511-2519.
75. Freed B.H., Gomberg-Maitland M., Chandra S., et al. Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension. JCardiovasc Magn Reson 2012, 14:11.
76. Ley S., Fink C., Risse F., et al. Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension. Eur Radiol 2013, 23:324-331.
77. Pandya B., Quail M.A., Steeden J.A., et al. Real-time magnetic resonance assessment of septal curvature accurately tracks acute hemodynamic changes in pediatric pulmonary hypertension. Circ Cardiovasc Imaging 2014, 7:706-713.
78. Vanderpool R.R., Pinsky M.R., Naeije R., et al. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart 2015, 101:37-43.
79. van Wolferen S.A., van de Veerdonk M.C., Mauritz G.J., et al. Clinically significant change in stroke volume in pulmonary hypertension. Chest 2011, 139:1003-1009.
80. Leeuwenburgh B.P., Steendijk P., Helbing W.A., Baan J. Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs. Am J Physiol Heart Circ Physiol 2002, 282:H1350-H1358.
81. Kuehne T., Yilmaz S., Steendijk P., et al. Magnetic resonance imaging analysis of right ventricular pressure-volume loops: invivo validation and clinical application in patients with pulmonary hypertension. Circulation 2004, 110:2010-2016.
82. Sanz J., Conroy J., Narula J. Imaging of the right ventricle. Cardiol Clin 2012, 30:189-203.