Sarcopenia: Prevalence, mechanisms, and functional consequences

Interdisciplinary Topics in Gerontology

Volumn 37, Issue , 2010, Pages 94-114

  Berger, Michael J ^a   Doherty, Timothy J ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ARTICLE; HUMAN; KNEE OSTEOARTHRITIS; MIDDLE AGED; MUSCLE ATROPHY; MUSCLE STRENGTH; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVALENCE;

ADULT; AGED; AGED, 80 AND OVER; AGING; HUMANS; MIDDLE AGED; MUSCLE STRENGTH; OSTEOARTHRITIS, KNEE; PREVALENCE; SARCOPENIA;

EID: 84925970732     PISSN: 00741132     EISSN: 16623800     Source Type: Book Series    
DOI: 10.1159/000319997     Document Type: Article

References (169)

1. Doherty TJ: Invited review: aging and sarcopenia. J Appl Physiol 2003;95:1717-1727.
2. Doherty TJ: The influence of aging and sex on skeletal muscle mass and strength. Curr Opin Clin Nutr Metab Care 2001;4:503-508.
3. Doherty TJ, Vandervoort AA, Brown WF: Effects of ageing on the motor unit: a brief review. Can J Appl Physiol 1993;18:331-358.
4. Rosenberg IH: Summary comments. Am J Clin Nutr 1989;50:1231-1233.
5. Abellan van Kan G, Andre E, Bischoff Ferrari HA, et al: Carla Task Force on Sarcopenia: propositions for clinical trials. J Nutr Health Aging 2009;13:700-707.
6. Porter MM, Vandervoort AA, Lexell J: Aging of human muscle: structure, function and adaptability. Scand J Med Sci Sports 1995;5:129-142.
7. Vandervoort AA: Aging of the human neuromuscular system. Muscle Nerve 2002;25:17-25.
8. Larsson L, Grimby G, Karlsson J: Muscle strength and speed of movement in relation to age and muscle morphology. J Appl Physiol 1979;46:451-456.
9. Murray MP, Duthie EHJ, Gambert SR, Sepic SB, Mollinger LA: Age-related differences in knee muscle strength in normal women. J Gerontol 1985;40:275-280.
10. Murray MP, Gardner GM, Mollinger LA, Sepic SB: Strength of isometric and isokinetic contractions: knee muscles of men aged 20 to 86. Phys Ther 1980;60:412-419.
11. Young A, Stokes M, Crowe M: The size and strength of the quadriceps muscles of old and young men. Clin Physiol 1985;5:145-154.
12. Young A, Stokes M, Crowe M: Size and strength of the quadriceps muscles of old and young women. Eur J Clin Invest 1984;14:282-287.
13. Lewis SF, Haller RG: Skeletal muscle disorders and associated factors that limit exercise performance. Exerc Sport Sci Rev 1989;17:67-113.
14. Bassey EJ, Harries UJ: Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors. Clin Sci (Colch) 1993;84:331-337.
15. Cunningham DA, Morrison D, Rice CL, Cooke C: Ageing and isokinetic plantar flexion. Eur J Appl Physiol 1987;56:24-29.
16. Davies CT, Thomas DO, White MJ: Mechanical properties of young and elderly human muscle. Acta Med Scand Suppl 1986;711:219-226.
17. Fisher MB, Birren JE: Age and strength. J Appl Psychol 1947;31:490-497.
18. Kallman DA, Plato CC, Tobin JD: The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives. J Gerontol 1990;45:M82-M88.
19. McDonagh MJ, White MJ, Davies CT: Different effects of ageing on the mechanical properties of human arm and leg muscles. Gerontology 1984;30:49-54.
20. Vandervoort AA, McComas AJ: Contractile changes in opposing muscles of the human ankle joint with aging. J Appl Physiol 1986;61:361-367.
21. Campbell MJ, McComas AJ, Petito F: Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry 1973;36:174-182.
22. Doherty TJ, Brown WF: Age-related changes in the twitch contractile properties of human thenar motor units. J Appl Physiol 1997;82:93-101.
23. Doherty TJ, Vandervoort AA, Taylor AW, Brown WF: Effects of motor unit losses on strength in older men and women. J Appl Physiol 1993;74:868-874.
24. Klein CS, Rice CL, Marsh GD: Normalized force, activation, and coactivation in the arm muscles of young and old men. J Appl Physiol 2001;91:1341-1349.
25. Narici MV, Bordini M, Cerretelli P: Effect of aging on human adductor pollicis muscle function. J Appl Physiol 1991;71:1277-1281.
26. Vandervoort AA, Hayes KC: Plantarflexion muscle function in young and elderly women. Eur J Appl Physiol 1989:389-394.
27. Overend TJ, Cunningham DA, Kramer JF, Lefcoe MS, Paterson DH: Knee extensor and knee flexor strength. J Gerontol 1992;47:M204-M210.
28. Poulin MJ, Vandervoort AA, Paterson DH, Kramer JF, Cunningham DA: Eccentric and concentric torques of knee and elbow extension in young and older men. Can J Sport Sci 1992;17:3-7.
29. Vandervoort AA, Kramer JF, Wharram ER: Eccentric knee strength of elderly females. J Gerontol 1990;45:B125-B128.
30. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ: High-intensity strength training in nonagenarians: effects on skeletal muscle. JAMA 1990;263:3029-3034.
31. Frontera WR, Meredith CN, O'Reilly KP, Knuttgen HG, Evans WJ: Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 1988;64:1038-1044.
32. Klitgaard H, Mantoni M, Schiaffino S, et al: Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds. Acta Physiol Scand 1990;140:41-54.
33. Overend TJ, Cunningham DA, Paterson DH, Lefcoe MS: Thigh composition in young and elderly men determined by computed tomography. Clin Physiol 1992;12:629-640.
34. Rice CL, Cunningham DA, Paterson DH, Lefcoe MS: Arm and leg composition determined by computed tomography in young and elderly men. Clin Physiol 1989;9:207-220.
35. Lexell J, Taylor CC, Sjostrom M: What is the cause of aging atrophy? J Neurol Sci 1988;84:275-294.
36. Baumgartner RN, Koehler KM, Gallagher D, et al: Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998;147:755-763.
37. Melton L Jr, Khosla S, Crowson CS, O'Connor MK, O'Fallon WM, Riggs BL: Epidemiology of sarcopenia. J Am Geriatr Soc 2000;48:625-630.
38. Iannuzzi-Sucich M, Prestwood KM, Kenny AM: Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 2002;57:M772-M777.
39. Janssen I, Heymsfield SB, Wang ZM, Ross R: Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol 2000;89:81-88.
40. Janssen I, Heymsfield SB, Ross R: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002;50:889-896.
41. Delmonico MJ, Harris TB, Visser M, et al: Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009;90:1579-1585.
42. Hughes VA, Frontera WR, Roubenoff R, Evans WJ, Singh MA: Longitudinal changes in body composition in older men and women: role of body weight change and physical activity. Am J Clin Nutr 2002;76:473-481.
43. Clark BC, Manini TM: Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci 2008;63:829-834.
44. Rolland Y, Czerwinski S, Abellan Van Kan G, et al: Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging 2008;12:433-450.
45. Doherty T, Simmons Z, O'Connell B, et al: Methods for estimating the numbers of motor units in human muscles. J Clin Neurophysiol 1995;12:565-584.
46. Doherty TJ, Brown WF: Motor unit number estimation: methods and applications; in Brown WF, Bolton CF, Aminoff MJ (eds): Neuromusculoar Function and Disease: Basic, Clinical, and Electrodiagnostic Aspects. Philadelphia, Saunders, 2002, pp 274-290.
47. Grimby G, Saltin B: The ageing muscle. Clin Physiol 1983;3:209-218.
48. Lexell J: Ageing and human muscle: observations from Sweden. Can J Appl Physiol 1993;18:2-18.
49. Lexell J, Downham DY: What determines the muscle cross-sectional area? J Neurol Sci 1992;111:113-114.
50. Roos MR, Rice CL, Vandervoort AA: Age-related changes in motor unit function. Muscle Nerve 1997;20:679-690.
51. Larsson L, Sjodin B, Karlsson J: Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22-65 years. Acta Physiol Scand 1978;103:31-39.
52. Andersen JL, Terzis G, Kryger A: Increase in the degree of coexpression of myosin heavy chain isoforms in skeletal muscle fibers of the very old. Muscle Nerve 1999;22:449-454.
53. Essen-Gustavsson B, Borges O: Histochemical and metabolic characteristics of human skeletal muscle in relation to age. Acta Physiol Scand 1986;126:107-114.
54. Oertel G: Changes in human skeletal muscles due to ageing: histological and histochemical observations on autopsy material. Acta Neuropathol (Berl) 1986;69:309-313.
55. Brown WF: A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing. J Neurol Neurosurg Psychiatry 1972;35:845-852.
56. Doherty TJ, Brown WF: The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle Nerve 1993;16:355-366.
57. Stalberg E: Macro EMG, a new recording technique. J Neurol Neurosurg Psychiatry 1980;43:475-482.
58. de Koning P, Wieneke GH, van der Most van Spijk D, van Huffelen AC, Gispen WH, Jennekens FG: Estimation of the number of motor units based on macro-EMG. J Neurol Neurosurg Psychiatry 1988;51:403-411.
59. Stalberg E, Borges O, Ericsson M, et al: The quadriceps femoris muscle in 20-70-year-old subjects: relationship between knee extension torque, electrophysiological parameters, and muscle fiber characteristics. Muscle Nerve 1989;12:382-389.
60. Brown WF, Strong MJ, Snow R: Methods for estimating numbers of motor units in biceps-brachialis muscles and losses of motor units with aging. Muscle Nerve 1988;11:423-432.
61. Sica RE, McComas AJ, Upton AR, Longmire D: Motor unit estimations in small muscles of the hand. J Neurol Neurosurg Psychiatry 1974;37:55-67.
62. Kawamura Y, O'Brien P, Okazaki H, Dyck PJ: Lumbar motoneurons of man. II. The number and diameter distribution of large- and intermediate diameter cytons in 'motoneuron columns' of spinal cord of man. J Neuropathol Exp Neurol 1977;36:861-870.
63. Kawamura Y, Okazaki H, O'Brien PC, Dych PJ: Lumbar motoneurons of man. I. Number and diameter histogram of alpha and gamma axons of ventral root. J Neuropathol Exp Neurol 1977;36:853-860.
64. Mittal KR, Logmani FH: Age-related reduction in 8th cervical ventral nerve root myelinated fiber diameters and numbers in man. J Gerontol 1987;42:8-10.
65. Tomlinson BE, Irving D: The numbers of limb motor neurons in the human lumbosacral cord throughout life. J Neurol Sci 1977;34:213-219.
66. Ansved T, Larsson L: Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats: relation to the number of soleus muscle fibers. J Neurol Sci 1990;96:269-282.
67. Caccia MR, Harris JB, Johnson MA: Morphology and physiology of skeletal muscle in aging rodents. Muscle Nerve 1979;2:202-212.
68. McComas AJ: 1998 ISEK Congress Keynote Lecture: motor units: how many, how large, what kind? International Society of Electrophysiology and Kinesiology. J Electromyogr Kinesiol 1998;8:391-402.
69. McComas AJ: Invited review: motor unit estimation: methods, results, and present status. Muscle Nerve 1991;14:585-597.
70. McNeil CJ, Doherty TJ, Stashuk DW, Rice CL: Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men. Muscle Nerve 2005;31:461-467.
71. Dalton BH, McNeil CJ, Doherty TJ, Rice CL: Agerelated reductions in the estimated numbers of motor units are minimal in the human soleus. Muscle Nerve 2008;38:1108-1115.
72. Power G, Dalton BH, Behm DG, Vandervoort AA, Doherty TJ, Rice CL: Motor unit number estimates in masters runners: use it or lose it? Med Sci Sports Exerc 2010; in press.
73. Skelton DA, Greig CA, Davies JM, Young A: Strength, power and related functional ability of healthy people aged 65-89 years. Age Ageing 1994;23:371-377.
74. Metter EJ, Conwit R, Tobin J, Fozard JL: Ageassociated loss of power and strength in the upper extremities in women and men. J Gerontol A Biol Sci Med Sci 1997;52:B267-B276.
75. Bean JF, Kiely DK, LaRose S, Leveille SG: Which impairments are most associated with high mobility performance in older adults? Implications for a rehabilitation prescription. Arch Phys Med Rehabil 2008;89:2278-2284.
76. Tipton CM, American College of Sports Medicine: ACSM's Advanced Exercise Physiology. Philadelphia, Lippincott Williams & Wilkins, 2006.
77. Raj IS, Bird SR, Shield AJ: Aging and the forcevelocity relationship of muscles. Exp Gerontol 2010;45:81-90.
78. Izquierdo M, Ibanez J, Gorostiaga E, et al: Maximal strength and power characteristics in isometric and dynamic actions of the upper and lower extremities in middle-aged and older men. Acta Physiol Scand 1999;167:57-68.
79. Lanza IR, Towse TF, Caldwell GE, Wigmore DM, Kent-Braun JA: Effects of age on human muscle torque, velocity, and power in two muscle groups. J Appl Physiol 2003;95:2361-2369.
80. Valour D, Ochala J, Ballay Y, Pousson M: The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles. Exp Gerontol 2003;38:387-395.
81. Toji H, Kaneko M: Effects of aging on force, velocity, and power in the elbow flexors of males. J Physiol Anthropol 2007;26:587-592.
82. McNeil CJ, Vandervoort AA, Rice CL: Peripheral impairments cause a progressive age-related loss of strength and velocity-dependent power in the dorsiflexors. J Appl Physiol 2007;102:1962-1968.
83. Thom JM, Morse CI, Birch KM, Narici MV: Triceps surae muscle power, volume, and quality in older versus younger healthy men. J Gerontol A Biol Sci Med Sci 2005;60:1111-1117.
84. Thom JM, Morse CI, Birch KM, Narici MV: Influence of muscle architecture on the torque and power-velocity characteristics of young and elderly men. Eur J Appl Physiol 2007;100:613-619.
85. Petrella JK, Kim JS, Tuggle SC, Hall SR, Bamman MM: Age differences in knee extension power, contractile velocity, and fatigability. J Appl Physiol 2005;98:211-220.
86. Caserotti P, Aagaard P, Puggaard L: Changes in power and force generation during coupled eccentric concentric versus concentric muscle contraction with training and aging. Eur J Appl Physiol 2008;103:151-161.
87. De Vito G, Bernardi M, Forte R, Pulejo C, Macaluso A, Figura F: Determinants of maximal instantaneous muscle power in women aged 50-75 years. Eur J Appl Physiol Occup Physiol 1998;78:59-64.
88. Harries UJ, Bassey EJ: Torque-velocity relationships for the knee extensors in women in their 3rd and 7th decades. Eur J Appl Physiol Occup Physiol 1990;60:187-190.
89. Gajdosik RL, Vander Linden DW, Williams AK: Influence of age on length and passive elastic stiffness characteristics of the calf muscle-tendon unit of women. Phys Ther 1999;79:827-838.
90. Yu F, Hedstrom M, Cristea A, Dalen N, Larsson L: Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres. Acta Physiol (Oxf) 2007;190:229-241.
91. Caserotti P, Aagaard P, Simonsen EB, Puggaard L: Contraction-specific differences in maximal muscle power during stretch-shortening cycle movements in elderly males and females. Eur J Appl Physiol 2001;84:206-212.
92. Lexell J, Taylor CC, Sjostrom M: What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 1988;84:275-294.
93. Hook P, Sriramoju V, Larsson L: Effects of aging on actin sliding speed on myosin from single skeletal muscle cells of mice, rats, and humans. Am J Physiol Cell Physiol 2001;280:C782-C788.
94. Trappe T: Influence of aging and long-term unloading on the structure and function of human skeletal muscle. Appl Physiol Nutr Metab 2009;34:459-464.
95. D'Antona G, Pellegrino MA, Carlizzi CN, Bottinelli R: Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity. Eur J Appl Physiol 2007;100:603-611.
96. Krivickas LS, Suh D, Wilkins J, Hughes VA, Roubenoff R, Frontera WR: Age- and gender-related differences in maximum shortening velocity of skeletal muscle fibers. Am J Phys Med Rehabil 2001;80:447-455; quiz 56-57.
97. Larsson L, Li X, Frontera WR: Effects of aging on shortening velocity and myosin isoform composition in single human skeletal muscle cells. Am J Physiol 1997;272:C638-C649.
98. Ochala J, Frontera WR, Dorer DJ, Van Hoecke J, Krivickas LS: Single skeletal muscle fiber elastic and contractile characteristics in young and older men. J Gerontol A Biol Sci Med Sci 2007;62:375-381.
99. Trappe S, Gallagher P, Harber M, Carrithers J, Fluckey J, Trappe T: Single muscle fibre contractile properties in young and old men and women. J Physiol 2003;552:47-58.
100. Jette AM, Assmann SF, Rooks D, Harris BA, Crawford S: Interrelationships among disablement concepts. J Gerontol A Biol Sci Med Sci 1998;53:M395-M404.
101. Guralnik JM, Simonsick EM, Ferrucci L, et al: A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M85-M94.
102. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB: Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995;332:556-561.
103. Wolfson L, Judge J, Whipple R, King M: Strength is a major factor in balance, gait, and the occurrence of falls. J Gerontol A Biol Sci Med Sci 1995;50 Spec No:64-67.
104. Moxley Scarborough D, Krebs DE, Harris BA: Quadriceps muscle strength and dynamic stability in elderly persons. Gait Posture 1999;10:10-20.
105. Corrigan D, Bohannon RW: Relationship between knee extension force and stand-up performance in community-dwelling elderly women. Arch Phys Med Rehabil 2001;82:1666-1672.
106. Salem GJ, Wang MY, Young JT, Marion M, Greendale GA: Knee strength and lower- and higherintensity functional performance in older adults. Med Sci Sports Exerc 2000;32:1679-1684.
107. Brown M, Sinacore DR, Host HH: The relationship of strength to function in the older adult. J Gerontol A Biol Sci Med Sci 1995:5055-5059.
108. Bassey EJ, Fiatarone MA, O'Neill EF, Kelly M, Evans WJ, Lipsitz LA: Leg extensor power and functional performance in very old men and women. Clin Sci (Lond) 1992;82:321-327.
109. Rantanen T, Avela J: Leg extension power and walking speed in very old people living independently. J Gerontol A Biol Sci Med Sci 1997;52:M225-M231.
110. Bean JF, Kiely DK, Herman S, et al: The relationship between leg power and physical performance in mobility-limited older people. J Am Geriatr Soc 2002;50:461-467.
111. Sayers SP, Guralnik JM, Thombs LA, Fielding RA: Effect of leg muscle contraction velocity on functional performance in older men and women. J Am Geriatr Soc 2005;53:467-471.
112. Foldvari M, Clark M, Laviolette LC, et al: Association of muscle power with functional status in community dwelling elderly women. J Gerontol A Biol Sci Med Sci 2000;55:M192-M199.
113. Cuoco A, Callahan DM, Sayers S, Frontera WR, Bean J, Fielding RA: Impact of muscle power and force on gait speed in disabled older men and women. J Gerontol A Biol Sci Med Sci 2004;59:1200-1206.
114. Puthoff ML, Janz KF, Nielson D: The relationship between lower extremity strength and power to everyday walking behaviors in older adults with functional limitations. J Geriatr Phys Ther 2008;31:24-31.
115. Suzuki T, Bean JF, Fielding RA: Muscle power of the ankle flexors predicts functional performance in community-dwelling older women. J Am Geriatr Soc 2001;49:1161-1167.
116. Herman S, Kiely DK, Leveille S, O'Neill E, Cyberey S, Bean JF: Upper and lower limb muscle power relationships in mobility-limited older adults. J Gerontol A Biol Sci Med Sci 2005;60:476-480.
117. Bean JF, Leveille SG, Kiely DK, Bandinelli S, Guralnik JM, Ferrucci L: A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more? J Gerontol A Biol Sci Med Sci 2003;58:728-733.
118. Mayson DJ, Kiely DK, LaRose SI, Bean JF: Leg strength or velocity of movement: which is more influential on the balance of mobility limited elders? Am J Phys Med Rehabil 2008;87:969-976.
119. Puthoff ML, Nielsen DH: Relationships among impairments in lower-extremity strength and power, functional limitations, and disability in older adults. Phys Ther 2007;87:1334-1347.
120. Ferrucci L, Guralnik JM, Buchner D, et al: Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci 1997;52:M275-M285.
121. Earles DR, Judge JO, Gunnarsson OT: Velocity training induces power-specific adaptations in highly functioning older adults. Arch Phys Med Rehabil 2001;82:872-878.
122. Orr R, de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Fiatarone-Singh MA: Power training improves balance in healthy older adults. J Gerontol A Biol Sci Med Sci 2006;61:78-85.
123. Caserotti P, Aagaard P, Larsen JB, Puggaard L: Explosive heavy-resistance training in old and very old adults: changes in rapid muscle force, strength and power. Scand J Med Sci Sports 2008;18:773-782.
124. de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Orr R, Fiatarone Singh MA: Effect of power-training intensity on the contribution of force and velocity to peak power in older adults. J Aging Phys Act 2008;16:393-407.
125. de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Orr R, Fiatarone Singh MA: Optimal load for increasing muscle power during explosive resistance training in older adults. J Gerontol A Biol Sci Med Sci 2005;60:638-647.
126. Bean JF, Kiely DK, LaRose S, O'Neill E, Goldstein R, Frontera WR: Increased velocity exercise specific to task training versus the National Institute on Aging's strength training program: changes in limb power and mobility. J Gerontol A Biol Sci Med Sci 2009;64:983-991.
127. Bottaro M, Machado SN, Nogueira W, Scales R, Veloso J: Effect of high versus low-velocity resistance training on muscular fitness and functional performance in older men. Eur J Appl Physiol 2007;99:257-264.
128. Katula JA, Rejeski WJ, Marsh AP: Enhancing quality of life in older adults: a comparison of muscular strength and power training. Health Qual Life Outcomes 2008;6:45.
129. Marsh AP, Miller ME, Rejeski WJ, Hutton SL, Kritchevsky SB: Lower extremity muscle function after strength or power training in older adults. J Aging Phys Act 2009;17:416-443.
130. Fielding RA, LeBrasseur NK, Cuoco A, Bean J, Mizer K, Fiatarone Singh MA: High-velocity resistance training increases skeletal muscle peak power in older women. J Am Geriatr Soc 2002;50:655-662.
131. Henwood TR, Riek S, Taaffe DR: Strength versus muscle power-specific resistance training in community dwelling older adults. J Gerontol A Biol Sci Med Sci 2008;63:83-91.
132. Reid KF, Callahan DM, Carabello RJ, Phillips EM, Frontera WR, Fielding RA: Lower extremity power training in elderly subjects with mobility limitations: a randomized controlled trial. Aging Clin Exp Res 2008;20:337-343.
133. Guccione AA, Felson DT, Anderson JJ, et al: The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health 1994;84:351-358.
134. Baker KR, Xu L, Zhang Y, et al: Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study. Arthritis Rheum 2004;50:1815-1821.
135. Felson DT: Clinical practice. Osteoarthritis of the knee. N Engl J Med 2006;354:841-848.
136. McAlindon TE, Cooper C, Kirwan JR, Dieppe PA: Determinants of disability in osteoarthritis of the knee. Ann Rheum Dis 1993;52:258-262.
137. O'Reilly SC, Jones A, Muir KR, Doherty M: Quadriceps weakness in knee osteoarthritis: the effect on pain and disability. Ann Rheum Dis 1998;57:588-594.
138. Hassan BS, Mockett S, Doherty M: Static postural sway, proprioception, and maximal voluntary quadriceps contraction in patients with knee osteoarthritis and normal control subjects. Ann Rheum Dis 2001;60:612-618.
139. Hurley MV, Newham DJ: The influence of arthrogenous muscle inhibition on quadriceps rehabilitation of patients with early, unilateral osteoarthritic knees. Br J Rheumatol 1993;32:127-131.
140. Hurley MV, Scott DL, Rees J, Newham DJ: Sensorimotor changes and functional performance in patients with knee osteoarthritis. Ann Rheum Dis 1997;56:641-648.
141. Lewek MD, Rudolph KS, Snyder-Mackler L: Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis. J Orthop Res 2004;22:110-115.
142. Ling SM, Conwit RA, Talbot L, et al: Electromyographic patterns suggest changes in motor unit physiology associated with early osteoarthritis of the knee. Osteoarthritis Cartilage 2007.
143. Hall KD, Hayes KW, Falconer J: Differential strength decline in patients with osteoarthritis of the knee: revision of a hypothesis. Arthritis Care Res 1993;6:89-96.
144. Hortobagyi T, Garry J, Holbert D, Devita P: Aberrations in the control of quadriceps muscle force in patients with knee osteoarthritis. Arthritis Rheum 2004;51:562-569.
145. Slemenda C, Brandt KD, Heilman DK, et al: Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med 1997;127:97-104.
146. Fisher NM, Pendergast DR: Reduced muscle function in patients with osteoarthritis. Scand J Rehab Med 1997;29:213-221.
147. Slemenda C, Heilman DK, Brandt KD, et al: Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum 1998;41:1951-1959.
148. Becker R, Berth A, Nehring M, Awiszus F: Neuromuscular quadriceps dysfunction prior to osteoarthritis of the knee. J Orthop Res 2004;22:768-773.
149. Brandt KD, Radin EL, Dieppe PA, van de Putte L: Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 2006;65:1261-1264.
150. Jefferson RJ, Collins JJ, Whittle MW, Radin EL, O'Connor JJ: The role of the quadriceps in controlling impulsive forces around heel strike. Proc Inst Mech Engn 1990;204:21-28.
151. Radin EL, Yang KH, Riegger C, Kish VL, O'Connor JJ: Relationship between lower limb dynamics and knee joint pain. J Orthop Res 1991;9:398-405.
152. Rudolph KS, Schmitt LC, Lewek MD: Age-related changes in strength, joint laxity, and walking patterns: are they related to knee osteoarthritis? Phys Ther 2007;87:1422-1432.
153. Schmitt LC, Rudolph KS: Influences on knee movement strategies during walking in persons with medial knee osteoarthritis. Arthritis Rheum 2007;57:1018-1026.
154. Longino D, Frank C, Herzog W: Acute botulinum toxin-induced muscle weakness in the anterior cruciate ligament-deficient rabbit. J Orthop Res 2005;23:1404-1410.
155. Rehan Youssef A, Longino D, Seerattan R, Leonard T, Herzog W: Muscle weakness causes joint degeneration in rabbits. Osteoarthritis Cartilage 2009;17:1228-1235.
156. Odding E, Valkenburg HA, Algra D, Vandenouweland FA, Grobbee DE, Hofman A: Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam Study. Ann Rheum Dis 1998;57:203-208.
157. Creamer P, Lethbridge-Cejku M, Hochberg MC: Factors associated with functional impairment in symptomatic knee osteoarthritis. Rheumatology (Oxford, England) 2000;39:490-496.
158. Ling SM, Xue QL, Simonsick EM, et al: Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study II. Arthritis Rheum 2006;55:256-263.
159. Ikeda S, Tsumura H, Torisu T: Age-related quadricepsdominant muscle atrophy and incident radiographic knee osteoarthritis. J Orthop Sci 2005;10:121-126.
160. Petterson SC, Barrance P, Buchanan T, Binder-Macleod S, Snyder-Mackler L: Mechanisms underlying quadriceps weakness in knee osteoarthritis. Med Sci Sports Exerc 2008;40:422-427.
161. Berth A, Urbach D, Awiszus F: Improvement of voluntary quadriceps muscle activation after total knee arthroplasty. Arch Phys Med Rehab 2002;83:1432-1436.
162. Stevens JE, Mizner RL, Snyder-Mackler L: Quadriceps strength and volitional activation before and after total knee arthroplasty for osteoarthritis. J Orthop Res 2003;21:775-779.
163. Heiden TL, Lloyd DG, Ackland TR: Knee extension and flexion weakness in people with knee osteoarthritis: is antagonist cocontraction a factor? J Orthop Sports Phys Ther 2009;39:807-815.
164. Lewek MD, Ramsey DK, Snyder-Mackler L, Rudolph KS: Knee stabilization in patients with medial compartment knee osteoarthritis. Arthr Rheum 2005;52:2845-2853.
165. Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthr Rheum 2000;43:1905-1915.
166. Baker K, McAlindon T: Exercise for knee osteoarthritis. Curr Opin Rheumatol 2000;12:456-463.
167. Mikesky AE, Mazzuca SA, Brandt KD, Perkins SM, Damush T, Lane KA: Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum 2006;55:690-699.
168. King LK, Birmingham TB, Kean CO, Jones IC, Bryant DM, Giffin JR: Resistance training for medial compartment knee osteoarthritis and malalignment. Med Sci Sports Exerc 2008;40:1376-1384.
169. Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW: Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann Intern Med 2003;138:613-619.