140 mmol/L of sodium versus 77 mmol/L of sodium in maintenance intravenous fluid therapy for children in hospital (PIMS): A randomised controlled double-blind trial

The Lancet

Volumn 385, Issue 9974, 2015, Pages 1190-1197

  McNab, Sarah ^a,b,c   Duke, Trevor ^a,b,c   South, Mike ^a,b,c   Babl, Franz E ^a,b   Lee, Katherine J ^b,c   Arnup, Sarah J ^b   Young, Simon ^a,b,c   Turner, Hannah ^b   Davidson, Andrew ^a,c  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CHLORIDE; CREATININE; HYPOTONIC SOLUTION; INFUSION FLUID; ISOTONIC SOLUTION; POTASSIUM; SODIUM; UREA; SODIUM CHLORIDE;

ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD GAS ANALYZER; BRAIN EDEMA; CHILD; CHILD CARE; CHILDHOOD MORTALITY; CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; ELECTROLYTE BLOOD LEVEL; ELECTROLYTE URINE LEVEL; FEMALE; FLUID THERAPY; HOSPITAL PATIENT; HUMAN; HUMAN EXPERIMENT; HYPERNATREMIA; HYPONATREMIA; INFANT; INTENSIVE CARE UNIT; INTENTION TO TREAT ANALYSIS; KIDNEY CONCENTRATING CAPACITY; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ERROR; MORBIDITY; PATIENT MONITORING; PATIENT SAFETY; POTASSIUM BLOOD LEVEL; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REHYDRATION; RISK ASSESSMENT; SCHOOL CHILD; SEIZURE; SENSITIVITY ANALYSIS; SODIUM BLOOD LEVEL; TREATMENT DURATION; UREA BLOOD LEVEL; ADOLESCENT; ADVERSE EFFECTS; DRUG ADMINISTRATION; HOSPITALIZATION; INTRAVENOUS DRUG ADMINISTRATION; PROCEDURES;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUID THERAPY; HOSPITALIZATION; HUMANS; HYPONATREMIA; HYPOTONIC SOLUTIONS; INFANT; INFUSIONS, INTRAVENOUS; ISOTONIC SOLUTIONS; MALE; SODIUM CHLORIDE;

EID: 84925954865     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)61459-8     Document Type: Article

References (41)

1. MA Holliday, PE Ray, AL Friedman Fluid therapy for children: facts, fashions and questions Arch Dis Child 92 2007 546 550
2. MA Holliday Isotonic saline expands extracellular fluid and is inappropriate for maintenance therapy Pediatrics 115 2005 193 194
3. ML Moritz, JC Ayus Hospital-acquired hyponatremia - why are hypotonic parenteral fluids still being used? Nat Clin Pract Nephrol 3 2007 374 382
4. ML Moritz, JC Ayus Prevention of hospital-acquired hyponatremia: do we have the answers? Pediatrics 128 2011 980 983
5. T Duke, EM Molyneux Intravenous fluids for seriously ill children: time to reconsider Lancet 362 2003 1320 1323
6. AI Arieff, JC Ayus, CL Fraser Hyponatraemia and death or permanent brain damage in healthy children BMJ 304 1992 1218 1222
7. AI Arieff Postoperative hyponatraemic encephalopathy following elective surgery in children Paediatr Anaesth 8 1998 1 4
8. M Halberthal, ML Halperin, D Bohn Acute hyponatraemia in children admitted to hospital: retrospective analysis of factors contributing to its development and resolution BMJ 322 2001 780 782
9. C Koczmara, AW Wade, P Skippen et al. Hospital-acquired acute hyponatremia and reports of pediatric deaths Dynamics 21 2010 21 26
10. PD Hughes, D McNicol, PM Mutton, GJ Flynn, R Tuck, P Yorke Postoperative hyponatraemic encephalopathy: water intoxication. Intravenous fluids for seriously ill children: time to reconsider Lancet 362 2003 1320 1323
11. H Hasegawa, S Okubo, Y Ikezumi et al. Hyponatremia due to an excess of arginine vasopressin is common in children with febrile disease Pediatr Nephrol 24 2009 507 511
12. J Mori, M Miura, H Shiro, K Fujioka, T Kohri, T Hasegawa Syndrome of inappropriate anti-diuretic hormone in Kawasaki disease Pediatr Int 53 2011 354 357
13. A Dhawan, A Narang, S Singhi Hyponatraemia and the inappropriate ADH syndrome in pneumonia Ann Trop Paediatr 12 1992 455 462
14. AK Patwari, BS Singh, DE Manorama Inappropriate secretion of antidiuretic hormone in acute bacterial meningitis Ann Trop Paediatr 15 1995 179 183
15. JE Fajardo, EM Stafford, JW Bass, JD Roscelli, AK Sato, JR Claybaugh Inappropriate antidiuretic hormone in children with viral meningitis Pediatr Int 5 1989 37 40
16. FA Burrows, JG Shutack, RK Crone Inappropriate secretion of antidiuretic hormone in a postsurgical pediatric population Crit Care Med 11 1983 527 531
17. BA Judd, GB Haycock, RN Dalton, C Chantler Antidiuretic hormone following surgery in children Acta Paediatr Scand 79 1990 461 466
18. National Patient Safety Agency Reducing the risk of hyponatraemia when administering intravenous infusions to children. 2007; Patient Safety Alert 22 NPSA/2007/22 http://www.nrls.npsa.nhs.uk/resources/?EntryId45=59809 (accessed April 26, 2014).
19. BA Foster, D Tom, V Hill Hypotonic versus isotonic fluids in hospitalized children: a systematic review and meta-analysis J Pediatr 165 2014 163 169
20. PW Brazel, IB McPhee Inappropriate secretion of antidiuretic hormone in postoperative scoliosis patients: the role of fluid management Spine 21 1996 724 727
21. K Choong, S Arora, J Cheng et al. Hypotonic versus isotonic maintenance fluids after surgery for children: a randomized controlled trial Pediatrics 128 2011 857 866
22. MG Coulthard, DA Long, AJ Ullman, RS Ware A randomised controlled trial of Hartmann's solution versus half normal saline in postoperative paediatric spinal instrumentation and craniotomy patients Arch Dis Child 97 2012 491 496
23. L Kannan, R Lodha, S Vivekanandhan, A Bagga, SK Kabra, M Kabra Intravenous fluid regimen and hyponatraemia among children: a randomized controlled trial Pediatr Nephrol 25 2010 2303 2309
24. PA Montañana, V Modesto i Alapont, AP Ocón, PO López, JL López Prats, JD Toledo Parreño The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study Pediatr Crit Care Med 9 2008 589 597
25. KA Neville, DJ Sandeman, A Rubinstein, GM Henry, M McGlynn, JL Walker Prevention of hyponatremia during maintenance intravenous fluid administration: a prospective randomized study of fluid type versus fluid rate J Pediatr 156 2010 313 319
26. C Rey, M Los-Arcos, A Hernández, A Sánchez, JJ Díaz, J López-Herce Hypotonic versus isotonic maintenance fluids in critically ill children: a multicenter prospective randomized study Acta Paediatr 100 2011 1138 1143
27. TG Saba, J Fairbairn, F Houghton, D Laforte, BJ Foster A randomized controlled trial of isotonic versus hypotonic maintenance intravenous fluids in hospitalized children BMC Pediatr 11 2011 82
28. M Yung, S Keeley Randomised controlled trial of intravenous maintenance fluids J Paediatr Child Health 45 2009 9 14
29. MA Holliday, WE Segar, A Friedman, R Chesney, L Finberg Intravenous fluids for seriously ill children Lancet 363 2004 241
30. MG Coulthard Will changing maintenance intravenous fluid from 0·18% to 0·45% saline do more harm than good? Arch Dis Child 93 2008 335 340
31. JAMDF Kellum Saline-induced hyperchloremic metabolic acidosis Crit Care Med 30 2002 259 261
32. PC Stewart, K McGrath Paediatric maintenance fluids Br J Anaesth 98 2007 406
33. MA Holliday, WE Segar The maintenance need for water in parenteral fluid therapy Pediatrics 19 1957 823 832
34. G Liamis, H Milionis, M Elisaf A review of drug-induced hyponatremia Am J Kidney Dis 52 2008 144 153
35. MA Holliday, AL Friedman, WE Segar, R Chesney, L Finberg Acute hospital-induced hyponatremia in children: a physiologic approach J Pediatr 145 2004 584 587
36. S Playfor Fatal iatrogenic hyponatraemia Arch Dis Child 88 2003 646 647
37. R Luu, PE DeWitt, PD Reiter, EL Dobyns, J Kaufman Hyponatremia in children with bronchiolitis admitted to the pediatric intensive care unit is associated with worse outcomes J Pediatr 163 2013 1652 1656 e1.
38. S Mohan, S Gu, A Parikh, J Radhakrishnan Prevalence of hyponatremia and association with mortality: results from NHANES Am J Med 126 2013 1127 1137
39. NJ Wilkes, R Woolf, M Mutch et al. The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients Anesth Analg 93 2001 811 816
40. AD Shaw, SM Bagshaw, SL Goldstein et al. Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte Ann Surg 255 2012 821 829
41. A Sutherland, S Playfor Use of concentrated potassium on PICU increased by the use of a balanced crystalloid Arch Dis Child 98 2013 e1