메뉴 건너뛰기




Volumn 24, Issue 2, 2015, Pages 347-358

Targeted therapies in melanoma

Author keywords

BRAF inhibitors; Immunotherapies; Melanoma; Next generation sequencing; Ocular melanoma

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; BINIMETINIB; DABRAFENIB; DNA REPAIR PROTEIN; ENCORAFENIB; IPILIMUMAB; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NUCLEIC ACID BINDING PROTEIN; RAS PROTEIN; RIBOCICLIB; SOTRASTAURIN; TRAMETINIB; UNCLASSIFIED DRUG; VEMURAFENIB;

EID: 84925943821     PISSN: 10553207     EISSN: 15585042     Source Type: Journal    
DOI: 10.1016/j.soc.2014.12.011     Document Type: Review
Times cited : (6)

References (60)
  • 1
    • 84874276048 scopus 로고    scopus 로고
    • Historical review of melanoma treatment and outcomes
    • Lee C., Collichio F., Ollila D., et al. Historical review of melanoma treatment and outcomes. Clin Dermatol 2013, 31:141-147.
    • (2013) Clin Dermatol , vol.31 , pp. 141-147
    • Lee, C.1    Collichio, F.2    Ollila, D.3
  • 2
    • 39149104690 scopus 로고    scopus 로고
    • Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials
    • Korn E.L., Liu P.Y., Lee S.J., et al. Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. JClin Oncol 2008, 26:527-534.
    • (2008) JClin Oncol , vol.26 , pp. 527-534
    • Korn, E.L.1    Liu, P.Y.2    Lee, S.J.3
  • 3
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network Comprehensive molecular portraits of human breast tumours. Nature 2012, 490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 4
    • 84879890360 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of clear cell renal cell carcinoma
    • Cancer Genome Atlas Research Network Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 2013, 499:43-49.
    • (2013) Nature , vol.499 , pp. 43-49
  • 5
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov L.B., Nik-Zainal S., Wedge D.C., et al. Signatures of mutational processes in human cancer. Nature 2013, 500:415-421.
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 6
    • 78049486226 scopus 로고    scopus 로고
    • Patterns of expression of DNA repair genes and relapse from melanoma
    • Jewell R., Conway C., Mitra A., et al. Patterns of expression of DNA repair genes and relapse from melanoma. Clin Cancer Res 2010, 16:5211-5221.
    • (2010) Clin Cancer Res , vol.16 , pp. 5211-5221
    • Jewell, R.1    Conway, C.2    Mitra, A.3
  • 7
    • 84864258996 scopus 로고    scopus 로고
    • Alandscape of driver mutations in melanoma
    • Hodis E., Watson I.R., Kryukov G.V., et al. Alandscape of driver mutations in melanoma. Cell 2012, 150:251-263.
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3
  • 9
    • 84901020194 scopus 로고    scopus 로고
    • Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer
    • Johnson G.L., Stuhlmiller T.J., Angus S.P., et al. Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer. Clin Cancer Res 2014, 20:2516-2522.
    • (2014) Clin Cancer Res , vol.20 , pp. 2516-2522
    • Johnson, G.L.1    Stuhlmiller, T.J.2    Angus, S.P.3
  • 10
    • 33746263912 scopus 로고    scopus 로고
    • BRAF and NRAS mutations in melanoma and melanocytic nevi
    • Poynter J.N., Elder J.T., Fullen D.R., et al. BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res 2006, 16:267-273.
    • (2006) Melanoma Res , vol.16 , pp. 267-273
    • Poynter, J.N.1    Elder, J.T.2    Fullen, D.R.3
  • 11
    • 84864042630 scopus 로고    scopus 로고
    • BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma
    • Colombino M., Capone M., Lissia A., et al. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. JClin Oncol 2012, 30:2522-2529.
    • (2012) JClin Oncol , vol.30 , pp. 2522-2529
    • Colombino, M.1    Capone, M.2    Lissia, A.3
  • 12
    • 84883482902 scopus 로고    scopus 로고
    • Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436)
    • Nathanson K.L., Martin A.M., Wubbenhorst B., et al. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436). Clin Cancer Res 2013, 19:4868-4878.
    • (2013) Clin Cancer Res , vol.19 , pp. 4868-4878
    • Nathanson, K.L.1    Martin, A.M.2    Wubbenhorst, B.3
  • 13
    • 84901246811 scopus 로고    scopus 로고
    • Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort
    • Ascierto P.A., Simeone E., Sileni V.C., et al. Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort. JTransl Med 2014, 12:116.
    • (2014) JTransl Med , vol.12 , pp. 116
    • Ascierto, P.A.1    Simeone, E.2    Sileni, V.C.3
  • 14
    • 84864722943 scopus 로고    scopus 로고
    • NRAS mutation status is an independent prognostic factor in metastatic melanoma
    • Jakob J.A., Bassett R.L., Ng C.S., et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer 2012, 118:4014-4023.
    • (2012) Cancer , vol.118 , pp. 4014-4023
    • Jakob, J.A.1    Bassett, R.L.2    Ng, C.S.3
  • 15
    • 84902536316 scopus 로고    scopus 로고
    • Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma
    • Jeck W.R., Parker J., Carson C.C., et al. Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. Pigment Cell Melanoma Res 2014, 27:653-663.
    • (2014) Pigment Cell Melanoma Res , vol.27 , pp. 653-663
    • Jeck, W.R.1    Parker, J.2    Carson, C.C.3
  • 16
    • 80051988510 scopus 로고    scopus 로고
    • Aphase 2 trial of complete resection for stage IV melanoma: results of Southwest Oncology Group Clinical Trial S9430
    • Sosman J.A., Moon J., Tuthill R.J., et al. Aphase 2 trial of complete resection for stage IV melanoma: results of Southwest Oncology Group Clinical Trial S9430. Cancer 2011, 117:4740-4746.
    • (2011) Cancer , vol.117 , pp. 4740-4746
    • Sosman, J.A.1    Moon, J.2    Tuthill, R.J.3
  • 17
    • 84896714827 scopus 로고    scopus 로고
    • Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study
    • McArthur G.A., Chapman P.B., Robert C., et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol 2014, 15:323-332.
    • (2014) Lancet Oncol , vol.15 , pp. 323-332
    • McArthur, G.A.1    Chapman, P.B.2    Robert, C.3
  • 18
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A., Grob J.J., Demidov L.V., et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012, 380:358-365.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3
  • 19
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty K.T., Robert C., Hersey P., et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. NEngl J Med 2012, 367:107-114.
    • (2012) NEngl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 20
    • 84863393623 scopus 로고    scopus 로고
    • Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    • Wilmott J.S., Long G.V., Howle J.R., et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res 2012, 18:1386-1394.
    • (2012) Clin Cancer Res , vol.18 , pp. 1386-1394
    • Wilmott, J.S.1    Long, G.V.2    Howle, J.R.3
  • 21
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick D.T., Piris A., Cogdill A.P., et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res 2013, 19:1225-1231.
    • (2013) Clin Cancer Res , vol.19 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3
  • 22
    • 84866918738 scopus 로고    scopus 로고
    • Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma
    • Khalili J.S., Liu S., Rodriguez-Cruz T.G., et al. Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma. Clin Cancer Res 2012, 18:5329-5340.
    • (2012) Clin Cancer Res , vol.18 , pp. 5329-5340
    • Khalili, J.S.1    Liu, S.2    Rodriguez-Cruz, T.G.3
  • 23
    • 84865112760 scopus 로고    scopus 로고
    • BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy
    • Koya R.C., Mok S., Otte N., et al. BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy. Cancer Res 2012, 72:3928-3937.
    • (2012) Cancer Res , vol.72 , pp. 3928-3937
    • Koya, R.C.1    Mok, S.2    Otte, N.3
  • 24
    • 84859765844 scopus 로고    scopus 로고
    • Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
    • Duncan J.S., Whittle M.C., Nakamura K., et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 2012, 149:307-321.
    • (2012) Cell , vol.149 , pp. 307-321
    • Duncan, J.S.1    Whittle, M.C.2    Nakamura, K.3
  • 25
    • 84925961500 scopus 로고    scopus 로고
    • Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma (abstr 4761)
    • AACR Annual Meeting, April 5-9. San Diego, CA
    • Angus SP, Stuhlmiller TJ, Reuther R, etal. Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma (abstr 4761). AACR Annual Meeting, April 5-9. San Diego, CA, 2014.
    • (2014)
    • Angus, S.P.1    Stuhlmiller, T.J.2    Reuther, R.3
  • 27
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty K.T., Puzanov I., Kim K.B., et al. Inhibition of mutated, activated BRAF in metastatic melanoma. NEngl J Med 2010, 363:809-819.
    • (2010) NEngl J Med , vol.363 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 28
    • 84862908097 scopus 로고    scopus 로고
    • RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
    • Su F., Viros A., Milagre C., et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. NEngl J Med 2012, 366:207-215.
    • (2012) NEngl J Med , vol.366 , pp. 207-215
    • Su, F.1    Viros, A.2    Milagre, C.3
  • 29
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial
    • Long G.V., Trefzer U., Davies M.A., et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol 2012, 13:1087-1095.
    • (2012) Lancet Oncol , vol.13 , pp. 1087-1095
    • Long, G.V.1    Trefzer, U.2    Davies, M.A.3
  • 30
    • 84893661769 scopus 로고    scopus 로고
    • Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study
    • Dummer R., Goldinger S.M., Turtschi C.P., et al. Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study. Eur J Cancer 2014, 50:611-621.
    • (2014) Eur J Cancer , vol.50 , pp. 611-621
    • Dummer, R.1    Goldinger, S.M.2    Turtschi, C.P.3
  • 31
    • 84904191651 scopus 로고    scopus 로고
    • Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: implications for combination therapy for melanoma brain metastases
    • Vaidhyanathan S., Mittapalli R.K., Sarkaria J.N., et al. Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: implications for combination therapy for melanoma brain metastases. Drug Metab Dispos 2014, 42:1292-1300.
    • (2014) Drug Metab Dispos , vol.42 , pp. 1292-1300
    • Vaidhyanathan, S.1    Mittapalli, R.K.2    Sarkaria, J.N.3
  • 32
    • 84925961498 scopus 로고    scopus 로고
    • Initial results from a phase I, open-label, dose escalation study of the oral BRAF inhibitor LGX818 in patients with BRAF V600 mutant advanced or metastatic melanoma (abstr 9028)
    • May 31-June 2. Chicago, IL
    • Dummer R, Robert C, Nyakas M, etal. Initial results from a phase I, open-label, dose escalation study of the oral BRAF inhibitor LGX818 in patients with BRAF V600 mutant advanced or metastatic melanoma (abstr 9028). ASCO Annual Meeting, May 31-June 2. Chicago, IL, 2013.
    • (2013) ASCO Annual Meeting
    • Dummer, R.1    Robert, C.2    Nyakas, M.3
  • 33
    • 2442689239 scopus 로고    scopus 로고
    • Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
    • Rodriguez-Viciana P., Sabatier C., McCormick F. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 2004, 24:4943-4954.
    • (2004) Mol Cell Biol , vol.24 , pp. 4943-4954
    • Rodriguez-Viciana, P.1    Sabatier, C.2    McCormick, F.3
  • 34
    • 84875235432 scopus 로고    scopus 로고
    • MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
    • Ascierto P.A., Schadendorf D., Berking C., et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol 2013, 14:249-256.
    • (2013) Lancet Oncol , vol.14 , pp. 249-256
    • Ascierto, P.A.1    Schadendorf, D.2    Berking, C.3
  • 35
    • 84864371119 scopus 로고    scopus 로고
    • Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
    • Falchook G.S., Lewis K.D., Infante J.R., et al. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol 2012, 13:782-789.
    • (2012) Lancet Oncol , vol.13 , pp. 782-789
    • Falchook, G.S.1    Lewis, K.D.2    Infante, J.R.3
  • 36
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin J.A., Busam K., Pinkel D., et al. Somatic activation of KIT in distinct subtypes of melanoma. JClin Oncol 2006, 24:4340-4346.
    • (2006) JClin Oncol , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3
  • 38
    • 78649700287 scopus 로고    scopus 로고
    • Frequent mutation of BAP1 in metastasizing uveal melanomas
    • Harbour J.W., Onken M.D., Roberson E.D., et al. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science 2010, 330:1410-1413.
    • (2010) Science , vol.330 , pp. 1410-1413
    • Harbour, J.W.1    Onken, M.D.2    Roberson, E.D.3
  • 39
    • 84902588435 scopus 로고    scopus 로고
    • Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial
    • Carvajal R.D., Sosman J.A., Quevedo J.F., et al. Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial. JAMA 2014, 311:2397-2405.
    • (2014) JAMA , vol.311 , pp. 2397-2405
    • Carvajal, R.D.1    Sosman, J.A.2    Quevedo, J.F.3
  • 40
    • 84925961497 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the protein kinase C inhibitor AEB071 in patients with metastatic uveal melanoma (abstr 9030)
    • Chicago, IL
    • Piperno-Neumann S, Kapiteijn E, Larkin JM, etal. Phase I dose-escalation study of the protein kinase C inhibitor AEB071 in patients with metastatic uveal melanoma (abstr 9030). ASCO Annual Meeting. Chicago, IL, 2014.
    • (2014) ASCO Annual Meeting
    • Piperno-Neumann, S.1    Kapiteijn, E.2    Larkin, J.M.3
  • 41
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty K.T., Infante J.R., Daud A., et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. NEngl J Med 2012, 367:1694-1703.
    • (2012) NEngl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 42
    • 84908257665 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
    • Long G.V., Stroyakovskiy D., Gogas H., et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med 2014, 371:1877-1888.
    • (2014) N Engl J Med , vol.371 , pp. 1877-1888
    • Long, G.V.1    Stroyakovskiy, D.2    Gogas, H.3
  • 43
    • 84904916223 scopus 로고    scopus 로고
    • Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study
    • Ribas A., Gonzalez R., Pavlick A., et al. Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study. Lancet Oncol 2014, 15:954-965.
    • (2014) Lancet Oncol , vol.15 , pp. 954-965
    • Ribas, A.1    Gonzalez, R.2    Pavlick, A.3
  • 44
    • 84916934286 scopus 로고    scopus 로고
    • Preliminary results from a phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in BRAF V600-dependent advanced solid tumors (abstr 9029)
    • ASCO Annual Meeting, May 31-June 2. Chicago, IL
    • Kefford R, Miller WH, Tan DS, etal. Preliminary results from a phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in BRAF V600-dependent advanced solid tumors (abstr 9029). ASCO Annual Meeting, May 31-June 2. Chicago, IL, 2013.
    • (2013)
    • Kefford, R.1    Miller, W.H.2    Tan, D.S.3
  • 45
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong L.N., Costello J.C., Liu H., et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med 2012, 18:1503-1510.
    • (2012) Nat Med , vol.18 , pp. 1503-1510
    • Kwong, L.N.1    Costello, J.C.2    Liu, H.3
  • 46
    • 84925961496 scopus 로고    scopus 로고
    • A phase 1b/2 study of LEE011 in combination with binimetinib (MEK162) in patients with NRAS-mutant melanoma: Early encouraging clinical activity (abstr 9009)
    • ASCO (ed): ASCO 2014 Annual Meeting, May 30-June 3. Chicago, IL.
    • Sosman JA, Kittaneh M, Lolkema MP, etal. A phase 1b/2 study of LEE011 in combination with binimetinib (MEK162) in patients with NRAS-mutant melanoma: Early encouraging clinical activity (abstr 9009). In ASCO (ed): ASCO 2014 Annual Meeting, May 30-June 3. Chicago, IL.
    • Sosman, J.A.1    Kittaneh, M.2    Lolkema, M.P.3
  • 47
    • 84856021675 scopus 로고    scopus 로고
    • New challenges in endpoints for drug development in advanced melanoma
    • Ribas A., Hersey P., Middleton M.R., et al. New challenges in endpoints for drug development in advanced melanoma. Clin Cancer Res 2012, 18:336-341.
    • (2012) Clin Cancer Res , vol.18 , pp. 336-341
    • Ribas, A.1    Hersey, P.2    Middleton, M.R.3
  • 48
    • 84892738557 scopus 로고    scopus 로고
    • Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy
    • Mok S., Koya R.C., Tsui C., et al. Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy. Cancer Res 2014, 74:153-161.
    • (2014) Cancer Res , vol.74 , pp. 153-161
    • Mok, S.1    Koya, R.C.2    Tsui, C.3
  • 49
    • 84872514398 scopus 로고    scopus 로고
    • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
    • Liu C., Peng W., Xu C., et al. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res 2013, 19:393-403.
    • (2013) Clin Cancer Res , vol.19 , pp. 393-403
    • Liu, C.1    Peng, W.2    Xu, C.3
  • 50
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A., Cogdill A.P., Dang P., et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010, 70:5213-5219.
    • (2010) Cancer Res , vol.70 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3
  • 51
    • 84912135461 scopus 로고    scopus 로고
    • Phase 1 study of the BRAF inhibitor dabrafenib with or without the MEK inhibitor trametinib in combination with ipilimumab for V600E/K mutation-positive unresectable or metastatic melanoma (abstr 2511)
    • ASCO Annual Meeting, May 30-June 3. Chicago, IL
    • Puzanov I, Callahan MK, Linette GP, etal. Phase 1 study of the BRAF inhibitor dabrafenib with or without the MEK inhibitor trametinib in combination with ipilimumab for V600E/K mutation-positive unresectable or metastatic melanoma (abstr 2511), ASCO Annual Meeting, May 30-June 3. Chicago, IL, 2014.
    • (2014)
    • Puzanov, I.1    Callahan, M.K.2    Linette, G.P.3
  • 52
    • 84887478023 scopus 로고    scopus 로고
    • Tumor adaptation and resistance to RAF inhibitors
    • Lito P., Rosen N., Solit D.B. Tumor adaptation and resistance to RAF inhibitors. Nat Med 2013, 19:1401-1409.
    • (2013) Nat Med , vol.19 , pp. 1401-1409
    • Lito, P.1    Rosen, N.2    Solit, D.B.3
  • 53
    • 84907997599 scopus 로고    scopus 로고
    • The nature and management of metastatic melanoma after progression on BRAF inhibitors: effects of extended BRAF inhibition
    • Chan M.M., Haydu L.E., Menzies A.M., et al. The nature and management of metastatic melanoma after progression on BRAF inhibitors: effects of extended BRAF inhibition. Cancer 2014, 120:3142-3153.
    • (2014) Cancer , vol.120 , pp. 3142-3153
    • Chan, M.M.1    Haydu, L.E.2    Menzies, A.M.3
  • 54
    • 84891893623 scopus 로고    scopus 로고
    • Anovel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition
    • Shi H., Hong A., Kong X., et al. Anovel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition. Cancer Discov 2014, 4:69-79.
    • (2014) Cancer Discov , vol.4 , pp. 69-79
    • Shi, H.1    Hong, A.2    Kong, X.3
  • 55
    • 84879496934 scopus 로고    scopus 로고
    • Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
    • Trunzer K., Pavlick A.C., Schuchter L., et al. Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. JClin Oncol 2013, 31:1767-1774.
    • (2013) JClin Oncol , vol.31 , pp. 1767-1774
    • Trunzer, K.1    Pavlick, A.C.2    Schuchter, L.3
  • 56
    • 84902811306 scopus 로고    scopus 로고
    • A phase I trial of BKM120 combined with vemurafenib in BRAFV600E/k mutant advanced melanoma (abstr 9101)
    • ASCO Annual Meeting, May 30-June 3. Chicago, IL
    • Algazi AP, Posch C, Ortiz-Urda S, etal. A phase I trial of BKM120 combined with vemurafenib in BRAFV600E/k mutant advanced melanoma (abstr 9101), ASCO Annual Meeting, May 30-June 3. Chicago, IL, 2014.
    • (2014)
    • Algazi, A.P.1    Posch, C.2    Ortiz-Urda, S.3
  • 57
    • 84883477049 scopus 로고    scopus 로고
    • BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage
    • Mar V.J., Wong S.Q., Li J., et al. BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage. Clin Cancer Res 2013, 19:4589-4598.
    • (2013) Clin Cancer Res , vol.19 , pp. 4589-4598
    • Mar, V.J.1    Wong, S.Q.2    Li, J.3
  • 58
    • 84899513979 scopus 로고    scopus 로고
    • Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
    • Nissan M.H., Pratilas C.A., Jones A.M., et al. Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res 2014, 74:2340-2350.
    • (2014) Cancer Res , vol.74 , pp. 2340-2350
    • Nissan, M.H.1    Pratilas, C.A.2    Jones, A.M.3
  • 59
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
    • Cerami E., Gao J., Dogrusoz U., et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012, 2:401-404.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 60
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao J., Aksoy B.A., Dogrusoz U., et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013, 6:pl1.
    • (2013) Sci Signal , vol.6 , pp. pl1
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.