Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery

Journal of Trauma and Acute Care Surgery

Volumn 78, Issue 2, 2015, Pages 282-288

  McIlroy, Daniel J ^a   Bigland, Mark ^a,c   White, Amanda E ^a   Hardy, Benjamin M ^a   Lott, Natalie ^b   Smith, Doug W ^a,c   Balogh, Zsolt J ^b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

DAMPs; mtDNA; SIRS; Trauma

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CELL NUCLEUS DNA; CREATINE KINASE; LACTATE DEHYDROGENASE; MITOCHONDRIAL DNA; BIOLOGICAL MARKER; DNA;

ADULT; CELL DEATH; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FLUID RESUSCITATION; HUMAN; INJURY; INJURY SCALE; LENGTH OF STAY; MALE; MULTIPLE TRAUMA; PERIOPERATIVE PERIOD; PILOT STUDY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; TIME TO TREATMENT; TISSUE NECROSIS; TRAUMATOLOGY; BLOOD; BLOOD TRANSFUSION; CASE CONTROL STUDY; FLUID THERAPY; NECROSIS; ORTHOPEDIC SURGERY; POLYMERASE CHAIN REACTION; STATISTICS AND NUMERICAL DATA; WOUNDS AND INJURIES;

ADULT; ASPARTATE AMINOTRANSFERASES; BIOMARKERS; BLOOD TRANSFUSION; CASE-CONTROL STUDIES; CREATINE KINASE; DNA; DNA, MITOCHONDRIAL; FEMALE; FLUID THERAPY; HUMANS; INJURY SEVERITY SCORE; L-LACTATE DEHYDROGENASE; MALE; NECROSIS; ORTHOPEDIC PROCEDURES; PILOT PROJECTS; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; WOUNDS AND INJURIES;

EID: 84925943331     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000519     Document Type: Conference Paper

References (33)

1. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, JungerW, Brohi K, Itagaki K, Hauser C. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285):104-107.
2. Zhang Q, Itagaki K, Hauser CJ. Mitochondrial DNA is released by shock and activates neutrophils via p38 MAP kinase. Shock. 2010;34(1):55-59.
3. Hauser C, Sursal T, Rodriguez EK, Appleton PT, Zhang Q, Itagaki K. Mitochondrial DAMPs from femoral reamings activate neutrophils via formyl peptide receptors and P44/42 MAP kinase. J Orthop Trauma. 2010;24(9):534-538.
4. Harris H, Raucci A. Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep. 2006;7:774-778.
5. Sagan L. On the origin of mitosing cells. J Theor Biol. 1967;14:255-274.
6. Andersson S, Karlberg O, Canback B, Kurland C. On the origin of mitochondria: a genomics perspective. Phil Trans R Soc Lond B. 2003;358:165-179.
7. Hemmi H, TakeuchiO, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, et al.A toll-like receptor recognizes bacterial DNA. Nature. 2000;408:740-745.
8. Hochhauser D. Relevance of mitochondrial DNA in cancer. Lancet. 2000;356:181-182.
9. Balogh ZJ, Reumann MK, Gruen RL, Mayer-Kuckuk P, Schuetz MA, Harris IA, Gabbe BJ. Advances and future directions for management of trauma patients with musculoskeletal injuries. Lancet. 2012;380:1109-1119.
10. Yamanouchi S, Kudo D, Yamada M, Miyagawa N, Furukawa H, Kushimoto S. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status. J Crit Care. 2013;28: 1027-1031.
11. Lo YM, Rainer TH, Chan LY, Hjelm NM, Cocks RA. Plasma DNA as a prognostic marker in trauma patients. Clin Chem. 2000;46:319-323.
12. Pape HC, Grimme K, Van Griensven M, Sott A, Giannoudis P, Morley J, Roise O, Ellingsen E, Hildebrand F, Wiese B, et al. Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group. J Trauma. 2003;55(1):7-13.
13. Pape HC, van Griensven M, Rice J, Gänsslen A, Hildebrand F, Zech S, Winny M, Lichtinghagen R, Krettek C. Major secondary surgery in blunt trauma patients and perioperative cytokine liberation: determination of the clinical relevance of biochemical markers. J Trauma. 2001;50(6):989-1000.
14. Muckart DJ, Bhagwanjee S. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med. 1997;25:1789-1795.
15. Ciesla DJ, Moore EE, Johnson JL, Burch JM, Cothren CC, Sauaia A. A 12- year prospective study of postinjury multiple organ failure: has anything changed? Arch Surg. 2005;140:432-438;discussion 438-440.
16. Chiu R, Chan L, Lam N, Tsui N, Ng E, Rainer T, Lo YM. Quantitative analysis of circulating mitochondrial DNA in plasma. Clin Chem. 2003;49(5):719-726.
17. Seaman MA, Levin JR, Serlin RC. New developments in pairwise multiple comparisons: some powerful and practicable procedures. Psychol Bull. 1991;110:577-586.
18. Margraf S, Lögters T, Reipen J, Altrichter J, Scholz M, Windolf J. Neutrophilderived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis. Shock. 2008;30(4):352-358.
19. Lam N, Rainer T, Chiu R, Joynt G, Lo Y. Plasma mitochondrial DNA concentrations after trauma. Clin Chem. 2004;50(1):213-216.
20. Lam N, Rainer T, Chan L, Joynt G, Lo Y. Time course of early and late changes in plasma DNA in trauma patients. Clin Chem. 2003;49(8):1286-1291.
21. Sursal T, Stearns-Kurosawa D, Itagaki K, Oh SY, Sun S, Kurosawa S, Hauser C. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 2013;39(1):55-62.
22. Fleischhacker M, Schmidt B. Circulating nucleic acids (CNAs) and cancerVa survey. Biochim Biophys Acta. 2007;1775:181-232.
23. van der Vaart M, Pretorius PJ, Circulating DNA. Its origin and fluctuation. Ann N Y Acad Sci. 2008;1137:18-26.
24. Gaipl US, Sheriff A, Franz S, Munoz LE, Voll RE, Kalden JR, Herrmann M. Inefficient clearance of dying cells and autoreactivity. Curr Topic Microbiol Immunol. 2006;305:161-176.
25. Ballard JW, Whitlock MC. The incomplete natural history of mitochondria. Mol Ecol. 2004;13:729-744.
26. Yousefi S, Mihalache C, Kozlowski E, Schmid I, Simon H. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ. 2009;16:1438-1444.
27. Yousefi S, Gold J, Andina N, Lee J, Kelly A, Kozlowski E, Schmid I, Straumann A, Reichenbach J, Gleich G, et al.Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med. 2007;14(9):949-953.
28. Brinkmann V, Zychlinsky A. Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol. 2012;198(5):773-783.
29. Brinkmann V, Zychlinsky A. Beneficial suicide: why neutrophils die to make NETs. Nat Rev Microbiol. 2007;5(8):577-582.
30. McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ. Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery. J Crit Care. 2014;29:1133.e1-5.
31. Gu X, Yao Y, Wu G, Lv T, Luo L, Song Y, The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome. PloS One. 8(8):e72834.
32. Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Gonzalez RP, Gillespie MN, Richards WO. Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. Ann Surg. 2013;258:591-596; discussion 596-598.
33. Balogh ZJ, McIlroy DJ, Smith DW, Hansbro PM. The origin and the role of mitochondrial DNA in post-injury inflammation. J Crit Care. 2013;28: 1099-1100.