Preliminary study of the effects of β-elemene on MCF-7/ADM breast cancer stem cells

Genetics and Molecular Research

Volumn 14, Issue 1, 2015, Pages 2347-2355

  Dong, Y ^a   Li, L ^a   Wang, L ^a   Zhou, T ^a   Liu, J W ^a   Gao, Y J ^a  

^a First Affiliated Hospital   (China)

Author keywords

Breast cancer stem cells (BCSCs); Drug resistance protein; elemene

Indexed keywords

BETA ELEMENE; BREAST CANCER RESISTANCE PROTEIN; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC ANTIBIOTIC; BETA-ELEMENE; CULTURE MEDIUM; SESQUITERPENE; TUMOR PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MCF 7 ADM CELL LINE; MCF 7 CELL LINE; MCF 7 S CELL LINE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BREAST TUMOR; CULTURE MEDIUM; CULTURE TECHNIQUE; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHARMACOLOGY; PROCEDURES;

ANTIBIOTICS, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CULTURE MEDIA, SERUM-FREE; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SESQUITERPENES; SPHEROIDS, CELLULAR;

EID: 84925936055     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2015.March.27.20     Document Type: Article

References (11)

1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, et al. (2003). Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 10: 3983-3988.
2. Clarke MF, Dick JE, Dirks PB, Eaves CJ, et al. (2006). Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 66: 9339-9344.
3. Clayton H, Titley I and Vivanco Md (2004). Growth and differentiation of progenitor/stem cells derived from the human mammary gland. Exp. Cell. Res. 15: 444-460.
4. Kondo T, Setoguchi T and Taga T (2004). Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc. Natl. Acad. Sci. U. S. A. 20: 781-786.
5. Kawabata S, Oka M, Shiozawa K, Tsukamoto K, et al. (2001). Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. Biochem. Biophys. Res. Commun. 280: 1216-1223.
6. Ponti D, Costa A, Zaffaroni N, Pratesi G, et al. (2005). Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 65: 5506-5511.
7. Phillips TM, McBride WH and Pajonk F (2006). The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J. Natl. Cancer Inst. 98: 1777-1785.
8. Scharenberg CW, Harkey MA and Torok-Storb B (2002). The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 15: 507-512.
9. Tang XH, Qin SD and Xie K (2010). Status and progress of basic researches of elemene injection for antitumor. Lin Chuang Zhang Liu Za Zhi 3: 266-273.
10. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, et al. (2001). The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat. Med. 7: 1028-1034.
11. Zhou S, Morris JJ, Barnes Y, Lan L, et al. (2002). Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 17: 12339-12344.