Ghrelin, reward and motivation

Endocrine Development

Volumn 25, Issue , 2013, Pages 101-111

  Menzies, John R W ^a   Skibicka, Karolina P ^b   Leng, Gareth ^a   Dickson, Suzanne L ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; OPIATE RECEPTOR;

ARTICLE; BRAIN; BRAIN REGION; FEEDING BEHAVIOR; FOOD INTAKE; FOOD PREFERENCE; HUMAN; HUNGER; HYPOTHALAMUS; INTESTINE; MOTIVATION; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REWARD; SEX;

EID: 84925872574     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000346058     Document Type: Article

References (53)

1. Volkow ND, Wang GJ, Telang F, Fowler JS, Thanos PK, Logan J, Alexoff D, Ding YS, Wong C, Ma Y, Pradhan K: Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage 2008; 42: 1537-1543.
2. Stice E, Yokum S, Blum K, Bohon C: Weight gain is associated with reduced striatal response to palatable food. J Neurosci 2010; 30: 13105-13109.
3. Stice E, Spoor S, Bohon C, Small DM: Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science 2008; 322: 449-452.
4. Geiger BM, Behr GG, Frank LE, Caldera-Siu AD, Beinfeld MC, Kokkotou EG, Pothos EN: Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB J 2008; 22: 2740-2746.
5. Olds J: Self-stimulation of the brain: its use to study local effects of hunger, sex, and drugs. Science 1958; 127: 315-324.
6. Johnson PM, Kenny PJ: Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 2010; 13: 635-641.
7. Avena NM, Rada P, Hoebel BG: Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 2008; 32: 20-39.
8. van der Lely AJ, Tschöp M, Heiman ML, Ghigo E: Biological, physiological, pathophysiological, and pharm a cological aspects of ghrelin. Endocr Rev 2004; 25: 426-457.
9. Menzies JRW, Skibicka KP, Egecioglu E, Leng G, Dickson SL: Peripheral signals modifying food reward. Handb Exp Pharmacol 2012; 209: 131-158.
10. Scott V, McDade DM, Luckman SM: Rapid changes in the sensitivity of arcuate nucleus neurons to central ghrelin in relation to feeding status. Physiol Behav 2007; 90: 180-185.
11. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, Van der Ploeg LH, Howard AD: Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997; 48: 23-29.
12. Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL: Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 2006; 116: 3229-3239.
13. Jerlhag E, Egecioglu E, Dickson SL, Douhan A, Svensson L, Engel JA: Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol 2007; 12: 6-16.
14. Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A: Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states. Neuroscience 2009; 161: 855-864.
15. Jerlhag E, Egecioglu E, Dickson SL, Andersson M, Svensson L, Engel JA: Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict Biol 2006; 11: 45-54.
16. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
17. Kojima M: The discovery of ghrelin - a personal memory. Regul Pept 2008; 145: 2-6.
18. Tschöp M, Smiley DL, Heiman ML: Ghrelin induces adiposity in rodents. Nature 2000; 407: 908-913.
19. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR: The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000; 141: 4325-4328.
20. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198.
21. Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, Heiman ML, Lehnert P, Fichter M, Tschöp M: Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001; 145: 669-673.
22. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML: Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50: 707-709.
23. Skibicka KP, Dickson SL: Ghrelin and food reward: the story of potential underlying substrates. Peptides 2011; 32: 2265-2273.
24. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR: Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50: 2540-2547.
25. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M: Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001; 120: 337-345.
26. Naleid AM, Grace MK, Cummings DE, Levine AS: Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 2005; 26: 2274-2279.
27. Skibicka KP, Hansson C, Alvarez-Crespo M, Friberg PA, Dickson SL: Ghrelin directly targets the ventral tegmental area to increase food motivation. Neuroscience 2011; 180: 129-137.
28. Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW: High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol Endocrinol 2003; 17: 2201-2210.
29. Jiang H, Betancourt L, Smith RG: Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol 2006; 20: 1772-1785.
30. Lenoir M, Serre F, Cantin L, Ahmed SH: Intense sweetness surpasses cocaine reward. PLoS One 2007; 2:e698.
31. Egecioglu E, Jerlhag E, Salom N, Skibicka KP, Haage D, Bohlooly-Y M, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL: Ghrelin increases intake of rewarding food in rodents. Addict Biol 2010; 15: 304-311.
32. Disse E, Bussier AL, Deblon N, Pfluger PT, Tschöp MH, Laville M, Rohner-Jeanrenaud F: Systemic ghrelin and reward: effect of cholinergic blockade. Physiol Behav 2011; 102: 481-484.
33. Perello M, Sakata I, Birnbaum S, Chuang JC, Osborne-Lawrence S, Rovinsky SA, Woloszyn J, Yanagisawa M, Lutter M, Zigman JM: Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol Psychiatry 2010; 67: 880-886.
34. Tordoff MG, Alarcon LK, Lawler MP: Preferences of 14 rat strains for 17 taste compounds. Physiol Behav 2008; 95: 308-332.
35. Domingos AI, Vaynshteyn J, Voss HU, Ren X, Gradinaru V, Zang F, Deisseroth K, de Araujo IE, Friedman J: Leptin regulates the reward value of nutrient. Nat Neurosci 2011; 14: 1562-1568.
36. Disse E, Bussier AL, Veyrat-Durebex C, Deblon N, Pfluger PT, Tschöp MH, Laville M, Rohner-Jeanrenaud F: Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content. Physiol Behav 2010; 101: 277-281.
37. Skibicka KP, Hansson C, Egecioglu E, Dickson SL: Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addict Biol 2012; 17: 95-107.
38. Weinberg ZY, Nicholson ML, Currie PJ: 6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior. Neurosci Lett 2011; 499: 70-73.
39. Skibicka KP, Shirazi RH, Hansson C, Dickson SL: Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward. Endocrinology 2012; 153: 1194-1205.
40. Verhagen LA, Egecioglu E, Luijendijk MC, Hillebrand JJ, Adan RA, Dickson SL: Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity. Eur Neuropsychopharmacol 2011; 21: 384-392.
41. Merkestein M, Brans MA, Luijendijk MC, de Jong JW, Egecioglu E, Dickson SL, Adan RA: Ghrelin mediates anticipation to a palatable meal in rats. Obesity (Silver Spring) 2012; 20: 963-971.
42. Malik S, McGlone F, Bedrossian D, Dagher A: Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 2008; 7: 400-409.
43. Roa J, Garca-Galiano D, Castellano JM, Gaytan F, Pinilla L, Tena-Sempere M: Metabolic control of puberty onset: new players, new mechanisms. Mol Cell Endocrinol 2010; 324: 87-94.
44. Shah SN, Nyby JG: Ghrelin's quick inhibition of androgen-dependent behaviors of male house mice ( Mus musculus ). Horm Behav 2010; 57: 291-296.
45. Caquineau C, Leng G, Douglas AJ: Sexual behaviour and neuronal activation in the vomeronasal pathway and hypothalamus of food-deprived male rats. J Neuroendocrinol 2012; 24: 712-723.
46. Bertoldi ML, Luque EM, Carlini VP, Vincenti LM, Stutz G, Santilln ME, Ruiz RD, Fiol de Cuneo M, Martini AC: Inhibitory effects of ghrelin on sexual behavior: role of the peptide in the receptivity reduction induced by food restriction in mice. Horm Metab Res 2011; 43: 494-499.
47. Jerlhag E, Egecioglu E, Landgren S, Salom N, Heilig M, Moechars D, Datta R, Perrissoud D, Dickson SL, Engel JA: Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci USA 2009; 106: 11318-11323.
48. Jerlhag E, Engel JA: Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice. Drug Alcohol Depend 2011; 117: 126-131.
49. Jerlhag E, Egecioglu E, Dickson SL, Engel JA: Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. Psychopharmacology 2010; 211: 415-422.
50. Jerlhag E: Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 2008; 13: 358-363.
51. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ: Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623-1630.
52. Briggs DI, Enriori PJ, Lemus MB, Cowley MA, Andrews ZB: Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons. Endocrinology 2010; 151: 4745-4755.
53. Finger BC, Dinan TG, Cryan JF: Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task. Psychopharmacology (Berl) 2012; 220: 173-181.