The brain-stomach connection

How Gut and Brain Control Metabolism

Volumn 42, Issue , 2014, Pages 83-92

  Folgueira, C ^a,c   Seoane, L M ^a,c   Casanueva, F F ^b,c  

^a Santiago University Clinical Hospital   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^c Instituto de Salud Carlos III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84925866319     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1159/000358316     Document Type: Chapter

References (25)

1. Al-Massadi O, Pardo M, Casanueva FF, Seoane LM: The stomach as an energy homeostasis regulating center. An approach for obesity. Recent Pat Endocr Metab Immune Drug Discov 2010; 4: 75-84.
2. Sawchenko PE: Central connections of the sensory and motor nuclei of the vagus nerve. J Auton Nerv Syst 1983; 9: 13-26.
3. Berthoud HR: The vagus nerve, food intake and obesity. Regul Pept 2008; 149: 15-25.
4. Konturek SJ, Brzozowski T, Konturek PC, Schubert ML, Pawlik WW, Padol S, Bayner J: Brain-gut and appetite regulating hormones in the control of gastric secretion and mucosal protection. J Physiol Pharmacol 2008; 59(suppl 2):7-31.
5. Seoane LM, Al-Massadi O, Caminos JE, Tovar SA, Dieguez C, Casanueva FF: Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. An ex vivo organ culture study. Endocrinology 2007; 148: 3998-4006.
6. Rehfeld JF: Accurate measurement of cholecystokinin in plasma. Clin Chem 1998; 44: 991-1001.
7. Seoane LM, Lopez M, Tovar S, Casanueva FF, Senaris R, Dieguez C: Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 2003; 144: 544-551.
8. Komarowska H, Jaskula M, Stangierski A, Wasko R, Sowinski J, Ruchala M: Influence of ghrelin on energy balance and endocrine physiology. Neuro Endocrinol Lett 2012; 33: 749-756.
9. Garcia-Galiano D, Tena-Sempere M: Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction. Curr Pharm Des 2013; 19: 6966-6972.
10. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
11. Al Massadi O, Tschop MH, Tong J: Ghrelin acylation and metabolic control. Peptides 2011; 32: 2301-2308.
12. Wren AM, Bloom SR: Gut hormones and appetite control. Gastroenterology 2007; 132: 2116-2130.
13. Seoane LM, Al-Massadi O, Barreiro F, Dieguez C, Casanueva FF: Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. J Endocrinol Invest 2007; 30: RC22-RC25.
14. Oh IS, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M: Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443: 709-712.
15. Goebel-Stengel M, Wang L: Central and peripheral expression and distribution of NUBC2/nesfatin-1. Curr Pharm Des 2014, Epub ahead of print.
16. Stengel A, Goebel M, Tache Y: Nesfatin-1: a novel inhibitory regulator of food intake and body weight. Obes Rev 2011; 12: 261-271.
17. Kirkham TC, Williams CM: Endogenous cannabinoids and appetite. Nutr Res Rev 2001; 14: 65-86 .
18. Di Marzo V, Petrosino S: Endocannabinoids and the regulation of their levels in health and disease. Curr Opin Lipidol 2007; 18: 129-140.
19. Burdyga G, Lal S, Varro A, Dimaline R, Thompson DG, Dockray GJ: Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 2004; 24: 2708-2715.
20. Senin L, Al-Massadi O, Folgueira C, Castelao C, Pardo M, Barja-Fernandez S, Roca-Rivada A, Amil M, Crujeiras AB, Garcia-Caballero T, Gabellieri E, Leis R, Dieguez C, Pagotto U, Casanueva FF, Seoane LM: Gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake. PLoS One 2013; 8:e80339.
21. Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 2006; 124: 471-484.
22. Khamzina L, Veilleux A, Bergeron S, Marette A: Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 2005; 146: 1473-1481.
23. Xu G, Li Y, An W, Li S, Guan Y, Wang N, Tang C, Wang X, Zhu Y, Li X, Mulholland MW, Zhang W: Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 2009; 150: 3637-3644.
24. Li Z, Xu G, Li Y, Zhao J, Mulholland MW, Zhang W: mTOR-dependent modulation of gastric nesfatin-1/NUCB2. Cell Physiol Biochem 2012; 29: 493-500.
25. Gomez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodriguez de Fonseca F: A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002; 22: 9612-9617.