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Volumn 10, Issue 2, 2015, Pages 90-95

Dynamic models of viral replication and latency

Author keywords

Cure; Dynamic model; HIV; Latency; Transcriptome dynamics

Indexed keywords

CD4+ T LYMPHOCYTE; DYNAMIC MODEL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATHEMATICAL ANALYSIS; MECHANISTIC MODEL; MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STATISTICAL MODEL; VIRUS CELL INTERACTION; VIRUS LATENCY; VIRUS PATHOGENESIS; VIRUS REACTIVATION; VIRUS REPLICATION; BIOLOGICAL MODEL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84925856204     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000136     Document Type: Review
Times cited : (8)

References (38)
  • 2
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney JB, Hill AL, Sanisetty S, et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 2014;512:74-77. This study shows that the viral reservoir is established very early in an animal model.
    • (2014) Nature , vol.512 , pp. 74-77
    • Whitney, J.B.1    Hill, A.L.2    Sanisetty, S.3
  • 3
    • 84905570028 scopus 로고    scopus 로고
    • HIV: Early treatment may not be early enough
    • Deng K, Siliciano RF. HIV: early treatment may not be early enough. Nature 2014;512:35-36.
    • (2014) Nature , vol.512 , pp. 35-36
    • Deng, K.1    Siliciano, R.F.2
  • 4
    • 84907267733 scopus 로고    scopus 로고
    • AIDS/HIV rekindled HIV infection
    • Siliciano JD, Siliciano RF. AIDS/HIV rekindled HIV infection. Science 2014;345:1005-1006.
    • (2014) Science , vol.345 , pp. 1005-1006
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 5
    • 84893830170 scopus 로고    scopus 로고
    • Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
    • Fletcher CV, Staskus K, Wietgrefe SW, et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci U S A 2014;111:2307-2312.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 2307-2312
    • Fletcher, C.V.1    Staskus, K.2    Wietgrefe, S.W.3
  • 7
    • 0037356314 scopus 로고    scopus 로고
    • Reservoirs, sanctuaries, and residual disease: The hiding spots of HIV-1
    • Pomerantz RJ. Reservoirs, sanctuaries, and residual disease: the hiding spots of HIV-1. HIV Clin Trials 2003;4:137-143.
    • (2003) HIV Clin Trials , vol.4 , pp. 137-143
    • Pomerantz, R.J.1
  • 8
    • 81855218589 scopus 로고    scopus 로고
    • HIV reservoirs and the possibility of a cure for HIV infection
    • Palmer S, Josefsson L, Coffin JM. HIV reservoirs and the possibility of a cure for HIV infection. J Intern Med 2011;270:550-560.
    • (2011) J Intern Med , vol.270 , pp. 550-560
    • Palmer, S.1    Josefsson, L.2    Coffin, J.M.3
  • 9
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont N, El-Far M, Ancuta P, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009;15:893-900.
    • (2009) Nat Med , vol.15 , pp. 893-900
    • Chomont, N.1    El-Far, M.2    Ancuta, P.3
  • 10
    • 84893761231 scopus 로고    scopus 로고
    • +T cells with stem celllike properties
    • +T cells with stem celllike properties. Nat Med 2014;20:139-142.
    • (2014) Nat Med , vol.20 , pp. 139-142
    • Buzon, M.J.1    Sun, H.2    Li, C.3
  • 11
    • 84892845657 scopus 로고    scopus 로고
    • + T cells from aviremic patients
    • + T cells from aviremic patients. PLoS Pathog 2013;9:e1003834. This study reveals the multifactorial nature of latently infected cells, being reactivated differently depending on the latency reactivating agent.
    • (2013) PLoS Pathog , vol.9 , pp. e1003834
    • Spina, C.A.1    Anderson, J.2    Archin, N.M.3
  • 12
    • 84901671711 scopus 로고    scopus 로고
    • + T cell model
    • + T cell model. PLoS Pathog 2014;10:e1004156. The first temporal analysis of the joint viral and cellular transcriptome in a latency model. This study highlights posttranscriptional block and cellular activation status as components of latency.
    • (2014) PLoS Pathog , vol.10 , pp. e1004156
    • Mohammadi, P.1    Di Iulio, J.2    Munoz, M.3
  • 13
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson S, Graf EH, Dahl V, et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog 2013;9:e1003174. This study compares the different methods currently used to assess the size of the reservoir.
    • (2013) PLoS Pathog , vol.9 , pp. e1003174
    • Eriksson, S.1    Graf, E.H.2    Dahl, V.3
  • 14
    • 84878482232 scopus 로고    scopus 로고
    • Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    • Laird GM, Eisele EE, Rabi SA, et al. Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay. PLoS Pathog 2013;9:e1003398.
    • (2013) PLoS Pathog , vol.9 , pp. e1003398
    • Laird, G.M.1    Eisele, E.E.2    Rabi, S.A.3
  • 15
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho YC, Shan L, Hosmane NN, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 2013;155:540-551.
    • (2013) Cell , vol.155 , pp. 540-551
    • Ho, Y.C.1    Shan, L.2    Hosmane, N.N.3
  • 16
    • 84900473405 scopus 로고    scopus 로고
    • + T cells from patients on suppressive antiretroviral therapy
    • + T cells from patients on suppressive antiretroviral therapy. Proc Natl Acad Sci U S A 2014;111:7078-7083. This study shows that SAHA, a latency reactivating agent, fails to induce viral particle production.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 7078-7083
    • Cillo, A.R.1    Sobolewski, M.D.2    Bosch, R.J.3
  • 17
    • 84900466413 scopus 로고    scopus 로고
    • Measuring reversal of HIV-1 latency ex vivo using cells from infected individuals
    • Ho YC, Laird GM, Siliciano RF. Measuring reversal of HIV-1 latency ex vivo using cells from infected individuals. Proc Natl Acad Sci U S A 2014;111:6860-6861. This study highlights the discrepancy among the defective viral reservoir, the inducible viral reservoir, and the induced viral reservoir.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 6860-6861
    • Ho, Y.C.1    Laird, G.M.2    Siliciano, R.F.3
  • 18
    • 84883171584 scopus 로고    scopus 로고
    • Modeling the within-host dynamics of HIV infection
    • Perelson AS, Ribeiro RM. Modeling the within-host dynamics of HIV infection. BMC Biol 2013;11:96.
    • (2013) BMC Biol , vol.11 , pp. 96
    • Perelson, A.S.1    Ribeiro, R.M.2
  • 19
    • 84885060782 scopus 로고    scopus 로고
    • Mathematical models of viral latency
    • Selinger C, Katze MG. Mathematical models of viral latency. Curr Opin Virol 2013;3:402-407.
    • (2013) Curr Opin Virol , vol.3 , pp. 402-407
    • Selinger, C.1    Katze, M.G.2
  • 20
    • 84925883421 scopus 로고    scopus 로고
    • Mathematical models of HIV replication and pathogenesis
    • Wodarz D. Mathematical models of HIV replication and pathogenesis. Methods Mol Biol 2014;1184:563-581.
    • (2014) Methods Mol Biol , vol.1184 , pp. 563-581
    • Wodarz, D.1
  • 21
    • 84891681304 scopus 로고    scopus 로고
    • Intracellular dynamics of HIV infection
    • Petravic J, Ellenberg P, Chan ML, et al. Intracellular dynamics of HIV infection. J Virol 2014;88:1113-1124.
    • (2014) J Virol , vol.88 , pp. 1113-1124
    • Petravic, J.1    Ellenberg, P.2    Chan, M.L.3
  • 22
    • 84878981012 scopus 로고    scopus 로고
    • Barriers to a cure for HIV: New ways to target and eradicate HIV-1 reservoirs
    • Katlama C, Deeks SG, Autran B, et al. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet 2013;381:2109-2117.
    • (2013) Lancet , vol.381 , pp. 2109-2117
    • Katlama, C.1    Deeks, S.G.2    Autran, B.3
  • 23
    • 84904128252 scopus 로고    scopus 로고
    • Immunologic strategies for HIV-1 remission and eradication
    • Barouch DH, Deeks SG. Immunologic strategies for HIV-1 remission and eradication. Science 2014;345:169-174.
    • (2014) Science , vol.345 , pp. 169-174
    • Barouch, D.H.1    Deeks, S.G.2
  • 24
    • 84891827613 scopus 로고    scopus 로고
    • Emerging strategies to deplete the HIV reservoir
    • Archin NM, Margolis DM. Emerging strategies to deplete the HIV reservoir. Curr Opin Infect Dis 2014;27:29-35.
    • (2014) Curr Opin Infect Dis , vol.27 , pp. 29-35
    • Archin, N.M.1    Margolis, D.M.2
  • 25
    • 84864243685 scopus 로고    scopus 로고
    • HIV: Shock and kill
    • Deeks SG. HIV: shock and kill. Nature 2012;487:439-440.
    • (2012) Nature , vol.487 , pp. 439-440
    • Deeks, S.G.1
  • 26
    • 84934888820 scopus 로고    scopus 로고
    • Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineages
    • Immonen TT, Leitner T. Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineages. Retrovirology 2014;11:81.
    • (2014) Retrovirology , vol.11 , pp. 81
    • Immonen, T.T.1    Leitner, T.2
  • 27
    • 84904891621 scopus 로고    scopus 로고
    • Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapy
    • Wang S, Rong L. Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapy. J Theor Biol 2014;360:137-148.
    • (2014) J Theor Biol , vol.360 , pp. 137-148
    • Wang, S.1    Rong, L.2
  • 28
    • 84907240033 scopus 로고    scopus 로고
    • Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1
    • Hill AL, Rosenbloom DI, Fu F, et al. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc Natl Acad Sci U S A 2014;111:13475-13480. This study sets a quantitative goal for the 'shock and kill' strategies.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 13475-13480
    • Hill, A.L.1    Rosenbloom, D.I.2    Fu, F.3
  • 29
    • 84911468121 scopus 로고    scopus 로고
    • Modeling the timing of antilatency drug administration during HIV treatment
    • Petravic J, Martyushev A, Reece JC, et al. Modeling the timing of antilatency drug administration during HIV treatment. J Virol 2014;88:14050-14056.
    • (2014) J Virol , vol.88 , pp. 14050-14056
    • Petravic, J.1    Martyushev, A.2    Reece, J.C.3
  • 30
    • 84908316840 scopus 로고    scopus 로고
    • Quantifying the turnover of transcriptional subclasses of HIV-1-infected cells
    • Althaus CL, Joos B, Perelson AS, Gunthard HF. Quantifying the turnover of transcriptional subclasses of HIV-1-infected cells. PLoS Comput Biol 2014;10:e1003871.
    • (2014) PLoS Comput Biol , vol.10 , pp. e1003871
    • Althaus, C.L.1    Joos, B.2    Perelson, A.S.3    Gunthard, H.F.4
  • 32
    • 84874589177 scopus 로고    scopus 로고
    • Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microrna expression patterns and candidate novel microRNAs differentially expressed upon infection
    • Chang ST, Thomas MJ, Sova P, et al. Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microrna expression patterns and candidate novel microRNAs differentially expressed upon infection. MBio 2013;4:e00549-e00612.
    • (2013) MBio , vol.4 , pp. e00549-e00612
    • Chang, S.T.1    Thomas, M.J.2    Sova, P.3
  • 33
    • 80052041081 scopus 로고    scopus 로고
    • Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell
    • Lefebvre G, Desfarges S, Uyttebroeck F, et al. Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell. J Virol 2011;85:6205-6211.
    • (2011) J Virol , vol.85 , pp. 6205-6211
    • Lefebvre, G.1    Desfarges, S.2    Uyttebroeck, F.3
  • 34
    • 84875082482 scopus 로고    scopus 로고
    • 24 h in the life of HIV-1 in a T cell line
    • Mohammadi P, Desfarges S, Bartha I, et al. 24 h in the life of HIV-1 in a T cell line. PLoS Pathog 2013;9:e1003161.
    • (2013) PLoS Pathog , vol.9 , pp. e1003161
    • Mohammadi, P.1    Desfarges, S.2    Bartha, I.3
  • 36
    • 84908068309 scopus 로고    scopus 로고
    • A proteomic glimpse into the initial global epigenetic changes during HIV infection
    • Britton LM, Sova P, Belisle S, et al. A proteomic glimpse into the initial global epigenetic changes during HIV infection. Proteomics 2014;14:2226-2230.
    • (2014) Proteomics , vol.14 , pp. 2226-2230
    • Britton, L.M.1    Sova, P.2    Belisle, S.3
  • 37
    • 84904908879 scopus 로고    scopus 로고
    • Deep sequencing of HIV-infected cells: Insights into nascent transcription and host-directed therapy
    • Peng X, Sova P, Green RR, et al. Deep sequencing of HIV-infected cells: insights into nascent transcription and host-directed therapy. J Virol 2014;88:8768-8782.
    • (2014) J Virol , vol.88 , pp. 8768-8782
    • Peng, X.1    Sova, P.2    Green, R.R.3
  • 38
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, et al. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat Med 2014;20:425-429. This study highlights posttranscriptional block and cellular activation status as components of latency.
    • (2014) Nat Med , vol.20 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.