Pitfalls in the diagnosis of central adrenal insufficiency in children

Endocrine Development

Volumn 17, Issue , 2009, Pages 96-107

  Kazlauskaite, Rasa ^a   Maghnie, Mohamad ^b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; INSULIN; METYRAPONE; PLASMA PROTEIN; TETRACOSACTIDE;

ADRENAL INSUFFICIENCY; ALGORITHM; ARTICLE; ASSAY; CHILD; CHRONIC DISEASE; CORTICOTROPIN TEST; DYNAMICS; HUMAN; HYPOPHYSIS DISEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN HYPOGLYCEMIA; LABORATORY TEST; LOW DRUG DOSE; MOBILIZATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RELIABILITY; RISK; SERUM; SLEEP PATTERN; STANDARDIZATION; SYSTEMIC CIRCULATION;

ADOLESCENT; ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; ALGORITHMS; ANTIMETABOLITES; CHILD; CHILD, PRESCHOOL; GLUCOSE TOLERANCE TEST; HUMANS; HYDROCORTISONE; INFANT; METYRAPONE; REFERENCE STANDARDS; ROC CURVE; YOUNG ADULT;

EID: 84925856036     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000262532     Document Type: Article

References (21)

1. Grinspoon SK, Biller BM: Clinical review 62: laboratory assessment of adrenal insufficiency. J Clin Endocrinol Metab 1994;79:923-931.
2. Hartzband PI, Van Herle AJ, Sorger L, Cope D: Assessment of hypothalamic-pituitary-adrenal (HPA) axis dysfunction: comparison of ACTH stimulation, insulin-hypoglycemia and metyrapone. J Endocrinol Invest 1988;11:769-776.
3. Wood JB, Frankland AW, James VH, Landon J: A rapid test of adrenocortical function. Lancet 1965; 191:243-245.
4. Kazlauskaite R, Evans AT, Villabona CV, Abdu TA, Ambrosi B, Atkinson AB, Choi CH, Clayton RN, Courtney CH, Gonc EN, Maghnie M, Rose SR, Soule SG, Tordjman K: Corticotropin tests for hypothalamic-pituitary adrenal insufficiency: a meta-analysis. J Clin Endocrinol Metab 2008;93: 4245-4253.
5. Ransohoff DF, Feinstein AR: Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med 1978;299:926-930.
6. Rose SR, Lustig RH, Burstein S, Pitukcheewanont P, Broome DC, Burghen GA: Diagnosis of ACTH deficiency: comparison of overnight metyrapone test to either low-dose or high-dose ACTH test. Horm Res 1999;52:73-79.
7. Gonc EN, Kandemir N, Kinik ST: Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. Horm Res 2003; 60:191-197.
8. Maghnie M, Uga E, Temporini F, Di Iorgi N, Secco A, Tinelli C, Papalia A, Casini MR, Loche S: Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamicpituitary disorders: comparison between insulininduced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests. Eur J Endocrinol 2005;152:735-741.
9. Nye EJ, Grice JE, Hockings GI, Strakosch CR, Crosbie GV, Walters MM, Jackson RV: Comparison of adrenocorticotropin (ACTH) stimulation tests and insulin hypoglycemia in normal humans: low dose, standard high dose, and 8-hour ACTH-(1-24) infusion tests. J Clin Endocrinol Metab 1999;84: 3648-3655.
10. Odagiri E, Naruse M, Terasaki K, Yamaguchi N, Jibiki K, Takagi S, Tanabe M, Takano K: The diagnostic standard of preclinical Cushings syndrome: evaluation of the dexamethasone suppression test using various cortisol kits. Endocr J 2004;51:295-302.
11. Clark PM, Neylon I, Raggatt PR, Sheppard MC, Stewart PM: Defining the normal cortisol response to the short Synacthen test: implications for the investigation of hypothalamic-pituitary disorders. Clin Endocrinol (Oxf) 1998;49:287-292.
12. Dickstein G, Shechner C, Nicholson WE, Rosner I, Shen-Orr Z, Adawi F, Lahav M: Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test. J Clin Endocrinol Metab 1991;72:773-778.
13. Park YJ, Park KS, Kim JH, Shin CS, Kim SY, Lee HK: Reproducibility of the cortisol response to stimulation with the low dose (1 microg) of ACTH. Clin Endocrinol (Oxf) 1999;51:153-158.
14. Murphy H, Livesey J, Espiner EA, Donald RA: The low dose ACTH test: a further word of caution. J Clin Endocrinol Metab 1998;83:712-713.
15. Oelkers W: The role of high- and low-dose corticotropin tests in the diagnosis of secondary adrenal insufficiency. Eur J Endocrinol 1998;139: 567-570.
16. Miller WA: Adrenal cortex; in Sperling MA (ed): Pediatric Endocrinology. Philadelphia, Saunders, 2008, p 461.
17. Nasrallah MP, Arafah BM: The value of dehydroepiandrosterone sulfate measurements in the assessment of adrenal function. J Clin Endocrinol Metab, 2003;88:5293-5298.
18. Fischli S, Jenni S, Allemann S, Zwahlen M, Diem P, Christ ER, Stettler C: Dehydroepiandrosterone sulfate in the assessment of the hypothalamic-pituitary- adrenal axis. J Clin Endocrinol Metab 2008;93: 539-542.
19. Vestergaard P, Hoeck HC, Jakobsen PE, Laurberg P: Reproducibility of growth hormone and cortisol responses to the insulin tolerance test and the short ACTH test in normal adults. Horm Metab Res 1997; 29:106-110.
20. Pfeifer M, Kanc K, Verhovec R, Kocijancic A: Reproducibility of the insulin tolerance test (ITT) for assessment of growth hormone and cortisol secretion in normal and hypopituitary adult men. Clin Endo crinol (Oxf) 2001;54:17-22.
21. Weintrob N, Sprecher E, Josefsberg Z, Weininger C, Aurbach-Klipper Y, Lazard D, Karp M, Pertzelan A: Standard and low-dose short adrenocorticotropin test compared with insulin-induced hypoglycemia for assessment of the hypothalamic-pituitary-adrenal axis in children with idiopathic multiple pituitary hormone deficiencies. J Clin Endocrinol Metab 1998;83:88-92.