Standard and low-dose short adrenocorticotropin test compared with insulin-induced hypoglycemia for assessment of the hypothalamic-pituitary- adrenal axis in children with idiopathic multiple pituitary hormone deficiencies

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 1, 1998, Pages 88-92

  Weintrob, Naomi ^a   Sprecher, Elliot ^b   Josefsberg, Zeev ^b   Weininger, Clara ^b   Aurbach Klipper, Yaffa ^b   Lazard, Daniel ^b   Karp, Moshe ^b   Pertzelan, Athalia ^b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN;

ADOLESCENT; ADRENAL INSUFFICIENCY; ARTICLE; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; ENZYME SPECIFICITY; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOGLYCEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IDIOPATHIC DISEASE; INSULIN RESISTANCE; MALE; PRIORITY JOURNAL; PROVOCATION TEST; RISK ASSESSMENT; STANDARD;

EID: 0031768102     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.83.1.4496     Document Type: Article

References (20)

1. August GP, Lippe BM, Blethen SL, et al. 1990 Growth hormone treatment in the United States: demographic and diagnostic features of 2331 children. J Pediatr. 116:899-903.
2. Rona RJ, Tanner JM. 1977 Aetiology of idiopathic growth hormone deficiency in England and Wales. Arch Dis Child. 52:197-208.
3. Rosenfeld RG, Albertsson-Wikland K, Cassorla F, et al. 1995 Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab. 80:1532-1540.
4. Grinspoon SK, Biller BMK. 1994 Laboratory assessment of adrenal insufficiency. J Clin Endocrinol Metab. 79:923-931.
5. Greenwood FC, Landon J, Stamp TCB. 1966 The plasma sugar, free fatty acid, cortisol and growth hormone response to insulin in control subjects. J Clin Invest. 45:429-436.
6. Shah A, Stanhope R, Matthew D. 1992 Hazards of pharmacological tests of growth hormone secretion in childhood. Br Med J. 304:173-174.
7. Fass B, Lippe BM, Kaplan SA. 1979 Relative usefulness of three growth hormone stimulation screening tests. Am J Dis Child. 133:931-933.
8. Gilad I, Topper E, Laron Z. 1979 Oral clonidine as a growth hormone stimulation test. Lancet. 2:278-280.
9. Borst GC, Michenfelder HJ, O'Briane JT. 1982 Discordant cortisol response to exogenous ACTH and insulin-induced hypoglycemia in patients with pituitary disease. N Engl J Med. 306:1301-1305.
10. Streeten DHP, Anderson GH, Bonaventura MM. 1996 The potential for serious consequences from misinterpreting normal responses to the rapid adrenocorticotropin test. J Clin Endocrinol Metab. 8:285-290.
11. Lindholm J, Kehlet H. 1987 Reevaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic-pituitary-adrenocortical function. Clin Endocrinol (Oxf). 26:53-59.
12. Clayton RN. 1996 Short synacthen test vs. insulin stress test for assessment of the hypothalamo-pituitary-adrenal axis: controversy revisited. Clin Endocrinol (Oxf). 44:147-149.
13. Dickstein G, Shechner C, Nicholson WE, et al. 1991 Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test. J Clin Endocrinol Metab. 72:773-778.
14. Crowley S, Hindmarsh PC, Holownia P, Honour JW, Brook CGD. 1991 The use of low doses of ACTH in the investigation of adrenal function in man. J Endocrinol. 130:475-479.
15. Tordjman K, Jaffe A, Grazas N, Apter C, Stern N. 1995 The role of the low dose (1 μcg) adrenocorticotropin test in the evaluation of patients with pituitary diseases. J Clin Endocrinol Metab. 80:1301-1305.
16. Broide J, Soferman R, Kivity S, et al. 1995 Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab. 80:1243-1246.
17. Rasmuson S, Olsson, Hagg E. 1996 A low dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol (Oxf). 44:151-156.
18. Taback SP, Dean HJ. 1996 Mortality in Canadian children with growth hormone (GH) deficiency receiving GH therapy 1962-1992. J Clin Endocrinol Metab. 81:1693-1696.
19. 1 24 corticotropin in man. J Clin Endocrinol Metab. 24:1206-1213.
20. Knutsson U, Dahlgren J, Marcus C, et al. 1997 Circadian cortisol rhythms in healthy boys and girls: relationship with age, growth, body composition, and pubertal development. J Clin Endocrinol Metab. 82:336-540.