Relationship between lipoprotein (a) and micro/macro complications In type 2 diabetes mellitus: A forgotten target

Journal of Geriatric Cardiology

Volumn 12, Issue 2, 2015, Pages 93-99

  Toro, Rocio ^a   Segura, Eduardo ^a,b   Nuñez Cortes, Jesús Millan ^c   Pedro Botet, Juan Carlos ^d   Quezada Feijoo, Maribel ^e   Mangas, Alipio ^a,b  

^a UNIVERSITY OF CÁDIZ   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e HOSPITAL CENTRAL DE LA CRUZ ROJA   (Spain)

Author keywords

Lipoprotein (a); Macrovascular complications; Risk factors; Type 2 diabetes

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; C PEPTIDE; CHOLESTEROL; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; ATHEROGENESIS; CARDIOVASCULAR RISK; CATARACT; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DESCRIPTIVE RESEARCH; DIABETIC ANGIOPATHY; DIABETIC MACROANGIOPATHY; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DIABETIC RETINOPATHY; DYSLIPIDEMIA; FEMALE; GLYCEMIC CONTROL; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OBSERVATIONAL STUDY; PERIPHERAL VASCULAR DISEASE; PROTEINURIA; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84925796428     PISSN: 16715411     EISSN: None     Source Type: Journal    
DOI: 10.11909/j.issn.1671-5411.2015.02.001     Document Type: Article

References (24)

1. Clarke R, Peden JF, Hopewell JC, et al. Genetic variants associated with Lp (a) lipoprotein level and coronary disease. N Engl J Med 2009;361:2518-2528.
2. El-Gendi SS, Bakeet MY, El-Hamed EA, et al. The value of lipoprotein (a), homocysteine, and Doppler of carotid and femoral arteries in assessment of atherosclerosis in asymptomatic cardiovascular risk patients. J Cardiol 2008;52:202-211.
3. Trégouët DA, König IR, Erdmann J, et al. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 2009;41:283-285.
4. Argraces KM, Korzasky KF, Fallon JJ, et al. The atherogenic lipoprotein Lp (a) is internalized and degraded in a process mediated by the VLDL receptor. J Clin Invest 1997;100:2170-2178.
5. Wu HD, Berglund L, Dimayuga C, et al. High lipoprotein (a) levels and small apolipoprotein (a) sizes are associated with endothelial dysfunction in a multiethnic cohort. J Am Coll Cardiol 2004;43(10):1828-1833.
6. Calmarza P, Vella JC. Lipids, lipoproteins and lipoprotein (a) isoformes in type 2 diabetic patients. J Cardiovas Risk 1999;6:171-175.
7. Hoogeveen RC, Gambhir JK, Gambhir DS, et al. Evaluation of Lp[a] and other independent risk factors for CHD in Asian Indians and their USA counterparts. J Lipid Res 2001;42:631-638.
8. Chasman DI, Shiffman D, Zee RY, et al. Polimorphism in the apolipoprotein (a) gene, plasma lipoprotein (a), cardiovascular disease, and low-dose aspirin therapy. Atherosclerosis 2009;203:371-376.
9. Suk Danik J, Rifai N, Buring JE, et al. Lipoprotein (a), measured with an assay independent of apolipoprotein (a) isoform size, and risk of future cardiovascular events among initially healthy women. JAMA 2006;296:1363-1370.
10. Ferre I, LLopart R, Moyano D, et al. Lipoprotein (a): its concentrations in children with insulin-dependent diabetes mellitus. Med Clin (Barc) 1995;104:565-567.
11. Tarkun I, Cetinarslan B, Cantürk Z. Lipoprotein (a) concentrations in patients with type 2 diabetes mellitus without cardiovascular disease: relationship to metabolic parameters and diabetic complications. Nutr Metab Cardiovasc Dis 2002;12:127-131.
12. Berglund L, Ramakrishnan R. Lipoprotein (a): an elusive cardiovascular risk factor. Arterioscler Thromb Vasc Biol 2004;24:2219-2226.
13. Haffner SM, Morales PA, Stern MP, et al. Lp (a) concentrations in NIDDM. Diabetes 1992;41:1267-1272.
14. Heller FR, Jamart J, Honore P, et al. Serum lipoprotein (a) in patients with diabetes mellitus. Diabetes Care 1993;16:819-823.
15. Kim SJ, Park YG, Kim JH, et al. Plasma fasting and nonfasting triglycerides and high-density lipoprotein cholesterol in atherosclerotic stroke: different profiles according to lowdensity lipoprotein cholesterol. Atherosclerosis 2012;223:463-467.
16. Makino K, Josephson MA, Feliner SK, et al. Plasma lipoprotein (a) levels in patiens having chronic renal failure with and without diabetes mellitus. Atherosclerosis 1993;98:255-256.
17. Aggarwal HK, Jain D, Lathar M, et al. Lipoprotein-A and carotid intima media thickness as cardiovascular risk factors in patients of chronic kidney disease. Ren Fail 2010;32:647-652.
18. Jensen JS, Borch-Johnsen K, Jens et al. Microalbuminuria reflects generalized transvascular albumin leakiness in clinically healthy subjects. Clin Sci (Lond). 1995;88:629-633.
19. Furtner M, Kiechl S, Mair A, et al. Urinary albumin excretion is independently associated with carotid and femoral artery atherosclerosis in the general population. Eur Heart J 2005;26:279-287.
20. Habib SS, Aslam M, Naveed AK, et al. Comparison of lipid profiles and lipoprotein a levels in patients with type 2 diabetes mellitus during oral hypoglycemic or insulin therapy. Saudi Med J 2006;27:174-180.
21. Scheer WD, Boudreau DA, Cook CB. Lipoprotein (a) levels in African-Americans with NIDDM. Diabetes Care 1996;16:742-747.
22. Lippi G, Targher G, Salvagno GL, et al. Relationship between lipoprotein (a) and fasting plasma glucose in the general population. Eur J Clin Invest 2007;37:826-827.
23. Haffner SM. Coronary heart disease in patients with diabetes. N Engl J Med 2000;342:1040-1042.
24. Qi Q, Qi L. Lipoprotein (a) and cardiovascular disease in diabetic patients. Clin Lipidol 2012;7:397-407.