High lipoprotein(a) levels and small apolipoprotein(a) sizes are associated with endothelial dysfunction in a multiethnic cohort

Journal of the American College of Cardiology

Volumn 43, Issue 10, 2004, Pages 1828-1833

  Wu, Henry D ^a   Berglund, Lars ^a   Dimayuga, Clarito ^a   Jones, Jeffery ^a   Sciacca, Robert R ^a   Di Tullio, Marco R ^a   Homma, Shunichi ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

apo(a); apolipoprotein(a); flow mediated dilation; FMD; HDL; high density lipoprotein; K4; kringle 4; LDL; lipoprotein(a); low density lipoprotein; Lp(a); nitrate induced dilation; NTG

Indexed keywords

LIPOPROTEIN A;

ADULT; AFRICAN AMERICAN; ARTERY DILATATION; ARTICLE; ATHEROGENESIS; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ECHOGRAPHY; ENDOTHELIUM LESION; ETHNIC DIFFERENCE; FEMALE; HUMAN; KRINGLE DOMAIN; MAJOR CLINICAL STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; AFRICAN AMERICANS; APOLIPOPROTEINS; APOPROTEIN(A); BRACHIAL ARTERY; DILATATION, PATHOLOGIC; ENDOTHELIUM, VASCULAR; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HISPANIC AMERICANS; HUMANS; LIPOPROTEIN(A); MALE; MIDDLE AGED; VASCULAR DISEASES;

EID: 2442510083     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2003.08.066     Document Type: Article

References (28)

1. Danesh J., Collins R., Peto R. Lipoprotein(a) and coronary heart disease Meta-analysis of prospective studies. Circulation. 102:2000;1082-1085
2. Jauhiainen M., Koskinen P., Ehnholm C., et al. Lipoprotein(a) and coronary heart disease risk A nested case-control study of the helsinki heart study participants. Atherosclerosis. 89:1991;59-67
3. Ridker P., Hennekens C.H., Stampfer M.J. A prospective study of lipoprotein(a) and the risk of myocardial infarction. JAMA. 270:1993;2195-2199
4. Alfthan G., Pekkanen J., Jauhiainen M., et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis. 106:1994;9-19
5. Sorrentino M.J., Vielhauer C., Eisenbart J.D., et al. Plasma lipoprotein(a) concentration and coronary artery disease in black patients compared with white patients. Am J Med. 93:1992;658-662
6. Moliterno D.J., Jokinen E.V., Miserez A.R., et al. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African Americans. Circ Res. 15:1995;850-855
7. Marcovina S.M., Albers J.J., Jacobs D.R. Jr, et al. Lipoprotein(a) concentrations and apolipoprotein(a) phenotypes in Caucasians and African Americans The cardia study. Arterioscler Thromb. 13:1993;1037-1045
8. Kraft H.G., Lingenhel A., Kochl S., et al. Apolipoprotein(a) kringle IV repeat number predicts risk for coronary artery disease. Arterioscler Thromb Vasc Biol. 16:1996;713-719
9. Sandholzer C., Saha N., Keark J.D., et al. Apo(a) isoforms predict risk for coronary artery disease A study in six populations. Arterioscler Thromb. 12:1992;1214-1226
10. Kronenberg F., Kronenberg M.F., Kiechl S., et al. Role of lipoprotein(a) and apolipoprotein(a) phenotype in atherogenesis Prospective results from the bruneck study. Circulation. 100:1999;1154-1160
11. Marcovina S.M., Albers J.J., Wijsman E., et al. Differences in Lp(a) concentrations and apo(a) polymorphs between black and white Americans. J Lipid Res. 37:1996;2569-2585
12. Paultre F., Pearson T.A., Weil H.F.C., et al. High levels of lipoprotein(a) carrying a small apolipoprotein(a) isoform is associated with coronary artery disease in both African American and Caucasian men. Arterioscler Thromb Vasc Biol. 20:2000;2619-2624
13. Ross R. The pathogenesis of atherosclerosis A perspective for the 1990s. Nature. 362:1993;801-809
14. Celermajer D.S., Sorensen K.E., Bull C., et al. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol. 24:1994;1468-1474
15. Sorensen K.E., Celermajer D.S., Georgakopolous D., et al. Impairment of endothelium dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest. 93:1994;27-36
16. Kamboth M.I., Ferrell R.E., Kottke B.A. Expressed hypervariable polymorphism of apolipoprotein(a). Am J Hum Genet. 87:1991;2153-2161
17. Schreiner P.J., Heiss G., Tyroler H.A., et al. Race and gender differences in the association of Lp(a) with carotid artery wall thickness The atherosclerosis risk in communities (aric) study. Arterioscler Thromb Vasc Biol. 16:1996;471-478
18. Paultre F., Tuck C.H., Bernadette B.A., et al. Relation of apo(a) size to carotid atherosclerosis in an elderly multiethnic population. Arterioscler Thromb Vasc Biol. 22:2002;141-146
19. Raitakari O.T., Adams M.R., Celermajer D.S. Effect of Lp(a) on the early functional and structural changes of atherosclerosis. Arterioscler Thromb Vasc Biol. 19:1999;990-995
20. Poon M., Zhang X., Dunsky K.G., et al. Apolipoprotein(a) induces monocyte chemotactic activity in human vascular endothelial cells. Circulation. 96:1997;2514-2519
21. Syrovets T., Thillet J., Chapman M.J., et al. Lipoprotein(a) is a potent chemoattractant for human peripheral monocytes. Blood. 90:1997;2027-2036
22. Takami S., Yamashita S., Kihara S., et al. Lipoprotein(a) enhances the expression of intercellular adhesion molecule-1 in cultured human umbilical vein endothelial cells. Circulation. 97:1998;721-728
23. Lawn R., Wade D., Hammer R., et al. Atherogenesis in transgenic mice expressing human apolipoprotein(a). Nature. 360:1992;670-672
24. Hervio L., Girard-Globa A., Durlach V., et al. The antifibrinolytic effect of lipoprotein(a) in heterozygous subjects is modulated by the relative concentration of each of the apolipoprotein(a) isoforms and their affinity for fibrin. Eur J Clin Invest. 26:1996;411-417
25. Leerink C.B., Duif P.F.C.C.M., Verhoeven N., et al. Apolipoprotein(a) isoform size influences binding of lipoprotein(a) to plasmin-modified des-AA-fibrinogen. Fibrinolysis. 8:1994;214-220
26. Paultre F, Tuck CH, Boden-Albala B, et al. Relation of apo(a) size to carotid atherosclerosis in an elderly multiethnic population. Arterioscler Thromb Vasc Biol 2002;21:141-6.
27. Anderson T.J., Uehata A., Gerhard M.D., et al. Close relationship of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 26:1995;1235-1241
28. Neunteufl T., Katzenschlager R., Hassan A., et al. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis. 129:1997;111-118