Reflections on mirror therapy: A systematic review of the effect of mirror visual feedback on the brain

Neurorehabilitation and Neural Repair

Volumn 29, Issue 4, 2015, Pages 349-361

  Deconinck, Frederik J A ^a,b   Smorenburg, Ana R P ^c   Benham, Alex ^d   Ledebt, Annick ^e   Feltham, Max G ^f   Savelsbergh, Geert J P ^e  

^a GHENT UNIVERSITY   (Belgium)

^b MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^c Burke Cornell Medical Research Institute   (United States)

^d BRADFORD INSTITUTE FOR HEALTH RESEARCH   (United Kingdom)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

cerebral palsy; hemiparesis; mirror; sensorimotor control; stroke; systematic review; visual feedback

Indexed keywords

ARTICLE; ATTENTION; BRAIN FUNCTION; CEREBROVASCULAR ACCIDENT; EXECUTIVE FUNCTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMISPHERIC DOMINANCE; HUMAN; INSULA; MIRROR NEURON; MIRROR VISUAL FEEDBACK; MIRROR VISUAL FEEDBACK THERAPY; MOTOR PERFORMANCE; MOVEMENT THERAPY; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NEUROIMAGING; NEUROMODULATION; PARIETAL CORTEX; POSTERIOR CINGULATE; POSTERIOR PARIETAL CORTEX; PRECUNEUS; PREFRONTAL CORTEX; PREMOTOR CORTEX; PRIMARY MOTOR CORTEX; SECONDARY SOMATOSENSORY CORTEX; SUPERIOR TEMPORAL GYRUS; SUPPLEMENTARY MOTOR AREA; SYLVIAN FISSURE; SYSTEMATIC REVIEW; VISUAL FEEDBACK; BRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PHYSIOTHERAPY; SENSORY FEEDBACK; STROKE;

BRAIN; FEEDBACK, SENSORY; HUMANS; MIRROR NEURONS; NEURONAL PLASTICITY; PHYSICAL THERAPY MODALITIES; STROKE;

EID: 84925767267     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968314546134     Document Type: Article

References (87)

1. Thompson P, Papadopoulou G, Vassiliou E. The origins of entasis: illusion, aesthetics or engineering?. Spat Vis. 2007 ; 20: 531-543
2. Gregory RL. Perceptual illusions and brain models. Proc R Soc Lond B Biol Sci. 1968 ; 171: 279-296
3. Ramachandran VS, Rogers-Ramachandran D, Cobb S. Touching the phantom limb. Nature. 1995 ; 377: 489-490
4. Von Holst E, Mittelstaedt H. The principle of reafference: interactions between the central nervous system and the peripheral organs. Naturwissenschaften. 1950 ; 37: 464-476
5. Von Helmholtz H Handbuch der physiologischen Optik. Leipzig, Germany: Voss ; 1867 :
6. Ramachandran VS, Hirstein W. The perception of phantom limbs (The D. O. Hebb lecture). Brain. 1998 ; 121: 1603-1630
7. Harris AJ. Cortical origin of pathological pain. Lancet. 1999 ; 354: 1464-1466
8. Gibson JJ. Observations on active touch. Psychol Rev. 1962 ; 69: 477-491
9. Mechsner F, Kerzel D, Knoblich G, Prinz W. Perceptual basis of bimanual coordination. Nature. 2001 ; 414: 69-73
10. Chan BL, Witt R, Charrow AP, et al. Mirror therapy for phantom limb pain. N Engl J Med. 2007 ; 357: 2206-2207
11. Darnall BD. Self-delivered home-based mirror therapy for lower limb phantom pain. Am J Phys Med Rehabil. 2009 ; 88: 78-81
12. Ramachandran VS, Altschuler EL. The use of visual feedback, in particular mirror visual feedback, in restoring brain function. Brain. 2009 ; 132 (pt 7). 1693-1710
13. Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C. Mirror therapy for improving motor function after stroke. Cochrane Database Syst Rev. 2012 ; (3). CD008449
14. Selles RW, Schreuders TAR, Stam HJ. Mirror therapy in patients with causalgia (complex regional pain syndrome type II) following peripheral nerve injury: two cases. J Rehabil Med. 2008 ; 40: 312-314
15. Karmakar A, Lieberman I. Mirror box therapy for complex regional pain syndrome. Anaesthesia. 2006 ; 61: 412-413
16. Tichelaar YIGV, Geertzen JHB, Keizer D, van Wilgen PC. Mirror box therapy added to cognitive behavioural therapy in three chronic complex regional pain syndrome type I patients: a pilot study. Int J Rehabil Res. 2007 ; 30: 181-188
17. Rosen B, Lundborg G. Training with a mirror in rehabilitation of the hand. Scand J Plast Reconstr Surg Hand Surg. 2005 ; 39: 104-108
18. McCabe CS, Haigh RC, Ring EFJ, Halligan PW, Wall PD, Blake DR. A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). Rheumatology. 2002 ; 42: 97-101
19. Sütbeyaz S, Yavuzer G, Sezer N, Koseoglu BF. Mirror therapy enhances lower-extremity motor recovery and motor functioning after stroke: a randomized controlled trial. Arch Phys Med Rehabil. 2007 ; 88: 555-559
20. Yavuzer G, Selles R, Sezer N, et al. Mirror therapy improves hand function in subacute stroke: a randomized controlled trial. Arch Phys Med Rehabil. 2008 ; 89: 393-398
21. Altschuler EL, Hu J. Mirror therapy in a patient with a fractured wrist and no active wrist extension. Scand J Plast Reconstr Surg Hand Surg. 2008 ; 42: 110-111
22. Gygax Jequier M, Schneider P, Newman CJ. Mirror therapy in children with hemiplegia: a pilot study. Dev Med Child Neurol. 2011 ; 53: 473-476
23. Brodie EE, Whyte A, Niven CA. Analgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a "virtual" limb upon phantom limb pain, sensation and movement. Eur J Pain. 2007 ; 11: 428-436
24. Cauraugh JH, Summers JJ. Neural plasticity and bilateral movements: a rehabilitation approach for chronic stroke. Prog Neurobiol. 2005 ; 75: 309-320
25. Buccino G, Solodkin A, Small SL. Functions of the mirror neuron system: implications for neurorehabilitation. Cogn Behav Neurol. 2006 ; 19: 55-63
26. Iacoboni M. Cortical mechanisms of human imitation. Science. 1999 ; 286: 2526-2528
27. Pomeroy VM, Clark CA, Miller JSG, Baron JC, Markus HS, Tallis RC. The potential for utilizing the "mirror neurone system" to enhance recovery of the severely affected upper limb early after stroke: a review and hypothesis. Neurorehabil Neural Repair. 2005 ; 19: 4-13
28. Stevens JA, Stoykov MEP. Using motor imagery in the rehabilitation of hemiparesis. Arch Phys Med Rehabil. 2003 ; 84: 1090-1092
29. Grèzes J, Decety J. Functional anatomy of execution, mental simulation, observation, and verb generation of actions: a meta-analysis. Hum Brain Mapp. 2001 ; 12: 1-19
30. Ezendam D, Bongers R, Jannink M. Systematic review of the effectiveness of mirror therapy in upper extremity function. Disabil Rehabil. 2009 ; 31: 2135-2149
31. Carr LJ, Harrison LM, Stephens JA. Evidence for bilateral innervation of certain homologous motoneurone pools in man. J Physiol. 1994 ; 475: 217-227
32. Staudt M, Grodd W, Gerloff C, Erb M, Stitz J, Krägeloh-Mann I. Two types of ipsilateral reorganization in congenital hemiparesis: a TMS and fMRI study. Brain. 2002 ; 125 (pt 10). 2222-2237
33. Schwerin S, Dewald JPA, Hatzi M, Jovanovich S, Nickeas M, MacKinnon C. Ipsilateral versus contralateral cortical motor projections to a shoulder adductor in chronic hemiparetic stroke: implications for the expression of arm synergies. Exp Brain Res. 2008 ; 185: 509-519
34. Benecke R, Meyer BU, Freund HJ. Reorganisation of descending motor pathways in patients after hemispherectomy and severe hemispheric lesions demonstrated by magnetic brain stimulation. Exp Brain Res. 1991 ; 83: 419-428
35. Dohle C, Püllen J, Nakaten A, Küst J, Rietz C, Karbe H. Mirror therapy promotes recovery from severe hemiparesis: a randomized controlled trial. Neurorehabil Neural Repair. 2009 ; 23: 209-217
36. Taub E, Crago JE, Uswatte G. Constraint-induced movement therapy: a new approach to treatment in physical rehabilitation. Rehabil Psychol. 1998 ; 43: 152-170
37. Diers M, Christmann C, Koeppe C, Ruf M, Flor H. Mirrored, imagined and executed movements differentially activate sensorimotor cortex in amputees with and without phantom limb pain. Pain. 2010 ; 149: 296-304
38. Dohle C, Kleiser R, Seitz RJ, Freund HJ. Body scheme gates visual processing. J Neurophysiol. 2004 ; 91: 2376-2379
39. Fritzsch C, Wang J, Dos Santos LF, Mauritz KH, Brunetti M, Dohle C. Different effects of the mirror illusion on motor and somatosensory processing. Restor Neurol Neurosci. 2013 ; 32: 269-280
40. Michielsen ME, Smits M, Ribbers GM, et al. The neuronal correlates of mirror therapy: an fMRI study on mirror induced visual illusions in patients with stroke. J Neurol Neurosurg Psychiatry. 2011 ; 82: 393-398
41. Shinoura N, Suzuki Y, Watanabe Y, et al. Mirror therapy activates outside of cerebellum and ipsilateral M1. NeuroRehabilitation. 2008 ; 23: 245-252
42. Wang J, Fritzsch C, Bernarding J, et al. A comparison of neural mechanisms in mirror therapy and movement observation therapy. J Rehabil Med. 2013 ; 45: 410-413
43. Wang J, Fritzsch C, Bernarding J, et al. Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects. NeuroRehabilitation. 2013 ; 33: 593-603
44. Hamzei F, Läppchen CH, Glauche V, Mader I, Rijntjes M, Weiller C. Functional plasticity induced by mirror training: the mirror as the element connecting both hands to one hemisphere. Neurorehabil Neural Repair. 2012 ; 26: 484-496
45. Michielsen ME, Selles RW, van der Geest JN, et al. Motor recovery and cortical reorganization after mirror therapy in chronic stroke patients: a phase II randomized controlled trial. Neurorehabil Neural Repair. 2011 ; 25: 223-233
46. Matthys K, Smits M, Van der Geest JN, et al. Mirror-induced visual illusion of hand movements: a functional magnetic resonance imaging study. Arch Phys Med Rehabil. 2009 ; 90: 675-681
47. Merians AS, Tunik E, Fluet GG, Qiu Q, Adamovich S V. Innovative approaches to the rehabilitation of upper extremity hemiparesis using virtual environments. Eur J Phys Rehabil Med. 2009 ; 45: 123-133
48. Hadoush H, Mano H, Sunagawa T, Nakanishi K, Ochi M. Optimization of mirror therapy to excite ipsilateral primary motor cortex. NeuroRehabilitation. 2013 ; 32: 617-624
49. Tominaga W, Matsubayashi J, Deguchi Y, et al. A mirror reflection of a hand modulates stimulus-induced 20-Hz activity. Neuroimage. 2009 ; 46: 500-504
50. Tominaga W, Matsubayashi J, Furuya M, et al. Asymmetric activation of the primary motor cortex during observation of a mirror reflection of a hand. PLoS One. 2011 ; 6 :
51. Wasaka T, Kakigi R. The effect of unpredicted visual feedback on activation in the secondary somatosensory cortex during movement execution. BMC Neurosci. 2012 ; 13 :
52. Wasaka T, Kakigi R. Conflict caused by visual feedback modulates activation in somatosensory areas during movement execution. Neuroimage. 2012 ; 59: 1501-1507
53. Touzalin-Chretien P, Ehrler S, Dufour A. Dominance of vision over proprioception on motor programming: evidence from ERP. Cereb Cortex. 2010 ; 20: 2007-2016
54. Bae SH, Jeong WS, Kim KY. Effects of mirror therapy on subacute stroke patients' brain waves and upper extremity functions. J Phys Ther Sci. 2012 ; 24: 1119-1122
55. Praamstra P, Torney L, Rawle CJ, Chris Miall R. Misconceptions about mirror-induced motor cortex activation. Cereb Cortex. 2011 ; 21: 1935-1940
56. Touzalin-Chretien P, Dufour A. Motor cortex activation induced by a mirror: evidence from lateralized readiness potentials. J Neurophysiol. 2008 ; 100: 19-23
57. Dohle C, Stephan KM, Valvoda JT, et al. Representation of virtual arm movements in precuneus. Exp Brain Res. 2011 ; 208: 543-555
58. Fink GR, Marshall JC, Halligan PW, et al. The neural consequences of conflict between intention and the senses. Brain. 1999 ; 122: 497-512
59. Imai I, Takeda K, Shiomi T, Taniguchi T, Kato H. Sensorimotor cortex activation during mirror therapy in healthy right-handed subjects: a study with near-infrared spectroscopy. J Phys Ther Sci. 2008 ; 20: 141-145
60. Mehnert J, Brunetti M, Steinbrink J, Niedeggen M, Dohle C. Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy. J Biomed Opt. 2013 ; 18: 66001
61. Laeppchen CH, Ringer T, Blessin J, et al. Optical illusion alters M1 excitability after mirror therapy - a TMS study. J Neurophysiol. 2012 ; 108: 2857-2861
62. Nojima I, Mima T, Koganemaru S, Thabit MN, Fukuyama H, Kawamata T. Human motor plasticity induced by mirror visual feedback. J Neurosci. 2012 ; 32: 1293-1300
63. Carson RG, Ruddy KL. Vision modulates corticospinal suppression in a functionally specific manner during movement of the opposite limb. J Neurosci. 2012 ; 32: 646-652
64. Funase K, Tabira T, Higashi T, Liang N, Kasai T. Increased corticospinal excitability during direct observation of self-movement and indirect observation with a mirror box. Neurosci Lett. 2007 ; 419: 108-112
65. Garry MI, Loftus A, Summers JJ. Mirror, mirror on the wall: viewing a mirror reflection of unilateral hand movements facilitates ipsilateral M1 excitability. Exp Brain Res. 2005 ; 163: 118-122
66. Kang YJ, Ku J, Kim HJ, Park HK. Facilitation of corticospinal excitability according to motor imagery and mirror therapy in healthy subjects and stroke patients. Ann Rehabil Med. 2011 ; 35: 747-758
67. Kang YJ, Park HK, Kim HJ, et al. Upper extremity rehabilitation of stroke: facilitation of corticospinal excitability using virtual mirror paradigm. J Neuroeng Rehabil. 2012 ; 9: 71
68. Fukumura K, Sugawara K, Tanabe S, Ushiba J, Tomita Y. Influence of mirror therapy on human motor cortex. Int J Neurosci. 2007 ; 117: 1039-1048
69. Bhasin A, Padma Srivastava M, Kumaran S, Bhatia R, Mohanty S. Neural interface of mirror therapy in chronic stroke patients: a functional magnetic resonance imaging study. Neurol India. 2013 ; 60: 570-576
70. Farrer C, Frith CD. Experiencing oneself vs another person as being the cause of an action: the neural correlates of the experience of agency. Neuroimage. 2002 ; 15: 596-603
71. Mima T, Nagamine T, Nakamura K, Shibasaki H. Attention modulates both primary and second somatosensory cortical activities in humans: a magnetoencephalographic study. J Neurophysiol. 1998 ; 80: 2215-2221
72. Hagmann P, Cammoun L, Gigandet X, et al. Mapping the structural core of human cerebral cortex. PLoS Biol. 2008 ; 6 :
73. Leech R, Braga R, Sharp DJ. Echoes of the brain within the posterior cingulate cortex. J Neurosci. 2012 ; 32: 215-222
74. Andersen RA. Encoding of intention and spatial location in the posterior parietal cortex. Cereb Cortex. 1995 ; 5: 457-469
75. Wenderoth N, Debaere F, Sunaert S, Swinnen SP. The role of anterior cingulate cortex and precuneus in the coordination of motor behaviour. Eur J Neurosci. 2005 ; 22: 235-246
76. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006 ; 129 (pt 3). 564-583
77. Schultz J, Imamizu H, Kawato M, Frith CD. Activation of the human superior temporal gyrus during observation of goal attribution by intentional objects. J Cogn Neurosci. 2004 ; 16: 1695-1705
78. Iacoboni M, Koski LM, Brass M, Bekkering H, Woods RP, Dubeau M. Reafferent copies of imitated actions in the right. Proc Natl Acad Sci USA. 2001 ; 98: 13995-13999
79. Schultz J, Friston KJ, O'Doherty J, Wolpert DM, Frith CD. Activation in posterior superior temporal sulcus parallels parameter inducing the percept of animacy. Neuron. 2005 ; 45: 625-635
80. Levy CE, Nichols DS, Schmalbrock PM, Keller P, Chakeres DW. Functional MRI evidence of cortical reorganization in upper-limb stroke hemiplegia treated with constraint-induced movement therapy. Am J Phys Med Rehabil. 2001 ; 80: 4-12
81. Liepert J, Bauder H, Miltner WHR, Taub E, Weiller C. Treatment-induced cortical reorganization after stroke in humans. Stroke. 2000 ; 31: 1210-1216
82. Calautti C, Baron JC. Functional neuroimaging studies of motor recovery after stroke in adults: a review. Stroke. 2003 ; 34: 1553-1566
83. Ward NS, Brown MM, Thompson AJ, Frackowiak RSJ. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain. 2003 ; 126 (pt 11). 2476-2496
84. Bullmore E, Sporns O. Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci. 2009 ; 10: 186-198
85. Feltham MG, Ledebt A, Bennett SJ, Deconinck FJA, Verheul MHG, Savelsbergh GJP. The "mirror box" illusion: effect of visual information on bimanual coordination in children with spastic hemiparetic cerebral palsy. Motor Control. 2010 ; 14: 68-82
86. Feltham MG, Ledebt A, Deconinck FJA, Savelsbergh GJP. Mirror visual feedback induces lower neuromuscular activity in children with spastic hemiparetic cerebral palsy. Res Dev Disabil. 2010 ; 31: 1525-1535
87. Smorenburg ARP, Ledebt A, Deconinck FJA, Savelsbergh GJP. Practicing a matching movement with a mirror in individuals with spastic hemiplegia. Res Dev Disabil. 2013 ; 34: 2507-2513