Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase

Nature Communications

Volumn 6, Issue , 2015, Pages

  Fenwick, Michael K ^a   Mehta, Angad P ^b   Zhang, Yang ^a   Abdelwahed, Sameh H ^b   Begley, Tadhg P ^b   Ealick, Steven E ^a  

^a Department of Chemistry and Chemical Biology Cornell University ^*  (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; METAL; PYRIMIDINE; RADICAL; S ADENOSYLMETHIONINE; SYNTHETASE; THIAMINE; BACTERIAL PROTEIN; COBAMAMIDE; IRON SULFUR PROTEIN; METHYLASPARTATE MUTASE; MUTASE; PYRIMIDINE DERIVATIVE; THIC PROTEIN, BACTERIA;

AMINO ACID; BIOCHEMISTRY; CATALYSIS; ENZYME ACTIVITY; RADICAL;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HYDROGEN BOND; NONHUMAN; X RAY FLUORESCENCE; BIOSYNTHESIS; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; COBAMIDES; CRYSTALLOGRAPHY, X-RAY; INTRAMOLECULAR TRANSFERASES; IRON-SULFUR PROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; S-ADENOSYLMETHIONINE; THIAMINE;

EID: 84925725808     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7480     Document Type: Article

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