Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation

ACS Chemical Neuroscience

Volumn 6, Issue 3, 2015, Pages 398-402

  Hare, Dominic J ^a,b,c   Doecke, James D ^d   Faux, Noel G ^b,e   Rembach, Alan ^b   Volitakis, Irene ^b   Fowler, Christopher J ^b,e   Grimm, Rudolf ^f   Doble, Philip A ^a   Cherny, Robert A ^b   Masters, Colin L ^b   Bush, Ashley I ^b   Roberts, Blaine R ^b,g  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d CSIRO   (Australia)

^e Department of Civil and Environmental Engineering   (Australia)

^f AGILENT TECHNOLOGIES   (United States)

^g Agilent Technologies ^*  (Australia)

Author keywords

Alzheimer's disease; iron; size exclusion chromatography inductively coupled plasma mass spectrometry; transferrin; transferrin saturation

Indexed keywords

IRON; TRANSFERRIN;

AGED; ALZHEIMER DISEASE; ANALYTICAL PARAMETERS; ARTICLE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; IRON BALANCE; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; MALE; MASS SPECTROMETRY; NEUROPATHOLOGY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TRANSFERRIN SATURATION; AUSTRALIA; BLOOD; CASE CONTROL STUDY; CHEMISTRY; METABOLISM; MIDDLE AGED; PLASMA; SIZE EXCLUSION CHROMATOGRAPHY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUSTRALIA; CASE-CONTROL STUDIES; CHROMATOGRAPHY, GEL; FEMALE; HUMANS; IRON; MALE; MASS SPECTROMETRY; MIDDLE AGED; PLASMA; PROSPECTIVE STUDIES; TRANSFERRIN;

EID: 84925682121     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5003557     Document Type: Article

References (36)

1. Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., and Crichton, R. R. (2004) Iron, brain ageing and neurodegenerative disorders Nat. Rev. Neurosci. 5, 863-873
2. Ward, R. J., Zucca, F. A., Duyn, J. H., and Crichton, R. R. (2014) The role of iron in brain ageing and neurodegenerative disorders Lancet Neurol. 13, 1045-1060
3. Hare, D., Ayton, S., Bush, A., and Lei, P. (2013) A delicate balance: Iron metabolism and diseases of the brain Front. Aging Neurosci. 5, 34
4. Barnham, K. J. and Bush, A. I. (2014) Biological metals and metal-targeting compounds in major neurodegenerative diseases Chem. Soc. Rev. 43, 6727-6749
5. Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, J. D. W., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., Nakamura, M., Nunomura, A., and Perry, G. (2010) Increased iron and free radical generation in preclinical alzheimer disease and mild cognitive impairment J. Alzheimer's Dis. 19, 363-372
6. Antharam, V., Collingwood, J. F., Bullivant, J.-P., Davidson, M. R., Chandra, S., Mikhaylova, A., Finnegan, M. E., Batich, C., Forder, J. R., and Dobson, J. (2012) High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron NeuroImage 59, 1249-1260
7. Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., and Bartzokis, G. (2013) Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging J. Alzheimer's Dis. 37, 127-136
8. Schrag, M., Mueller, C., Oyoyo, U., Smith, M. A., and Kirsch, W. M. (2011) Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion Prog. Neurobiol. 94, 296-306
9. Lopes da Silva, S., Vellas, B., Elemans, S., Luchsinger, J., Kamphuis, P., Yaffe, K., Sijben, J., Groenendijk, M., and Stijnen, T. (2014) Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis Alzheimer's Dementia 10, 485-502
10. Ellis, K. A., Bush, A. I., Darby, D., De Fazio, D., Foster, J., Hudson, P., Lautenschlager, N. T., Lenzo, N., Martins, R. N., Maruff, P., Masters, C., Milner, A., Pike, K., Rowe, C., Savage, G., Szoeke, C., Taddei, K., Villemagne, V., Woodward, M., Ames, D., and the AIBL Research Group (2009) The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease Int. Psychogeriatr. 21, 672-687
11. Rembach, A., Hare, D. J., Doecke, J. D., Burnham, S. C., Volitakis, I., Fowler, C. J., Cherny, R. A., McLean, C., Grimm, R., Martins, R., Ames, D., Masters, C. L., Bush, A. I., and Roberts, B. R. (2014) Decreased serum zinc is an effect of ageing and not Alzheimer's disease Metallomics 6, 1216-1219
12. Faux, N. G., Rembach, A., Wiley, J., Ellis, K. A., Ames, D., Fowler, C. J., Martins, R. N., Pertile, K. K., Rumble, R. L., Trounson, B., Masters, C. L., Bush, A. I., and The AIBL Research Group (2014) An anemia of Alzheimer's disease Mol. Psychiatry 19, 1227-1234
13. Loeffler, D. A., Connor, J. R., Juneau, P. L., Snyder, B. S., Kanaley, L., DeMaggio, A. J., Nguyen, H., Brickman, C. M., and LeWitt, P. A. (1995) Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions J. Neurochem. 65, 710-716
14. Connor, J. R., Menzies, S. L., St Martin, S. M., and Mufson, E. J. (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains J. Neurosci. Res. 31, 75-83
15. Doecke, J. D., Laws, S. M., Faux, N. G., Wilson, W., Burnham, S. C., Lam, C.-P., Mondal, A., Bedo, J., Bush, A. I., Brown, B., De Ruyck, K., Ellis, K. A., Fowler, C., Gupta, V. B., Head, R., Macaulay, S. L., Pertile, K., Rowe, C. C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C. L., Martins, R. N., and the Alzheimer's Disease Neuroimaging Initiative and Australian Imaging Biomarker and Lifestyle Research Group (2012) Blood-based protein biomarkers for diagnosis of Alzheimer disease Arch. Neurol. 69, 1318-1325
16. Squitti, R. (2012) Metals in Alzheimer's disease: A systemic perspective Front. Biosci. 17, 451-472
17. Tao, Y., Wang, Y., Rogers, J. T., and Wang, F. (2014) Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis J. Alzheimer's Dis. 42, 679-690
18. Bal, W., Sokołowska, M., Kurowska, E., and Faller, P. (2013) Binding of transition metal ions to albumin: Sites, affinities and rates Biochim. Biophys. Acta 1830, 5444-5455
19. Yamanishi, H., Iyama, S., Yamaguchi, Y., Kanakura, Y., and Iwatani, Y. (2003) Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity Clin. Chem. 49, 175-178
20. Green, J. M. (1996) A practical guide to analytical method validation Anal. Chem. 68, 305A-309A
21. Lehmann, D. J., Schuur, M., Warden, D. R., Hammond, N., Belbin, O., Kölsch, H., Lehmann, M. G., Wilcock, G. K., Brown, K., Kehoe, P. G., Morris, C. M., Barker, R., Coto, E., Alvarez, V., Deloukas, P., Mateo, I., Gwilliam, R., Combarros, O., Arias-Vásquez, A., Aulchenko, Y. S., Ikram, M. A., Breteler, M. M., van Duijn, C. M., Oulhaj, A., Heun, R., Cortina-Borja, M., Morgan, K., Robson, K., and Smith, A. D. (2012) Transferrin and HFE genes interact in Alzheimer's disease risk: The Epistasis Project Neurobiol. Aging 33, 202.e201-202.e213
22. Giambattistelli, F., Bucossi, S., Salustri, C., Panetta, V., Mariani, S., Siotto, M., Ventriglia, M., Vernieri, F., Dell'acqua, M. L., Cassetta, E., Rossini, P. M., and Squitti, R. (2012) Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease Neurobiol. Aging 33, 1633-1641
23. Ebrahimi, K. H., Hagedoorn, P.-L., and Hagen, W. R. (2012) A synthetic peptide with the putative iron binding motif of amyloid precursor protein (APP) does not catalytically oxidize iron PLoS One 7, e40287
24. Osaki, S., Johnson, D. A., and Frieden, E. (1966) The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum J. Biol. Chem. 241, 2746-2751
25. Rembach, A., Doecke, J. D., Roberts, B. R., Watt, A. D., Faux, N. G., Volitakis, I., Pertile, K. K., Rumble, R. L., Trounson, B. O., Fowler, C. J., Wilson, W., Ellis, K. A., Martins, R. N., Rowe, C. C., Villemagne, V. L., Ames, D., Masters, C. L., and Bush, A. I. (2013) Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease J. Alzheimer's Dis. 34, 171-182
26. Squitti, R., Simonelli, I., Ventriglia, M., Siotto, M., Pasqualetti, P., Rembach, A., Doecke, J., and Bush, A. I. (2014) Meta-analysis of serum non-ceruloplasmin copper in Alzheimer's disease J. Alzheimer's Dis. 38, 809-822
27. Ayton, S., Lei, P., Duce, J. A., Wong, B. X. W., Sedjahtera, A., Adlard, P. A., Bush, A. I., and Finkelstein, D. I. (2013) Ceruloplasmin dysfunction and therapeutic potential for Parkinson's disease Ann. Neurol. 73, 554-559
28. Brewer, G. J., Kanzer, S. H., Zimmerman, E. A., Celmins, D. F., Heckman, S. M., and Dick, R. (2010) Copper and ceruloplasmin abnormalities in Alzheimer's disease Am. J. Alzheimers Dis. Other Dementias 25, 490-497
29. Kristinsson, J., Snaedal, J., Torsdottir, G., and Jóhannesson, T. (2012) Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies Neuropsychiatr. Dis. Treat. 8, 515-521
30. Squitti, R., Quattrocchi, C. C., Salustri, C., and Rossini, P. M. (2008) Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease Prion 2, 23-27
31. Torsdottir, G., Kristinsson, J., Snaedal, J., and Jóhannesson, T. (2011) Ceruloplasmin and iron proteins in the serum of patients with Alzheimer's disease Dementia Geriatr. Cogn. Disord. Extra 1, 366-371
32. Twomey, P. J., Viljoen, A., House, I. M., Reynolds, T. M., and Wierzbicki, A. S. (2005) Relationship between serum copper, ceruloplasmin, and non-ceruloplasmin-bound copper in routine clinical practice Clin. Chem. 51, 1558-1559
33. Hellman, N. E. and Gitlin, J. D. (2002) Ceruloplasmin metabolism and function Annu. Rev. Nutr. 22, 439-458
34. Hare, D. J., Grubman, A., Ryan, T. M., Lothian, A., Liddell, J. R., Grimm, R., Matsuda, T., Doble, P. A., Cherny, R. A., Bush, A. I., White, A. R., Masters, C. L., and Roberts, B. R. (2013) Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry Metallomics 5, 1656-1662
35. Benjamini, Y. and Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing J. R. Stat. Soc. B 57, 289-300
36. Florkowski, C. M. (2008) Sensitivity, specificity, receiver-operating characteristic (ROC) curves and likelihood ratios: Communicating the performance of diagnostic tests Clin. Biochem. Rev. 29, S83