Elevated interferon-stimulated gene transcription in peripheral blood mononuclear cells occurs in patients infected with genotype 1 but not genotype 3 hepatitis C virus

Journal of Viral Hepatitis

Volumn 22, Issue 4, 2015, Pages 384-390

  Robinson, M W ^a,e   Swann, R ^a,b   Sigruener, A ^c   Barclay, S T ^d   Mills, P R ^b   McLauchlan, John ^a   Patel, Arvind H ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^d GLASGOW ROYAL INFIRMARY   (United Kingdom)

^e TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

genotype; HCV; IFN; interferon stimulated genes; transcriptomics

Indexed keywords

INTERFERON; LIPID;

ADULT; ARTICLE; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY LIVER; FEMALE; GENE INDUCTION; GENETIC TRANSCRIPTION; HEPATITIS C VIRUS GENOTYPE 1; HEPATITIS C VIRUS GENOTYPE 3; HUMAN; IMMUNE RESPONSE; MALE; MICROARRAY ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; CHRONIC HEPATITIS C; CLASSIFICATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; GENOTYPE; GREAT BRITAIN; HEPACIVIRUS; IMMUNOLOGY; LIPID METABOLISM; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOTYPE; GREAT BRITAIN; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPID METABOLISM; MALE; METABOLIC NETWORKS AND PATHWAYS; MICROARRAY ANALYSIS; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 84925642151     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12310     Document Type: Article

References (33)

1. Smith DB, Bukh J, Kuiken C, et al,. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource. Hepatology 2014; 59: 318-327.
2. Gravitz L,. A smouldering public-health crisis. Nature 2011; 474: S2-S4.
3. Harris KA, Gilham C, Mortimer PP, Teo CG,. The most prevalent hepatitis C virus genotypes in England and Wales are 3a and 1a. J Med Virol 1999; 58: 127-131.
4. Zeuzem S, Berg T, Moeller B, et al,. Expert opinion on the treatment of patients with chronic hepatitis C. J Viral Hepat 2009; 16: 75-90.
5. Fried MW, Shiffman ML, Reddy KR, et al,. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-982.
6. Lawitz E, Mangia A, Wyles D, et al,. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013; 368: 1878-1887.
7. Bochud P-Y, Cai T, Overbeck K, et al,. Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol 2009; 51: 655-666.
8. Mihm S, Fayyazi A, Hartmann H, Ramadori G,. Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype. Hepatology 1997; 25: 735-739.
9. Poynard T, Ratziu V, McHutchison J, et al,. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003; 38: 75-85.
10. Rubbia-Brandt L, Quadri R, Abid K, et al,. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 2000; 33: 106-115.
11. Yvan-Charvet L, Welch C, Pagler T, et al,. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation 2008; 118: 1837-1847.
12. Murphy AJ, Woollard KJ, Hoang A, et al,. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol 2008; 28: 2071-2077.
13. Bolen CR, Robek MD, Brodsky L, et al,. The blood transcriptional signature of chronic hepatitis C virus is consistent with an ongoing interferon-mediated antiviral response. J Interferon Cytokine Res 2013; 33: 15-23.
14. Kottilil S, Yan MY, Reitano KN, et al,. Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells. Hepatology 2009; 50: 34-45.
15. Boursier J, de Ledinghen V, Zarski J-P, et al,. Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive. Hepatology 2012; 55: 58-67.
16. Huang DW, Sherman BT, Lempicki R,. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
17. Schmittgen TD, Livak KJ,. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101-1108.
18. Sarasin-Filipowicz M, Oakeley EJ, Duong FHT, et al,. Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci USA 2008; 105: 7034-7039.
19. Nilsson NE, Kotarsky K, Owman C, Olde B,. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 2003; 303: 1047-1052.
20. Fensterl V, Sen GC,. The ISG56/IFIT1 gene family. J Interferon Cytokine Res 2011; 31: 71-78.
21. Waddell SJ, Popper SJ, Rubins KH, et al,. Dissecting interferon-induced transcriptional programs in human peripheral blood cells. PLoS One 2010; 5: e9753.
22. Chen L, Borozan I, Sun J, et al,. Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection. Gastroenterology 2010; 138: 1123-1133.
23. Pham TNQ, Lin DMH, Mulrooney-Cousins PM, et al,. Hepatitis C virus load and expression of a unique subset of cellular genes in circulating lymphoid cells differentiate non-responders from responders to pegylated interferon alpha-ribavirin treatment. J Med Virol 2013; 85: 441-448.
24. McGilvray I, Feld JJ, Chen L, et al,. Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype. Gastroenterology 2012; 142: 1122-1131.
25. Dill MT, Duong FHT, Vogt JE, et al,. Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C. Gastroenterology 2011; 140: 1021-1031.
26. Asselah T, Bieche I, Narguet S, et al,. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C. Gut 2008; 57: 516-524.
27. Dill MT, Makowska Z, Duong FHT, et al,. Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C. Gastroenterology 2012; 143: 777-786.
28. Francois-Newton V, Livingstone M, Payelle-Brogard B, Uzé G, Pellegrini S,. USP18 establishes the transcriptional and anti-proliferative interferon α/β differential. Biochem J 2012; 446: 509-516.
29. Park S-H, Rehermann B,. Immune responses to HCV and other hepatitis viruses. Immunity 2014; 40: 13-24.
30. Grebely J, Page K, Sacks-Davis R, et al,. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C Virus infection. Hepatology 2013; 59: 109-120.
31. Blackham S, Baillie A, Al-Hababi F, et al,. Gene expression profiling indicates the roles of host oxidative stress, apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus. J Virol 2010; 84: 5404-5414.
32. Woodhouse SD, Narayan R, Latham S, et al,. Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro. Hepatology 2010; 52: 443-453.
33. Clark PJ, Thompson AJ, Vock DM, et al,. Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. Hepatology 2012; 56: 49-56.