Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin

Arthritis Research and Therapy

Volumn 17, Issue 1, 2015, Pages

  Xu, Xingquan ^a   Shi, Dongquan ^a   Shen, Yeshuai ^a   Xu, Zhihong ^a   Dai, Jin ^a   Chen, Dongyang ^a   Teng, Huajian ^a   Jiang, Qing ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; DIMETHYL SULFOXIDE; GROWTH PROMOTOR; KARTOGENIN; UNCLASSIFIED DRUG; ANILIDE; PHTHALIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; FEMALE; FULL THICKNESS CARTILAGE DEFECT; HISTOLOGY; HYALINE CARTILAGE; IMMUNOHISTOCHEMISTRY; LESIONS AND DEFECTS; MICROFRACTURE; MODIFIED O DRISCOLL HISTOLOGIC SCORING SYTEM; NEW ZEALAND WHITE (RABBIT); NONHUMAN; RABBIT MODEL; SCORING SYSTEM; TISSUE REPAIR; ANIMAL; ARTICULAR CARTILAGE; FRACTURES, CARTILAGE; INJURIES; INTRAARTICULAR DRUG ADMINISTRATION; KNEE INJURIES; PATHOLOGY; PROCEDURES; RABBIT;

ANILIDES; ANIMALS; CARTILAGE, ARTICULAR; FEMALE; FRACTURES, CARTILAGE; INJECTIONS, INTRA-ARTICULAR; KNEE INJURIES; MODELS, ANIMAL; PHTHALIC ACIDS; RABBITS;

EID: 84925639999     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0537-1     Document Type: Article

References (33)

1. Chen FS, Frenkel S, Di Cesare P. Repair of articular cartilage defects: part II. Treatment options. Am J Orthop (Belle Mead NJ). 1999;28:88-96.
2. Steadman JR, Rodkey WG, Singleton SB, Briggs KK. Microfracture technique forfull-thickness chondral defects: Technique and clinical results. Oper Tech Orthop. 1997;7:300-4.
3. Krusche-Mandl I, Schmitt B, Zak L, Apprich S, Aldrian S, Juras V, et al. Long-term results 8 years after autologous osteochondral transplantation: 7 T gagCEST and sodium magnetic resonance imaging with morphological and clinical correlation. Osteoarthritis Cartilage. 2012;20:357-63.
4. Moreira-Teixeira LS, Georgi N, Leijten J, Wu L, Karperien M. Cartilage tissue engineering. Endocr Dev. 2011;21:102-15.
5. Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR. Clinical efficacy of the microfracture technique for articular cartilage repair in the knee an evidence-based systematic analysis. Am J Sports Med. 2009;37:2053-63.
6. Mithoefer K, Williams III RJ, Warren RF, Potter HG, Spock CR, Jones EC, et al. The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study. J Bone Joint Surg. 2005;87:1911-20.
7. Kreuz P, Steinwachs M, Erggelet C, Krause S, Konrad G, Uhl M, et al. Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage. 2006;14:1119-25.
8. Von Keudell A, Atzwanger J, Forstner R, Resch H, Hoffelner T, Mayer M. Radiological evaluation of cartilage after microfracture treatment: A long-term follow-up study. Eur J Radiol. 2012;81:1618-24.
9. Frisbie DD, Oxford JT, Southwood L, Trotter GW, Rodkey WG, Steadman JR, et al. Early events in cartilage repair after subchondral bone microfracture. Clin Orthop Relat Res. 2003;407:215-27.
10. Furukawa T, Eyre D, Koide S, Glimcher M. Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee. J Bone Joint Surg. 1980;62:79-89.
11. Steadman J, Rodkey W, Briggs K. Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes. J Knee Surg. 2002;15:170-6.
12. Gilbert JE. Current treatment options for the restoration of articular cartilage. Am J Knee Surg. 1997;11:42-6.
13. Steinwachs M, Guggi T, Kreuz P. Marrow stimulation techniques. Injury. 2008;39:26-31.
14. Milano G, Sanna Passino E, Deriu L, Careddu G, Manunta L, Manunta A, et al. The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model. Osteoarthritis Cartilage. 2010;18:971-80.
15. Power J, Hernandez P, Guehring H, Getgood A, Henson F. Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model. J Orthop Res. 2014;32:669-76.
16. Doral M, Bilge O, Batmaz G, Donmez G, Turhan E, Demirel M, et al. Treatment of osteochondral lesions of the talus with microfracture technique and postoperative hyaluronan injection. Knee Surg Sports Traumatol Arthrosc. 2012;20:1398-403.
17. Erggelet C, Endres M, Neumann K, Morawietz L, Ringe J, Haberstroh K, et al. Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants. J Orthop Res. 2009;27:1353-60.
18. Gille J, Schuseil E, Wimmer J, Gellissen J, Schulz A, Behrens P. Mid-term results of autologous matrix-induced chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surg Sports Traumatol Arthrosc. 2010;18:1456-64.
19. Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, et al. A stem cell-based approach to cartilage repair. Science. 2012;336:717-21.
20. Van Den Borne M, Raijmakers N, Vanlauwe J, Victor J, de Jong S, Bellemans J, et al. International Cartilage Repair Society (ICRS) and Oswestry macroscopic cartilage evaluation scores validated for use in Autologous Chondrocyte Implantation (ACI) and microfracture. Osteoarthritis Cartilage. 2007;15:1397-402.
21. O'Driscoll SW, Marx RG, Beaton DE, Miura Y, Gallay SH, Fitzsimmons JS. Validation of a simple histological-histochemical cartilage scoring system. Tissue Eng. 2001;7:313-20.
22. Zhang W, Chen J, Tao J, Jiang Y, Hu C, Huang L, et al. The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair. Biomaterials. 2013;34:713-23.
23. Shapiro F, Koide S, Glimcher M. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg. 1993;75:532-53.
24. Erggelet C, Neumann K, Endres M, Haberstroh K, Sittinger M, Kaps C. Regeneration of ovine articular cartilage defects by cell-free polymer-based implants. Biomaterials. 2007;28:5570-80.
25. Caplan AI. The mesengenic process. Clin Plast Surg. 1994;21:429-35.
26. Sekiya I, Ojima M, Suzuki S, Yamaga M, Horie M, Koga H, et al. Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis. J Orthop Res. 2012;30:943-9.
27. Khan IM, Francis L, Theobald PS, Perni S, Young RD, Prokopovich P, et al. In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials. 2013;34:1478-87.
28. Lee CH, Cook JL, Mendelson A, Moioli EK, Yao H, Mao JJ. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet. 2010;376:440-8.
29. Lo KW, Ashe KM, Kan HM, Laurencin CT. The role of small molecules in musculoskeletal regeneration. Regen Med. 2012;7:535-49.
30. Baker MP, Carr FJ. Pre-clinical considerations in the assessment of immunogenicity for protein therapeutics. Curr Drug Saf. 2010;5:308-13.
31. Blaich G, Janssen B, Roth G, Salfeld J. Overview: differentiating issues in the development of macromolecules compared with small molecules. In: Handbook of Pharmaceutical Biotechnology. 2007. p. 89-123.
32. WH Lo K, D Ulery B, Deng M, MAshe K, T Laurencin C. Current patents on osteoinductive molecules for bone tissue engineering. Recent Pat Biomed Eng. 2011;4:153-67.
33. Segar CE, E Ogle M, A Botchwey E. Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. Curr Pharm Des. 2013;19:3403-19.